YDR391C_p

Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR391C / YDR391C

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.57|P-value:1.87E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:3.28|P-value:4.47E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.48|P-value:2.12E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.67|P-value:1.01E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-3.08|P-value:8.62E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.75|P-value:3.91E-12 ID:SGTC_312|Compound:4092-0653|FD-Score:6.26|P-value:1.09E-10 ID:SGTC_345|Compound:1362-0200|FD-Score:3.70|P-value:8.92E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.22|P-value:5.60E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.50|P-value:1.85E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.38|P-value:4.67E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:3.25|P-value:5.08E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.39|P-value:2.76E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.42|P-value:2.53E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.18|P-value:7.56E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.16|P-value:6.40E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.90|P-value:3.45E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.15|P-value:1.22E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.06|P-value:1.83E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:4.01|P-value:2.43E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.64|P-value:1.14E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.59|P-value:1.40E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.31|P-value:4.03E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.08|P-value:8.63E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.65|P-value:1.09E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.02|P-value:2.38E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.67|P-value:1.03E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:6.38|P-value:5.04E-11 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.47|P-value:2.26E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.50|P-value:1.86E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.78|P-value:6.40E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.57|P-value:1.37E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.48|P-value:2.12E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.76|P-value:7.18E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.58|P-value:1.46E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.17|P-value:6.19E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-5.27|P-value:4.29E-8 ID:SGTC_2120|Compound:5538279|FD-Score:-3.04|P-value:9.91E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.12|P-value:7.40E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.35|P-value:3.20E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.53|P-value:1.66E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.25|P-value:5.00E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.15|P-value:7.09E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-4.19|P-value:9.92E-6 ID:SGTC_2452|Compound:5863136|FD-Score:-5.97|P-value:6.26E-10 ID:SGTC_2811|Compound:7967822|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.75|P-value:7.64E-7 ID:SGTC_2842|Compound:9000675|FD-Score:3.24|P-value:5.25E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.25|P-value:5.07E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.21|P-value:1.58E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:4.57|P-value:1.87E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:3.28|P-value:4.47E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.48|P-value:2.12E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.67|P-value:1.01E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-3.08|P-value:8.62E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.75|P-value:3.91E-12 ID:SGTC_312|Compound:4092-0653|FD-Score:6.26|P-value:1.09E-10 ID:SGTC_345|Compound:1362-0200|FD-Score:3.70|P-value:8.92E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.22|P-value:5.60E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.50|P-value:1.85E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.38|P-value:4.67E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:3.25|P-value:5.08E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-3.39|P-value:2.76E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.42|P-value:2.53E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.18|P-value:7.56E-8 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.16|P-value:6.40E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.90|P-value:3.45E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.15|P-value:1.22E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-4.06|P-value:1.83E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:4.01|P-value:2.43E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.64|P-value:1.14E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.59|P-value:1.40E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.31|P-value:4.03E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.08|P-value:8.63E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.65|P-value:1.09E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.02|P-value:2.38E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.67|P-value:1.03E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:6.38|P-value:5.04E-11 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.47|P-value:2.26E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.50|P-value:1.86E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.78|P-value:6.40E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.57|P-value:1.37E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.48|P-value:2.12E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.76|P-value:7.18E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.58|P-value:1.46E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.17|P-value:6.19E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-5.27|P-value:4.29E-8 ID:SGTC_2120|Compound:5538279|FD-Score:-3.04|P-value:9.91E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.12|P-value:7.40E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.35|P-value:3.20E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.53|P-value:1.66E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.25|P-value:5.00E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.15|P-value:7.09E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-4.19|P-value:9.92E-6 ID:SGTC_2452|Compound:5863136|FD-Score:-5.97|P-value:6.26E-10 ID:SGTC_2811|Compound:7967822|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.75|P-value:7.64E-7 ID:SGTC_2842|Compound:9000675|FD-Score:3.24|P-value:5.25E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.25|P-value:5.07E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.21|P-value:1.58E-10

Top fitness defect scores for YDR391C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 6.75 406.0 nM 3.91E-12 sphingolipid biosynthesis & PDR1 18 7.40E-12
2 SGTC_1281 0884-0031 6.38 11.8 µM 5.04E-11 fatty acid desaturase (OLE1) 6 8.90E-11
3 SGTC_312 4092-0653 6.26 6.8 µM 1.09E-10 ergosterol depletion effects on membrane 36 1.88E-10
4 SGTC_2858 9025781 6.21 9.0 µM 1.58E-10 sphingolipid biosynthesis & PDR1 43 2.70E-10
5 SGTC_669 0108-0021 5.18 26.2 µM 7.56E-8 fatty acid desaturase (OLE1) 34 1.09E-7
6 SGTC_674 0498-0004 4.90 451.0 µM 3.45E-7 heme requiring 8 4.79E-7
7 SGTC_2837 9008476 4.75 45.5 µM 7.64E-7 16 1.04E-6
8 SGTC_43 0570-0105 4.57 72.5 µM 1.87E-6 ERG2 65 2.48E-6
9 SGTC_457 grayanotoxin iii 4.38 135.0 µM 4.67E-6 48 6.05E-6
10 SGTC_453 enantio-paf c16 4.09 10.0 µM 1.70E-5 131 2.13E-5
11 SGTC_1263 0774-1208 4.02 64.8 µM 2.38E-5 45 2.95E-5
12 SGTC_865 0488-0499 4.01 301.0 µM 2.43E-5 17 3.02E-5
13 SGTC_1679 4130-1276 3.78 6.7 µM 6.40E-5 Golgi 72 7.74E-5
14 SGTC_1794 st048918 3.76 76.9 µM 7.18E-5 13 8.67E-5
15 SGTC_345 1362-0200 3.70 395.0 µM 8.92E-5 23 1.07E-4
16 SGTC_217 ketoconazole 3.67 989.0 nM 1.01E-4 ergosterol depletion effects on membrane 34 1.20E-4
17 SGTC_1277 0873-0036 3.67 22.0 µM 1.03E-4 PDR1 34 1.23E-4
18 SGTC_1228 0124-0032 3.65 52.5 µM 1.09E-4 28 1.30E-4
19 SGTC_1083 didemethylchlorpromazine sulfoxide 3.64 707.4 nM 1.14E-4 redox potentiating 98 1.36E-4
20 SGTC_1145 3546-0597 3.59 10.2 µM 1.40E-4 mitochondrial processes 26 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 6.30E-37 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.156 8.96E-20 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.150 2.07E-18 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.147 1.15E-17 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.133 9.57E-15 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.126 2.73E-13 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.124 5.45E-13 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.124 6.46E-13 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.119 5.57E-12 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.118 6.86E-12 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.115 2.77E-11 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.113 5.57E-11 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.113 6.42E-11 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.111 1.15E-10 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.111 1.30E-10 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data