YDR369C / XRS2

Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR369C / XRS2

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:5.41|P-value:1.68E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:4.24|P-value:3.13E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.42|P-value:6.28E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.29|P-value:9.65E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.25|P-value:3.03E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.30|P-value:2.79E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:4.23|P-value:3.21E-5 ID:SGTC_251|Compound:melphalan|FD-Score:4.50|P-value:1.07E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.31|P-value:8.98E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.43|P-value:6.07E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:4.33|P-value:2.17E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.75|P-value:1.99E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-6.22|P-value:2.12E-9 ID:SGTC_956|Compound:1185-0240|FD-Score:5.80|P-value:2.21E-8 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.29|P-value:9.50E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.55|P-value:4.09E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.24|P-value:3.12E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.86|P-value:2.24E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.33|P-value:2.20E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.95|P-value:9.56E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.34|P-value:8.19E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.68|P-value:2.53E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.78|P-value:1.80E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.03|P-value:7.05E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.70|P-value:4.56E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:6.16|P-value:3.00E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.77|P-value:1.89E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.37|P-value:1.85E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:6.21|P-value:2.23E-9 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.71|P-value:2.34E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.37|P-value:7.41E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.88|P-value:1.24E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.89|P-value:1.92E-6 ID:SGTC_1682|Compound:st012968|FD-Score:4.87|P-value:2.16E-6 ID:SGTC_1691|Compound:st019933|FD-Score:-3.55|P-value:4.06E-4 ID:SGTC_1707|Compound:st032323|FD-Score:6.24|P-value:1.93E-9 ID:SGTC_1713|Compound:st033146|FD-Score:3.60|P-value:3.45E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.83|P-value:1.48E-4 ID:SGTC_1834|Compound:st055981|FD-Score:6.51|P-value:3.96E-10 ID:SGTC_1845|Compound:st056753|FD-Score:3.81|P-value:1.61E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.33|P-value:8.38E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.86|P-value:2.26E-6 ID:SGTC_2022|Compound:5136654|FD-Score:4.44|P-value:1.38E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.05|P-value:6.63E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-3.29|P-value:9.57E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.70|P-value:2.43E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.42|P-value:1.57E-7 ID:SGTC_2307|Compound:7538926|FD-Score:6.64|P-value:1.82E-10 ID:SGTC_2310|Compound:7668677|FD-Score:-3.93|P-value:1.03E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.41|P-value:6.36E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.55|P-value:8.74E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.48|P-value:5.08E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.72|P-value:2.26E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.62|P-value:3.12E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.10|P-value:5.39E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.78|P-value:1.83E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.96|P-value:1.45E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.97|P-value:8.80E-5 ID:SGTC_2710|Compound:st078562|FD-Score:3.46|P-value:5.50E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.22|P-value:4.11E-7 ID:SGTC_2918|Compound:7977171|FD-Score:4.40|P-value:1.63E-5 ID:SGTC_2926|Compound:9010726|FD-Score:6.80|P-value:7.05E-11 ID:SGTC_3008|Compound:9078912|FD-Score:4.29|P-value:2.55E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.57|P-value:3.78E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.50|P-value:4.80E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.41|P-value:1.56E-5 ID:SGTC_3247|Compound:9135149|FD-Score:6.53|P-value:3.61E-10 ID:SGTC_3254|Compound:9136651|FD-Score:3.83|P-value:1.49E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.48|P-value:5.03E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.41|P-value:1.68E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:4.24|P-value:3.13E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.42|P-value:6.28E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.29|P-value:9.65E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.25|P-value:3.03E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.30|P-value:2.79E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:4.23|P-value:3.21E-5 ID:SGTC_251|Compound:melphalan|FD-Score:4.50|P-value:1.07E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.31|P-value:8.98E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.43|P-value:6.07E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:4.33|P-value:2.17E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.75|P-value:1.99E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-6.22|P-value:2.12E-9 ID:SGTC_956|Compound:1185-0240|FD-Score:5.80|P-value:2.21E-8 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.29|P-value:9.50E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.55|P-value:4.09E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.24|P-value:3.12E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.86|P-value:2.24E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.33|P-value:2.20E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.95|P-value:9.56E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.34|P-value:8.19E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.68|P-value:2.53E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.78|P-value:1.80E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.03|P-value:7.05E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.70|P-value:4.56E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:6.16|P-value:3.00E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.77|P-value:1.89E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.37|P-value:1.85E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:6.21|P-value:2.23E-9 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.71|P-value:2.34E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.37|P-value:7.41E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.88|P-value:1.24E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.89|P-value:1.92E-6 ID:SGTC_1682|Compound:st012968|FD-Score:4.87|P-value:2.16E-6 ID:SGTC_1691|Compound:st019933|FD-Score:-3.55|P-value:4.06E-4 ID:SGTC_1707|Compound:st032323|FD-Score:6.24|P-value:1.93E-9 ID:SGTC_1713|Compound:st033146|FD-Score:3.60|P-value:3.45E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.83|P-value:1.48E-4 ID:SGTC_1834|Compound:st055981|FD-Score:6.51|P-value:3.96E-10 ID:SGTC_1845|Compound:st056753|FD-Score:3.81|P-value:1.61E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.33|P-value:8.38E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.86|P-value:2.26E-6 ID:SGTC_2022|Compound:5136654|FD-Score:4.44|P-value:1.38E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.05|P-value:6.63E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-3.29|P-value:9.57E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.70|P-value:2.43E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.42|P-value:1.57E-7 ID:SGTC_2307|Compound:7538926|FD-Score:6.64|P-value:1.82E-10 ID:SGTC_2310|Compound:7668677|FD-Score:-3.93|P-value:1.03E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.41|P-value:6.36E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.55|P-value:8.74E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.48|P-value:5.08E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.72|P-value:2.26E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.62|P-value:3.12E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.10|P-value:5.39E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.78|P-value:1.83E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.96|P-value:1.45E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.97|P-value:8.80E-5 ID:SGTC_2710|Compound:st078562|FD-Score:3.46|P-value:5.50E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.22|P-value:4.11E-7 ID:SGTC_2918|Compound:7977171|FD-Score:4.40|P-value:1.63E-5 ID:SGTC_2926|Compound:9010726|FD-Score:6.80|P-value:7.05E-11 ID:SGTC_3008|Compound:9078912|FD-Score:4.29|P-value:2.55E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.57|P-value:3.78E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.50|P-value:4.80E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.41|P-value:1.56E-5 ID:SGTC_3247|Compound:9135149|FD-Score:6.53|P-value:3.61E-10 ID:SGTC_3254|Compound:9136651|FD-Score:3.83|P-value:1.49E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.48|P-value:5.03E-4

Top fitness defect scores for YDR369C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2926 9010726 6.80 65.2 µM 7.05E-11 6 5.40E-12
2 SGTC_2307 7538926 6.64 6.3 µM 1.82E-10 7 1.56E-11
3 SGTC_3247 9135149 6.53 49.5 µM 3.61E-10 DNA damage response 10 3.36E-11
4 SGTC_1834 st055981 6.51 52.8 µM 3.96E-10 RPP1 & pyrimidine depletion 4 3.72E-11
5 SGTC_1707 st032323 6.24 6.3 µM 1.93E-9 DNA damage response 19 2.19E-10
6 SGTC_1265 0819-1001 6.21 68.8 µM 2.23E-9 1 2.58E-10
7 SGTC_1245 0418-0076 6.16 17.2 µM 3.00E-9 ERG2 5 3.60E-10
8 SGTC_956 1185-0240 5.80 191.0 µM 2.21E-8 7 3.35E-9
9 SGTC_2306 7482397 5.42 179.5 µM 1.57E-7 RPP1 & pyrimidine depletion 4 3.00E-8
10 SGTC_71 0417-1750 5.41 47.8 µM 1.68E-7 Golgi 21 3.23E-8
11 SGTC_219 mitoxanthrone 5.30 164.4 µM 2.79E-7 DNA intercalators 24 5.70E-8
12 SGTC_2870 9038528 5.22 13.0 µM 4.11E-7 6 8.80E-8
13 SGTC_2662 daunorubicin 4.96 22.4 µM 1.45E-6 anthracycline transcription coupled DNA repair 8 3.60E-7
14 SGTC_1682 st012968 4.87 530.0 nM 2.16E-6 7 5.63E-7
15 SGTC_1082 camptothecin 4.86 424.9 nM 2.24E-6 DNA damage response 31 5.85E-7
16 SGTC_1982 st072467 4.86 71.9 µM 2.26E-6 15 5.91E-7
17 SGTC_1237 0330-0133 4.70 46.1 µM 4.56E-6 ergosterol biosynthesis 16 1.30E-6
18 SGTC_2421 5690543 4.55 90.7 µM 8.74E-6 10 2.68E-6
19 SGTC_251 melphalan 4.50 456.5 µM 1.07E-5 DNA damage response 11 3.35E-6
20 SGTC_2022 5136654 4.44 200.0 µM 1.38E-5 14 4.46E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.252 6.22E-50 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.242 4.32E-46 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.236 8.87E-44 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.209 1.37E-34 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.202 3.34E-32 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.193 2.01E-29 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.178 3.39E-25 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.175 2.40E-24 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.169 6.19E-23 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.165 5.35E-22 YJL047C RTT101 hom Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
0.153 3.93E-19 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.153 5.88E-19 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.129 7.32E-14 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.116 1.89E-11 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.111 1.26E-10 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase