YDR353W / TRR1

Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR353W / TRR1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.79|P-value:9.99E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:8.70|P-value:2.96E-18 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.29|P-value:7.98E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.42|P-value:3.55E-4 ID:SGTC_57|Compound:miconazole|FD-Score:4.91|P-value:5.42E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:4.29|P-value:1.05E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:4.87|P-value:6.62E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.43|P-value:3.40E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:5.19|P-value:1.32E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:4.77|P-value:1.10E-6 ID:SGTC_394|Compound:menadione|FD-Score:4.03|P-value:3.11E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.32|P-value:4.86E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.68|P-value:1.71E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.18|P-value:4.20E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:3.50|P-value:2.56E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.97|P-value:4.07E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.49|P-value:2.71E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.17|P-value:8.29E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.95|P-value:4.49E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:3.92|P-value:4.89E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.27|P-value:5.88E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:5.41|P-value:4.00E-8 ID:SGTC_820|Compound:1582-0060|FD-Score:3.12|P-value:9.58E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.41|P-value:3.63E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.93|P-value:4.67E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.14|P-value:9.53E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.44|P-value:5.13E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.13|P-value:9.39E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.83|P-value:7.06E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.43|P-value:3.24E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.22|P-value:6.91E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:-3.47|P-value:3.02E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.61|P-value:1.78E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.35|P-value:5.60E-8 ID:SGTC_1638|Compound:st008370|FD-Score:-3.12|P-value:0.00100 ID:SGTC_1713|Compound:st033146|FD-Score:4.07|P-value:2.66E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.99|P-value:2.41E-19 ID:SGTC_1810|Compound:st050138|FD-Score:5.00|P-value:3.55E-7 ID:SGTC_1813|Compound:st051246|FD-Score:5.35|P-value:5.60E-8 ID:SGTC_1815|Compound:st051655|FD-Score:3.32|P-value:4.93E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.79|P-value:8.48E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.15|P-value:1.86E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.03|P-value:3.20E-5 ID:SGTC_1977|Compound:st070720|FD-Score:-3.77|P-value:9.31E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-5.53|P-value:2.18E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.32|P-value:9.04E-6 ID:SGTC_2275|Compound:7947463|FD-Score:3.75|P-value:9.83E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.93|P-value:4.73E-5 ID:SGTC_2297|Compound:7971671|FD-Score:4.84|P-value:7.91E-7 ID:SGTC_2482|Compound:5981709|FD-Score:4.27|P-value:1.11E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.38|P-value:6.72E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:6.97|P-value:2.35E-12 ID:SGTC_2492|Compound:derrusnin|FD-Score:5.29|P-value:7.70E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.56|P-value:2.94E-6 ID:SGTC_2706|Compound:st078239|FD-Score:-3.35|P-value:4.63E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.15|P-value:1.89E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-5.27|P-value:8.87E-8 ID:SGTC_2810|Compound:7959871|FD-Score:6.08|P-value:8.08E-10 ID:SGTC_2811|Compound:7967822|FD-Score:4.17|P-value:1.70E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.80|P-value:8.20E-5 ID:SGTC_2842|Compound:9000675|FD-Score:5.15|P-value:1.63E-7 ID:SGTC_2844|Compound:9010103|FD-Score:4.47|P-value:4.59E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.47|P-value:2.82E-4 ID:SGTC_2984|Compound:9022109|FD-Score:4.95|P-value:4.52E-7 ID:SGTC_2991|Compound:9074669|FD-Score:4.62|P-value:2.24E-6 ID:SGTC_3045|Compound:9092950|FD-Score:-3.42|P-value:3.55E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.93|P-value:4.68E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.99|P-value:3.75E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.73|P-value:1.34E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.68|P-value:1.35E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.79|P-value:9.99E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:8.70|P-value:2.96E-18 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.29|P-value:7.98E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.42|P-value:3.55E-4 ID:SGTC_57|Compound:miconazole|FD-Score:4.91|P-value:5.42E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:4.29|P-value:1.05E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:4.87|P-value:6.62E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.43|P-value:3.40E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:5.19|P-value:1.32E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:4.77|P-value:1.10E-6 ID:SGTC_394|Compound:menadione|FD-Score:4.03|P-value:3.11E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.32|P-value:4.86E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.68|P-value:1.71E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.18|P-value:4.20E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:3.50|P-value:2.56E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.97|P-value:4.07E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.49|P-value:2.71E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.17|P-value:8.29E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.95|P-value:4.49E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:3.92|P-value:4.89E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.27|P-value:5.88E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:5.41|P-value:4.00E-8 ID:SGTC_820|Compound:1582-0060|FD-Score:3.12|P-value:9.58E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.41|P-value:3.63E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.93|P-value:4.67E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.14|P-value:9.53E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.44|P-value:5.13E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.13|P-value:9.39E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.83|P-value:7.06E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.43|P-value:3.24E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.22|P-value:6.91E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:-3.47|P-value:3.02E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.61|P-value:1.78E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.35|P-value:5.60E-8 ID:SGTC_1638|Compound:st008370|FD-Score:-3.12|P-value:0.00100 ID:SGTC_1713|Compound:st033146|FD-Score:4.07|P-value:2.66E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.99|P-value:2.41E-19 ID:SGTC_1810|Compound:st050138|FD-Score:5.00|P-value:3.55E-7 ID:SGTC_1813|Compound:st051246|FD-Score:5.35|P-value:5.60E-8 ID:SGTC_1815|Compound:st051655|FD-Score:3.32|P-value:4.93E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.79|P-value:8.48E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.15|P-value:1.86E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.03|P-value:3.20E-5 ID:SGTC_1977|Compound:st070720|FD-Score:-3.77|P-value:9.31E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-5.53|P-value:2.18E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.32|P-value:9.04E-6 ID:SGTC_2275|Compound:7947463|FD-Score:3.75|P-value:9.83E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.93|P-value:4.73E-5 ID:SGTC_2297|Compound:7971671|FD-Score:4.84|P-value:7.91E-7 ID:SGTC_2482|Compound:5981709|FD-Score:4.27|P-value:1.11E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.38|P-value:6.72E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:6.97|P-value:2.35E-12 ID:SGTC_2492|Compound:derrusnin|FD-Score:5.29|P-value:7.70E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.56|P-value:2.94E-6 ID:SGTC_2706|Compound:st078239|FD-Score:-3.35|P-value:4.63E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.15|P-value:1.89E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-5.27|P-value:8.87E-8 ID:SGTC_2810|Compound:7959871|FD-Score:6.08|P-value:8.08E-10 ID:SGTC_2811|Compound:7967822|FD-Score:4.17|P-value:1.70E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.80|P-value:8.20E-5 ID:SGTC_2842|Compound:9000675|FD-Score:5.15|P-value:1.63E-7 ID:SGTC_2844|Compound:9010103|FD-Score:4.47|P-value:4.59E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.47|P-value:2.82E-4 ID:SGTC_2984|Compound:9022109|FD-Score:4.95|P-value:4.52E-7 ID:SGTC_2991|Compound:9074669|FD-Score:4.62|P-value:2.24E-6 ID:SGTC_3045|Compound:9092950|FD-Score:-3.42|P-value:3.55E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.93|P-value:4.68E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.99|P-value:3.75E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.73|P-value:1.34E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.68|P-value:1.35E-4

Top fitness defect scores for YDR353W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1745 st081495 8.99 74.0 µM 2.41E-19 RNA processing & uracil transport 4 1.27E-19 0.14
2 SGTC_40 0327-0103 8.70 19.8 µM 2.96E-18 1 1.62E-18 2.87
3 SGTC_2490 carminic acid 6.97 95.4 µM 2.35E-12 1 1.61E-12 1.93
4 SGTC_457 grayanotoxin iii 6.18 135.0 µM 4.20E-10 8 3.13E-10 0.11
5 SGTC_2810 7959871 6.08 45.5 µM 8.08E-10 copper-dependent oxidative stress 4 6.07E-10 0.05
6 SGTC_781 4335-2806 5.41 94.4 µM 4.00E-8 1 3.20E-8 1.17
7 SGTC_1813 st051246 5.35 8.6 µM 5.60E-8 TSC3-RPN4 1 4.50E-8 1.00
8 SGTC_1597 7-benzyloxygramine 5.35 47.5 µM 5.60E-8 calcium & mitochondrial duress 40 4.50E-8 0.08
9 SGTC_2492 derrusnin 5.29 100.0 µM 7.70E-8 2 6.22E-8 0.89
10 SGTC_374 0880-0231 5.19 82.3 µM 1.32E-7 iron homeostasis 4 1.08E-7 0.12
11 SGTC_2842 9000675 5.15 19.5 µM 1.63E-7 4 1.33E-7 0.06
12 SGTC_1810 st050138 5.00 53.0 µM 3.55E-7 PDR1 1 2.94E-7 0.86
13 SGTC_649 1123-0311 4.95 367.0 µM 4.49E-7 endomembrane recycling 7 3.72E-7 0.21
14 SGTC_2984 9022109 4.95 39.0 µM 4.52E-7 1 3.76E-7 1.09
15 SGTC_57 miconazole 4.91 162.5 nM 5.42E-7 ergosterol depletion effects on membrane 18 4.51E-7 0.07
16 SGTC_363 0455-0021 4.87 3.1 µM 6.62E-7 azole & statin 13 5.52E-7 0.22
17 SGTC_2297 7971671 4.84 152.3 µM 7.91E-7 RNA processing & uracil transport 5 6.63E-7 0.20
18 SGTC_39 0986-0283 4.79 58.4 µM 9.99E-7 calcium & mitochondrial duress 7 8.40E-7 0.80
19 SGTC_384 k007-0144 4.77 5.2 µM 1.10E-6 ERAD & cell cycle 7 9.26E-7 0.02
20 SGTC_3152 9099253 4.73 49.5 µM 1.34E-6 NEO1-PIK1 18 1.13E-6 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.44E-18 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.137 1.86E-15 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.134 6.53E-15 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.92E-13 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.124 4.84E-13 YFL005W SEC4 het Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
0.121 2.42E-12 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.119 3.93E-12 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.112 8.11E-11 YCL043C PDI1 het Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
0.112 8.33E-11 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.110 1.94E-10 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.109 2.72E-10 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.108 3.23E-10 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.106 9.03E-10 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.100 6.26E-9 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.099 1.02E-8 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C