YDR396W_d

Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR396W / YDR396W

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:4.05|P-value:4.99E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.43|P-value:3.65E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.90|P-value:1.22E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.52|P-value:2.63E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.62|P-value:2.59E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.70|P-value:3.08E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:6.83|P-value:2.12E-11 ID:SGTC_742|Compound:0kpi-0133|FD-Score:5.12|P-value:4.13E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.25|P-value:9.33E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.21|P-value:7.73E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.70|P-value:1.92E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.82|P-value:8.64E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.89|P-value:6.38E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.72|P-value:2.78E-6 ID:SGTC_1526|Compound:st051518|FD-Score:3.88|P-value:9.63E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.25|P-value:2.20E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.99|P-value:6.37E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.41|P-value:5.39E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.36|P-value:6.36E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.88|P-value:1.33E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.66|P-value:2.25E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.97|P-value:4.72E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.54|P-value:6.33E-6 ID:SGTC_2119|Compound:5528445|FD-Score:3.48|P-value:4.22E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.30|P-value:7.87E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.57|P-value:3.06E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.39|P-value:5.76E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.32|P-value:5.40E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.32|P-value:1.66E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.26|P-value:9.04E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.62|P-value:1.84E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.33|P-value:7.08E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.16|P-value:9.03E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-3.17|P-value:8.93E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.30|P-value:7.74E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-4.27|P-value:1.36E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.27|P-value:8.56E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.15|P-value:9.44E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.13|P-value:9.94E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.24|P-value:9.48E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:4.05|P-value:4.99E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.43|P-value:3.65E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.90|P-value:1.22E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.52|P-value:2.63E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.62|P-value:2.59E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.70|P-value:3.08E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:6.83|P-value:2.12E-11 ID:SGTC_742|Compound:0kpi-0133|FD-Score:5.12|P-value:4.13E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.25|P-value:9.33E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.21|P-value:7.73E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.70|P-value:1.92E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.82|P-value:8.64E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.89|P-value:6.38E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.72|P-value:2.78E-6 ID:SGTC_1526|Compound:st051518|FD-Score:3.88|P-value:9.63E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.25|P-value:2.20E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.99|P-value:6.37E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.41|P-value:5.39E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.36|P-value:6.36E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.88|P-value:1.33E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.66|P-value:2.25E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.97|P-value:4.72E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.54|P-value:6.33E-6 ID:SGTC_2119|Compound:5528445|FD-Score:3.48|P-value:4.22E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.30|P-value:7.87E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.57|P-value:3.06E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.39|P-value:5.76E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.32|P-value:5.40E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.32|P-value:1.66E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.26|P-value:9.04E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.62|P-value:1.84E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.33|P-value:7.08E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.16|P-value:9.03E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-3.17|P-value:8.93E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.30|P-value:7.74E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-4.27|P-value:1.36E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.27|P-value:8.56E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.15|P-value:9.44E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.13|P-value:9.94E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.24|P-value:9.48E-4

Top fitness defect scores for YDR396W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_669 0108-0021 6.83 26.2 µM 2.12E-11 fatty acid desaturase (OLE1) 3 4.15E-12 1.50
2 SGTC_742 0kpi-0133 5.12 140.0 µM 4.13E-7 ERG2 4 1.53E-7 1.16
3 SGTC_122 0236-0016 4.90 402.4 µM 1.22E-6 RNA processing & uracil transport 9 4.86E-7 0.15
4 SGTC_1847 st056231 4.88 15.0 µM 1.33E-6 3 5.34E-7 0.90
5 SGTC_1249 0481-0015 4.72 10.2 µM 2.78E-6 2 1.17E-6 0.03
6 SGTC_145 3737-0113 4.70 38.4 µM 3.08E-6 DNA intercalators 34 1.31E-6 0.02
7 SGTC_2059 5238311 4.54 157.0 µM 6.33E-6 2 2.82E-6 0.34
8 SGTC_2601 securinine 4.32 100.0 µM 1.66E-5 15 7.89E-6 0.01
9 SGTC_1527 coumarin 4.25 137.0 µM 2.20E-5 5 1.06E-5 0.44
10 SGTC_1 0258-0098 4.05 57.4 µM 4.99E-5 heme biosynthesis & mitochondrial translocase 16 2.55E-5 0.03
11 SGTC_1810 st050138 3.99 53.0 µM 6.37E-5 PDR1 3 3.31E-5 0.12
12 SGTC_1526 st051518 3.88 75.0 µM 9.63E-5 6 5.14E-5 0.04
13 SGTC_960 1222-0186 3.70 7.7 µM 1.92E-4 11 1.07E-4 0.06
14 SGTC_2216 7189485 3.69 200.0 µM 2.01E-4 3 1.13E-4 0.07
15 SGTC_2049 5262831 3.66 67.2 µM 2.25E-4 11 1.27E-4 0.08
16 SGTC_125 0133-0007 3.62 11.8 µM 2.59E-4 DNA intercalators 8 1.48E-4 0.08
17 SGTC_1975 st070967 3.58 30.8 µM 3.03E-4 14 1.74E-4 0.04
18 SGTC_2260 7964312 3.57 200.0 µM 3.06E-4 11 1.76E-4 0.24
19 SGTC_2119 5528445 3.48 120.6 µM 4.22E-4 5 2.49E-4 0.08
20 SGTC_1819 st053448 3.41 58.6 µM 5.39E-4 amide catabolism 4 3.23E-4 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.97E-13 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 5.14E-12 YGR137W_d YGR137W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.08E-10 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.098 1.22E-8 YOL136C PFK27 hom 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
0.097 1.72E-8 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.095 3.14E-8 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.092 9.56E-8 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.090 1.68E-7 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.090 1.75E-7 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.089 2.32E-7 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.088 3.67E-7 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.087 4.36E-7 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.086 5.68E-7 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.084 1.12E-6 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.082 2.00E-6 YDR255C RMD5 hom Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain