YDR392W / SPT3

Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR392W / SPT3

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:7.92|P-value:7.29E-10 ID:SGTC_8|Compound:0354-0001|FD-Score:5.95|P-value:2.75E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:10.10|P-value:6.88E-15 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.32|P-value:4.91E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.68|P-value:7.08E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:6.88|P-value:7.39E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.12|P-value:4.66E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.50|P-value:1.31E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:6.23|P-value:9.78E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.26|P-value:5.58E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.14|P-value:7.73E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.67|P-value:7.40E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:6.43|P-value:4.43E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:7.30|P-value:1.22E-8 ID:SGTC_205|Compound:1486-1330|FD-Score:4.75|P-value:1.41E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.02|P-value:4.05E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:10.20|P-value:2.67E-15 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.11|P-value:8.49E-4 ID:SGTC_252|Compound:miconazole|FD-Score:7.58|P-value:3.41E-9 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:5.79|P-value:4.91E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:5.71|P-value:6.40E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.52|P-value:1.22E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:5.28|P-value:2.74E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:4.82|P-value:1.16E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.26|P-value:8.91E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.54|P-value:2.62E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.65|P-value:2.64E-9 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.41|P-value:3.82E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.69|P-value:6.82E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.69|P-value:1.72E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:12.90|P-value:3.43E-23 ID:SGTC_447|Compound:ml7|FD-Score:4.66|P-value:1.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.19|P-value:3.60E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.94|P-value:8.04E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.61|P-value:9.15E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.28|P-value:2.69E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:4.05|P-value:9.92E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.67|P-value:1.78E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:18.70|P-value:1.95E-46 ID:SGTC_513|Compound:4245-1575|FD-Score:8.76|P-value:1.10E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.14|P-value:7.97E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.66|P-value:1.82E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.18|P-value:2.04E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.70|P-value:1.68E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:7.79|P-value:1.32E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.55|P-value:2.57E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.35|P-value:4.46E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:5.89|P-value:3.33E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:10.00|P-value:1.11E-14 ID:SGTC_634|Compound:1611-4317|FD-Score:7.66|P-value:2.38E-9 ID:SGTC_639|Compound:0833-0042|FD-Score:5.23|P-value:3.22E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:-4.16|P-value:7.44E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-6.11|P-value:1.57E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.05|P-value:9.96E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:18.70|P-value:2.09E-46 ID:SGTC_683|Compound:panaxydol|FD-Score:8.25|P-value:1.49E-10 ID:SGTC_800|Compound:3448-7362|FD-Score:4.48|P-value:3.05E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.87|P-value:3.68E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:6.86|P-value:7.85E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:5.02|P-value:6.31E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:4.41|P-value:3.77E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.30|P-value:5.10E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:6.77|P-value:1.13E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:17.50|P-value:5.02E-41 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.35|P-value:4.50E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.67|P-value:1.80E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.46|P-value:1.52E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-5.53|P-value:1.21E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:-4.19|P-value:6.87E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:-4.08|P-value:9.18E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:9.23|P-value:8.98E-13 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.61|P-value:2.22E-7 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.11|P-value:8.48E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:21.80|P-value:1.64E-62 ID:SGTC_1304|Compound:1165-0502|FD-Score:9.02|P-value:2.75E-12 ID:SGTC_1550|Compound:gossypolone|FD-Score:-4.08|P-value:9.26E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.24|P-value:5.98E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.02|P-value:6.17E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-7.80|P-value:1.32E-9 ID:SGTC_1687|Compound:st020778|FD-Score:19.90|P-value:1.87E-52 ID:SGTC_1694|Compound:st024011|FD-Score:12.00|P-value:2.10E-20 ID:SGTC_1712|Compound:st032288|FD-Score:-4.44|P-value:3.52E-4 ID:SGTC_1754|Compound:st042065|FD-Score:16.10|P-value:5.29E-35 ID:SGTC_1760|Compound:st045453|FD-Score:8.54|P-value:3.41E-11 ID:SGTC_1800|Compound:st050079|FD-Score:10.40|P-value:1.05E-15 ID:SGTC_1801|Compound:st050089|FD-Score:12.20|P-value:4.63E-21 ID:SGTC_1803|Compound:st050068|FD-Score:11.70|P-value:1.81E-19 ID:SGTC_1810|Compound:st050138|FD-Score:4.67|P-value:1.80E-4 ID:SGTC_1818|Compound:st052136|FD-Score:7.36|P-value:9.47E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.20|P-value:1.93E-8 ID:SGTC_1861|Compound:st057647|FD-Score:5.54|P-value:1.15E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:9.86|P-value:2.43E-14 ID:SGTC_1909|Compound:st060837|FD-Score:4.15|P-value:7.52E-4 ID:SGTC_1934|Compound:st074720|FD-Score:6.89|P-value:6.95E-8 ID:SGTC_1941|Compound:st076221|FD-Score:9.25|P-value:7.69E-13 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.11|P-value:8.50E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-5.12|P-value:4.69E-5 ID:SGTC_1991|Compound:st073000|FD-Score:8.96|P-value:3.87E-12 ID:SGTC_1997|Compound:st073024|FD-Score:4.79|P-value:1.25E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.58|P-value:2.30E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.80|P-value:4.63E-6 ID:SGTC_2018|Compound:5133068|FD-Score:5.76|P-value:5.43E-6 ID:SGTC_2021|Compound:4019055|FD-Score:-5.73|P-value:6.00E-6 ID:SGTC_2023|Compound:5144124|FD-Score:4.69|P-value:1.68E-4 ID:SGTC_2132|Compound:5317594|FD-Score:6.70|P-value:1.52E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.28|P-value:5.37E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.86|P-value:1.03E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.25|P-value:5.83E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.30|P-value:1.20E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.45|P-value:1.57E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.80|P-value:1.25E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.86|P-value:7.92E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.75|P-value:1.27E-7 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:5.48|P-value:1.39E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.17|P-value:3.86E-5 ID:SGTC_2699|Compound:st077704|FD-Score:7.91|P-value:7.52E-10 ID:SGTC_2701|Compound:st077767|FD-Score:6.56|P-value:2.71E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.60|P-value:2.90E-29 ID:SGTC_2765|Compound:myclobutanil|FD-Score:6.79|P-value:1.07E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.03|P-value:2.06E-6 ID:SGTC_2812|Compound:7970281|FD-Score:4.12|P-value:8.16E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.13|P-value:4.40E-5 ID:SGTC_2816|Compound:7982706|FD-Score:5.56|P-value:1.06E-5 ID:SGTC_2858|Compound:9025781|FD-Score:26.80|P-value:1.01E-93 ID:SGTC_2887|Compound:9044784|FD-Score:-5.31|P-value:2.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-15.20|P-value:1.42E-31 ID:SGTC_2932|Compound:9016711|FD-Score:44.50|P-value:1.69E-253 ID:SGTC_2943|Compound:9068529|FD-Score:-6.45|P-value:4.17E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-7.38|P-value:8.83E-9 ID:SGTC_2948|Compound:9070189|FD-Score:-10.00|P-value:9.30E-15 ID:SGTC_2953|Compound:9074162|FD-Score:5.08|P-value:5.12E-5 ID:SGTC_2976|Compound:9009005|FD-Score:17.30|P-value:2.97E-40 ID:SGTC_3025|Compound:9087895|FD-Score:5.38|P-value:1.96E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:10.30|P-value:2.24E-15 ID:SGTC_3060|Compound:1327-0027|FD-Score:8.25|P-value:1.46E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.48|P-value:2.24E-13 ID:SGTC_3098|Compound:9119039|FD-Score:4.30|P-value:5.10E-4 ID:SGTC_3174|Compound:9107204|FD-Score:5.65|P-value:7.80E-6 ID:SGTC_3189|Compound:9110682|FD-Score:4.06|P-value:9.63E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-4.25|P-value:5.91E-4 ID:SGTC_3265|Compound:9137266|FD-Score:4.20|P-value:6.68E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.10|P-value:1.59E-6 ID:SGTC_3281|Compound:9140613|FD-Score:4.14|P-value:7.83E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:7.92|P-value:7.29E-10 ID:SGTC_8|Compound:0354-0001|FD-Score:5.95|P-value:2.75E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:10.10|P-value:6.88E-15 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.32|P-value:4.91E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.68|P-value:7.08E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:6.88|P-value:7.39E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.12|P-value:4.66E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.50|P-value:1.31E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:6.23|P-value:9.78E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.26|P-value:5.58E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.14|P-value:7.73E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.67|P-value:7.40E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:6.43|P-value:4.43E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:7.30|P-value:1.22E-8 ID:SGTC_205|Compound:1486-1330|FD-Score:4.75|P-value:1.41E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.02|P-value:4.05E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:10.20|P-value:2.67E-15 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.11|P-value:8.49E-4 ID:SGTC_252|Compound:miconazole|FD-Score:7.58|P-value:3.41E-9 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:5.79|P-value:4.91E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:5.71|P-value:6.40E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.52|P-value:1.22E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:5.28|P-value:2.74E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:4.82|P-value:1.16E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.26|P-value:8.91E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.54|P-value:2.62E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.65|P-value:2.64E-9 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.41|P-value:3.82E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.69|P-value:6.82E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.69|P-value:1.72E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:12.90|P-value:3.43E-23 ID:SGTC_447|Compound:ml7|FD-Score:4.66|P-value:1.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.19|P-value:3.60E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.94|P-value:8.04E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.61|P-value:9.15E-6 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.28|P-value:2.69E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:4.05|P-value:9.92E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.67|P-value:1.78E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:18.70|P-value:1.95E-46 ID:SGTC_513|Compound:4245-1575|FD-Score:8.76|P-value:1.10E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.14|P-value:7.97E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.66|P-value:1.82E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.18|P-value:2.04E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.70|P-value:1.68E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:7.79|P-value:1.32E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.55|P-value:2.57E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.35|P-value:4.46E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:5.89|P-value:3.33E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:10.00|P-value:1.11E-14 ID:SGTC_634|Compound:1611-4317|FD-Score:7.66|P-value:2.38E-9 ID:SGTC_639|Compound:0833-0042|FD-Score:5.23|P-value:3.22E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:-4.16|P-value:7.44E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-6.11|P-value:1.57E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.05|P-value:9.96E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:18.70|P-value:2.09E-46 ID:SGTC_683|Compound:panaxydol|FD-Score:8.25|P-value:1.49E-10 ID:SGTC_800|Compound:3448-7362|FD-Score:4.48|P-value:3.05E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.87|P-value:3.68E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:6.86|P-value:7.85E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:5.02|P-value:6.31E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:4.41|P-value:3.77E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.30|P-value:5.10E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:6.77|P-value:1.13E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:17.50|P-value:5.02E-41 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.35|P-value:4.50E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.67|P-value:1.80E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.46|P-value:1.52E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-5.53|P-value:1.21E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:-4.19|P-value:6.87E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:-4.08|P-value:9.18E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:9.23|P-value:8.98E-13 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.61|P-value:2.22E-7 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.11|P-value:8.48E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:21.80|P-value:1.64E-62 ID:SGTC_1304|Compound:1165-0502|FD-Score:9.02|P-value:2.75E-12 ID:SGTC_1550|Compound:gossypolone|FD-Score:-4.08|P-value:9.26E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.24|P-value:5.98E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.02|P-value:6.17E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-7.80|P-value:1.32E-9 ID:SGTC_1687|Compound:st020778|FD-Score:19.90|P-value:1.87E-52 ID:SGTC_1694|Compound:st024011|FD-Score:12.00|P-value:2.10E-20 ID:SGTC_1712|Compound:st032288|FD-Score:-4.44|P-value:3.52E-4 ID:SGTC_1754|Compound:st042065|FD-Score:16.10|P-value:5.29E-35 ID:SGTC_1760|Compound:st045453|FD-Score:8.54|P-value:3.41E-11 ID:SGTC_1800|Compound:st050079|FD-Score:10.40|P-value:1.05E-15 ID:SGTC_1801|Compound:st050089|FD-Score:12.20|P-value:4.63E-21 ID:SGTC_1803|Compound:st050068|FD-Score:11.70|P-value:1.81E-19 ID:SGTC_1810|Compound:st050138|FD-Score:4.67|P-value:1.80E-4 ID:SGTC_1818|Compound:st052136|FD-Score:7.36|P-value:9.47E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.20|P-value:1.93E-8 ID:SGTC_1861|Compound:st057647|FD-Score:5.54|P-value:1.15E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:9.86|P-value:2.43E-14 ID:SGTC_1909|Compound:st060837|FD-Score:4.15|P-value:7.52E-4 ID:SGTC_1934|Compound:st074720|FD-Score:6.89|P-value:6.95E-8 ID:SGTC_1941|Compound:st076221|FD-Score:9.25|P-value:7.69E-13 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.11|P-value:8.50E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-5.12|P-value:4.69E-5 ID:SGTC_1991|Compound:st073000|FD-Score:8.96|P-value:3.87E-12 ID:SGTC_1997|Compound:st073024|FD-Score:4.79|P-value:1.25E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.58|P-value:2.30E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.80|P-value:4.63E-6 ID:SGTC_2018|Compound:5133068|FD-Score:5.76|P-value:5.43E-6 ID:SGTC_2021|Compound:4019055|FD-Score:-5.73|P-value:6.00E-6 ID:SGTC_2023|Compound:5144124|FD-Score:4.69|P-value:1.68E-4 ID:SGTC_2132|Compound:5317594|FD-Score:6.70|P-value:1.52E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.28|P-value:5.37E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.86|P-value:1.03E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.25|P-value:5.83E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.30|P-value:1.20E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.45|P-value:1.57E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.80|P-value:1.25E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.86|P-value:7.92E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.75|P-value:1.27E-7 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:5.48|P-value:1.39E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.17|P-value:3.86E-5 ID:SGTC_2699|Compound:st077704|FD-Score:7.91|P-value:7.52E-10 ID:SGTC_2701|Compound:st077767|FD-Score:6.56|P-value:2.71E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.60|P-value:2.90E-29 ID:SGTC_2765|Compound:myclobutanil|FD-Score:6.79|P-value:1.07E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.03|P-value:2.06E-6 ID:SGTC_2812|Compound:7970281|FD-Score:4.12|P-value:8.16E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.13|P-value:4.40E-5 ID:SGTC_2816|Compound:7982706|FD-Score:5.56|P-value:1.06E-5 ID:SGTC_2858|Compound:9025781|FD-Score:26.80|P-value:1.01E-93 ID:SGTC_2887|Compound:9044784|FD-Score:-5.31|P-value:2.56E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-15.20|P-value:1.42E-31 ID:SGTC_2932|Compound:9016711|FD-Score:44.50|P-value:1.69E-253 ID:SGTC_2943|Compound:9068529|FD-Score:-6.45|P-value:4.17E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-7.38|P-value:8.83E-9 ID:SGTC_2948|Compound:9070189|FD-Score:-10.00|P-value:9.30E-15 ID:SGTC_2953|Compound:9074162|FD-Score:5.08|P-value:5.12E-5 ID:SGTC_2976|Compound:9009005|FD-Score:17.30|P-value:2.97E-40 ID:SGTC_3025|Compound:9087895|FD-Score:5.38|P-value:1.96E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:10.30|P-value:2.24E-15 ID:SGTC_3060|Compound:1327-0027|FD-Score:8.25|P-value:1.46E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.48|P-value:2.24E-13 ID:SGTC_3098|Compound:9119039|FD-Score:4.30|P-value:5.10E-4 ID:SGTC_3174|Compound:9107204|FD-Score:5.65|P-value:7.80E-6 ID:SGTC_3189|Compound:9110682|FD-Score:4.06|P-value:9.63E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-4.25|P-value:5.91E-4 ID:SGTC_3265|Compound:9137266|FD-Score:4.20|P-value:6.68E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.10|P-value:1.59E-6 ID:SGTC_3281|Compound:9140613|FD-Score:4.14|P-value:7.83E-4

Top fitness defect scores for YDR392W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2932 9016711 44.50 44.5 µM 1.69E-253 1 0
2 SGTC_2858 9025781 26.80 9.0 µM 1.01E-93 sphingolipid biosynthesis & PDR1 1 5.55E-159
3 SGTC_1287 0971-0001 21.80 34.6 µM 1.64E-62 sphingolipid biosynthesis & PDR1 1 1.47E-105
4 SGTC_1687 st020778 19.90 55.4 µM 1.87E-52 9 2.38E-88
5 SGTC_505 gw-5074 18.70 63.9 µM 1.95E-46 3 4.65E-78
6 SGTC_664 1222-0054 18.70 14.9 µM 2.09E-46 sphingolipid biosynthesis & PDR1 3 5.24E-78
7 SGTC_955 1216-0110 17.50 33.0 µM 5.02E-41 sphingolipid biosynthesis & PDR1 5 8.35E-69
8 SGTC_2976 9009005 17.30 19.5 µM 2.97E-40 3 1.74E-67
9 SGTC_1754 st042065 16.10 16.1 µM 5.29E-35 NEO1-PIK1 7 1.65E-58
10 SGTC_2752 diclazuril 14.60 33.1 µM 2.90E-29 9 1.05E-48
11 SGTC_439 amiodarone 12.90 34.4 µM 3.43E-23 NEO1-PIK1 8 2.48E-38
12 SGTC_1801 st050089 12.20 28.4 µM 4.63E-21 NEO1-PIK1 5 1.07E-34
13 SGTC_1694 st024011 12.00 44.9 µM 2.10E-20 ERG2 7 1.40E-33
14 SGTC_1803 st050068 11.70 52.4 µM 1.81E-19 NEO1-PIK1 16 5.54E-32
15 SGTC_1800 st050079 10.40 29.1 µM 1.05E-15 NEO1-PIK1 2 1.43E-25
16 SGTC_3059 1327-0034 10.30 3.0 µM 2.24E-15 9 5.21E-25
17 SGTC_227 fluconazole 10.20 33.5 µM 2.67E-15 azole & statin 16 7.04E-25
18 SGTC_43 0570-0105 10.10 72.5 µM 6.88E-15 ERG2 10 3.52E-24
19 SGTC_628 1636-0253 10.00 16.0 µM 1.11E-14 sphingolipid biosynthesis & PDR1 3 7.90E-24
20 SGTC_1877 wortmannin 9.86 25.0 µM 2.43E-14 16 3.02E-23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.532 1.62E-244 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.422 4.08E-145 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.396 4.33E-126 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.345 3.55E-94 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.328 3.16E-85 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.318 7.49E-80 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.298 1.23E-69 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.294 8.18E-68 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.284 4.12E-63 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.282 1.92E-62 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.279 5.10E-61 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.279 4.59E-61 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.269 1.74E-56 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.259 2.11E-52 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.256 3.79E-51 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion