YDR361C / BCP1

Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR361C / BCP1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.10|P-value:9.40E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.58|P-value:2.07E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:4.21|P-value:1.17E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.12|P-value:1.31E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.33|P-value:4.28E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:5.15|P-value:1.15E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:-5.20|P-value:6.24E-8 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.21|P-value:5.21E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.24|P-value:6.96E-8 ID:SGTC_541|Compound:4513-1321|FD-Score:5.97|P-value:9.18E-10 ID:SGTC_645|Compound:0845-0943|FD-Score:-3.12|P-value:7.20E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.90|P-value:4.56E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.03|P-value:9.73E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.54|P-value:1.90E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.06|P-value:2.31E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.22|P-value:6.32E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.21|P-value:6.43E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.26|P-value:5.46E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.36|P-value:6.02E-6 ID:SGTC_1871|Compound:st057448|FD-Score:-3.09|P-value:7.93E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-4.10|P-value:1.50E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.13|P-value:8.43E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.17|P-value:7.55E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.85|P-value:5.56E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.41|P-value:3.17E-4 ID:SGTC_2411|Compound:st077133|FD-Score:5.93|P-value:1.17E-9 ID:SGTC_2412|Compound:st077135|FD-Score:-3.77|P-value:6.22E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.13|P-value:1.26E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.74|P-value:9.45E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.41|P-value:3.10E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-5.93|P-value:8.21E-10 ID:SGTC_2487|Compound:5918373|FD-Score:3.97|P-value:3.33E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.24|P-value:5.73E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.25|P-value:6.55E-8 ID:SGTC_2830|Compound:7992007|FD-Score:3.83|P-value:5.95E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.25|P-value:7.70E-6 ID:SGTC_2942|Compound:9052777|FD-Score:4.56|P-value:2.31E-6 ID:SGTC_2948|Compound:9070189|FD-Score:4.47|P-value:3.55E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.19|P-value:6.85E-4 ID:SGTC_3083|Compound:9117465|FD-Score:5.48|P-value:1.75E-8 ID:SGTC_3088|Compound:9117578|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.14|P-value:8.40E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.29|P-value:4.84E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.41|P-value:4.73E-6 ID:SGTC_3143|Compound:9086658|FD-Score:5.57|P-value:1.03E-8 ID:SGTC_3204|Compound:9114183|FD-Score:-3.93|P-value:3.15E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.10|P-value:9.40E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.58|P-value:2.07E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:4.21|P-value:1.17E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.12|P-value:1.31E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.33|P-value:4.28E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:5.15|P-value:1.15E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:-5.20|P-value:6.24E-8 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.21|P-value:5.21E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.24|P-value:6.96E-8 ID:SGTC_541|Compound:4513-1321|FD-Score:5.97|P-value:9.18E-10 ID:SGTC_645|Compound:0845-0943|FD-Score:-3.12|P-value:7.20E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.90|P-value:4.56E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.03|P-value:9.73E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.54|P-value:1.90E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.06|P-value:2.31E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.22|P-value:6.32E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.21|P-value:6.43E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.26|P-value:5.46E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.36|P-value:6.02E-6 ID:SGTC_1871|Compound:st057448|FD-Score:-3.09|P-value:7.93E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-4.10|P-value:1.50E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.13|P-value:8.43E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.17|P-value:7.55E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.85|P-value:5.56E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.41|P-value:3.17E-4 ID:SGTC_2411|Compound:st077133|FD-Score:5.93|P-value:1.17E-9 ID:SGTC_2412|Compound:st077135|FD-Score:-3.77|P-value:6.22E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.13|P-value:1.26E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.74|P-value:9.45E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.41|P-value:3.10E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-5.93|P-value:8.21E-10 ID:SGTC_2487|Compound:5918373|FD-Score:3.97|P-value:3.33E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.24|P-value:5.73E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.25|P-value:6.55E-8 ID:SGTC_2830|Compound:7992007|FD-Score:3.83|P-value:5.95E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.25|P-value:7.70E-6 ID:SGTC_2942|Compound:9052777|FD-Score:4.56|P-value:2.31E-6 ID:SGTC_2948|Compound:9070189|FD-Score:4.47|P-value:3.55E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.19|P-value:6.85E-4 ID:SGTC_3083|Compound:9117465|FD-Score:5.48|P-value:1.75E-8 ID:SGTC_3088|Compound:9117578|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.14|P-value:8.40E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.29|P-value:4.84E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.41|P-value:4.73E-6 ID:SGTC_3143|Compound:9086658|FD-Score:5.57|P-value:1.03E-8 ID:SGTC_3204|Compound:9114183|FD-Score:-3.93|P-value:3.15E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.39|P-value:3.42E-4

Top fitness defect scores for YDR361C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_541 4513-1321 5.97 94.0 µM 9.18E-10 3 1.16E-9 0.06
2 SGTC_2411 st077133 5.93 39.9 µM 1.17E-9 RNA pol III & RNase P/MRP 12 1.47E-9 0.06
3 SGTC_3143 9086658 5.57 49.5 µM 1.03E-8 5 1.25E-8 0.78
4 SGTC_3083 9117465 5.48 49.5 µM 1.75E-8 1 2.10E-8 0.56
5 SGTC_2824 7998404 5.25 52.0 µM 6.55E-8 5 7.69E-8 0.63
6 SGTC_534 k292-0788 5.24 63.4 µM 6.96E-8 mitochondrial processes 3 8.17E-8 0.58
7 SGTC_335 4077-0256 5.15 27.6 µM 1.15E-7 3 1.33E-7 0.61
8 SGTC_2418 pentamidine 5.13 31.7 µM 1.26E-7 mitochondrial processes 8 1.46E-7 0.07
9 SGTC_184 1494-0393 5.12 24.7 µM 1.31E-7 16 1.53E-7 0.05
10 SGTC_2419 paclitaxel 4.74 166.5 µM 9.45E-7 3 1.06E-6 0.57
11 SGTC_81 0411-0046 4.58 10.0 µM 2.07E-6 31 2.30E-6 0.02
12 SGTC_2942 9052777 4.56 62.2 µM 2.31E-6 5 2.57E-6 0.03
13 SGTC_2948 9070189 4.47 9.4 µM 3.55E-6 plasma membrane duress 8 3.92E-6 0.94
14 SGTC_3139 9095020 4.41 49.5 µM 4.73E-6 3 5.19E-6 0.39
15 SGTC_1578 josamycin 4.36 24.2 µM 6.02E-6 2 6.59E-6 0.43
16 SGTC_150 3970-0969 4.21 77.2 µM 1.17E-5 13 1.27E-5 0.15
17 SGTC_852 0418-0143 4.06 439.0 µM 2.31E-5 calcium & mitochondrial duress 12 2.47E-5 0.01
18 SGTC_2487 5918373 3.97 44.0 µM 3.33E-5 5 3.55E-5 0.12
19 SGTC_661 1304-0007 3.90 33.6 µM 4.56E-5 4 4.84E-5 0.17
20 SGTC_2256 7954252 3.85 200.0 µM 5.56E-5 mitochondrial processes 10 5.89E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.99E-12 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.116 1.78E-11 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.108 4.25E-10 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.102 3.17E-9 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.101 4.88E-9 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.099 1.01E-8 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.094 5.94E-8 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.093 6.23E-8 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.090 1.68E-7 YGR186W TFG1 het TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
0.090 1.79E-7 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.088 3.26E-7 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.086 5.60E-7 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.086 6.43E-7 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.085 9.32E-7 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.084 1.13E-6 YDR182W CDC1 het Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution