YDR367W / KEI1

Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR367W / KEI1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.56|P-value:8.18E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.08|P-value:3.60E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.63|P-value:7.24E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.87|P-value:8.12E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.00|P-value:2.02E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.87|P-value:8.35E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:3.79|P-value:3.91E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.74|P-value:4.59E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.55|P-value:8.42E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:10.00|P-value:4.66E-19 ID:SGTC_576|Compound:1073-0113|FD-Score:5.11|P-value:3.12E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.66|P-value:6.03E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:5.71|P-value:2.22E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.76|P-value:1.26E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:4.30|P-value:7.03E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:4.15|P-value:1.19E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:5.41|P-value:8.55E-7 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.79|P-value:3.94E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.69|P-value:5.37E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.51|P-value:3.34E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.58|P-value:2.55E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.62|P-value:6.76E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:6.23|P-value:1.82E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.84|P-value:3.40E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.37|P-value:1.02E-6 ID:SGTC_1832|Compound:st054113|FD-Score:4.24|P-value:8.69E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.78|P-value:1.18E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.85|P-value:3.32E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.96|P-value:2.32E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.82|P-value:3.56E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-5.46|P-value:7.84E-7 ID:SGTC_2164|Compound:5685496|FD-Score:8.66|P-value:1.04E-14 ID:SGTC_2165|Compound:5727197|FD-Score:-3.55|P-value:9.08E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.20|P-value:1.03E-4 ID:SGTC_2360|Compound:9040895|FD-Score:4.05|P-value:1.70E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:45.50|P-value:0 ID:SGTC_2442|Compound:5158906|FD-Score:-4.10|P-value:1.59E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.96|P-value:2.25E-4 ID:SGTC_2472|Compound:5377652|FD-Score:11.10|P-value:4.43E-23 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.80|P-value:3.79E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:45.20|P-value:0 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.55|P-value:9.31E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.98|P-value:5.29E-6 ID:SGTC_2796|Compound:7949634|FD-Score:6.08|P-value:3.92E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.85|P-value:3.69E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.86|P-value:3.18E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.18|P-value:1.08E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.37|P-value:5.51E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.79|P-value:4.34E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.93|P-value:2.51E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.92|P-value:2.88E-4 ID:SGTC_3018|Compound:9082602|FD-Score:5.27|P-value:1.59E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-4.77|P-value:1.41E-5 ID:SGTC_3199|Compound:9111318|FD-Score:5.21|P-value:2.08E-6 ID:SGTC_3201|Compound:9113999|FD-Score:-5.66|P-value:3.22E-7 ID:SGTC_3304|Compound:9125678|FD-Score:7.07|P-value:2.10E-10 ID:SGTC_3324|Compound:9138759|FD-Score:5.79|P-value:1.52E-7 ID:SGTC_3|Compound:0833-0587|FD-Score:3.56|P-value:8.18E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.08|P-value:3.60E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.63|P-value:7.24E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.87|P-value:8.12E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.00|P-value:2.02E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.87|P-value:8.35E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:3.79|P-value:3.91E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.74|P-value:4.59E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.55|P-value:8.42E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:10.00|P-value:4.66E-19 ID:SGTC_576|Compound:1073-0113|FD-Score:5.11|P-value:3.12E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.66|P-value:6.03E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:5.71|P-value:2.22E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.76|P-value:1.26E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:4.30|P-value:7.03E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:4.15|P-value:1.19E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:5.41|P-value:8.55E-7 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.79|P-value:3.94E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.69|P-value:5.37E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.51|P-value:3.34E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.58|P-value:2.55E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.62|P-value:6.76E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:6.23|P-value:1.82E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.84|P-value:3.40E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.37|P-value:1.02E-6 ID:SGTC_1832|Compound:st054113|FD-Score:4.24|P-value:8.69E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.78|P-value:1.18E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.85|P-value:3.32E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.96|P-value:2.32E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.82|P-value:3.56E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-5.46|P-value:7.84E-7 ID:SGTC_2164|Compound:5685496|FD-Score:8.66|P-value:1.04E-14 ID:SGTC_2165|Compound:5727197|FD-Score:-3.55|P-value:9.08E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.20|P-value:1.03E-4 ID:SGTC_2360|Compound:9040895|FD-Score:4.05|P-value:1.70E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:45.50|P-value:0 ID:SGTC_2442|Compound:5158906|FD-Score:-4.10|P-value:1.59E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.96|P-value:2.25E-4 ID:SGTC_2472|Compound:5377652|FD-Score:11.10|P-value:4.43E-23 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.80|P-value:3.79E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:45.20|P-value:0 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.55|P-value:9.31E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.98|P-value:5.29E-6 ID:SGTC_2796|Compound:7949634|FD-Score:6.08|P-value:3.92E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.85|P-value:3.69E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.86|P-value:3.18E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.18|P-value:1.08E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.37|P-value:5.51E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.79|P-value:4.34E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.93|P-value:2.51E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.92|P-value:2.88E-4 ID:SGTC_3018|Compound:9082602|FD-Score:5.27|P-value:1.59E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-4.77|P-value:1.41E-5 ID:SGTC_3199|Compound:9111318|FD-Score:5.21|P-value:2.08E-6 ID:SGTC_3201|Compound:9113999|FD-Score:-5.66|P-value:3.22E-7 ID:SGTC_3304|Compound:9125678|FD-Score:7.07|P-value:2.10E-10 ID:SGTC_3324|Compound:9138759|FD-Score:5.79|P-value:1.52E-7

Top fitness defect scores for YDR367W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2420 aureobasidin a 45.50 50.0 nM 0 1 0 34.40
2 SGTC_2567 aureobasidin a 45.20 60.0 nM 0 1 0 10.60
3 SGTC_2472 5377652 11.10 49.4 µM 4.43E-23 TRP & mitochondrial translation 1 4.54E-29 3.34
4 SGTC_431 k089-0097 10.00 107.0 µM 4.66E-19 iron homeostasis 1 6.50E-24 2.98
5 SGTC_2164 5685496 8.66 200.0 µM 1.04E-14 1 2.41E-18 1.39
6 SGTC_3304 9125678 7.07 46.1 µM 2.10E-10 17 7.75E-13 0.35
7 SGTC_1365 1672-3266 6.23 55.4 µM 1.82E-8 1 2.30E-10 1.76
8 SGTC_2796 7949634 6.08 45.5 µM 3.92E-8 1 6.13E-10 0.99
9 SGTC_3324 9138759 5.79 60.8 µM 1.52E-7 2 3.44E-9 1.17
10 SGTC_779 1360-0071 5.71 233.0 µM 2.22E-7 fatty acid desaturase (OLE1) 1 5.59E-9 1.28
11 SGTC_1106 tegaserod maleate 5.41 11.7 µM 8.55E-7 3 3.11E-8 1.14
12 SGTC_1636 st007707 5.37 68.9 µM 1.02E-6 4 3.89E-8 1.01
13 SGTC_3018 9082602 5.27 49.5 µM 1.59E-6 2 6.87E-8 0.05
14 SGTC_3199 9111318 5.21 49.5 µM 2.08E-6 6 9.64E-8 0.45
15 SGTC_576 1073-0113 5.11 22.7 µM 3.12E-6 redox potentiating 24 1.62E-7 0.08
16 SGTC_22 0964-0034 5.08 14.5 µM 3.60E-6 unfolded protein response 22 1.94E-7 0.47
17 SGTC_2794 7785382 4.98 27.3 µM 5.29E-6 8 3.16E-7 0.03
18 SGTC_103 0844-0104 4.87 51.8 µM 8.12E-6 ERAD & cell cycle 39 5.45E-7 0.15
19 SGTC_288 1315-0019 4.87 35.1 µM 8.35E-6 RSC & ERG11 14 5.64E-7 0.49
20 SGTC_1844 rapamycin 4.78 4.0 nM 1.18E-5 36 8.76E-7 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.540 2.60E-253 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.307 6.12E-74 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.302 1.53E-71 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.291 2.66E-66 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.246 1.88E-47 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.217 3.80E-37 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.194 7.06E-30 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.192 4.26E-29 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.182 2.12E-26 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.181 3.55E-26 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
0.181 4.75E-26 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.179 1.23E-25 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.177 6.33E-25 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.176 8.65E-25 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.175 2.07E-24 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data