YDR376W / ARH1

Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR376W / ARH1

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-3.29|P-value:1.58E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.49|P-value:6.91E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.04|P-value:4.49E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.35|P-value:1.26E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.60|P-value:4.22E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.16|P-value:2.83E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.54|P-value:5.66E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.61|P-value:3.96E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.05|P-value:4.30E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:13.50|P-value:1.48E-49 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.40|P-value:1.01E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.14|P-value:3.01E-4 ID:SGTC_1621|Compound:st003705|FD-Score:2.85|P-value:9.30E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:15.90|P-value:1.15E-67 ID:SGTC_1737|Compound:st035557|FD-Score:-3.64|P-value:3.42E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-2.85|P-value:9.11E-4 ID:SGTC_2013|Compound:4024628|FD-Score:2.92|P-value:7.20E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.36|P-value:1.20E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.46|P-value:8.04E-5 ID:SGTC_2162|Compound:5663267|FD-Score:5.37|P-value:2.30E-9 ID:SGTC_2372|Compound:9071633|FD-Score:3.17|P-value:2.73E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.05|P-value:4.42E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:2.89|P-value:8.10E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.17|P-value:2.67E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.34|P-value:2.26E-12 ID:SGTC_2537|Compound:larixol|FD-Score:7.57|P-value:6.70E-17 ID:SGTC_2602|Compound:kawain|FD-Score:2.87|P-value:8.64E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.06|P-value:4.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.94|P-value:6.69E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.52|P-value:6.06E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.15|P-value:2.92E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.05|P-value:4.28E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.83|P-value:9.97E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.28|P-value:1.65E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.25|P-value:1.91E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-4.17|P-value:2.58E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.08|P-value:3.88E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.69|P-value:1.54E-7 ID:SGTC_2958|Compound:9077254|FD-Score:3.57|P-value:4.84E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.00|P-value:5.16E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.19|P-value:2.45E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-2.83|P-value:9.84E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.00|P-value:6.18E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.19|P-value:2.52E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.54|P-value:5.54E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.29|P-value:1.58E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.49|P-value:6.91E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.04|P-value:4.49E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.35|P-value:1.26E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.60|P-value:4.22E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.16|P-value:2.83E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.54|P-value:5.66E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.61|P-value:3.96E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.05|P-value:4.30E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:13.50|P-value:1.48E-49 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.40|P-value:1.01E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.14|P-value:3.01E-4 ID:SGTC_1621|Compound:st003705|FD-Score:2.85|P-value:9.30E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:15.90|P-value:1.15E-67 ID:SGTC_1737|Compound:st035557|FD-Score:-3.64|P-value:3.42E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-2.85|P-value:9.11E-4 ID:SGTC_2013|Compound:4024628|FD-Score:2.92|P-value:7.20E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.36|P-value:1.20E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.46|P-value:8.04E-5 ID:SGTC_2162|Compound:5663267|FD-Score:5.37|P-value:2.30E-9 ID:SGTC_2372|Compound:9071633|FD-Score:3.17|P-value:2.73E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.05|P-value:4.42E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:2.89|P-value:8.10E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.17|P-value:2.67E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.34|P-value:2.26E-12 ID:SGTC_2537|Compound:larixol|FD-Score:7.57|P-value:6.70E-17 ID:SGTC_2602|Compound:kawain|FD-Score:2.87|P-value:8.64E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.06|P-value:4.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.94|P-value:6.69E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.52|P-value:6.06E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.15|P-value:2.92E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.05|P-value:4.28E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.83|P-value:9.97E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.28|P-value:1.65E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.25|P-value:1.91E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-4.17|P-value:2.58E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.08|P-value:3.88E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.69|P-value:1.54E-7 ID:SGTC_2958|Compound:9077254|FD-Score:3.57|P-value:4.84E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.00|P-value:5.16E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.19|P-value:2.45E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-2.83|P-value:9.84E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.00|P-value:6.18E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.19|P-value:2.52E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.54|P-value:5.54E-5

Top fitness defect scores for YDR376W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1718 roemerine 15.90 11.9 µM 1.15E-67 redox potentiating 2 4.84E-57 3.81
2 SGTC_1083 didemethylchlorpromazine sulfoxide 13.50 707.4 nM 1.48E-49 redox potentiating 5 7.36E-42 0.92
3 SGTC_2537 larixol 7.57 68.9 µM 6.70E-17 1 1.85E-14 1.68
4 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.34 92.6 µM 2.26E-12 2 1.18E-10 0.80
5 SGTC_2162 5663267 5.37 200.0 µM 2.30E-9 3 4.01E-8 0.01
6 SGTC_2957 9076800 4.69 11.5 µM 1.54E-7 1 1.39E-6 0.40
7 SGTC_3187 9109394 4.00 49.5 µM 6.18E-6 Golgi 8 3.13E-5 0.03
8 SGTC_982 1491-0518 3.61 27.5 µM 3.96E-5 6 1.51E-4 0.08
9 SGTC_358 0075-0058 3.60 9.4 µM 4.22E-5 6 1.59E-4 0.02
10 SGTC_2958 9077254 3.57 16.7 µM 4.84E-5 8 1.78E-4 0.04
11 SGTC_628 1636-0253 3.54 16.0 µM 5.66E-5 sphingolipid biosynthesis & PDR1 13 2.04E-4 0.06
12 SGTC_2781 5567276 3.52 71.4 µM 6.06E-5 14 2.16E-4 0.03
13 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.49 44.4 nM 6.91E-5 DNA damage response 10 2.41E-4 0.01
14 SGTC_2158 5657123 3.46 3.6 µM 8.04E-5 19 2.74E-4 0.02
15 SGTC_1122 capsaicin 3.40 818.6 nM 1.01E-4 10 3.32E-4 0.13
16 SGTC_2024 5144227 3.36 134.0 µM 1.20E-4 10 3.84E-4 0.03
17 SGTC_353 1988-1175 3.35 58.3 µM 1.26E-4 unfolded protein response 16 4.02E-4 6.11E-4
18 SGTC_1213 1315-0166 3.30 115.0 µM 1.58E-4 25 4.87E-4 0.03
19 SGTC_2824 7998404 3.25 52.0 µM 1.91E-4 10 5.72E-4 0.08
20 SGTC_3217 9129673 3.19 49.5 µM 2.52E-4 23 7.22E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.524 6.95E-236 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.502 5.94E-214 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.346 5.03E-95 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.294 8.76E-68 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.199 2.61E-31 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.198 4.35E-31 YCL017C NFS1 het Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
0.182 1.61E-26 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.168 1.05E-22 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.167 2.34E-22 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.167 2.20E-22 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.166 3.31E-22 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.166 4.68E-22 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.163 1.67E-21 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.162 4.49E-21 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.159 1.73E-20 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes