YDR383C / NKP1

Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR383C / NKP1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.68|P-value:1.45E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:4.08|P-value:2.37E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.60|P-value:2.15E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:5.70|P-value:5.62E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.36|P-value:4.13E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.27|P-value:5.72E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.10|P-value:7.51E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.26|P-value:5.92E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.72|P-value:1.07E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:5.46|P-value:2.31E-8 ID:SGTC_358|Compound:0075-0058|FD-Score:5.59|P-value:1.13E-8 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.19|P-value:7.60E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.09|P-value:1.06E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:3.77|P-value:8.59E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.29|P-value:5.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.77|P-value:5.70E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.16|P-value:8.42E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.76|P-value:8.95E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.56|P-value:2.63E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:4.36|P-value:6.54E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.12|P-value:1.28E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.48|P-value:2.62E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.74|P-value:9.65E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.15|P-value:6.24E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.20|P-value:7.33E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.64|P-value:1.43E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.10|P-value:7.48E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.71|P-value:1.25E-6 ID:SGTC_1632|Compound:st005650|FD-Score:4.60|P-value:2.10E-6 ID:SGTC_1714|Compound:st033236|FD-Score:4.00|P-value:3.30E-5 ID:SGTC_1806|Compound:st050005|FD-Score:4.59|P-value:2.21E-6 ID:SGTC_1922|Compound:5578187|FD-Score:5.78|P-value:3.53E-9 ID:SGTC_1983|Compound:st071813|FD-Score:3.56|P-value:1.93E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.16|P-value:8.33E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.50|P-value:2.45E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.31|P-value:4.91E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.51|P-value:2.07E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.15|P-value:8.69E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.39|P-value:3.68E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.40|P-value:3.60E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.49|P-value:2.55E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.14|P-value:1.20E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-4.07|P-value:1.64E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:5.48|P-value:2.06E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.90|P-value:5.01E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.21|P-value:6.98E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.29|P-value:5.37E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.17|P-value:8.16E-4 ID:SGTC_2877|Compound:9040724|FD-Score:4.79|P-value:8.53E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.68|P-value:1.45E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:4.08|P-value:2.37E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.60|P-value:2.15E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:5.70|P-value:5.62E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:3.36|P-value:4.13E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.27|P-value:5.72E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.10|P-value:7.51E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.26|P-value:5.92E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.72|P-value:1.07E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:5.46|P-value:2.31E-8 ID:SGTC_358|Compound:0075-0058|FD-Score:5.59|P-value:1.13E-8 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.19|P-value:7.60E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.09|P-value:1.06E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:3.77|P-value:8.59E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.29|P-value:5.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.77|P-value:5.70E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.16|P-value:8.42E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.76|P-value:8.95E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.56|P-value:2.63E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:4.36|P-value:6.54E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.12|P-value:1.28E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.48|P-value:2.62E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.74|P-value:9.65E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.15|P-value:6.24E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.20|P-value:7.33E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.64|P-value:1.43E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.10|P-value:7.48E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.71|P-value:1.25E-6 ID:SGTC_1632|Compound:st005650|FD-Score:4.60|P-value:2.10E-6 ID:SGTC_1714|Compound:st033236|FD-Score:4.00|P-value:3.30E-5 ID:SGTC_1806|Compound:st050005|FD-Score:4.59|P-value:2.21E-6 ID:SGTC_1922|Compound:5578187|FD-Score:5.78|P-value:3.53E-9 ID:SGTC_1983|Compound:st071813|FD-Score:3.56|P-value:1.93E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.16|P-value:8.33E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.50|P-value:2.45E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.31|P-value:4.91E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.51|P-value:2.07E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.15|P-value:8.69E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.39|P-value:3.68E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.40|P-value:3.60E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.49|P-value:2.55E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.14|P-value:1.20E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-4.07|P-value:1.64E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:5.48|P-value:2.06E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.90|P-value:5.01E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.21|P-value:6.98E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.29|P-value:5.37E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.17|P-value:8.16E-4 ID:SGTC_2877|Compound:9040724|FD-Score:4.79|P-value:8.53E-7

Top fitness defect scores for YDR383C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1922 5578187 5.78 25.0 µM 3.53E-9 TRP & mitochondrial translation 5 3.69E-9
2 SGTC_73 0327-0325 5.70 16.2 µM 5.62E-9 DNA damage response 17 5.85E-9
3 SGTC_358 0075-0058 5.59 9.4 µM 1.13E-8 24 1.17E-8
4 SGTC_2521 angolensin 5.48 13.4 µM 2.06E-8 2 2.12E-8
5 SGTC_291 4130-1278 5.46 35.5 µM 2.31E-8 Golgi 4 2.37E-8
6 SGTC_2877 9040724 4.79 71.4 µM 8.53E-7 3 8.44E-7
7 SGTC_1626 st003712 4.71 1.8 µM 1.25E-6 13 1.23E-6
8 SGTC_46 0329-0187a 4.68 2.2 µM 1.45E-6 48 1.43E-6
9 SGTC_1632 st005650 4.60 90.0 µM 2.10E-6 13 2.06E-6
10 SGTC_70 0141-0289 4.60 43.3 µM 2.15E-6 mitochondrial stress 131 2.12E-6
11 SGTC_1806 st050005 4.59 60.3 µM 2.21E-6 3 2.17E-6
12 SGTC_818 4072-2707 4.56 53.5 µM 2.63E-6 7 2.58E-6
13 SGTC_825 1988-2224 4.36 89.6 µM 6.54E-6 cell wall signaling 26 6.36E-6
14 SGTC_65 0798-0905 4.08 35.0 µM 2.37E-5 calcium & mitochondrial duress 83 2.28E-5
15 SGTC_1714 st033236 4.00 13.6 µM 3.30E-5 20 3.17E-5
16 SGTC_2627 acetyl isogambogic acid 3.90 100.0 µM 5.01E-5 TSC3-RPN4 46 4.79E-5
17 SGTC_679 0422-0091 3.77 41.4 µM 8.59E-5 Golgi 35 8.20E-5
18 SGTC_801 0866-0028 3.76 10.1 µM 8.95E-5 35 8.54E-5
19 SGTC_952 1185-0122 3.74 232.0 µM 9.65E-5 23 9.20E-5
20 SGTC_278 4092-0821 3.72 23.9 µM 1.07E-4 plasma membrane duress 49 1.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.03E-14 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.121 2.09E-12 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 2.15E-12 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.111 1.01E-10 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.111 1.24E-10 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.104 1.59E-9 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.103 2.18E-9 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.102 3.13E-9 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.093 6.06E-8 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.092 8.00E-8 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.092 8.14E-8 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.092 1.09E-7 YBR162W-A YSY6 hom Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.091 1.41E-7 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.090 1.79E-7 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.086 5.90E-7 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex