HIPHOP chemogenomics database

YDR362C / TFC6

One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR362C / TFC6

Click on Significant Values for Screen Details

Top fitness defect scores for YDR362C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_867	0518-0118	9.41	155.0 µM	2.60E-20	DNA intercalators	1	2.47E-21	1.78
2	SGTC_2638	epoxomicin	8.09	18.0 µM	1.66E-15		1	3.08E-16	3.20
3	SGTC_1966	st070145	7.81	16.1 µM	1.32E-14		1	2.78E-15	2.33
4	SGTC_852	0418-0143	7.64	439.0 µM	4.85E-14	calcium & mitochondrial duress	2	1.10E-14	1.47
5	SGTC_2785	7756463	5.94	72.7 µM	3.38E-9		3	1.47E-9	0.47
6	SGTC_3040	9091894	5.66	49.5 µM	1.60E-8	DNA intercalators	3	7.55E-9	0.06
7	SGTC_1459	k035-0031	5.52	35.7 µM	3.41E-8	DNA intercalators	3	1.68E-8	0.43
8	SGTC_3283	9109332	5.19	35.8 µM	1.96E-7	DNA intercalators	1	1.07E-7	0.64
9	SGTC_2639	lactacystin	5.18	53.0 µM	2.03E-7		4	1.11E-7	0.65
10	SGTC_2666	tannic acid	5.18	100.0 µM	2.08E-7	iron homeostasis	7	1.14E-7	0.22
11	SGTC_633	0437-0093	5.07	97.7 µM	3.52E-7	DNA intercalators	4	1.98E-7	0.76
12	SGTC_1926	methyl fluorone black	4.95	53.6 µM	6.54E-7	DNA intercalators	18	3.80E-7	0.01
13	SGTC_632	0781-2353	4.79	4.7 µM	1.35E-6	Golgi	10	8.17E-7	5.04E-4
14	SGTC_1415	3966-0071	4.72	78.1 µM	1.93E-6	DNA intercalators	4	1.19E-6	0.46
15	SGTC_1985	st071382	4.59	65.5 µM	3.43E-6		1	2.18E-6	0.47
16	SGTC_412	gemfibrozil	4.59	100.0 µM	3.51E-6	DNA intercalators	3	2.23E-6	0.35
17	SGTC_2128	5255449	4.48	168.5 µM	5.63E-6		3	3.67E-6	0.38
18	SGTC_1794	st048918	4.48	76.9 µM	5.70E-6		1	3.72E-6	0.78
19	SGTC_2958	9077254	4.48	16.7 µM	5.77E-6		3	3.77E-6	0.24
20	SGTC_874	0599-0792	4.40	117.0 µM	7.96E-6		2	5.29E-6	0.23

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.308	1.01E-74	YDL058W	USO1	het	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.286	4.66E-64	YMR208W	ERG12	het	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.275	3.08E-59	YDR458C	HEH2	hom	Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.252	9.07E-50	YER003C	PMI40	het	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.225	1.52E-39	YGR156W	PTI1	het	Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.213	1.44E-35	YOR294W	RRS1	het	Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.204	6.27E-33	YGL200C	EMP24	hom	Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.204	7.38E-33	YDR060W	MAK21	het	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.196	3.79E-30	YMR119W	ASI1	hom	Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.192	4.44E-29	YNL317W	PFS2	het	Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.177	7.24E-25	YOR278W	HEM4	het	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.164	1.23E-21	YJL085W	EXO70	het	Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.151	1.24E-18	YDL223C	HBT1	hom	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.143	9.36E-17	YGL041C_d	YGL041C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140	3.90E-16	YHR172W	SPC97	het	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque