YDR349C / YPS7

Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR349C / YPS7

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.64|P-value:7.68E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.23|P-value:2.85E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:5.21|P-value:2.79E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.43|P-value:1.25E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.07|P-value:5.28E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.35|P-value:6.95E-9 ID:SGTC_314|Compound:1671-0008|FD-Score:-2.90|P-value:9.78E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.33|P-value:3.25E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.33|P-value:3.29E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.24|P-value:4.98E-6 ID:SGTC_469|Compound:w7|FD-Score:3.40|P-value:2.07E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-2.93|P-value:8.81E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.26|P-value:3.66E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.72|P-value:5.54E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.86|P-value:1.99E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.93|P-value:8.67E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.91|P-value:9.19E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.54|P-value:1.19E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.42|P-value:2.06E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:4.18|P-value:6.87E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.19|P-value:4.68E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.64|P-value:7.75E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.53|P-value:1.24E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.64|P-value:7.66E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.18|P-value:4.81E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.31|P-value:3.65E-6 ID:SGTC_1715|Compound:st032160|FD-Score:3.30|P-value:3.12E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.01|P-value:9.06E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.30|P-value:3.12E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.76|P-value:4.54E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-3.52|P-value:8.86E-5 ID:SGTC_2120|Compound:5538279|FD-Score:4.27|P-value:4.43E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.63|P-value:5.38E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.06|P-value:7.66E-6 ID:SGTC_2254|Compound:7938975|FD-Score:3.59|P-value:9.53E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.91|P-value:1.54E-7 ID:SGTC_2333|Compound:9017922|FD-Score:3.21|P-value:4.34E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.47|P-value:1.08E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.15|P-value:5.40E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.65|P-value:7.57E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.28|P-value:2.33E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.56|P-value:1.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.67|P-value:6.96E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.22|P-value:4.05E-11 ID:SGTC_2699|Compound:st077704|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_2704|Compound:st078022|FD-Score:4.09|P-value:1.03E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.36|P-value:1.70E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.24|P-value:2.69E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.58|P-value:6.90E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-2.90|P-value:9.79E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.08|P-value:7.06E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.83|P-value:2.24E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.64|P-value:7.68E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.23|P-value:2.85E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:5.21|P-value:2.79E-8 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.43|P-value:1.25E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.07|P-value:5.28E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.35|P-value:6.95E-9 ID:SGTC_314|Compound:1671-0008|FD-Score:-2.90|P-value:9.78E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.33|P-value:3.25E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.33|P-value:3.29E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.24|P-value:4.98E-6 ID:SGTC_469|Compound:w7|FD-Score:3.40|P-value:2.07E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-2.93|P-value:8.81E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.26|P-value:3.66E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.72|P-value:5.54E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.86|P-value:1.99E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.93|P-value:8.67E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.91|P-value:9.19E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.54|P-value:1.19E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.42|P-value:2.06E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:4.18|P-value:6.87E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.19|P-value:4.68E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.64|P-value:7.75E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.53|P-value:1.24E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.64|P-value:7.66E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.18|P-value:4.81E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.31|P-value:3.65E-6 ID:SGTC_1715|Compound:st032160|FD-Score:3.30|P-value:3.12E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.01|P-value:9.06E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.30|P-value:3.12E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.76|P-value:4.54E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-3.52|P-value:8.86E-5 ID:SGTC_2120|Compound:5538279|FD-Score:4.27|P-value:4.43E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.63|P-value:5.38E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.06|P-value:7.66E-6 ID:SGTC_2254|Compound:7938975|FD-Score:3.59|P-value:9.53E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.91|P-value:1.54E-7 ID:SGTC_2333|Compound:9017922|FD-Score:3.21|P-value:4.34E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.47|P-value:1.08E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.15|P-value:5.40E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.65|P-value:7.57E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.28|P-value:2.33E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.56|P-value:1.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.67|P-value:6.96E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.22|P-value:4.05E-11 ID:SGTC_2699|Compound:st077704|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_2704|Compound:st078022|FD-Score:4.09|P-value:1.03E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.36|P-value:1.70E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.24|P-value:2.69E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.58|P-value:6.90E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-2.90|P-value:9.79E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.08|P-value:7.06E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.83|P-value:2.24E-5

Top fitness defect scores for YDR349C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 6.22 96.7 µM 4.05E-11 calcium & mitochondrial duress 145 2.47E-10
2 SGTC_151 3013-0144 5.21 2.3 µM 2.79E-8 iron homeostasis 8 9.59E-8
3 SGTC_2289 7946404 4.91 165.1 µM 1.54E-7 57 4.56E-7
4 SGTC_964 1287-0107 4.42 19.4 µM 2.06E-6 cell wall 28 4.90E-6
5 SGTC_345 1362-0200 4.33 395.0 µM 3.25E-6 10 7.43E-6
6 SGTC_453 enantio-paf c16 4.33 10.0 µM 3.29E-6 116 7.53E-6
7 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 4.31 67.5 µM 3.65E-6 27 8.26E-6
8 SGTC_2120 5538279 4.27 152.0 µM 4.43E-6 14 9.88E-6
9 SGTC_464 bw-b 70c 4.24 158.0 µM 4.98E-6 14 1.10E-5
10 SGTC_989 1501-0895 4.18 10.3 µM 6.87E-6 5 1.47E-5
11 SGTC_2704 st078022 4.09 71.1 µM 1.03E-5 11 2.14E-5
12 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.76 70.1 µM 4.54E-5 32 8.33E-5
13 SGTC_647 0140-0236 3.72 81.0 µM 5.54E-5 13 1.00E-4
14 SGTC_2675 theaflavin digallate 3.67 100.0 µM 6.96E-5 iron homeostasis 37 1.23E-4
15 SGTC_2642 cholecalciferol 3.65 100.0 µM 7.57E-5 24 1.33E-4
16 SGTC_1482 3346-2049 3.64 8.5 µM 7.66E-5 36 1.35E-4
17 SGTC_58 0957-0393 3.64 9.0 µM 7.68E-5 cell wall 408 1.35E-4
18 SGTC_1313 1220-0047 3.64 237.0 µM 7.75E-5 51 1.36E-4
19 SGTC_2254 7938975 3.59 95.2 µM 9.53E-5 64 1.65E-4
20 SGTC_1906 st060206 3.56 94.7 µM 1.08E-4 29 1.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.95E-16 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 1.59E-15 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.135 4.15E-15 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.133 9.25E-15 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.122 1.19E-12 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.118 7.26E-12 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.116 1.74E-11 YDR109C_p YDR109C_p hom Putative kinase
0.114 4.02E-11 YDL073W_p YDL073W_p hom Putative protein of unknown function; YDL073W is not an essential gene
0.112 7.25E-11 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.109 2.41E-10 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.108 2.97E-10 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.108 3.64E-10 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.106 7.36E-10 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.103 1.93E-9 YOR034C-A_p YOR034C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.103 2.24E-9 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p