YDR363W / ESC2

Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR363W / ESC2

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.83|P-value:1.27E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.69|P-value:2.13E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.27|P-value:9.21E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.92|P-value:1.23E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.33|P-value:7.51E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.48|P-value:4.57E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.26|P-value:9.38E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.40|P-value:4.07E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.76|P-value:1.64E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.37|P-value:1.43E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.34|P-value:7.33E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.15|P-value:9.48E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.30|P-value:8.23E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.20|P-value:2.95E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.61|P-value:4.98E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.84|P-value:1.23E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.31|P-value:1.83E-5 ID:SGTC_1611|Compound:st001856|FD-Score:6.49|P-value:2.29E-10 ID:SGTC_1677|Compound:st019204|FD-Score:3.48|P-value:4.55E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.61|P-value:4.97E-6 ID:SGTC_1733|Compound:st037357|FD-Score:4.13|P-value:3.95E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-5.25|P-value:1.38E-7 ID:SGTC_1820|Compound:st053765|FD-Score:-3.61|P-value:1.93E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.38|P-value:6.29E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.80|P-value:9.14E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-4.66|P-value:2.42E-6 ID:SGTC_2063|Compound:5246145|FD-Score:-3.33|P-value:5.11E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.39|P-value:1.35E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.56|P-value:3.42E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.58|P-value:3.17E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.42|P-value:5.48E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.69|P-value:2.10E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.09|P-value:2.88E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.42|P-value:1.15E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.55|P-value:3.59E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.48|P-value:7.29E-8 ID:SGTC_2783|Compound:7738165|FD-Score:3.89|P-value:9.99E-5 ID:SGTC_3084|Compound:9116877|FD-Score:-3.54|P-value:2.44E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.98|P-value:7.22E-5 ID:SGTC_3350|Compound:9150499|FD-Score:5.78|P-value:1.43E-8 ID:SGTC_3351|Compound:9150312|FD-Score:4.80|P-value:2.16E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.83|P-value:1.27E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.69|P-value:2.13E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.27|P-value:9.21E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.92|P-value:1.23E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.33|P-value:7.51E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.48|P-value:4.57E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.26|P-value:9.38E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.40|P-value:4.07E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.76|P-value:1.64E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.37|P-value:1.43E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.34|P-value:7.33E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.15|P-value:9.48E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.30|P-value:8.23E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.20|P-value:2.95E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.61|P-value:4.98E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.84|P-value:1.23E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.31|P-value:1.83E-5 ID:SGTC_1611|Compound:st001856|FD-Score:6.49|P-value:2.29E-10 ID:SGTC_1677|Compound:st019204|FD-Score:3.48|P-value:4.55E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.61|P-value:4.97E-6 ID:SGTC_1733|Compound:st037357|FD-Score:4.13|P-value:3.95E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-5.25|P-value:1.38E-7 ID:SGTC_1820|Compound:st053765|FD-Score:-3.61|P-value:1.93E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.38|P-value:6.29E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.80|P-value:9.14E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-4.66|P-value:2.42E-6 ID:SGTC_2063|Compound:5246145|FD-Score:-3.33|P-value:5.11E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.39|P-value:1.35E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.56|P-value:3.42E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.58|P-value:3.17E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.42|P-value:5.48E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.69|P-value:2.10E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.09|P-value:2.88E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.42|P-value:1.15E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.55|P-value:3.59E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.48|P-value:7.29E-8 ID:SGTC_2783|Compound:7738165|FD-Score:3.89|P-value:9.99E-5 ID:SGTC_3084|Compound:9116877|FD-Score:-3.54|P-value:2.44E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.98|P-value:7.22E-5 ID:SGTC_3350|Compound:9150499|FD-Score:5.78|P-value:1.43E-8 ID:SGTC_3351|Compound:9150312|FD-Score:4.80|P-value:2.16E-6

Top fitness defect scores for YDR363W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1611 st001856 6.49 99.4 µM 2.29E-10 2 4.42E-11
2 SGTC_3350 9150499 5.78 3.6 µM 1.43E-8 cell wall 16 3.72E-9
3 SGTC_2628 lathosterol 5.48 100.0 µM 7.29E-8 8 2.13E-8
4 SGTC_479 n-linoleoylglycine 4.92 10.0 µM 1.23E-6 3 4.43E-7
5 SGTC_3351 9150312 4.80 21.6 µM 2.16E-6 cell wall 20 8.05E-7
6 SGTC_1727 st034309 4.61 9.9 µM 4.97E-6 19 1.97E-6
7 SGTC_1408 3909-7976 4.61 48.8 µM 4.98E-6 Golgi 12 1.98E-6
8 SGTC_2622 2-methoxyxanthone 4.42 59.9 µM 1.15E-5 10 4.87E-6
9 SGTC_2078 5212016 4.39 200.0 µM 1.35E-5 60S ribosome export 9 5.77E-6
10 SGTC_1134 3477-0009 4.37 42.5 µM 1.43E-5 35 6.12E-6
11 SGTC_1590 st077108 4.31 57.8 µM 1.83E-5 5 8.02E-6
12 SGTC_1389 3405-0187 4.20 19.0 µM 2.95E-5 9 1.34E-5
13 SGTC_1733 st037357 4.13 54.9 µM 3.95E-5 60S ribosome export 21 1.83E-5
14 SGTC_3346 9158254 3.98 43.6 µM 7.22E-5 12 3.50E-5
15 SGTC_2783 7738165 3.89 71.4 µM 9.99E-5 30 4.96E-5
16 SGTC_244 nsc-207895 3.86 1.3 µM 1.13E-4 DNA damage response 20 5.63E-5
17 SGTC_1442 4112-3290 3.84 3.0 µM 1.23E-4 17 6.19E-5
18 SGTC_115 0527-0192 3.83 112.0 µM 1.27E-4 79 6.40E-5
19 SGTC_1082 camptothecin 3.76 424.9 nM 1.64E-4 DNA damage response 46 8.42E-5
20 SGTC_2409 alverine citrate 3.69 64.0 µM 2.10E-4 62 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.01E-20 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.149 3.11E-18 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.139 6.69E-16 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.119 4.12E-12 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.102 3.59E-9 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.098 1.36E-8 YDR092W UBC13 hom Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
0.095 3.40E-8 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.095 3.43E-8 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.092 8.12E-8 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.091 1.28E-7 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.091 1.39E-7 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.090 1.57E-7 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.090 1.75E-7 YBR025C OLA1 hom P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress
0.089 2.39E-7 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.089 2.81E-7 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance