YDR351W / SBE2

Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR351W / SBE2

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.92|P-value:5.79E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:4.01|P-value:3.62E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.29|P-value:5.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.20|P-value:1.32E-28 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.77|P-value:1.23E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.51|P-value:2.60E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.17|P-value:8.83E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:16.50|P-value:4.17E-60 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.30|P-value:5.63E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:4.58|P-value:3.06E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.80|P-value:8.56E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.27|P-value:6.07E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:9.08|P-value:1.46E-19 ID:SGTC_354|Compound:2783-3500|FD-Score:6.71|P-value:1.67E-11 ID:SGTC_360|Compound:0957-0399|FD-Score:6.54|P-value:5.19E-11 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.16|P-value:9.11E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.46|P-value:8.39E-11 ID:SGTC_515|Compound:4092-1064|FD-Score:3.15|P-value:9.24E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.25|P-value:6.61E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.62|P-value:1.36E-8 ID:SGTC_649|Compound:1123-0311|FD-Score:4.15|P-value:2.03E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.59|P-value:1.93E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.39|P-value:4.01E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.90|P-value:5.79E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:5.30|P-value:8.18E-8 ID:SGTC_896|Compound:0964-0007|FD-Score:3.31|P-value:5.26E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.54|P-value:2.35E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.20|P-value:7.69E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.72|P-value:1.19E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-5.14|P-value:1.90E-7 ID:SGTC_1296|Compound:1068-0102|FD-Score:4.47|P-value:5.04E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.14|P-value:2.12E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.36|P-value:4.48E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.80|P-value:8.50E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.44|P-value:3.33E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.38|P-value:4.12E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.46|P-value:3.16E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_1832|Compound:st054113|FD-Score:5.51|P-value:2.65E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.79|P-value:8.93E-5 ID:SGTC_1897|Compound:st060201|FD-Score:3.33|P-value:4.94E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.33|P-value:9.50E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.22|P-value:7.18E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.51|P-value:4.17E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.61|P-value:1.79E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.18|P-value:8.33E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.79|P-value:1.09E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.40|P-value:3.88E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.58|P-value:2.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.50|P-value:2.68E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.53|P-value:2.40E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.23|P-value:7.02E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.56|P-value:2.18E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.55|P-value:2.12E-8 ID:SGTC_2857|Compound:9024691|FD-Score:-5.61|P-value:1.49E-8 ID:SGTC_2859|Compound:9028643|FD-Score:5.64|P-value:1.24E-8 ID:SGTC_2912|Compound:7964298|FD-Score:5.17|P-value:1.58E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.39|P-value:7.25E-6 ID:SGTC_3227|Compound:9130768|FD-Score:-3.14|P-value:9.60E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.10|P-value:2.59E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.55|P-value:3.52E-6 ID:SGTC_3351|Compound:9150312|FD-Score:3.85|P-value:7.17E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:4.92|P-value:5.79E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:4.01|P-value:3.62E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.29|P-value:5.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.20|P-value:1.32E-28 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.77|P-value:1.23E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.51|P-value:2.60E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.17|P-value:8.83E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:16.50|P-value:4.17E-60 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.30|P-value:5.63E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:4.58|P-value:3.06E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.80|P-value:8.56E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.27|P-value:6.07E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:9.08|P-value:1.46E-19 ID:SGTC_354|Compound:2783-3500|FD-Score:6.71|P-value:1.67E-11 ID:SGTC_360|Compound:0957-0399|FD-Score:6.54|P-value:5.19E-11 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.16|P-value:9.11E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.46|P-value:8.39E-11 ID:SGTC_515|Compound:4092-1064|FD-Score:3.15|P-value:9.24E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.25|P-value:6.61E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.62|P-value:1.36E-8 ID:SGTC_649|Compound:1123-0311|FD-Score:4.15|P-value:2.03E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.59|P-value:1.93E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.39|P-value:4.01E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.90|P-value:5.79E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:5.30|P-value:8.18E-8 ID:SGTC_896|Compound:0964-0007|FD-Score:3.31|P-value:5.26E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.54|P-value:2.35E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.20|P-value:7.69E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.72|P-value:1.19E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-5.14|P-value:1.90E-7 ID:SGTC_1296|Compound:1068-0102|FD-Score:4.47|P-value:5.04E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.14|P-value:2.12E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.36|P-value:4.48E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.80|P-value:8.50E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.44|P-value:3.33E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.38|P-value:4.12E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.46|P-value:3.16E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_1832|Compound:st054113|FD-Score:5.51|P-value:2.65E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.79|P-value:8.93E-5 ID:SGTC_1897|Compound:st060201|FD-Score:3.33|P-value:4.94E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.33|P-value:9.50E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.22|P-value:7.18E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.51|P-value:4.17E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.61|P-value:1.79E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.18|P-value:8.33E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.79|P-value:1.09E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.40|P-value:3.88E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.58|P-value:2.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.50|P-value:2.68E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.53|P-value:2.40E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.23|P-value:7.02E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.56|P-value:2.18E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.55|P-value:2.12E-8 ID:SGTC_2857|Compound:9024691|FD-Score:-5.61|P-value:1.49E-8 ID:SGTC_2859|Compound:9028643|FD-Score:5.64|P-value:1.24E-8 ID:SGTC_2912|Compound:7964298|FD-Score:5.17|P-value:1.58E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.39|P-value:7.25E-6 ID:SGTC_3227|Compound:9130768|FD-Score:-3.14|P-value:9.60E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.10|P-value:2.59E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.55|P-value:3.52E-6 ID:SGTC_3351|Compound:9150312|FD-Score:3.85|P-value:7.17E-5

Top fitness defect scores for YDR351W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 16.50 40.9 µM 4.17E-60 cell wall 13 1.67E-61
2 SGTC_58 0957-0393 11.20 9.0 µM 1.32E-28 cell wall 62 3.02E-29
3 SGTC_351 caspofungin 9.08 25.0 nM 1.46E-19 cell wall 10 5.48E-20
4 SGTC_354 2783-3500 6.71 4.9 µM 1.67E-11 cell wall 14 9.76E-12
5 SGTC_360 0957-0399 6.54 1.0 µM 5.19E-11 cell wall 9 3.12E-11
6 SGTC_514 4466-0038 6.46 2.6 nM 8.39E-11 cell wall 62 5.09E-11
7 SGTC_2859 9028643 5.64 45.5 µM 1.24E-8 2 8.46E-9
8 SGTC_586 0957-0265 5.62 8.2 µM 1.36E-8 cell wall 20 9.30E-9
9 SGTC_1832 st054113 5.51 55.0 µM 2.65E-8 2 1.84E-8
10 SGTC_875 0709-0210 5.30 25.7 µM 8.18E-8 fatty acid desaturase (OLE1) 16 5.84E-8
11 SGTC_2912 7964298 5.17 10.9 µM 1.58E-7 cell wall 63 1.14E-7
12 SGTC_15 0266-0086 4.92 27.1 µM 5.79E-7 endomembrane recycling 34 4.32E-7
13 SGTC_305 1682-2595 4.58 20.8 µM 3.06E-6 RNA processing & uracil transport 14 2.37E-6
14 SGTC_3311 9131146 4.55 2.9 µM 3.52E-6 cell wall 96 2.74E-6
15 SGTC_2243 6634756 4.51 200.0 µM 4.17E-6 11 3.26E-6
16 SGTC_1296 1068-0102 4.47 11.9 µM 5.04E-6 8 3.96E-6
17 SGTC_3142 9086498 4.39 49.5 µM 7.25E-6 iron homeostasis 25 5.74E-6
18 SGTC_2021 4019055 4.33 173.0 µM 9.50E-6 endomembrane recycling 101 7.56E-6
19 SGTC_649 1123-0311 4.15 367.0 µM 2.03E-5 endomembrane recycling 62 1.64E-5
20 SGTC_1308 1187-1617 4.14 41.4 µM 2.12E-5 fatty acid desaturase (OLE1) 34 1.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.412 1.65E-137 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.377 1.42E-113 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.366 5.16E-107 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.354 1.03E-99 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.332 2.84E-87 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.317 3.72E-79 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.315 2.70E-78 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.315 6.72E-78 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.309 3.77E-75 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.307 3.84E-74 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.306 9.28E-74 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.305 3.90E-73 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.296 6.39E-69 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.285 7.31E-64 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.285 1.37E-63 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress