YDR355C_d

Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR355C / YDR355C

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:2.93|P-value:2.67E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.01|P-value:1.66E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.70|P-value:7.10E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.89|P-value:2.09E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.65|P-value:8.03E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.49|P-value:1.63E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.19|P-value:7.91E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.04|P-value:8.54E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:2.62|P-value:9.89E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.78|P-value:3.94E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.85|P-value:3.78E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:2.71|P-value:6.86E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.83|P-value:4.05E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-3.76|P-value:3.85E-6 ID:SGTC_1744|Compound:st037937|FD-Score:2.68|P-value:7.63E-4 ID:SGTC_1921|Compound:5740136|FD-Score:2.76|P-value:5.52E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.28|P-value:2.01E-7 ID:SGTC_1927|Compound:st060202|FD-Score:4.16|P-value:4.30E-7 ID:SGTC_1935|Compound:st074532|FD-Score:2.84|P-value:4.01E-4 ID:SGTC_2113|Compound:5491891|FD-Score:2.65|P-value:8.71E-4 ID:SGTC_2282|Compound:7944268|FD-Score:2.93|P-value:2.64E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.29|P-value:1.86E-7 ID:SGTC_2463|Compound:5473429|FD-Score:2.93|P-value:2.61E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-5.02|P-value:1.22E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.62|P-value:9.35E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.78|P-value:5.15E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.73|P-value:4.41E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.33|P-value:3.75E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-5.09|P-value:6.98E-10 ID:SGTC_3284|Compound:9108171|FD-Score:2.77|P-value:5.25E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.35|P-value:3.63E-5 ID:SGTC_3320|Compound:9137005|FD-Score:2.69|P-value:7.43E-4 ID:SGTC_3325|Compound:9138760|FD-Score:2.94|P-value:2.60E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.93|P-value:2.67E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.01|P-value:1.66E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.70|P-value:7.10E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.89|P-value:2.09E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.65|P-value:8.03E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.49|P-value:1.63E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.19|P-value:7.91E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.04|P-value:8.54E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:2.62|P-value:9.89E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.78|P-value:3.94E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.85|P-value:3.78E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:2.71|P-value:6.86E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:2.83|P-value:4.05E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-3.76|P-value:3.85E-6 ID:SGTC_1744|Compound:st037937|FD-Score:2.68|P-value:7.63E-4 ID:SGTC_1921|Compound:5740136|FD-Score:2.76|P-value:5.52E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.28|P-value:2.01E-7 ID:SGTC_1927|Compound:st060202|FD-Score:4.16|P-value:4.30E-7 ID:SGTC_1935|Compound:st074532|FD-Score:2.84|P-value:4.01E-4 ID:SGTC_2113|Compound:5491891|FD-Score:2.65|P-value:8.71E-4 ID:SGTC_2282|Compound:7944268|FD-Score:2.93|P-value:2.64E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.29|P-value:1.86E-7 ID:SGTC_2463|Compound:5473429|FD-Score:2.93|P-value:2.61E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-5.02|P-value:1.22E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.62|P-value:9.35E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.78|P-value:5.15E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.73|P-value:4.41E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.33|P-value:3.75E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-5.09|P-value:6.98E-10 ID:SGTC_3284|Compound:9108171|FD-Score:2.77|P-value:5.25E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.35|P-value:3.63E-5 ID:SGTC_3320|Compound:9137005|FD-Score:2.69|P-value:7.43E-4 ID:SGTC_3325|Compound:9138760|FD-Score:2.94|P-value:2.60E-4

Top fitness defect scores for YDR355C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2444 5485484 4.29 36.4 µM 1.86E-7 6 8.76E-6 0.04
2 SGTC_1924 st058459 4.28 75.1 µM 2.01E-7 4 9.27E-6 0.08
3 SGTC_1927 st060202 4.16 13.8 µM 4.30E-7 5 1.60E-5 0.16
4 SGTC_1043 0916-0009 4.04 19.3 µM 8.54E-7 6 2.63E-5 0.31
5 SGTC_419 nsc-638432 3.89 893.0 µM 2.09E-6 DNA damage response 5 5.03E-5 0.32
6 SGTC_1140 3229-1848 3.78 3.0 µM 3.94E-6 5 7.95E-5 0.02
7 SGTC_2608 thymoquinone 3.62 42.7 µM 9.35E-6 4 1.49E-4 0.04
8 SGTC_3287 9117173 3.35 37.1 µM 3.63E-5 60S ribosome export 4 3.98E-4 0.68
9 SGTC_1035 k081-0041 3.19 55.2 µM 7.91E-5 Golgi 12 7.00E-4 0.01
10 SGTC_3325 9138760 2.94 55.2 µM 2.60E-4 Golgi 13 0.00167 0.00
11 SGTC_2463 5473429 2.93 200.0 µM 2.61E-4 ERG2 11 0.00167 0.01
12 SGTC_2282 7944268 2.93 200.0 µM 2.64E-4 RPP1 & pyrimidine depletion 17 0.00168 0.03
13 SGTC_46 0329-0187a 2.93 2.2 µM 2.67E-4 24 0.00170 0.01
14 SGTC_1224 0823-0416 2.85 294.0 µM 3.78E-4 10 0.00219 0.04
15 SGTC_1935 st074532 2.84 41.6 µM 4.01E-4 23 0.00229 0.05
16 SGTC_1475 4092-1048 2.83 11.7 µM 4.05E-4 plasma membrane duress 23 0.00230 0.02
17 SGTC_2625 euphol 2.78 100.0 µM 5.15E-4 25 0.00274 0.02
18 SGTC_3284 9108171 2.77 64.9 µM 5.25E-4 23 0.00278 0.01
19 SGTC_1921 5740136 2.76 50.0 µM 5.52E-4 TRP & mitochondrial translation 20 0.00289 0.10
20 SGTC_1420 4'-methoxyflavone 2.71 42.0 µM 6.86E-4 10 0.00338 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.77E-12 YDR365C ESF1 het Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
0.120 2.85E-12 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.114 3.28E-11 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.113 5.41E-11 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.113 5.94E-11 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.109 2.37E-10 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.109 2.92E-10 YPR194C OPT2 hom Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
0.108 3.90E-10 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.103 2.01E-9 YOL164W-A_p YOL164W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.103 2.38E-9 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.102 3.52E-9 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
0.100 6.88E-9 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.099 1.11E-8 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.097 1.64E-8 YGL227W VID30 hom Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
0.093 6.66E-8 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene