YDR379C-A

Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR379C-A / YDR379C-A

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.32|P-value:3.69E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.35|P-value:3.20E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.36|P-value:3.15E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.86|P-value:2.31E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.81|P-value:2.28E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.61|P-value:4.45E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.83|P-value:2.59E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.82|P-value:2.67E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:5.22|P-value:8.39E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.44|P-value:7.81E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.25|P-value:4.80E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:4.01|P-value:1.15E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.74|P-value:2.90E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.93|P-value:1.54E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.26|P-value:4.57E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.63|P-value:4.23E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.96|P-value:1.66E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.07|P-value:1.11E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.45|P-value:7.53E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.90|P-value:1.99E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.81|P-value:2.29E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.24|P-value:5.96E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.11|P-value:9.77E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.54|P-value:5.67E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.42|P-value:8.33E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.81|P-value:2.30E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.38|P-value:2.88E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.54|P-value:5.58E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.44|P-value:7.75E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.48|P-value:2.48E-7 ID:SGTC_2128|Compound:5255449|FD-Score:3.88|P-value:1.84E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.88|P-value:3.44E-8 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.95|P-value:1.41E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.98|P-value:1.27E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:3.71|P-value:3.20E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.46|P-value:7.31E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.46|P-value:2.11E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.75|P-value:3.35E-4 ID:SGTC_2988|Compound:9073640|FD-Score:6.09|P-value:1.18E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.57|P-value:5.09E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.99|P-value:1.48E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-4.77|P-value:7.49E-6 ID:SGTC_3315|Compound:9136395|FD-Score:4.55|P-value:1.49E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.47|P-value:7.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.94|P-value:1.48E-4 ID:SGTC_3332|Compound:9141069|FD-Score:5.21|P-value:8.54E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:4.32|P-value:3.69E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.35|P-value:3.20E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.36|P-value:3.15E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.86|P-value:2.31E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.81|P-value:2.28E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.61|P-value:4.45E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.83|P-value:2.59E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.82|P-value:2.67E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:5.22|P-value:8.39E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.44|P-value:7.81E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.25|P-value:4.80E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:4.01|P-value:1.15E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.74|P-value:2.90E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.93|P-value:1.54E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.26|P-value:4.57E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.63|P-value:4.23E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.96|P-value:1.66E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.07|P-value:1.11E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.45|P-value:7.53E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.90|P-value:1.99E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.81|P-value:2.29E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.24|P-value:5.96E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.11|P-value:9.77E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.54|P-value:5.67E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.42|P-value:8.33E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.81|P-value:2.30E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.38|P-value:2.88E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.54|P-value:5.58E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.44|P-value:7.75E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.48|P-value:2.48E-7 ID:SGTC_2128|Compound:5255449|FD-Score:3.88|P-value:1.84E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.88|P-value:3.44E-8 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.95|P-value:1.41E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.98|P-value:1.27E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:3.71|P-value:3.20E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.46|P-value:7.31E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.46|P-value:2.11E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.75|P-value:3.35E-4 ID:SGTC_2988|Compound:9073640|FD-Score:6.09|P-value:1.18E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.57|P-value:5.09E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.99|P-value:1.48E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-4.77|P-value:7.49E-6 ID:SGTC_3315|Compound:9136395|FD-Score:4.55|P-value:1.49E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.47|P-value:7.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.94|P-value:1.48E-4 ID:SGTC_3332|Compound:9141069|FD-Score:5.21|P-value:8.54E-7

Top fitness defect scores for YDR379C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2988 9073640 6.09 71.4 µM 1.18E-8 4 5.70E-10
2 SGTC_2496 diffractaic acid 5.88 79.8 µM 3.44E-8 5 2.03E-9
3 SGTC_2056 5235370 5.48 200.0 µM 2.48E-7 17 2.12E-8
4 SGTC_329 k048-0121 5.22 21.3 µM 8.39E-7 RSC & ERG11 3 9.01E-8
5 SGTC_3332 9141069 5.21 11.2 µM 8.54E-7 3 9.20E-8
6 SGTC_3315 9136395 4.55 68.5 µM 1.49E-5 4 2.72E-6
7 SGTC_2912 7964298 4.46 10.9 µM 2.11E-5 cell wall 79 4.12E-6
8 SGTC_2010 4012422 4.38 159.0 µM 2.88E-5 15 5.96E-6
9 SGTC_70 0141-0289 4.36 43.3 µM 3.15E-5 mitochondrial stress 148 6.62E-6
10 SGTC_69 0096-0274 4.35 206.7 µM 3.20E-5 mitochondrial processes 29 6.74E-6
11 SGTC_64 000l-0018 4.32 272.1 µM 3.69E-5 ubiquinone biosynthesis & proteasome 132 7.97E-6
12 SGTC_1123 mangostin 4.26 811.3 nM 4.57E-5 mitochondrial response to ROS 30 1.03E-5
13 SGTC_673 1082-0474 4.25 110.0 µM 4.80E-5 RSC complex & mRNA processing 54 1.09E-5
14 SGTC_737 1950-0117 4.01 57.9 µM 1.15E-4 22 3.07E-5
15 SGTC_2558 carylophyllene oxide 3.98 100.0 µM 1.27E-4 12 3.45E-5
16 SGTC_2555 cholic acid 3.95 100.0 µM 1.41E-4 17 3.90E-5
17 SGTC_3330 9141424 3.94 71.4 µM 1.48E-4 amide catabolism 18 4.12E-5
18 SGTC_1694 st024011 3.93 44.9 µM 1.52E-4 ERG2 40 4.24E-5
19 SGTC_997 3996-0078 3.93 137.0 µM 1.54E-4 24 4.31E-5
20 SGTC_742 0kpi-0133 3.89 140.0 µM 1.72E-4 ERG2 25 4.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.07E-11 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
0.085 8.17E-7 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.083 1.55E-6 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.078 5.84E-6 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.077 8.31E-6 YOR186W_p YOR186W_p hom Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
0.076 9.68E-6 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.076 1.03E-5 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.074 1.96E-5 YCL043C PDI1 het Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
0.074 1.99E-5 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.071 4.12E-5 YOR132W VPS17 hom Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
0.071 4.40E-5 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.070 4.62E-5 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.070 4.59E-5 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.068 7.28E-5 YPR131C NAT3 hom Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
0.068 9.13E-5 YER123W YCK3 hom Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway