YDR378C / LSM6

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR378C / LSM6

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:4.75|P-value:3.53E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:5.25|P-value:3.41E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:4.27|P-value:2.69E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.99|P-value:7.66E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.07|P-value:7.61E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.30|P-value:8.91E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.45|P-value:1.25E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.19|P-value:3.75E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.28|P-value:2.50E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.59|P-value:3.35E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.56|P-value:7.95E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.25|P-value:1.66E-9 ID:SGTC_232|Compound:clozapine|FD-Score:4.67|P-value:5.07E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.94|P-value:9.62E-9 ID:SGTC_291|Compound:4130-1278|FD-Score:3.34|P-value:7.96E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.51|P-value:3.47E-10 ID:SGTC_301|Compound:4119-0100|FD-Score:5.67|P-value:3.94E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.12|P-value:2.90E-18 ID:SGTC_379|Compound:3970-0972|FD-Score:4.29|P-value:2.48E-5 ID:SGTC_443|Compound:clozapine|FD-Score:3.61|P-value:3.23E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:11.70|P-value:5.97E-29 ID:SGTC_446|Compound:go6976|FD-Score:6.31|P-value:1.19E-9 ID:SGTC_447|Compound:ml7|FD-Score:5.83|P-value:1.71E-8 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.95|P-value:2.39E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.31|P-value:1.13E-9 ID:SGTC_505|Compound:gw-5074|FD-Score:5.49|P-value:1.01E-7 ID:SGTC_518|Compound:1021-0119|FD-Score:3.90|P-value:1.12E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:5.23|P-value:3.71E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:3.59|P-value:3.47E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:4.30|P-value:2.38E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:4.58|P-value:7.46E-6 ID:SGTC_687|Compound:k029-0044|FD-Score:3.62|P-value:3.08E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.10|P-value:5.25E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.32|P-value:8.41E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.76|P-value:1.87E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.18|P-value:3.88E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:8.08|P-value:1.01E-14 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.56|P-value:3.77E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.59|P-value:3.37E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:7.90|P-value:3.89E-14 ID:SGTC_1628|Compound:st004252|FD-Score:-3.66|P-value:2.61E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.52|P-value:8.60E-8 ID:SGTC_1687|Compound:st020778|FD-Score:6.17|P-value:2.60E-9 ID:SGTC_1694|Compound:st024011|FD-Score:4.86|P-value:2.17E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.26|P-value:1.51E-9 ID:SGTC_1750|Compound:st081859|FD-Score:4.64|P-value:5.61E-6 ID:SGTC_1754|Compound:st042065|FD-Score:6.18|P-value:2.54E-9 ID:SGTC_1760|Compound:st045453|FD-Score:5.17|P-value:5.08E-7 ID:SGTC_1781|Compound:st038725|FD-Score:12.70|P-value:9.19E-34 ID:SGTC_1797|Compound:st048695|FD-Score:7.29|P-value:2.61E-12 ID:SGTC_1803|Compound:st050068|FD-Score:3.38|P-value:6.95E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.48|P-value:1.12E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.71|P-value:4.13E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.58|P-value:3.56E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.44|P-value:5.75E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.37|P-value:7.07E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.49|P-value:1.01E-7 ID:SGTC_1998|Compound:st075797|FD-Score:-3.91|P-value:1.06E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.82|P-value:2.57E-6 ID:SGTC_2082|Compound:5219693|FD-Score:4.26|P-value:2.78E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.94|P-value:9.33E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.48|P-value:4.91E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.55|P-value:7.57E-8 ID:SGTC_2367|Compound:9070478|FD-Score:-5.11|P-value:6.29E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-3.67|P-value:2.54E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.98|P-value:8.25E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.83|P-value:2.45E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.28|P-value:2.59E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.10|P-value:5.29E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.01|P-value:1.05E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.11|P-value:4.99E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.40|P-value:1.62E-7 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.61|P-value:3.21E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.83|P-value:1.44E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.24|P-value:3.01E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-4.95|P-value:1.35E-6 ID:SGTC_2896|Compound:9052656|FD-Score:5.56|P-value:7.29E-8 ID:SGTC_2906|Compound:7926292|FD-Score:-3.40|P-value:6.32E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-4.25|P-value:2.85E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.83|P-value:1.44E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.50|P-value:1.03E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.46|P-value:1.21E-7 ID:SGTC_3193|Compound:9111931|FD-Score:4.38|P-value:1.70E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.54|P-value:3.95E-4 ID:SGTC_3337|Compound:9144342|FD-Score:5.65|P-value:4.56E-8 ID:SGTC_11|Compound:0438-0307|FD-Score:4.75|P-value:3.53E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:5.25|P-value:3.41E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:4.27|P-value:2.69E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.99|P-value:7.66E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.07|P-value:7.61E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.30|P-value:8.91E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.45|P-value:1.25E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.19|P-value:3.75E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.28|P-value:2.50E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.59|P-value:3.35E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.56|P-value:7.95E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.25|P-value:1.66E-9 ID:SGTC_232|Compound:clozapine|FD-Score:4.67|P-value:5.07E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.94|P-value:9.62E-9 ID:SGTC_291|Compound:4130-1278|FD-Score:3.34|P-value:7.96E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.51|P-value:3.47E-10 ID:SGTC_301|Compound:4119-0100|FD-Score:5.67|P-value:3.94E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.12|P-value:2.90E-18 ID:SGTC_379|Compound:3970-0972|FD-Score:4.29|P-value:2.48E-5 ID:SGTC_443|Compound:clozapine|FD-Score:3.61|P-value:3.23E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:11.70|P-value:5.97E-29 ID:SGTC_446|Compound:go6976|FD-Score:6.31|P-value:1.19E-9 ID:SGTC_447|Compound:ml7|FD-Score:5.83|P-value:1.71E-8 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.95|P-value:2.39E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.31|P-value:1.13E-9 ID:SGTC_505|Compound:gw-5074|FD-Score:5.49|P-value:1.01E-7 ID:SGTC_518|Compound:1021-0119|FD-Score:3.90|P-value:1.12E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:5.23|P-value:3.71E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:3.59|P-value:3.47E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:4.30|P-value:2.38E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:4.58|P-value:7.46E-6 ID:SGTC_687|Compound:k029-0044|FD-Score:3.62|P-value:3.08E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.10|P-value:5.25E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.32|P-value:8.41E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.76|P-value:1.87E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.18|P-value:3.88E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:8.08|P-value:1.01E-14 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.56|P-value:3.77E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.59|P-value:3.37E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:7.90|P-value:3.89E-14 ID:SGTC_1628|Compound:st004252|FD-Score:-3.66|P-value:2.61E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.52|P-value:8.60E-8 ID:SGTC_1687|Compound:st020778|FD-Score:6.17|P-value:2.60E-9 ID:SGTC_1694|Compound:st024011|FD-Score:4.86|P-value:2.17E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.26|P-value:1.51E-9 ID:SGTC_1750|Compound:st081859|FD-Score:4.64|P-value:5.61E-6 ID:SGTC_1754|Compound:st042065|FD-Score:6.18|P-value:2.54E-9 ID:SGTC_1760|Compound:st045453|FD-Score:5.17|P-value:5.08E-7 ID:SGTC_1781|Compound:st038725|FD-Score:12.70|P-value:9.19E-34 ID:SGTC_1797|Compound:st048695|FD-Score:7.29|P-value:2.61E-12 ID:SGTC_1803|Compound:st050068|FD-Score:3.38|P-value:6.95E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.48|P-value:1.12E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.71|P-value:4.13E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.58|P-value:3.56E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.44|P-value:5.75E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.37|P-value:7.07E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.49|P-value:1.01E-7 ID:SGTC_1998|Compound:st075797|FD-Score:-3.91|P-value:1.06E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.82|P-value:2.57E-6 ID:SGTC_2082|Compound:5219693|FD-Score:4.26|P-value:2.78E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.94|P-value:9.33E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.48|P-value:4.91E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.55|P-value:7.57E-8 ID:SGTC_2367|Compound:9070478|FD-Score:-5.11|P-value:6.29E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-3.67|P-value:2.54E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.98|P-value:8.25E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.83|P-value:2.45E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.28|P-value:2.59E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.10|P-value:5.29E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.01|P-value:1.05E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.11|P-value:4.99E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.40|P-value:1.62E-7 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.61|P-value:3.21E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-3.83|P-value:1.44E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.24|P-value:3.01E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-4.95|P-value:1.35E-6 ID:SGTC_2896|Compound:9052656|FD-Score:5.56|P-value:7.29E-8 ID:SGTC_2906|Compound:7926292|FD-Score:-3.40|P-value:6.32E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-4.25|P-value:2.85E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.83|P-value:1.44E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.50|P-value:1.03E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.46|P-value:1.21E-7 ID:SGTC_3193|Compound:9111931|FD-Score:4.38|P-value:1.70E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.54|P-value:3.95E-4 ID:SGTC_3337|Compound:9144342|FD-Score:5.65|P-value:4.56E-8

Top fitness defect scores for YDR378C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 12.70 66.3 µM 9.19E-34 NEO1 12 1.91E-37
2 SGTC_445 e6 berbamine 11.70 66.0 µM 5.97E-29 NEO1-PIK1 3 4.43E-32
3 SGTC_1287 0971-0001 8.08 34.6 µM 1.01E-14 sphingolipid biosynthesis & PDR1 15 3.18E-16
4 SGTC_1581 himbacine 7.90 57.9 µM 3.89E-14 Golgi 10 1.43E-15
5 SGTC_1797 st048695 7.29 56.8 µM 2.61E-12 NEO1 26 1.55E-13
6 SGTC_449 xestospongin c 6.95 11.2 µM 2.39E-11 NEO1-PIK1 13 1.82E-12
7 SGTC_446 go6976 6.31 132.0 µM 1.19E-9 2 1.41E-10
8 SGTC_221 trifluoperazine 6.25 10.3 µM 1.66E-9 NEO1-PIK1 116 2.05E-10
9 SGTC_1754 st042065 6.18 16.1 µM 2.54E-9 NEO1-PIK1 95 3.29E-10
10 SGTC_1687 st020778 6.17 55.4 µM 2.60E-9 105 3.37E-10
11 SGTC_268 camptothecin 5.94 39.6 µM 9.62E-9 DNA damage response 30 1.45E-9
12 SGTC_447 ml7 5.83 120.0 µM 1.71E-8 NEO1-PIK1 10 2.74E-9
13 SGTC_301 4119-0100 5.67 24.5 µM 3.94E-8 NEO1 44 6.95E-9
14 SGTC_3337 9144342 5.65 33.5 µM 4.56E-8 13 8.18E-9
15 SGTC_2896 9052656 5.56 71.4 µM 7.29E-8 endomembrane recycling 44 1.38E-8
16 SGTC_2322 7413319 5.55 38.2 µM 7.57E-8 ERAD & cell cycle 72 1.44E-8
17 SGTC_1679 4130-1276 5.52 6.7 µM 8.60E-8 Golgi 30 1.66E-8
18 SGTC_505 gw-5074 5.49 63.9 µM 1.01E-7 29 1.97E-8
19 SGTC_1991 st073000 5.49 8.9 µM 1.01E-7 NEO1 44 1.97E-8
20 SGTC_3188 9110789 5.46 49.5 µM 1.21E-7 iron homeostasis 6 2.41E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.412 5.78E-137 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.389 1.60E-121 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.352 1.03E-97 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.350 4.55E-97 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.339 1.59E-90 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.323 6.99E-82 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.318 2.02E-79 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.315 5.08E-78 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.312 1.92E-76 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.310 5.64E-75 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.304 2.47E-72 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.298 1.91E-69 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.282 3.20E-62 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.277 6.20E-60 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.269 1.11E-56 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress