YDR354W / TRP4

Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR354W / TRP4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:21.20|P-value:2.44E-24 ID:SGTC_14|Compound:0354-0009|FD-Score:11.10|P-value:8.09E-8 ID:SGTC_17|Compound:0960-0276|FD-Score:8.72|P-value:2.03E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:6.81|P-value:7.21E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:15.80|P-value:3.18E-14 ID:SGTC_23|Compound:0213-0011|FD-Score:11.00|P-value:1.12E-7 ID:SGTC_24|Compound:0417-1663|FD-Score:11.50|P-value:2.77E-8 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:11.90|P-value:9.71E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:11.70|P-value:1.63E-8 ID:SGTC_50|Compound:0929-0078|FD-Score:19.40|P-value:1.54E-20 ID:SGTC_51|Compound:1013-0126|FD-Score:19.90|P-value:1.12E-21 ID:SGTC_57|Compound:miconazole|FD-Score:8.02|P-value:8.18E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-10.80|P-value:6.73E-8 ID:SGTC_129|Compound:0088-0017|FD-Score:19.50|P-value:7.44E-21 ID:SGTC_133|Compound:0724-0033|FD-Score:8.27|P-value:5.05E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:15.20|P-value:2.72E-13 ID:SGTC_161|Compound:4065-0411|FD-Score:9.75|P-value:2.13E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:7.48|P-value:2.27E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:10.60|P-value:2.50E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:16.90|P-value:4.04E-16 ID:SGTC_207|Compound:4185-0010|FD-Score:11.40|P-value:3.81E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:6.80|P-value:7.31E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:7.47|P-value:2.28E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:7.51|P-value:2.11E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:8.03|P-value:8.03E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.86|P-value:6.63E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:8.64|P-value:2.40E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:19.10|P-value:4.97E-20 ID:SGTC_507|Compound:nimesulide|FD-Score:10.40|P-value:4.79E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-6.26|P-value:9.87E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:14.20|P-value:9.17E-12 ID:SGTC_523|Compound:1934-0222|FD-Score:7.60|P-value:1.82E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:10.30|P-value:5.48E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:10.10|P-value:9.24E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:7.14|P-value:4.11E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:8.67|P-value:2.27E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:8.71|P-value:2.07E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:12.40|P-value:2.39E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:9.18|P-value:7.60E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:7.70|P-value:1.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.17|P-value:3.87E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:7.48|P-value:2.25E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:10.40|P-value:4.89E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.84|P-value:6.84E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:9.86|P-value:1.65E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:8.94|P-value:1.26E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:9.62|P-value:2.85E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:7.09|P-value:4.50E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-7.05|P-value:2.60E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:9.74|P-value:2.17E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:7.88|P-value:1.08E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:7.46|P-value:2.34E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.64|P-value:9.44E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:13.50|P-value:8.19E-11 ID:SGTC_933|Compound:2914-0560|FD-Score:16.30|P-value:4.09E-15 ID:SGTC_961|Compound:1252-1571|FD-Score:8.69|P-value:2.14E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:7.08|P-value:4.57E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:12.60|P-value:1.06E-9 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.01|P-value:1.09E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.74|P-value:8.02E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:13.10|P-value:3.01E-10 ID:SGTC_1047|Compound:2043-3044|FD-Score:7.31|P-value:3.06E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.24|P-value:5.32E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.70|P-value:8.59E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:8.71|P-value:2.06E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:8.15|P-value:6.36E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:8.48|P-value:3.32E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:19.50|P-value:1.02E-20 ID:SGTC_1114|Compound:scopoletin|FD-Score:9.10|P-value:8.98E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:9.47|P-value:4.04E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-8.35|P-value:2.11E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:7.01|P-value:5.15E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.91|P-value:6.06E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:7.56|P-value:1.96E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:11.10|P-value:7.85E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:10.30|P-value:6.44E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:11.20|P-value:6.61E-8 ID:SGTC_1336|Compound:1486-0901|FD-Score:6.66|P-value:9.20E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:8.57|P-value:2.78E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-7.22|P-value:1.89E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:7.93|P-value:9.67E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:10.30|P-value:5.38E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:14.90|P-value:8.73E-13 ID:SGTC_1496|Compound:4469-0713|FD-Score:9.29|P-value:5.94E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:8.35|P-value:4.33E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:10.10|P-value:9.80E-7 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:8.63|P-value:2.42E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:8.76|P-value:1.86E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:12.90|P-value:4.93E-10 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:11.10|P-value:7.17E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:13.30|P-value:1.59E-10 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:8.26|P-value:5.11E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:6.76|P-value:7.78E-4 ID:SGTC_1603|Compound:st002045|FD-Score:12.50|P-value:1.41E-9 ID:SGTC_1617|Compound:st002906|FD-Score:11.70|P-value:1.45E-8 ID:SGTC_1636|Compound:st007707|FD-Score:12.50|P-value:1.42E-9 ID:SGTC_1649|Compound:st011737|FD-Score:9.59|P-value:3.07E-6 ID:SGTC_1673|Compound:st016611|FD-Score:17.10|P-value:1.83E-16 ID:SGTC_1697|Compound:st025554|FD-Score:6.82|P-value:7.06E-4 ID:SGTC_1715|Compound:st032160|FD-Score:7.17|P-value:3.91E-4 ID:SGTC_1750|Compound:st081859|FD-Score:9.56|P-value:3.25E-6 ID:SGTC_1772|Compound:st048439|FD-Score:8.41|P-value:3.83E-5 ID:SGTC_1778|Compound:st046819|FD-Score:16.50|P-value:2.50E-15 ID:SGTC_1797|Compound:st048695|FD-Score:31.30|P-value:6.63E-51 ID:SGTC_1824|Compound:st053723|FD-Score:12.30|P-value:3.17E-9 ID:SGTC_1829|Compound:berberine|FD-Score:-8.19|P-value:2.90E-5 ID:SGTC_1835|Compound:st008666|FD-Score:9.96|P-value:1.29E-6 ID:SGTC_1838|Compound:st055369|FD-Score:6.86|P-value:6.57E-4 ID:SGTC_1881|Compound:5652484|FD-Score:12.00|P-value:6.90E-9 ID:SGTC_1882|Compound:5615643|FD-Score:10.70|P-value:2.03E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:14.10|P-value:1.07E-11 ID:SGTC_1933|Compound:st074711|FD-Score:7.07|P-value:4.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:9.60|P-value:2.99E-6 ID:SGTC_1937|Compound:st074714|FD-Score:8.75|P-value:1.89E-5 ID:SGTC_1952|Compound:st077036|FD-Score:13.20|P-value:1.76E-10 ID:SGTC_1955|Compound:wogonin|FD-Score:6.95|P-value:5.70E-4 ID:SGTC_1975|Compound:st070967|FD-Score:6.62|P-value:9.75E-4 ID:SGTC_1999|Compound:st074831|FD-Score:18.00|P-value:4.89E-18 ID:SGTC_2015|Compound:5119600|FD-Score:7.43|P-value:2.45E-4 ID:SGTC_2024|Compound:5144227|FD-Score:11.10|P-value:7.99E-8 ID:SGTC_2032|Compound:5185112|FD-Score:7.59|P-value:1.83E-4 ID:SGTC_2034|Compound:5197015|FD-Score:6.98|P-value:5.37E-4 ID:SGTC_2036|Compound:5160441|FD-Score:13.20|P-value:1.78E-10 ID:SGTC_2038|Compound:4100038|FD-Score:17.90|P-value:7.98E-18 ID:SGTC_2064|Compound:5220758|FD-Score:8.65|P-value:2.33E-5 ID:SGTC_2081|Compound:5214970|FD-Score:8.43|P-value:3.67E-5 ID:SGTC_2093|Compound:5331342|FD-Score:9.05|P-value:1.01E-5 ID:SGTC_2094|Compound:5332512|FD-Score:7.10|P-value:4.40E-4 ID:SGTC_2137|Compound:5261020|FD-Score:12.60|P-value:1.32E-9 ID:SGTC_2175|Compound:5807670|FD-Score:8.41|P-value:3.79E-5 ID:SGTC_2198|Compound:6589944|FD-Score:7.85|P-value:1.15E-4 ID:SGTC_2203|Compound:7227154|FD-Score:6.61|P-value:9.91E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:12.70|P-value:9.87E-10 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.28|P-value:3.22E-4 ID:SGTC_2254|Compound:7938975|FD-Score:9.93|P-value:1.39E-6 ID:SGTC_2286|Compound:7945697|FD-Score:7.20|P-value:3.72E-4 ID:SGTC_2296|Compound:7971656|FD-Score:12.10|P-value:4.82E-9 ID:SGTC_2299|Compound:7976368|FD-Score:9.74|P-value:2.16E-6 ID:SGTC_2301|Compound:7769476|FD-Score:13.80|P-value:2.88E-11 ID:SGTC_2304|Compound:7443016|FD-Score:8.47|P-value:3.37E-5 ID:SGTC_2312|Compound:7706453|FD-Score:8.45|P-value:3.51E-5 ID:SGTC_2322|Compound:7413319|FD-Score:9.18|P-value:7.63E-6 ID:SGTC_2384|Compound:9036245|FD-Score:12.00|P-value:7.17E-9 ID:SGTC_2403|Compound:6032726|FD-Score:7.38|P-value:2.70E-4 ID:SGTC_2437|Compound:5741531|FD-Score:7.88|P-value:1.07E-4 ID:SGTC_2445|Compound:5742597|FD-Score:9.28|P-value:6.15E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:10.30|P-value:5.83E-7 ID:SGTC_2472|Compound:5377652|FD-Score:10.60|P-value:2.44E-7 ID:SGTC_2478|Compound:5763493|FD-Score:17.30|P-value:7.95E-17 ID:SGTC_2486|Compound:5283202|FD-Score:18.00|P-value:6.62E-18 ID:SGTC_2488|Compound:5268135|FD-Score:25.90|P-value:2.51E-35 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.77|P-value:7.67E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:7.49|P-value:2.22E-4 ID:SGTC_2523|Compound:spermine|FD-Score:8.15|P-value:6.38E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:9.85|P-value:1.67E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:12.30|P-value:3.10E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:30.50|P-value:2.94E-48 ID:SGTC_2616|Compound:abietic acid|FD-Score:13.30|P-value:1.66E-10 ID:SGTC_2618|Compound:avocadyne|FD-Score:28.30|P-value:6.95E-42 ID:SGTC_2620|Compound:irigenin|FD-Score:11.70|P-value:1.50E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:9.94|P-value:1.37E-6 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:11.90|P-value:8.62E-9 ID:SGTC_2650|Compound:prasterone|FD-Score:10.50|P-value:3.57E-7 ID:SGTC_2669|Compound:eugenol|FD-Score:7.10|P-value:4.41E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:11.20|P-value:5.25E-8 ID:SGTC_2725|Compound:haloperidol|FD-Score:23.00|P-value:3.13E-28 ID:SGTC_2727|Compound:riluzole|FD-Score:6.99|P-value:5.35E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:14.90|P-value:8.46E-13 ID:SGTC_2735|Compound:sertaconazole|FD-Score:9.77|P-value:2.04E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:9.80|P-value:1.88E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:24.20|P-value:4.72E-31 ID:SGTC_2752|Compound:diclazuril|FD-Score:20.00|P-value:8.77E-22 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:24.70|P-value:2.03E-32 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.60|P-value:2.22E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:14.70|P-value:1.67E-12 ID:SGTC_2811|Compound:7967822|FD-Score:7.72|P-value:1.44E-4 ID:SGTC_2910|Compound:7948405|FD-Score:8.03|P-value:8.08E-5 ID:SGTC_2939|Compound:9044578|FD-Score:15.40|P-value:1.41E-13 ID:SGTC_2948|Compound:9070189|FD-Score:11.90|P-value:8.51E-9 ID:SGTC_2991|Compound:9074669|FD-Score:11.40|P-value:3.62E-8 ID:SGTC_2993|Compound:9054257|FD-Score:21.40|P-value:1.11E-24 ID:SGTC_3018|Compound:9082602|FD-Score:24.30|P-value:2.22E-31 ID:SGTC_3052|Compound:9092717|FD-Score:-6.40|P-value:7.97E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.37|P-value:2.76E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:9.13|P-value:8.55E-6 ID:SGTC_3091|Compound:9116372|FD-Score:6.77|P-value:7.66E-4 ID:SGTC_3152|Compound:9099253|FD-Score:9.85|P-value:1.68E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-10.70|P-value:7.95E-8 ID:SGTC_3284|Compound:9108171|FD-Score:7.18|P-value:3.81E-4 ID:SGTC_3308|Compound:9128332|FD-Score:20.40|P-value:1.29E-22 ID:SGTC_3348|Compound:9149464|FD-Score:12.70|P-value:9.62E-10 ID:SGTC_10|Compound:0279-0212|FD-Score:21.20|P-value:2.44E-24 ID:SGTC_14|Compound:0354-0009|FD-Score:11.10|P-value:8.09E-8 ID:SGTC_17|Compound:0960-0276|FD-Score:8.72|P-value:2.03E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:6.81|P-value:7.21E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:15.80|P-value:3.18E-14 ID:SGTC_23|Compound:0213-0011|FD-Score:11.00|P-value:1.12E-7 ID:SGTC_24|Compound:0417-1663|FD-Score:11.50|P-value:2.77E-8 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:11.90|P-value:9.71E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:11.70|P-value:1.63E-8 ID:SGTC_50|Compound:0929-0078|FD-Score:19.40|P-value:1.54E-20 ID:SGTC_51|Compound:1013-0126|FD-Score:19.90|P-value:1.12E-21 ID:SGTC_57|Compound:miconazole|FD-Score:8.02|P-value:8.18E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-10.80|P-value:6.73E-8 ID:SGTC_129|Compound:0088-0017|FD-Score:19.50|P-value:7.44E-21 ID:SGTC_133|Compound:0724-0033|FD-Score:8.27|P-value:5.05E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:15.20|P-value:2.72E-13 ID:SGTC_161|Compound:4065-0411|FD-Score:9.75|P-value:2.13E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:7.48|P-value:2.27E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:10.60|P-value:2.50E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:16.90|P-value:4.04E-16 ID:SGTC_207|Compound:4185-0010|FD-Score:11.40|P-value:3.81E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:6.80|P-value:7.31E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:7.47|P-value:2.28E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:7.51|P-value:2.11E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:8.03|P-value:8.03E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.86|P-value:6.63E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:8.64|P-value:2.40E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:19.10|P-value:4.97E-20 ID:SGTC_507|Compound:nimesulide|FD-Score:10.40|P-value:4.79E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-6.26|P-value:9.87E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:14.20|P-value:9.17E-12 ID:SGTC_523|Compound:1934-0222|FD-Score:7.60|P-value:1.82E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:10.30|P-value:5.48E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:10.10|P-value:9.24E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:7.14|P-value:4.11E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:8.67|P-value:2.27E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:8.71|P-value:2.07E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:12.40|P-value:2.39E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:9.18|P-value:7.60E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:7.70|P-value:1.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.17|P-value:3.87E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:7.48|P-value:2.25E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:10.40|P-value:4.89E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.84|P-value:6.84E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:9.86|P-value:1.65E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:8.94|P-value:1.26E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:9.62|P-value:2.85E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:7.09|P-value:4.50E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-7.05|P-value:2.60E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:9.74|P-value:2.17E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:7.88|P-value:1.08E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:7.46|P-value:2.34E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.64|P-value:9.44E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:13.50|P-value:8.19E-11 ID:SGTC_933|Compound:2914-0560|FD-Score:16.30|P-value:4.09E-15 ID:SGTC_961|Compound:1252-1571|FD-Score:8.69|P-value:2.14E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:7.08|P-value:4.57E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:12.60|P-value:1.06E-9 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.01|P-value:1.09E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.74|P-value:8.02E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:13.10|P-value:3.01E-10 ID:SGTC_1047|Compound:2043-3044|FD-Score:7.31|P-value:3.06E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.24|P-value:5.32E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.70|P-value:8.59E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:8.71|P-value:2.06E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:8.15|P-value:6.36E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:8.48|P-value:3.32E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:19.50|P-value:1.02E-20 ID:SGTC_1114|Compound:scopoletin|FD-Score:9.10|P-value:8.98E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:9.47|P-value:4.04E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-8.35|P-value:2.11E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:7.01|P-value:5.15E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.91|P-value:6.06E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:7.56|P-value:1.96E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:11.10|P-value:7.85E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:10.30|P-value:6.44E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:11.20|P-value:6.61E-8 ID:SGTC_1336|Compound:1486-0901|FD-Score:6.66|P-value:9.20E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:8.57|P-value:2.78E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-7.22|P-value:1.89E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:7.93|P-value:9.67E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:10.30|P-value:5.38E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:14.90|P-value:8.73E-13 ID:SGTC_1496|Compound:4469-0713|FD-Score:9.29|P-value:5.94E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:8.35|P-value:4.33E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:10.10|P-value:9.80E-7 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:8.63|P-value:2.42E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:8.76|P-value:1.86E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:12.90|P-value:4.93E-10 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:11.10|P-value:7.17E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:13.30|P-value:1.59E-10 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:8.26|P-value:5.11E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:6.76|P-value:7.78E-4 ID:SGTC_1603|Compound:st002045|FD-Score:12.50|P-value:1.41E-9 ID:SGTC_1617|Compound:st002906|FD-Score:11.70|P-value:1.45E-8 ID:SGTC_1636|Compound:st007707|FD-Score:12.50|P-value:1.42E-9 ID:SGTC_1649|Compound:st011737|FD-Score:9.59|P-value:3.07E-6 ID:SGTC_1673|Compound:st016611|FD-Score:17.10|P-value:1.83E-16 ID:SGTC_1697|Compound:st025554|FD-Score:6.82|P-value:7.06E-4 ID:SGTC_1715|Compound:st032160|FD-Score:7.17|P-value:3.91E-4 ID:SGTC_1750|Compound:st081859|FD-Score:9.56|P-value:3.25E-6 ID:SGTC_1772|Compound:st048439|FD-Score:8.41|P-value:3.83E-5 ID:SGTC_1778|Compound:st046819|FD-Score:16.50|P-value:2.50E-15 ID:SGTC_1797|Compound:st048695|FD-Score:31.30|P-value:6.63E-51 ID:SGTC_1824|Compound:st053723|FD-Score:12.30|P-value:3.17E-9 ID:SGTC_1829|Compound:berberine|FD-Score:-8.19|P-value:2.90E-5 ID:SGTC_1835|Compound:st008666|FD-Score:9.96|P-value:1.29E-6 ID:SGTC_1838|Compound:st055369|FD-Score:6.86|P-value:6.57E-4 ID:SGTC_1881|Compound:5652484|FD-Score:12.00|P-value:6.90E-9 ID:SGTC_1882|Compound:5615643|FD-Score:10.70|P-value:2.03E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:14.10|P-value:1.07E-11 ID:SGTC_1933|Compound:st074711|FD-Score:7.07|P-value:4.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:9.60|P-value:2.99E-6 ID:SGTC_1937|Compound:st074714|FD-Score:8.75|P-value:1.89E-5 ID:SGTC_1952|Compound:st077036|FD-Score:13.20|P-value:1.76E-10 ID:SGTC_1955|Compound:wogonin|FD-Score:6.95|P-value:5.70E-4 ID:SGTC_1975|Compound:st070967|FD-Score:6.62|P-value:9.75E-4 ID:SGTC_1999|Compound:st074831|FD-Score:18.00|P-value:4.89E-18 ID:SGTC_2015|Compound:5119600|FD-Score:7.43|P-value:2.45E-4 ID:SGTC_2024|Compound:5144227|FD-Score:11.10|P-value:7.99E-8 ID:SGTC_2032|Compound:5185112|FD-Score:7.59|P-value:1.83E-4 ID:SGTC_2034|Compound:5197015|FD-Score:6.98|P-value:5.37E-4 ID:SGTC_2036|Compound:5160441|FD-Score:13.20|P-value:1.78E-10 ID:SGTC_2038|Compound:4100038|FD-Score:17.90|P-value:7.98E-18 ID:SGTC_2064|Compound:5220758|FD-Score:8.65|P-value:2.33E-5 ID:SGTC_2081|Compound:5214970|FD-Score:8.43|P-value:3.67E-5 ID:SGTC_2093|Compound:5331342|FD-Score:9.05|P-value:1.01E-5 ID:SGTC_2094|Compound:5332512|FD-Score:7.10|P-value:4.40E-4 ID:SGTC_2137|Compound:5261020|FD-Score:12.60|P-value:1.32E-9 ID:SGTC_2175|Compound:5807670|FD-Score:8.41|P-value:3.79E-5 ID:SGTC_2198|Compound:6589944|FD-Score:7.85|P-value:1.15E-4 ID:SGTC_2203|Compound:7227154|FD-Score:6.61|P-value:9.91E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:12.70|P-value:9.87E-10 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.28|P-value:3.22E-4 ID:SGTC_2254|Compound:7938975|FD-Score:9.93|P-value:1.39E-6 ID:SGTC_2286|Compound:7945697|FD-Score:7.20|P-value:3.72E-4 ID:SGTC_2296|Compound:7971656|FD-Score:12.10|P-value:4.82E-9 ID:SGTC_2299|Compound:7976368|FD-Score:9.74|P-value:2.16E-6 ID:SGTC_2301|Compound:7769476|FD-Score:13.80|P-value:2.88E-11 ID:SGTC_2304|Compound:7443016|FD-Score:8.47|P-value:3.37E-5 ID:SGTC_2312|Compound:7706453|FD-Score:8.45|P-value:3.51E-5 ID:SGTC_2322|Compound:7413319|FD-Score:9.18|P-value:7.63E-6 ID:SGTC_2384|Compound:9036245|FD-Score:12.00|P-value:7.17E-9 ID:SGTC_2403|Compound:6032726|FD-Score:7.38|P-value:2.70E-4 ID:SGTC_2437|Compound:5741531|FD-Score:7.88|P-value:1.07E-4 ID:SGTC_2445|Compound:5742597|FD-Score:9.28|P-value:6.15E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:10.30|P-value:5.83E-7 ID:SGTC_2472|Compound:5377652|FD-Score:10.60|P-value:2.44E-7 ID:SGTC_2478|Compound:5763493|FD-Score:17.30|P-value:7.95E-17 ID:SGTC_2486|Compound:5283202|FD-Score:18.00|P-value:6.62E-18 ID:SGTC_2488|Compound:5268135|FD-Score:25.90|P-value:2.51E-35 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.77|P-value:7.67E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:7.49|P-value:2.22E-4 ID:SGTC_2523|Compound:spermine|FD-Score:8.15|P-value:6.38E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:9.85|P-value:1.67E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:12.30|P-value:3.10E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:30.50|P-value:2.94E-48 ID:SGTC_2616|Compound:abietic acid|FD-Score:13.30|P-value:1.66E-10 ID:SGTC_2618|Compound:avocadyne|FD-Score:28.30|P-value:6.95E-42 ID:SGTC_2620|Compound:irigenin|FD-Score:11.70|P-value:1.50E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:9.94|P-value:1.37E-6 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:11.90|P-value:8.62E-9 ID:SGTC_2650|Compound:prasterone|FD-Score:10.50|P-value:3.57E-7 ID:SGTC_2669|Compound:eugenol|FD-Score:7.10|P-value:4.41E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:11.20|P-value:5.25E-8 ID:SGTC_2725|Compound:haloperidol|FD-Score:23.00|P-value:3.13E-28 ID:SGTC_2727|Compound:riluzole|FD-Score:6.99|P-value:5.35E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:14.90|P-value:8.46E-13 ID:SGTC_2735|Compound:sertaconazole|FD-Score:9.77|P-value:2.04E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:9.80|P-value:1.88E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:24.20|P-value:4.72E-31 ID:SGTC_2752|Compound:diclazuril|FD-Score:20.00|P-value:8.77E-22 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:24.70|P-value:2.03E-32 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.60|P-value:2.22E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:14.70|P-value:1.67E-12 ID:SGTC_2811|Compound:7967822|FD-Score:7.72|P-value:1.44E-4 ID:SGTC_2910|Compound:7948405|FD-Score:8.03|P-value:8.08E-5 ID:SGTC_2939|Compound:9044578|FD-Score:15.40|P-value:1.41E-13 ID:SGTC_2948|Compound:9070189|FD-Score:11.90|P-value:8.51E-9 ID:SGTC_2991|Compound:9074669|FD-Score:11.40|P-value:3.62E-8 ID:SGTC_2993|Compound:9054257|FD-Score:21.40|P-value:1.11E-24 ID:SGTC_3018|Compound:9082602|FD-Score:24.30|P-value:2.22E-31 ID:SGTC_3052|Compound:9092717|FD-Score:-6.40|P-value:7.97E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.37|P-value:2.76E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:9.13|P-value:8.55E-6 ID:SGTC_3091|Compound:9116372|FD-Score:6.77|P-value:7.66E-4 ID:SGTC_3152|Compound:9099253|FD-Score:9.85|P-value:1.68E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-10.70|P-value:7.95E-8 ID:SGTC_3284|Compound:9108171|FD-Score:7.18|P-value:3.81E-4 ID:SGTC_3308|Compound:9128332|FD-Score:20.40|P-value:1.29E-22 ID:SGTC_3348|Compound:9149464|FD-Score:12.70|P-value:9.62E-10

Top fitness defect scores for YDR354W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1797 st048695 31.30 56.8 µM 6.63E-51 NEO1 1 1.37E-215
2 SGTC_2607 solasodine 30.50 47.4 µM 2.94E-48 3 4.25E-204
3 SGTC_2618 avocadyne 28.30 43.4 µM 6.95E-42 3 2.01E-176
4 SGTC_2488 5268135 25.90 45.7 µM 2.51E-35 1 5.94E-148
5 SGTC_2758 dehydroepiandrosterone 24.70 69.3 µM 2.03E-32 3 2.50E-135
6 SGTC_3018 9082602 24.30 49.5 µM 2.22E-31 2 7.99E-131
7 SGTC_2741 miltefosine 24.20 3.0 µM 4.72E-31 1 2.10E-129
8 SGTC_2725 haloperidol 23.00 53.2 µM 3.13E-28 plasma membrane duress 2 3.71E-117
9 SGTC_2993 9054257 21.40 71.4 µM 1.11E-24 fatty acid desaturase (OLE1) 3 9.22E-102
10 SGTC_10 0279-0212 21.20 42.6 µM 2.44E-24 TRP & mitochondrial translation 1 2.81E-100
11 SGTC_3308 9128332 20.40 17.6 µM 1.29E-22 plasma membrane duress 5 8.53E-93
12 SGTC_2752 diclazuril 20.00 33.1 µM 8.77E-22 3 3.41E-89
13 SGTC_51 1013-0126 19.90 23.4 µM 1.12E-21 1 9.92E-89
14 SGTC_129 0088-0017 19.50 176.6 µM 7.44E-21 3 3.62E-85
15 SGTC_1104 tacrolimus 19.50 29.8 µM 1.02E-20 1 1.40E-84
16 SGTC_50 0929-0078 19.40 56.4 µM 1.54E-20 1 8.51E-84
17 SGTC_505 gw-5074 19.10 63.9 µM 4.97E-20 2 1.36E-81
18 SGTC_1999 st074831 18.00 12.5 µM 4.89E-18 plasma membrane duress 2 5.87E-73
19 SGTC_2486 5283202 18.00 22.4 µM 6.62E-18 1 2.17E-72
20 SGTC_2038 4100038 17.90 31.0 µM 7.98E-18 plasma membrane duress 7 4.88E-72

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.779 0 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.739 0 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.717 0 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.704 0 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.633 0 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.622 0 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.583 1.16E-303 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.556 8.11E-271 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.555 3.46E-268 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.516 1.09E-226 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.475 2.10E-187 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.449 5.54E-165 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.332 9.31E-87 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.203 1.73E-32 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.200 1.27E-31 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p