YDR360W_d / OPI7

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR360W / OPI7

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.21|P-value:1.64E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.27|P-value:1.30E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.24|P-value:4.07E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:4.68|P-value:2.06E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.12|P-value:2.50E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:5.30|P-value:8.87E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.78|P-value:9.57E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.29|P-value:9.64E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:6.82|P-value:9.79E-12 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.75|P-value:1.18E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.20|P-value:8.54E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.27|P-value:6.75E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.28|P-value:6.16E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.45|P-value:5.79E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.72|P-value:1.31E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.17|P-value:9.47E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.19|P-value:8.26E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.37|P-value:4.71E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:6.01|P-value:1.62E-9 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.33|P-value:5.54E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.30|P-value:6.15E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:5.26|P-value:1.13E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:5.49|P-value:3.15E-8 ID:SGTC_792|Compound:4534-1957|FD-Score:3.25|P-value:6.85E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.31|P-value:1.07E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.19|P-value:9.01E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:5.62|P-value:1.53E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.42|P-value:6.76E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.28|P-value:6.13E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.46|P-value:3.19E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.41|P-value:4.09E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.05|P-value:3.55E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-6.01|P-value:1.85E-9 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.56|P-value:2.39E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-5.23|P-value:1.42E-7 ID:SGTC_2019|Compound:4016004|FD-Score:-4.95|P-value:5.93E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.87|P-value:6.77E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.52|P-value:2.64E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-4.29|P-value:1.27E-5 ID:SGTC_2246|Compound:7293507|FD-Score:4.33|P-value:1.01E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-7.20|P-value:7.62E-13 ID:SGTC_2255|Compound:7941087|FD-Score:5.73|P-value:8.41E-9 ID:SGTC_2262|Compound:9014885|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.44|P-value:3.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.29|P-value:9.56E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.42|P-value:4.02E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.94|P-value:2.83E-15 ID:SGTC_2694|Compound:st077685|FD-Score:-3.88|P-value:6.99E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.84|P-value:1.03E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.18|P-value:8.51E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.14|P-value:9.68E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.13|P-value:2.35E-5 ID:SGTC_3007|Compound:9078383|FD-Score:4.22|P-value:1.60E-5 ID:SGTC_3017|Compound:9080681|FD-Score:3.30|P-value:5.75E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.68|P-value:2.22E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.57|P-value:2.33E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.34|P-value:9.71E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-3.49|P-value:3.08E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.33|P-value:5.21E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.19|P-value:8.40E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.49|P-value:3.13E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:4.21|P-value:1.64E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.27|P-value:1.30E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.24|P-value:4.07E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:4.68|P-value:2.06E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.12|P-value:2.50E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:5.30|P-value:8.87E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.78|P-value:9.57E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.29|P-value:9.64E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:6.82|P-value:9.79E-12 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.75|P-value:1.18E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.20|P-value:8.54E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.27|P-value:6.75E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.28|P-value:6.16E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.45|P-value:5.79E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.72|P-value:1.31E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.17|P-value:9.47E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.19|P-value:8.26E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.37|P-value:4.71E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:6.01|P-value:1.62E-9 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.33|P-value:5.54E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.30|P-value:6.15E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:5.26|P-value:1.13E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:5.49|P-value:3.15E-8 ID:SGTC_792|Compound:4534-1957|FD-Score:3.25|P-value:6.85E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.31|P-value:1.07E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.19|P-value:9.01E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:5.62|P-value:1.53E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.42|P-value:6.76E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.28|P-value:6.13E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.46|P-value:3.19E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.41|P-value:4.09E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.05|P-value:3.55E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-6.01|P-value:1.85E-9 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.56|P-value:2.39E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-5.23|P-value:1.42E-7 ID:SGTC_2019|Compound:4016004|FD-Score:-4.95|P-value:5.93E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.87|P-value:6.77E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.52|P-value:2.64E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.32|P-value:5.38E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-4.29|P-value:1.27E-5 ID:SGTC_2246|Compound:7293507|FD-Score:4.33|P-value:1.01E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-7.20|P-value:7.62E-13 ID:SGTC_2255|Compound:7941087|FD-Score:5.73|P-value:8.41E-9 ID:SGTC_2262|Compound:9014885|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.44|P-value:3.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.29|P-value:9.56E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.42|P-value:4.02E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.94|P-value:2.83E-15 ID:SGTC_2694|Compound:st077685|FD-Score:-3.88|P-value:6.99E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.84|P-value:1.03E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.18|P-value:8.51E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.14|P-value:9.68E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.13|P-value:2.35E-5 ID:SGTC_3007|Compound:9078383|FD-Score:4.22|P-value:1.60E-5 ID:SGTC_3017|Compound:9080681|FD-Score:3.30|P-value:5.75E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.68|P-value:2.22E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.57|P-value:2.33E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.34|P-value:9.71E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-3.49|P-value:3.08E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.33|P-value:5.21E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.19|P-value:8.40E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.49|P-value:3.13E-8

Top fitness defect scores for YDR360W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.94 96.7 µM 2.83E-15 calcium & mitochondrial duress 65 1.04E-15
2 SGTC_117 lucigenin 6.82 22.1 µM 9.79E-12 redox potentiating 32 4.71E-12
3 SGTC_58 0957-0393 6.24 9.0 µM 4.07E-10 cell wall 202 2.21E-10
4 SGTC_548 1436-0017 6.01 110.0 µM 1.62E-9 TSC3-RPN4 11 9.22E-10
5 SGTC_2255 7941087 5.73 197.4 µM 8.41E-9 11 5.04E-9
6 SGTC_960 1222-0186 5.62 7.7 µM 1.53E-8 11 9.37E-9
7 SGTC_3308 9128332 5.49 17.6 µM 3.13E-8 plasma membrane duress 44 1.96E-8
8 SGTC_788 1182-0090 5.49 188.0 µM 3.15E-8 endomembrane recycling 43 1.97E-8
9 SGTC_78 0336-0123 5.30 156.8 µM 8.87E-8 9 5.73E-8
10 SGTC_2582 agaric acid 5.29 100.0 µM 9.56E-8 redox potentiating 204 6.20E-8
11 SGTC_108 0509-0257 5.29 621.1 µM 9.64E-8 19 6.24E-8
12 SGTC_738 1315-0003 5.26 72.4 µM 1.13E-7 5 7.38E-8
13 SGTC_69 0096-0274 4.68 206.7 µM 2.06E-6 mitochondrial processes 24 1.47E-6
14 SGTC_351 caspofungin 4.45 25.0 nM 5.79E-6 cell wall 76 4.27E-6
15 SGTC_1026 k007-1105 4.42 30.6 µM 6.76E-6 ERAD & cell cycle 78 5.01E-6
16 SGTC_3174 9107204 4.34 49.5 µM 9.71E-6 ERG2 22 7.28E-6
17 SGTC_2246 7293507 4.33 91.6 µM 1.01E-5 25 7.62E-6
18 SGTC_922 1866-0035 4.31 480.0 µM 1.07E-5 excess fatty acid 39 8.05E-6
19 SGTC_28 pentachloropyridine N-oxide 4.27 1.6 µM 1.30E-5 TSC3-RPN4 59 9.84E-6
20 SGTC_3007 9078383 4.22 71.4 µM 1.60E-5 10 1.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.218 2.65E-37 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.175 1.76E-24 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.161 5.95E-21 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.159 2.52E-20 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.158 3.13E-20 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.156 1.07E-19 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.152 6.53E-19 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.149 4.00E-18 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.145 2.84E-17 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.144 6.43E-17 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.139 6.30E-16 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.133 1.27E-14 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.132 1.45E-14 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.132 1.56E-14 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.129 6.08E-14 YNL136W EAF7 hom Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A