YDR356W / SPC110

Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR356W / SPC110

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:-3.82|P-value:2.36E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.10|P-value:4.25E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:-2.99|P-value:7.37E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.28|P-value:2.09E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.22|P-value:2.92E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.91|P-value:6.99E-8 ID:SGTC_761|Compound:k216-0224|FD-Score:3.39|P-value:1.36E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.12|P-value:4.03E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.17|P-value:3.69E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.05|P-value:5.19E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.93|P-value:8.09E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.22|P-value:3.02E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:2.99|P-value:6.44E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.16|P-value:3.43E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.08|P-value:5.24E-4 ID:SGTC_1774|Compound:st048371|FD-Score:2.97|P-value:6.94E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.14|P-value:4.07E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.36|P-value:4.38E-9 ID:SGTC_2029|Compound:5175081|FD-Score:2.91|P-value:8.64E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.04|P-value:5.46E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.27|P-value:2.47E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.12|P-value:4.01E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.38|P-value:1.59E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.27|P-value:2.18E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.03|P-value:5.52E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.69|P-value:2.89E-7 ID:SGTC_2487|Compound:5918373|FD-Score:-3.70|P-value:4.05E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.95|P-value:1.13E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:2.96|P-value:7.22E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.60|P-value:6.11E-5 ID:SGTC_2958|Compound:9077254|FD-Score:5.85|P-value:1.80E-10 ID:SGTC_2960|Compound:9079389|FD-Score:3.65|P-value:4.35E-5 ID:SGTC_2989|Compound:9073649|FD-Score:-2.93|P-value:9.21E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.92|P-value:8.47E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.57|P-value:6.21E-5 ID:SGTC_3102|Compound:9121669|FD-Score:3.13|P-value:3.88E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.14|P-value:3.73E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.21|P-value:3.10E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.15|P-value:3.49E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-2.96|P-value:7.99E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.48|P-value:9.26E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-3.56|P-value:7.33E-5 ID:SGTC_3342|Compound:9147791|FD-Score:-4.10|P-value:6.24E-6 ID:SGTC_3352|Compound:9151559|FD-Score:4.15|P-value:4.15E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.82|P-value:2.36E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.10|P-value:4.25E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:-2.99|P-value:7.37E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.28|P-value:2.09E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.22|P-value:2.92E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.91|P-value:6.99E-8 ID:SGTC_761|Compound:k216-0224|FD-Score:3.39|P-value:1.36E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.12|P-value:4.03E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.17|P-value:3.69E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.05|P-value:5.19E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.93|P-value:8.09E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.22|P-value:3.02E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:2.99|P-value:6.44E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.16|P-value:3.43E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.08|P-value:5.24E-4 ID:SGTC_1774|Compound:st048371|FD-Score:2.97|P-value:6.94E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.14|P-value:4.07E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.36|P-value:4.38E-9 ID:SGTC_2029|Compound:5175081|FD-Score:2.91|P-value:8.64E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.04|P-value:5.46E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.27|P-value:2.47E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.12|P-value:4.01E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.38|P-value:1.59E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.27|P-value:2.18E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.03|P-value:5.52E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.69|P-value:2.89E-7 ID:SGTC_2487|Compound:5918373|FD-Score:-3.70|P-value:4.05E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.95|P-value:1.13E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:2.96|P-value:7.22E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.60|P-value:6.11E-5 ID:SGTC_2958|Compound:9077254|FD-Score:5.85|P-value:1.80E-10 ID:SGTC_2960|Compound:9079389|FD-Score:3.65|P-value:4.35E-5 ID:SGTC_2989|Compound:9073649|FD-Score:-2.93|P-value:9.21E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.92|P-value:8.47E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.57|P-value:6.21E-5 ID:SGTC_3102|Compound:9121669|FD-Score:3.13|P-value:3.88E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.14|P-value:3.73E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.21|P-value:3.10E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.15|P-value:3.49E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-2.96|P-value:7.99E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.48|P-value:9.26E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-3.56|P-value:7.33E-5 ID:SGTC_3342|Compound:9147791|FD-Score:-4.10|P-value:6.24E-6 ID:SGTC_3352|Compound:9151559|FD-Score:4.15|P-value:4.15E-6

Top fitness defect scores for YDR356W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2958 9077254 5.85 16.7 µM 1.80E-10 1 2.52E-9 0.82
2 SGTC_2028 5153890 5.36 36.4 µM 4.38E-9 cell wall signaling 5 4.10E-8 0.59
3 SGTC_754 3474-0146 4.91 171.0 µM 6.99E-8 copper-dependent oxidative stress 2 4.63E-7 0.85
4 SGTC_421 streptovitacin 4.22 30.0 mM 2.92E-6 3 1.21E-5 0.73
5 SGTC_3352 9151559 4.15 45.6 µM 4.15E-6 1 1.65E-5 0.48
6 SGTC_2756 carbadox 3.95 75.1 µM 1.13E-5 22 3.97E-5 0.07
7 SGTC_2960 9079389 3.65 6.0 µM 4.35E-5 5 1.29E-4 0.58
8 SGTC_3087 9117406 3.57 49.5 µM 6.21E-5 4 1.77E-4 0.01
9 SGTC_3285 9112818 3.48 20.9 µM 9.26E-5 cell wall 23 2.51E-4 0.24
10 SGTC_761 k216-0224 3.39 480.0 µM 1.36E-4 9 3.51E-4 0.07
11 SGTC_2997 9067075 3.36 71.4 µM 1.50E-4 unfolded protein response 29 3.84E-4 0.00
12 SGTC_291 4130-1278 3.28 35.5 µM 2.09E-4 Golgi 11 5.13E-4 0.03
13 SGTC_2161 5662504 3.27 8.5 µM 2.18E-4 tubulin folding & SWR complex 14 5.33E-4 0.04
14 SGTC_1583 clindamycin 3.16 39.6 µM 3.43E-4 mitochondrial processes 14 7.93E-4 0.00
15 SGTC_3154 9100113 3.15 49.5 µM 3.49E-4 21 8.04E-4 0.03
16 SGTC_3116 9124943 3.14 49.5 µM 3.73E-4 7 8.53E-4 0.03
17 SGTC_3102 9121669 3.13 49.5 µM 3.88E-4 7 8.83E-4 0.03
18 SGTC_2131 toluylene red 3.12 5.3 µM 4.01E-4 60S ribosome export 24 9.09E-4 0.09
19 SGTC_891 0929-0073 3.12 133.0 µM 4.03E-4 7 9.13E-4 0.01
20 SGTC_208 k072-0098 3.10 12.4 µM 4.25E-4 heme biosynthesis & mitochondrial translocase 33 9.56E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.60E-9 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.099 8.21E-9 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.098 1.53E-8 YDR214W AHA1 hom Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
0.092 9.96E-8 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.092 1.07E-7 YJR084W YJR084W hom Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome
0.089 2.57E-7 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.088 3.41E-7 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.087 3.92E-7 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.085 8.30E-7 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.081 2.77E-6 YLR116W MSL5 het Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
0.079 4.87E-6 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 7.46E-6 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.076 9.63E-6 YER060W FCY21 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.075 1.49E-5 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.073 2.17E-5 YGR137W_d YGR137W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data