YDR379W / RGA2

GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR379W / RGA2

Click on Significant Values for Screen Details ID:SGTC_212|Compound:3807-4682|FD-Score:2.90|P-value:7.68E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.49|P-value:6.91E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-2.93|P-value:6.84E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:5.32|P-value:3.21E-9 ID:SGTC_617|Compound:3770-0098|FD-Score:2.96|P-value:6.34E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.70|P-value:2.68E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.01|P-value:6.05E-6 ID:SGTC_736|Compound:0958-0254|FD-Score:3.23|P-value:2.10E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.50|P-value:6.73E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.94|P-value:6.60E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.25|P-value:1.93E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.09|P-value:3.69E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.01|P-value:5.89E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.15|P-value:2.94E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.25|P-value:1.93E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.56|P-value:5.06E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.98|P-value:5.77E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.91|P-value:9.76E-6 ID:SGTC_1734|Compound:st037168|FD-Score:-7.19|P-value:1.99E-15 ID:SGTC_1737|Compound:st035557|FD-Score:-4.84|P-value:6.28E-8 ID:SGTC_1859|Compound:st055998|FD-Score:2.93|P-value:6.99E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.89|P-value:8.19E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.16|P-value:2.80E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.34|P-value:1.34E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.38|P-value:1.12E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.94|P-value:6.64E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.49|P-value:7.10E-5 ID:SGTC_2272|Compound:7805186|FD-Score:6.55|P-value:4.56E-13 ID:SGTC_2279|Compound:7948423|FD-Score:6.11|P-value:1.33E-11 ID:SGTC_2300|Compound:7976697|FD-Score:3.29|P-value:1.64E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.17|P-value:2.68E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-4.00|P-value:6.19E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.97|P-value:5.81E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.06|P-value:4.06E-4 ID:SGTC_2333|Compound:9017922|FD-Score:6.21|P-value:5.97E-12 ID:SGTC_2334|Compound:9017922|FD-Score:5.81|P-value:1.13E-10 ID:SGTC_2338|Compound:7999974|FD-Score:4.50|P-value:4.54E-7 ID:SGTC_2423|Compound:st077119|FD-Score:-4.63|P-value:2.15E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.41|P-value:9.86E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.54|P-value:5.56E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.36|P-value:9.43E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.20|P-value:2.35E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-2.93|P-value:6.75E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.30|P-value:1.62E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.11|P-value:3.41E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:2.90|P-value:7.68E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.49|P-value:6.91E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-2.93|P-value:6.84E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:5.32|P-value:3.21E-9 ID:SGTC_617|Compound:3770-0098|FD-Score:2.96|P-value:6.34E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.70|P-value:2.68E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.01|P-value:6.05E-6 ID:SGTC_736|Compound:0958-0254|FD-Score:3.23|P-value:2.10E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.50|P-value:6.73E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.94|P-value:6.60E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.25|P-value:1.93E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.09|P-value:3.69E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.01|P-value:5.89E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.15|P-value:2.94E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.25|P-value:1.93E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.56|P-value:5.06E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.98|P-value:5.77E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.91|P-value:9.76E-6 ID:SGTC_1734|Compound:st037168|FD-Score:-7.19|P-value:1.99E-15 ID:SGTC_1737|Compound:st035557|FD-Score:-4.84|P-value:6.28E-8 ID:SGTC_1859|Compound:st055998|FD-Score:2.93|P-value:6.99E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.89|P-value:8.19E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.16|P-value:2.80E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.34|P-value:1.34E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.38|P-value:1.12E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.94|P-value:6.64E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.49|P-value:7.10E-5 ID:SGTC_2272|Compound:7805186|FD-Score:6.55|P-value:4.56E-13 ID:SGTC_2279|Compound:7948423|FD-Score:6.11|P-value:1.33E-11 ID:SGTC_2300|Compound:7976697|FD-Score:3.29|P-value:1.64E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.17|P-value:2.68E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-4.00|P-value:6.19E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.97|P-value:5.81E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.06|P-value:4.06E-4 ID:SGTC_2333|Compound:9017922|FD-Score:6.21|P-value:5.97E-12 ID:SGTC_2334|Compound:9017922|FD-Score:5.81|P-value:1.13E-10 ID:SGTC_2338|Compound:7999974|FD-Score:4.50|P-value:4.54E-7 ID:SGTC_2423|Compound:st077119|FD-Score:-4.63|P-value:2.15E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.41|P-value:9.86E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.54|P-value:5.56E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.36|P-value:9.43E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.20|P-value:2.35E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-2.93|P-value:6.75E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.30|P-value:1.62E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.11|P-value:3.41E-4

Top fitness defect scores for YDR379W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2272 7805186 6.55 180.0 µM 4.56E-13 cell wall signaling 6 2.95E-11
2 SGTC_2333 9017922 6.21 200.0 µM 5.97E-12 6 2.58E-10
3 SGTC_2279 7948423 6.11 32.9 µM 1.33E-11 2 5.07E-10
4 SGTC_2334 9017922 5.81 200.0 µM 1.13E-10 3 3.08E-9
5 SGTC_424 splitomicin 5.32 100.0 mM 3.21E-9 6 5.17E-8
6 SGTC_2338 7999974 4.50 200.0 µM 4.54E-7 9 3.38E-6
7 SGTC_2306 7482397 4.17 179.5 µM 2.68E-6 RPP1 & pyrimidine depletion 17 1.51E-5
8 SGTC_669 0108-0021 4.01 26.2 µM 6.05E-6 fatty acid desaturase (OLE1) 77 3.02E-5
9 SGTC_1603 st002045 3.56 67.8 µM 5.06E-5 TSC3-RPN4 24 1.82E-4
10 SGTC_2618 avocadyne 3.54 43.4 µM 5.56E-5 43 1.98E-4
11 SGTC_747 3448-8087 3.50 38.7 µM 6.73E-5 38 2.33E-4
12 SGTC_350 k064-0020 3.49 19.8 µM 6.91E-5 heme requiring 39 2.38E-4
13 SGTC_2271 7849410 3.49 118.6 µM 7.10E-5 20 2.43E-4
14 SGTC_2041 5107442 3.38 45.3 µM 1.12E-4 RSC complex & mRNA processing 43 3.57E-4
15 SGTC_2021 4019055 3.34 173.0 µM 1.34E-4 endomembrane recycling 176 4.18E-4
16 SGTC_2930 9013230 3.31 14.9 µM 1.51E-4 heme biosynthesis & mitochondrial translocase 68 4.63E-4
17 SGTC_2938 9059746 3.30 27.3 µM 1.62E-4 fatty acid desaturase (OLE1) 60 4.89E-4
18 SGTC_2300 7976697 3.29 71.6 µM 1.64E-4 ERG2 58 4.95E-4
19 SGTC_1294 1000-1494 3.25 117.0 µM 1.93E-4 46 5.68E-4
20 SGTC_736 0958-0254 3.23 92.6 µM 2.10E-4 Golgi 59 6.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.72E-18 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.147 1.07E-17 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.69E-13 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.111 1.36E-10 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.110 1.70E-10 YJR068W RFC2 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.110 1.84E-10 YDL231C BRE4 hom Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
0.109 2.75E-10 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.106 6.39E-10 YJL041W NSP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.098 1.32E-8 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.096 2.30E-8 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.095 3.69E-8 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.093 7.08E-8 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.090 1.85E-7 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
0.088 3.78E-7 YPL127C HHO1 hom Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
0.087 4.95E-7 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint