YDR373W / FRQ1

N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR373W / FRQ1

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:3.13|P-value:9.33E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.47|P-value:5.02E-11 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.67|P-value:1.02E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.51|P-value:1.87E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.69|P-value:1.19E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.60|P-value:2.22E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:-4.90|P-value:3.68E-7 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.87|P-value:4.56E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:-5.00|P-value:2.23E-7 ID:SGTC_913|Compound:3487-1245|FD-Score:6.42|P-value:6.70E-11 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.12|P-value:7.69E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.19|P-value:7.44E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.14|P-value:8.81E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:5.60|P-value:1.09E-8 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.48|P-value:2.68E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.22|P-value:6.76E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.24|P-value:6.24E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.43|P-value:3.20E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.78|P-value:8.37E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.81|P-value:7.27E-5 ID:SGTC_1762|Compound:st045503|FD-Score:7.27|P-value:1.71E-13 ID:SGTC_1767|Compound:st044992|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.72|P-value:8.15E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.26|P-value:4.74E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.09|P-value:2.28E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-6.20|P-value:1.95E-10 ID:SGTC_2057|Compound:5236571|FD-Score:-4.40|P-value:4.29E-6 ID:SGTC_2073|Compound:5212005|FD-Score:4.66|P-value:1.66E-6 ID:SGTC_2075|Compound:5212009|FD-Score:-4.86|P-value:4.49E-7 ID:SGTC_2243|Compound:6634756|FD-Score:3.12|P-value:9.54E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.36|P-value:4.08E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.28|P-value:4.48E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.66|P-value:1.32E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.92|P-value:4.61E-5 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.08|P-value:9.06E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.07|P-value:9.08E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.77|P-value:8.44E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.17|P-value:6.54E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.79|P-value:7.86E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.57|P-value:1.91E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.99|P-value:3.48E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.76|P-value:8.87E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.75|P-value:9.38E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.26|P-value:5.90E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.41|P-value:5.41E-6 ID:SGTC_2926|Compound:9010726|FD-Score:3.91|P-value:4.83E-5 ID:SGTC_2943|Compound:9068529|FD-Score:4.87|P-value:5.73E-7 ID:SGTC_2974|Compound:9094440|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.47|P-value:4.11E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.39|P-value:3.68E-4 ID:SGTC_3045|Compound:9092950|FD-Score:8.20|P-value:1.09E-16 ID:SGTC_3052|Compound:9092717|FD-Score:-4.43|P-value:3.65E-6 ID:SGTC_3054|Compound:9094397|FD-Score:4.02|P-value:3.05E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-10.80|P-value:9.52E-28 ID:SGTC_3094|Compound:9117742|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.54|P-value:2.09E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.50|P-value:1.95E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.20|P-value:5.91E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.29|P-value:5.22E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.83|P-value:6.65E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.77|P-value:8.54E-5 ID:SGTC_3319|Compound:9138450|FD-Score:5.00|P-value:2.97E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:3.13|P-value:9.33E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.47|P-value:5.02E-11 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.67|P-value:1.02E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.51|P-value:1.87E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.69|P-value:1.19E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.60|P-value:2.22E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:-4.90|P-value:3.68E-7 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.87|P-value:4.56E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:-5.00|P-value:2.23E-7 ID:SGTC_913|Compound:3487-1245|FD-Score:6.42|P-value:6.70E-11 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.12|P-value:7.69E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.19|P-value:7.44E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.14|P-value:8.81E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:5.60|P-value:1.09E-8 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.48|P-value:2.68E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.22|P-value:6.76E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.24|P-value:6.24E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.43|P-value:3.20E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.78|P-value:8.37E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.81|P-value:7.27E-5 ID:SGTC_1762|Compound:st045503|FD-Score:7.27|P-value:1.71E-13 ID:SGTC_1767|Compound:st044992|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.72|P-value:8.15E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.26|P-value:4.74E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.09|P-value:2.28E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-6.20|P-value:1.95E-10 ID:SGTC_2057|Compound:5236571|FD-Score:-4.40|P-value:4.29E-6 ID:SGTC_2073|Compound:5212005|FD-Score:4.66|P-value:1.66E-6 ID:SGTC_2075|Compound:5212009|FD-Score:-4.86|P-value:4.49E-7 ID:SGTC_2243|Compound:6634756|FD-Score:3.12|P-value:9.54E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.36|P-value:4.08E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.28|P-value:4.48E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.66|P-value:1.32E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.92|P-value:4.61E-5 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.08|P-value:9.06E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.07|P-value:9.08E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.77|P-value:8.44E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.17|P-value:6.54E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.79|P-value:7.86E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.57|P-value:1.91E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.99|P-value:3.48E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.76|P-value:8.87E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.75|P-value:9.38E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.26|P-value:5.90E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.41|P-value:5.41E-6 ID:SGTC_2926|Compound:9010726|FD-Score:3.91|P-value:4.83E-5 ID:SGTC_2943|Compound:9068529|FD-Score:4.87|P-value:5.73E-7 ID:SGTC_2974|Compound:9094440|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.47|P-value:4.11E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.39|P-value:3.68E-4 ID:SGTC_3045|Compound:9092950|FD-Score:8.20|P-value:1.09E-16 ID:SGTC_3052|Compound:9092717|FD-Score:-4.43|P-value:3.65E-6 ID:SGTC_3054|Compound:9094397|FD-Score:4.02|P-value:3.05E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-10.80|P-value:9.52E-28 ID:SGTC_3094|Compound:9117742|FD-Score:3.61|P-value:1.60E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.54|P-value:2.09E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.50|P-value:1.95E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.20|P-value:5.91E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.29|P-value:5.22E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.83|P-value:6.65E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.77|P-value:8.54E-5 ID:SGTC_3319|Compound:9138450|FD-Score:5.00|P-value:2.97E-7

Top fitness defect scores for YDR373W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3045 9092950 8.20 49.5 µM 1.09E-16 1 1.16E-16 3.95
2 SGTC_1762 st045503 7.27 25.5 µM 1.71E-13 1 1.74E-13 2.37
3 SGTC_163 1327-0036 6.47 7.5 µM 5.02E-11 29 5.00E-11 0.13
4 SGTC_913 3487-1245 6.42 167.0 µM 6.70E-11 3 6.67E-11 0.83
5 SGTC_1186 1319-0216 5.60 26.0 µM 1.09E-8 2 1.06E-8 1.23
6 SGTC_3319 9138450 5.00 16.8 µM 2.97E-7 1 2.86E-7 0.67
7 SGTC_2943 9068529 4.87 45.3 µM 5.73E-7 9 5.50E-7 0.21
8 SGTC_2073 5212005 4.66 126.0 µM 1.66E-6 2 1.59E-6 0.83
9 SGTC_616 4092-0450 4.60 108.0 µM 2.22E-6 2 2.12E-6 0.63
10 SGTC_2975 9084847 4.47 53.7 µM 4.11E-6 3 3.92E-6 0.08
11 SGTC_2925 9010536 4.41 32.5 µM 5.41E-6 azole & statin 3 5.17E-6 0.09
12 SGTC_1992 st073643 4.09 23.3 µM 2.28E-5 mitochondrial processes 9 2.17E-5 0.00
13 SGTC_3054 9094397 4.02 49.5 µM 3.05E-5 fatty acid desaturase (OLE1) 9 2.90E-5 0.30
14 SGTC_2815 7968870 3.99 71.4 µM 3.48E-5 6 3.31E-5 0.23
15 SGTC_2511 berberine 3.92 10.5 µM 4.61E-5 60S ribosome export 10 4.38E-5 0.32
16 SGTC_2926 9010726 3.91 65.2 µM 4.83E-5 7 4.59E-5 0.01
17 SGTC_3200 9114385 3.83 49.5 µM 6.65E-5 22 6.32E-5 0.03
18 SGTC_1752 st044819 3.81 83.0 µM 7.27E-5 9 6.90E-5 0.09
19 SGTC_2676 harmalol 3.79 100.0 µM 7.86E-5 mitochondrial processes 10 7.47E-5 0.04
20 SGTC_1737 st035557 3.78 69.7 µM 8.37E-5 8 7.95E-5 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.38E-25 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.141 2.86E-16 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.118 6.70E-12 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.117 8.85E-12 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.116 1.44E-11 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.115 2.03E-11 YER018C SPC25 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.115 2.80E-11 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.105 1.08E-9 YER126C NSA2 het Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
0.105 1.14E-9 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.102 3.03E-9 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.101 4.80E-9 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.099 7.73E-9 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.096 2.62E-8 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
0.096 2.66E-8 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.095 3.31E-8 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M