YDR358W / GGA1

Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR358W / GGA1

Click on Significant Values for Screen Details ID:SGTC_308|Compound:4092-1169|FD-Score:3.18|P-value:2.46E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.04|P-value:4.41E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.10|P-value:1.08E-8 ID:SGTC_382|Compound:3229-0966|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.96|P-value:5.99E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.21|P-value:2.16E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.34|P-value:7.98E-7 ID:SGTC_480|Compound:am 92016|FD-Score:-3.28|P-value:1.44E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.07|P-value:3.34E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.12|P-value:3.13E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.38|P-value:9.03E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.93|P-value:3.10E-8 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.18|P-value:2.16E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.23|P-value:1.72E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:4.25|P-value:1.53E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:3.37|P-value:1.13E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.40|P-value:9.85E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.54|P-value:4.55E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.36|P-value:9.97E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-2.89|P-value:6.91E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.08|P-value:3.28E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.31|P-value:9.44E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.89|P-value:6.97E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.88|P-value:8.12E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.39|P-value:1.01E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.79|P-value:9.95E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.36|P-value:1.00E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_1694|Compound:st024011|FD-Score:-3.08|P-value:3.20E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.05|P-value:4.20E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-2.99|P-value:4.66E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-2.97|P-value:4.96E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.50|P-value:5.45E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-3.68|P-value:2.36E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.98|P-value:6.28E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-5.75|P-value:1.04E-10 ID:SGTC_2052|Compound:5265182|FD-Score:-3.32|P-value:1.22E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.85|P-value:8.09E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.04|P-value:3.85E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-4.13|P-value:2.42E-6 ID:SGTC_2348|Compound:9022543|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.79|P-value:9.96E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.84|P-value:1.28E-5 ID:SGTC_2839|Compound:9003951|FD-Score:4.35|P-value:8.96E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.15|P-value:2.42E-4 ID:SGTC_2844|Compound:9010103|FD-Score:6.63|P-value:1.66E-13 ID:SGTC_3159|Compound:9100096|FD-Score:-2.85|P-value:7.97E-4 ID:SGTC_3163|Compound:9099914|FD-Score:-3.26|P-value:1.57E-4 ID:SGTC_3171|Compound:9103192|FD-Score:-2.90|P-value:6.57E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.38|P-value:1.09E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-4.36|P-value:7.25E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.18|P-value:2.46E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.04|P-value:4.41E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.10|P-value:1.08E-8 ID:SGTC_382|Compound:3229-0966|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.96|P-value:5.99E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.21|P-value:2.16E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.34|P-value:7.98E-7 ID:SGTC_480|Compound:am 92016|FD-Score:-3.28|P-value:1.44E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.07|P-value:3.34E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.12|P-value:3.13E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.38|P-value:9.03E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.93|P-value:3.10E-8 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.18|P-value:2.16E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.23|P-value:1.72E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:4.25|P-value:1.53E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:3.37|P-value:1.13E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.40|P-value:9.85E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.54|P-value:4.55E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.36|P-value:9.97E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-2.89|P-value:6.91E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.08|P-value:3.28E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.31|P-value:9.44E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.89|P-value:6.97E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.88|P-value:8.12E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.39|P-value:1.01E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.79|P-value:9.95E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.36|P-value:1.00E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_1694|Compound:st024011|FD-Score:-3.08|P-value:3.20E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.05|P-value:4.20E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-2.99|P-value:4.66E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-2.97|P-value:4.96E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.50|P-value:5.45E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-3.68|P-value:2.36E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.98|P-value:6.28E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-5.75|P-value:1.04E-10 ID:SGTC_2052|Compound:5265182|FD-Score:-3.32|P-value:1.22E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.85|P-value:8.09E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.04|P-value:3.85E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-4.13|P-value:2.42E-6 ID:SGTC_2348|Compound:9022543|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.79|P-value:9.96E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.84|P-value:1.28E-5 ID:SGTC_2839|Compound:9003951|FD-Score:4.35|P-value:8.96E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.15|P-value:2.42E-4 ID:SGTC_2844|Compound:9010103|FD-Score:6.63|P-value:1.66E-13 ID:SGTC_3159|Compound:9100096|FD-Score:-2.85|P-value:7.97E-4 ID:SGTC_3163|Compound:9099914|FD-Score:-3.26|P-value:1.57E-4 ID:SGTC_3171|Compound:9103192|FD-Score:-2.90|P-value:6.57E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.38|P-value:1.09E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-4.36|P-value:7.25E-7

Top fitness defect scores for YDR358W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2844 9010103 6.63 26.0 µM 1.66E-13 1 1.70E-11
2 SGTC_376 3970-0862 5.10 59.1 µM 1.08E-8 6 1.69E-7
3 SGTC_609 0986-0026 4.93 86.3 µM 3.10E-8 calcium & mitochondrial duress 10 4.06E-7
4 SGTC_2839 9003951 4.35 26.0 µM 8.96E-7 6 6.70E-6
5 SGTC_749 1000-0129 4.25 128.0 µM 1.53E-6 amide catabolism 14 1.05E-5
6 SGTC_736 0958-0254 4.23 92.6 µM 1.72E-6 Golgi 25 1.15E-5
7 SGTC_2021 4019055 3.98 173.0 µM 6.28E-6 endomembrane recycling 121 3.40E-5
8 SGTC_2758 dehydroepiandrosterone 3.84 69.3 µM 1.28E-5 40 6.18E-5
9 SGTC_811 0416-0114 3.40 265.0 µM 9.85E-5 43 3.40E-4
10 SGTC_1230 0170-0365 3.39 3.8 µM 1.01E-4 endomembrane recycling 101 3.48E-4
11 SGTC_3197 9113331 3.38 49.5 µM 1.09E-4 56 3.69E-4
12 SGTC_809 3998-0021 3.37 90.0 µM 1.13E-4 RNA processing & uracil transport 19 3.81E-4
13 SGTC_438 sphingosine 3.21 6.7 µM 2.16E-4 46 6.57E-4
14 SGTC_308 4092-1169 3.18 104.0 µM 2.46E-4 plasma membrane duress 86 7.32E-4
15 SGTC_495 decylubiquinone 3.12 155.0 µM 3.13E-4 copper-dependent oxidative stress 69 8.97E-4
16 SGTC_1673 st016611 3.08 27.3 µM 3.67E-4 90 0.00102
17 SGTC_382 3229-0966 3.08 23.2 µM 3.67E-4 52 0.00103
18 SGTC_1739 st037196 3.05 92.5 µM 4.20E-4 64 0.00115
19 SGTC_360 0957-0399 3.04 1.0 µM 4.41E-4 cell wall 93 0.00120
20 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 2.96 8.0 µM 5.99E-4 71 0.00155

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.90E-19 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.131 2.95E-14 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.117 8.75E-12 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.106 6.88E-10 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.104 1.65E-9 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.104 1.67E-9 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.102 3.11E-9 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.095 4.06E-8 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.089 2.18E-7 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.089 2.22E-7 YNR015W SMM1 hom Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
0.089 2.72E-7 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.37E-7 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.087 4.25E-7 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.084 1.25E-6 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.084 1.28E-6 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene