YDR359C / EAF1

Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR359C / EAF1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.72|P-value:2.71E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:3.58|P-value:3.00E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.26|P-value:9.10E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.31|P-value:7.86E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.05|P-value:2.46E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:7.97|P-value:5.03E-15 ID:SGTC_115|Compound:0527-0192|FD-Score:4.58|P-value:5.09E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:5.30|P-value:1.55E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:3.25|P-value:9.57E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.52|P-value:3.70E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.52|P-value:1.30E-10 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.49|P-value:4.22E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.08|P-value:4.69E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.64|P-value:1.26E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.74|P-value:8.38E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.14|P-value:7.72E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.36|P-value:3.51E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.08|P-value:9.26E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.95|P-value:1.53E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.48|P-value:8.12E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.14|P-value:4.79E-10 ID:SGTC_608|Compound:k048-0125|FD-Score:3.52|P-value:3.76E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.83|P-value:1.18E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:5.29|P-value:1.65E-7 ID:SGTC_799|Compound:1310-0557|FD-Score:3.49|P-value:4.17E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.19|P-value:2.79E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.69|P-value:1.91E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:4.07|P-value:4.50E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:5.28|P-value:1.67E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.76|P-value:1.55E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.35|P-value:6.88E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.53|P-value:3.67E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.36|P-value:6.44E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.30|P-value:7.90E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.47|P-value:8.40E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.65|P-value:2.33E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.41|P-value:1.08E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.24|P-value:9.78E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.95|P-value:7.46E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.01|P-value:5.81E-5 ID:SGTC_2414|Compound:st077232|FD-Score:5.09|P-value:4.48E-7 ID:SGTC_2415|Compound:st077333|FD-Score:5.51|P-value:4.98E-8 ID:SGTC_2416|Compound:tofa|FD-Score:4.56|P-value:5.54E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.96|P-value:4.02E-9 ID:SGTC_2521|Compound:angolensin|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.29|P-value:4.55E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.29|P-value:8.28E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.91|P-value:8.72E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.28|P-value:1.95E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-6.22|P-value:2.97E-10 ID:SGTC_2795|Compound:7780010|FD-Score:-6.96|P-value:2.17E-12 ID:SGTC_3009|Compound:9080819|FD-Score:3.54|P-value:3.54E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.19|P-value:2.81E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.91|P-value:8.66E-5 ID:SGTC_3080|Compound:9117754|FD-Score:-3.08|P-value:9.16E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.08|P-value:4.35E-5 ID:SGTC_3158|Compound:9100007|FD-Score:5.05|P-value:5.49E-7 ID:SGTC_3166|Compound:9102297|FD-Score:3.41|P-value:5.59E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.26|P-value:9.17E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.72|P-value:2.71E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:3.58|P-value:3.00E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.26|P-value:9.10E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.31|P-value:7.86E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.05|P-value:2.46E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:7.97|P-value:5.03E-15 ID:SGTC_115|Compound:0527-0192|FD-Score:4.58|P-value:5.09E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:5.30|P-value:1.55E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:3.25|P-value:9.57E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.52|P-value:3.70E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.52|P-value:1.30E-10 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.49|P-value:4.22E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.08|P-value:4.69E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.64|P-value:1.26E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.74|P-value:8.38E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.14|P-value:7.72E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.36|P-value:3.51E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.08|P-value:9.26E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.95|P-value:1.53E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.48|P-value:8.12E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.14|P-value:4.79E-10 ID:SGTC_608|Compound:k048-0125|FD-Score:3.52|P-value:3.76E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.83|P-value:1.18E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:5.29|P-value:1.65E-7 ID:SGTC_799|Compound:1310-0557|FD-Score:3.49|P-value:4.17E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.19|P-value:2.79E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.69|P-value:1.91E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:4.07|P-value:4.50E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:5.28|P-value:1.67E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.76|P-value:1.55E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.35|P-value:6.88E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.53|P-value:3.67E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.36|P-value:6.44E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.30|P-value:7.90E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.47|P-value:8.40E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.65|P-value:2.33E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.41|P-value:1.08E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.24|P-value:9.78E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.95|P-value:7.46E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.01|P-value:5.81E-5 ID:SGTC_2414|Compound:st077232|FD-Score:5.09|P-value:4.48E-7 ID:SGTC_2415|Compound:st077333|FD-Score:5.51|P-value:4.98E-8 ID:SGTC_2416|Compound:tofa|FD-Score:4.56|P-value:5.54E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.96|P-value:4.02E-9 ID:SGTC_2521|Compound:angolensin|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.29|P-value:4.55E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.29|P-value:8.28E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.91|P-value:8.72E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.28|P-value:1.95E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-6.22|P-value:2.97E-10 ID:SGTC_2795|Compound:7780010|FD-Score:-6.96|P-value:2.17E-12 ID:SGTC_3009|Compound:9080819|FD-Score:3.54|P-value:3.54E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.19|P-value:2.81E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.91|P-value:8.66E-5 ID:SGTC_3080|Compound:9117754|FD-Score:-3.08|P-value:9.16E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.08|P-value:4.35E-5 ID:SGTC_3158|Compound:9100007|FD-Score:5.05|P-value:5.49E-7 ID:SGTC_3166|Compound:9102297|FD-Score:3.41|P-value:5.59E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.26|P-value:9.17E-4

Top fitness defect scores for YDR359C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_108 0509-0257 7.97 621.1 µM 5.03E-15 5 8.14E-16
2 SGTC_221 trifluoperazine 6.52 10.3 µM 1.30E-10 NEO1-PIK1 108 3.45E-11
3 SGTC_2489 cantharidin 5.96 73.4 µM 4.02E-9 cell wall signaling 12 1.26E-9
4 SGTC_863 0466-0191 5.69 129.0 µM 1.91E-8 cell wall 32 6.49E-9
5 SGTC_2415 st077333 5.51 57.7 µM 4.98E-8 14 1.77E-8
6 SGTC_150 3970-0969 5.30 77.2 µM 1.55E-7 31 5.86E-8
7 SGTC_667 1498-1044 5.29 59.0 µM 1.65E-7 RPP1 & pyrimidine depletion 3 6.24E-8
8 SGTC_916 4466-0038 5.28 42.0 nM 1.67E-7 cell wall 33 6.34E-8
9 SGTC_2414 st077232 5.09 92.9 µM 4.48E-7 8 1.79E-7
10 SGTC_268 camptothecin 5.08 39.6 µM 4.69E-7 DNA damage response 45 1.88E-7
11 SGTC_3158 9100007 5.05 49.5 µM 5.49E-7 8 2.21E-7
12 SGTC_46 0329-0187a 4.72 2.2 µM 2.71E-6 47 1.19E-6
13 SGTC_115 0527-0192 4.58 112.0 µM 5.09E-6 46 2.31E-6
14 SGTC_2416 tofa 4.56 880.0 nM 5.54E-6 sphingolipid biosynthesis & PDR1 36 2.53E-6
15 SGTC_445 e6 berbamine 4.48 66.0 µM 8.12E-6 NEO1-PIK1 82 3.78E-6
16 SGTC_1627 st003713 4.47 25.6 µM 8.40E-6 calcium & mitochondrial duress 55 3.92E-6
17 SGTC_1750 st081859 4.41 2.4 µM 1.08E-5 endomembrane recycling 156 5.09E-6
18 SGTC_2771 fluoxetine 4.28 41.0 µM 1.95E-5 12 9.50E-6
19 SGTC_855 0428-0020 4.19 25.0 µM 2.79E-5 Golgi 21 1.39E-5
20 SGTC_3014 9081533 4.19 49.5 µM 2.81E-5 8 1.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 3.76E-34 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.174 3.67E-24 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.154 2.74E-19 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.144 6.53E-17 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.143 8.00E-17 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.142 1.73E-16 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.139 7.32E-16 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.136 2.13E-15 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.133 1.04E-14 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.133 1.06E-14 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.131 2.27E-14 YBR111W-A SUS1 hom Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP
0.131 2.48E-14 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.130 4.37E-14 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.129 6.10E-14 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.125 3.21E-13 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p