YDR370C / DXO1

Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR370C / DXO1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR370C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_430 0958-0115 7.18 16.4 µM 5.05E-14 3 3.57E-13
2 SGTC_1257 0669-0121 5.68 16.0 µM 1.99E-9 5 6.76E-9
3 SGTC_1735 st034310 4.35 56.8 µM 3.36E-6 Golgi 17 6.86E-6
4 SGTC_3337 9144342 4.32 33.5 µM 3.77E-6 19 7.64E-6
5 SGTC_429 1112-0049 4.16 25.5 µM 8.10E-6 DNA damage response 31 1.56E-5
6 SGTC_43 0570-0105 4.16 72.5 µM 8.13E-6 ERG2 87 1.56E-5
7 SGTC_2989 9073649 4.09 71.4 µM 1.14E-5 32 2.15E-5
8 SGTC_669 0108-0021 4.04 26.2 µM 1.43E-5 fatty acid desaturase (OLE1) 75 2.65E-5
9 SGTC_2342 7990637 3.99 118.9 µM 1.84E-5 RNA processing & uracil transport 35 3.35E-5
10 SGTC_1927 st060202 3.92 13.8 µM 2.49E-5 20 4.44E-5
11 SGTC_1738 st035555 3.71 74.0 µM 6.19E-5 TSC3-RPN4 38 1.04E-4
12 SGTC_155 k072-0202 3.65 43.6 µM 8.08E-5 22 1.33E-4
13 SGTC_2831 7999036 3.55 19.5 µM 1.20E-4 58 1.93E-4
14 SGTC_1929 genistein trimethyl ether 3.51 50.5 µM 1.39E-4 28 2.22E-4
15 SGTC_1924 st058459 3.48 75.1 µM 1.61E-4 19 2.53E-4
16 SGTC_2566 crystal violet carbinol 3.47 226.0 nM 1.67E-4 58 2.62E-4
17 SGTC_156 3474-0145 3.40 5.6 µM 2.18E-4 endomembrane recycling 73 3.37E-4
18 SGTC_1689 st020265 3.36 53.5 µM 2.50E-4 28 3.84E-4
19 SGTC_2537 larixol 3.31 68.9 µM 3.13E-4 53 4.73E-4
20 SGTC_39 0986-0283 3.29 58.4 µM 3.29E-4 calcium & mitochondrial duress 62 4.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 8.76E-19 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.124 4.64E-13 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.114 3.78E-11 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.114 4.03E-11 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.113 5.12E-11 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.112 8.24E-11 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.105 1.05E-9 YOL164W-A_p YOL164W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.102 3.32E-9 YGR019W UGA1 hom Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
0.101 4.54E-9 YKR049C FMP46 hom Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.101 5.07E-9 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.100 6.03E-9 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.099 7.69E-9 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.098 1.38E-8 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.095 3.58E-8 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.094 4.88E-8 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress