YDR393W / SHE9

Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR393W / SHE9

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:4.13|P-value:2.63E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.07|P-value:3.39E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-4.82|P-value:5.22E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.40|P-value:4.56E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.03|P-value:9.71E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.45|P-value:2.13E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.14|P-value:2.59E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:3.50|P-value:3.18E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:5.23|P-value:1.39E-7 ID:SGTC_724|Compound:3910-0327|FD-Score:3.37|P-value:5.21E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.84|P-value:4.59E-9 ID:SGTC_754|Compound:3474-0146|FD-Score:-6.21|P-value:1.77E-10 ID:SGTC_756|Compound:0508-1999|FD-Score:-4.01|P-value:2.26E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:4.01|P-value:4.41E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.27|P-value:7.38E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.45|P-value:3.90E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.46|P-value:6.13E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.70|P-value:1.03E-8 ID:SGTC_1483|Compound:3453-0561|FD-Score:-5.06|P-value:1.48E-7 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.01|P-value:4.44E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:5.84|P-value:4.53E-9 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.42|P-value:7.34E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.20|P-value:9.14E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.19|P-value:5.65E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.14|P-value:2.59E-5 ID:SGTC_2057|Compound:5236571|FD-Score:5.13|P-value:2.34E-7 ID:SGTC_2058|Compound:5236698|FD-Score:5.98|P-value:2.02E-9 ID:SGTC_2177|Compound:5811945|FD-Score:3.86|P-value:8.22E-5 ID:SGTC_2353|Compound:9059630|FD-Score:4.59|P-value:3.44E-6 ID:SGTC_2354|Compound:9060492|FD-Score:5.31|P-value:9.01E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.13|P-value:1.37E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.26|P-value:7.42E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.60|P-value:1.23E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.89|P-value:3.79E-5 ID:SGTC_3146|Compound:9095609|FD-Score:5.33|P-value:8.28E-8 ID:SGTC_3150|Compound:9097574|FD-Score:-4.26|P-value:7.60E-6 ID:SGTC_3154|Compound:9100113|FD-Score:8.27|P-value:1.50E-16 ID:SGTC_3156|Compound:9099931|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_3267|Compound:9137951|FD-Score:5.17|P-value:1.92E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:4.13|P-value:2.63E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.07|P-value:3.39E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-4.82|P-value:5.22E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.40|P-value:4.56E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.03|P-value:9.71E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.45|P-value:2.13E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.14|P-value:2.59E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:3.50|P-value:3.18E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:5.23|P-value:1.39E-7 ID:SGTC_724|Compound:3910-0327|FD-Score:3.37|P-value:5.21E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.84|P-value:4.59E-9 ID:SGTC_754|Compound:3474-0146|FD-Score:-6.21|P-value:1.77E-10 ID:SGTC_756|Compound:0508-1999|FD-Score:-4.01|P-value:2.26E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:4.01|P-value:4.41E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.27|P-value:7.38E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.45|P-value:3.90E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.46|P-value:6.13E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.70|P-value:1.03E-8 ID:SGTC_1483|Compound:3453-0561|FD-Score:-5.06|P-value:1.48E-7 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.01|P-value:4.44E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:5.84|P-value:4.53E-9 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.42|P-value:7.34E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.20|P-value:9.14E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.19|P-value:5.65E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.14|P-value:2.59E-5 ID:SGTC_2057|Compound:5236571|FD-Score:5.13|P-value:2.34E-7 ID:SGTC_2058|Compound:5236698|FD-Score:5.98|P-value:2.02E-9 ID:SGTC_2177|Compound:5811945|FD-Score:3.86|P-value:8.22E-5 ID:SGTC_2353|Compound:9059630|FD-Score:4.59|P-value:3.44E-6 ID:SGTC_2354|Compound:9060492|FD-Score:5.31|P-value:9.01E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.13|P-value:1.37E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.26|P-value:7.42E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.60|P-value:1.23E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.89|P-value:3.79E-5 ID:SGTC_3146|Compound:9095609|FD-Score:5.33|P-value:8.28E-8 ID:SGTC_3150|Compound:9097574|FD-Score:-4.26|P-value:7.60E-6 ID:SGTC_3154|Compound:9100113|FD-Score:8.27|P-value:1.50E-16 ID:SGTC_3156|Compound:9099931|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_3267|Compound:9137951|FD-Score:5.17|P-value:1.92E-7

Top fitness defect scores for YDR393W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3154 9100113 8.27 49.5 µM 1.50E-16 5 6.58E-17
2 SGTC_2058 5236698 5.98 133.0 µM 2.02E-9 8 1.15E-9
3 SGTC_1494 4358-1428 5.84 177.0 µM 4.53E-9 5 2.61E-9
4 SGTC_743 1275-0778 5.84 158.0 µM 4.59E-9 excess fatty acid 13 2.65E-9
5 SGTC_1468 k284-1086 5.70 134.0 µM 1.03E-8 DNA intercalators 5 5.99E-9
6 SGTC_3146 9095609 5.33 49.5 µM 8.28E-8 5 5.03E-8
7 SGTC_2354 9060492 5.31 162.0 µM 9.01E-8 2 5.48E-8
8 SGTC_701 4424-0219 5.23 185.0 µM 1.39E-7 calcium & mitochondrial duress 7 8.54E-8
9 SGTC_3267 9137951 5.17 49.5 µM 1.92E-7 2 1.19E-7
10 SGTC_2057 5236571 5.13 38.3 µM 2.34E-7 RPP1 & pyrimidine depletion 11 1.45E-7
11 SGTC_2353 9059630 4.59 146.7 µM 3.44E-6 14 2.25E-6
12 SGTC_1370 2001-0092 4.46 44.6 µM 6.13E-6 18 4.06E-6
13 SGTC_1501 4491-0275 4.42 38.4 µM 7.34E-6 4 4.87E-6
14 SGTC_609 0986-0026 4.14 86.3 µM 2.59E-5 calcium & mitochondrial duress 26 1.77E-5
15 SGTC_2017 5132927 4.14 60.6 µM 2.59E-5 29 1.77E-5
16 SGTC_63 0099-0242 4.13 26.7 µM 2.63E-5 mitochondrial stress 80 1.79E-5
17 SGTC_236 1509-0011 4.07 5.3 µM 3.39E-5 375 2.33E-5
18 SGTC_771 0250-0039 4.01 27.3 µM 4.41E-5 12 3.05E-5
19 SGTC_1485 3909-9022 4.01 254.0 µM 4.44E-5 RPP1 & pyrimidine depletion 6 3.07E-5
20 SGTC_2177 5811945 3.86 192.0 µM 8.22E-5 31 5.76E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 1.05E-16 YDL068W_d YDL068W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.122 1.36E-12 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.121 2.00E-12 YKR025W RPC37 het RNA polymerase III subunit C37
0.121 2.07E-12 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.118 8.03E-12 YBR268W MRPL37 hom Mitochondrial ribosomal protein of the large subunit
0.115 2.21E-11 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.114 4.23E-11 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.113 5.90E-11 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.112 7.63E-11 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.112 8.92E-11 YDR114C_p YDR114C_p hom Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.112 9.51E-11 YHR100C GEP4 hom Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT
0.110 1.86E-10 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.107 4.53E-10 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.106 7.15E-10 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.106 8.65E-10 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA