YDR377W / ATP17

Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR377W / ATP17

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.21|P-value:8.95E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.37|P-value:7.17E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:5.74|P-value:9.48E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.69|P-value:2.22E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.38|P-value:4.97E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.34|P-value:5.74E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.99|P-value:5.26E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:5.60|P-value:2.02E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.19|P-value:2.17E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.33|P-value:4.19E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.19|P-value:9.69E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.18|P-value:9.74E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.90|P-value:8.94E-56 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.32|P-value:2.88E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:7.20|P-value:7.60E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.26|P-value:1.60E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.53|P-value:2.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.21|P-value:6.26E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.54|P-value:2.83E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:5.11|P-value:2.87E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:3.76|P-value:1.25E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.79|P-value:1.39E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.63|P-value:1.98E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.45|P-value:3.85E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.18|P-value:6.90E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.23|P-value:8.21E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.32|P-value:6.10E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.32|P-value:6.11E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.65|P-value:1.87E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.42|P-value:4.30E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.10|P-value:9.19E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.51|P-value:2.16E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.21|P-value:8.96E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.25|P-value:7.87E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.96|P-value:5.60E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.60|P-value:1.52E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.13|P-value:8.28E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.15|P-value:7.77E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.40|P-value:3.22E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.24|P-value:1.72E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.11|P-value:3.04E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.94|P-value:6.01E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.49|P-value:3.41E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-4.21|P-value:1.27E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.23|P-value:8.39E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.86|P-value:8.38E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.99|P-value:4.93E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.12|P-value:8.61E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.53|P-value:2.88E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.88|P-value:5.17E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.35|P-value:3.84E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.37|P-value:5.21E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.00|P-value:4.66E-5 ID:SGTC_2826|Compound:7992541|FD-Score:4.56|P-value:4.18E-6 ID:SGTC_2835|Compound:9006588|FD-Score:4.73|P-value:1.84E-6 ID:SGTC_2870|Compound:9038528|FD-Score:3.36|P-value:5.32E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.63|P-value:1.98E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-4.42|P-value:4.87E-6 ID:SGTC_3016|Compound:9080866|FD-Score:-3.39|P-value:3.33E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.56|P-value:2.63E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.28|P-value:7.07E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.27|P-value:7.16E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.21|P-value:8.95E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.37|P-value:7.17E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:5.74|P-value:9.48E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.69|P-value:2.22E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.38|P-value:4.97E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.34|P-value:5.74E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.99|P-value:5.26E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:5.60|P-value:2.02E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:3.75|P-value:1.27E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.19|P-value:2.17E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.33|P-value:4.19E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.19|P-value:9.69E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.18|P-value:9.74E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.90|P-value:8.94E-56 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.32|P-value:2.88E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:7.20|P-value:7.60E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.26|P-value:1.60E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.53|P-value:2.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.21|P-value:6.26E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.54|P-value:2.83E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:5.11|P-value:2.87E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:3.76|P-value:1.25E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.79|P-value:1.39E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.63|P-value:1.98E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.45|P-value:3.85E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.18|P-value:6.90E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.23|P-value:8.21E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.32|P-value:6.10E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.32|P-value:6.11E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.65|P-value:1.87E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.42|P-value:4.30E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.10|P-value:9.19E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.51|P-value:2.16E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.21|P-value:8.96E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.25|P-value:7.87E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.96|P-value:5.60E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.60|P-value:1.52E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.13|P-value:8.28E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.15|P-value:7.77E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.40|P-value:3.22E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.24|P-value:1.72E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.11|P-value:3.04E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.94|P-value:6.01E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.49|P-value:3.41E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-4.21|P-value:1.27E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.23|P-value:8.39E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.86|P-value:8.38E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.99|P-value:4.93E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.12|P-value:8.61E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.53|P-value:2.88E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.88|P-value:5.17E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.35|P-value:3.84E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.37|P-value:5.21E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.00|P-value:4.66E-5 ID:SGTC_2826|Compound:7992541|FD-Score:4.56|P-value:4.18E-6 ID:SGTC_2835|Compound:9006588|FD-Score:4.73|P-value:1.84E-6 ID:SGTC_2870|Compound:9038528|FD-Score:3.36|P-value:5.32E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.63|P-value:1.98E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-4.42|P-value:4.87E-6 ID:SGTC_3016|Compound:9080866|FD-Score:-3.39|P-value:3.33E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.56|P-value:2.63E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.28|P-value:7.07E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.27|P-value:7.16E-4

Top fitness defect scores for YDR377W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.90 5.3 µM 8.94E-56 87 2.38E-57
2 SGTC_310 1273-0058 7.20 1.1 µM 7.60E-13 mitochondrial stress 114 2.94E-13
3 SGTC_275 trichlorophene 6.32 5.7 µM 2.88E-10 mitochondrial stress 107 1.33E-10
4 SGTC_63 0099-0242 5.74 26.7 µM 9.48E-9 mitochondrial stress 32 4.86E-9
5 SGTC_134 0269-0018 5.60 6.9 µM 2.02E-8 88 1.06E-8
6 SGTC_59 0330-0160 5.37 1.3 µM 7.17E-8 49 3.92E-8
7 SGTC_550 4123-0385 5.11 25.7 µM 2.87E-7 TSC3-RPN4 7 1.64E-7
8 SGTC_127 0180-0333 4.99 59.1 µM 5.26E-7 mitochondrial response to ROS 16 3.06E-7
9 SGTC_744 1594-0068 4.79 283.0 µM 1.39E-6 amide catabolism 12 8.35E-7
10 SGTC_2835 9006588 4.73 71.4 µM 1.84E-6 23 1.12E-6
11 SGTC_70 0141-0289 4.69 43.3 µM 2.22E-6 mitochondrial stress 124 1.35E-6
12 SGTC_2826 7992541 4.56 19.5 µM 4.18E-6 9 2.60E-6
13 SGTC_314 1671-0008 4.26 2.7 µM 1.60E-5 39 1.04E-5
14 SGTC_1722 st034304 4.24 3.6 µM 1.72E-5 mitochondrial processes 16 1.12E-5
15 SGTC_149 3970-0822 4.19 46.1 µM 2.17E-5 tubulin folding & SWR complex 84 1.42E-5
16 SGTC_1807 st050092 4.11 58.9 µM 3.04E-5 60S ribosome export 10 2.02E-5
17 SGTC_2823 7987624 4.00 58.4 µM 4.66E-5 29 3.13E-5
18 SGTC_2250 alverine citrate 3.99 130.0 µM 4.93E-5 153 3.32E-5
19 SGTC_1353 1498-1206 3.96 8.1 µM 5.60E-5 mitochondrial response to ROS 54 3.79E-5
20 SGTC_2011 4012611 3.94 177.0 µM 6.01E-5 mitochondrial processes 32 4.08E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.496 1.11E-207 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.483 6.80E-196 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.472 5.93E-186 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.468 1.42E-182 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.468 3.37E-182 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.468 5.59E-182 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.459 2.29E-174 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.456 3.73E-172 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.452 6.54E-169 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.449 2.01E-166 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.439 5.72E-158 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.437 1.79E-156 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.432 1.11E-152 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.429 2.39E-150 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.428 5.76E-150 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci