YDR395W / SXM1

Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR395W / SXM1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.12|P-value:1.96E-7 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.27|P-value:6.39E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.71|P-value:1.30E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.19|P-value:1.64E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.75|P-value:1.02E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-7.17|P-value:7.52E-13 ID:SGTC_182|Compound:3448-4371|FD-Score:4.89|P-value:6.58E-7 ID:SGTC_188|Compound:3229-0966|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.66|P-value:1.47E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.16|P-value:8.62E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.18|P-value:1.92E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.71|P-value:1.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.73|P-value:1.08E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.65|P-value:2.07E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:3.83|P-value:7.41E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:-4.90|P-value:6.81E-7 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.97|P-value:4.48E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.45|P-value:3.12E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-5.77|P-value:6.18E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.20|P-value:1.72E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.00|P-value:3.63E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:4.06|P-value:2.87E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.14|P-value:9.29E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.48|P-value:3.06E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.17|P-value:8.97E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.11|P-value:2.36E-7 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.15|P-value:9.52E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.35|P-value:4.76E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.97|P-value:4.61E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.20|P-value:7.60E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.43|P-value:6.34E-6 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.16|P-value:8.63E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.36|P-value:4.63E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.40|P-value:6.60E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.22|P-value:4.31E-10 ID:SGTC_1745|Compound:st081495|FD-Score:8.29|P-value:1.20E-16 ID:SGTC_1897|Compound:st060201|FD-Score:4.11|P-value:2.35E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.16|P-value:9.23E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.73|P-value:1.11E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.73|P-value:1.12E-4 ID:SGTC_2149|Compound:5554786|FD-Score:7.48|P-value:6.61E-14 ID:SGTC_2153|Compound:5569715|FD-Score:7.61|P-value:2.65E-14 ID:SGTC_2156|Compound:5649887|FD-Score:4.42|P-value:5.97E-6 ID:SGTC_2158|Compound:5657123|FD-Score:3.87|P-value:6.43E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.57|P-value:1.73E-8 ID:SGTC_2289|Compound:7946404|FD-Score:4.08|P-value:2.61E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.24|P-value:1.36E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.20|P-value:8.11E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.56|P-value:2.11E-4 ID:SGTC_2482|Compound:5981709|FD-Score:7.37|P-value:1.55E-13 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.31|P-value:9.97E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.80|P-value:1.62E-31 ID:SGTC_2696|Compound:st077691|FD-Score:-3.24|P-value:7.07E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.50|P-value:2.62E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.14|P-value:9.17E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.74|P-value:7.48E-9 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.90|P-value:5.51E-5 ID:SGTC_2871|Compound:9038510|FD-Score:4.17|P-value:1.78E-5 ID:SGTC_2997|Compound:9067075|FD-Score:4.74|P-value:1.34E-6 ID:SGTC_3017|Compound:9080681|FD-Score:-3.41|P-value:3.85E-4 ID:SGTC_3019|Compound:9081971|FD-Score:5.05|P-value:2.92E-7 ID:SGTC_3041|Compound:9091929|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.31|P-value:5.16E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.16|P-value:8.57E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.12|P-value:1.96E-7 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.27|P-value:6.39E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.71|P-value:1.30E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.19|P-value:1.64E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.75|P-value:1.02E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-7.17|P-value:7.52E-13 ID:SGTC_182|Compound:3448-4371|FD-Score:4.89|P-value:6.58E-7 ID:SGTC_188|Compound:3229-0966|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.66|P-value:1.47E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.16|P-value:8.62E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.18|P-value:1.92E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.71|P-value:1.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.73|P-value:1.08E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.65|P-value:2.07E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:3.83|P-value:7.41E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:-4.90|P-value:6.81E-7 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.97|P-value:4.48E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.45|P-value:3.12E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-5.77|P-value:6.18E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.20|P-value:1.72E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.00|P-value:3.63E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:4.06|P-value:2.87E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.14|P-value:9.29E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.48|P-value:3.06E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.17|P-value:8.97E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.11|P-value:2.36E-7 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.15|P-value:9.52E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.35|P-value:4.76E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.97|P-value:4.61E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.20|P-value:7.60E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.43|P-value:6.34E-6 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.16|P-value:8.63E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.36|P-value:4.63E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.40|P-value:6.60E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.22|P-value:4.31E-10 ID:SGTC_1745|Compound:st081495|FD-Score:8.29|P-value:1.20E-16 ID:SGTC_1897|Compound:st060201|FD-Score:4.11|P-value:2.35E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.16|P-value:9.23E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.73|P-value:1.11E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.73|P-value:1.12E-4 ID:SGTC_2149|Compound:5554786|FD-Score:7.48|P-value:6.61E-14 ID:SGTC_2153|Compound:5569715|FD-Score:7.61|P-value:2.65E-14 ID:SGTC_2156|Compound:5649887|FD-Score:4.42|P-value:5.97E-6 ID:SGTC_2158|Compound:5657123|FD-Score:3.87|P-value:6.43E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.57|P-value:1.73E-8 ID:SGTC_2289|Compound:7946404|FD-Score:4.08|P-value:2.61E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.24|P-value:1.36E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.20|P-value:8.11E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.56|P-value:2.11E-4 ID:SGTC_2482|Compound:5981709|FD-Score:7.37|P-value:1.55E-13 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.31|P-value:9.97E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.80|P-value:1.62E-31 ID:SGTC_2696|Compound:st077691|FD-Score:-3.24|P-value:7.07E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.50|P-value:2.62E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.14|P-value:9.17E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.74|P-value:7.48E-9 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.90|P-value:5.51E-5 ID:SGTC_2871|Compound:9038510|FD-Score:4.17|P-value:1.78E-5 ID:SGTC_2997|Compound:9067075|FD-Score:4.74|P-value:1.34E-6 ID:SGTC_3017|Compound:9080681|FD-Score:-3.41|P-value:3.85E-4 ID:SGTC_3019|Compound:9081971|FD-Score:5.05|P-value:2.92E-7 ID:SGTC_3041|Compound:9091929|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.31|P-value:5.16E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.16|P-value:8.57E-4

Top fitness defect scores for YDR395W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 11.80 96.7 µM 1.62E-31 calcium & mitochondrial duress 13 3.47E-32
2 SGTC_1745 st081495 8.29 74.0 µM 1.20E-16 RNA processing & uracil transport 11 5.68E-17
3 SGTC_2153 5569715 7.61 200.0 µM 2.65E-14 iron homeostasis 4 1.42E-14
4 SGTC_2149 5554786 7.48 194.8 µM 6.61E-14 cell wall signaling 7 3.61E-14
5 SGTC_2482 5981709 7.37 142.7 µM 1.55E-13 PDR1 3 8.60E-14
6 SGTC_2286 7945697 5.57 125.0 µM 1.73E-8 22 1.25E-8
7 SGTC_15 0266-0086 5.12 27.1 µM 1.96E-7 endomembrane recycling 32 1.49E-7
8 SGTC_3019 9081971 5.05 49.5 µM 2.92E-7 6 2.24E-7
9 SGTC_663 1486-0733 5.00 13.9 µM 3.63E-7 cell wall signaling 31 2.79E-7
10 SGTC_182 3448-4371 4.89 550.5 µM 6.58E-7 12 5.13E-7
11 SGTC_2997 9067075 4.74 71.4 µM 1.34E-6 unfolded protein response 35 1.06E-6
12 SGTC_439 amiodarone 4.65 34.4 µM 2.07E-6 NEO1-PIK1 71 1.66E-6
13 SGTC_2156 5649887 4.42 115.0 µM 5.97E-6 RPP1 & pyrimidine depletion 5 4.89E-6
14 SGTC_1717 st033143 4.40 58.0 µM 6.60E-6 27 5.41E-6
15 SGTC_2636 apigenin dimethyl ether 4.31 100.0 µM 9.97E-6 33 8.25E-6
16 SGTC_2291 7917025 4.24 104.3 µM 1.36E-5 iron homeostasis 42 1.13E-5
17 SGTC_362 0310-0100 4.23 9.0 µM 1.43E-5 RPP1 & pyrimidine depletion 27 1.19E-5
18 SGTC_79 0052-0007 4.19 94.1 µM 1.64E-5 33 1.37E-5
19 SGTC_2871 9038510 4.17 13.0 µM 1.78E-5 12 1.49E-5
20 SGTC_358 0075-0058 4.14 9.4 µM 2.03E-5 53 1.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 9.99E-22 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.156 8.35E-20 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.145 3.92E-17 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.139 6.28E-16 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.137 1.47E-15 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.135 4.13E-15 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.133 1.01E-14 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.132 1.33E-14 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.130 4.26E-14 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.127 1.32E-13 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.126 2.50E-13 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.123 7.55E-13 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.121 2.10E-12 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.119 3.83E-12 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.119 3.95E-12 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family