HIPHOP chemogenomics database

YDR398W / UTP5

Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR398W / UTP5

Click on Significant Values for Screen Details

Top fitness defect scores for YDR398W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1712	st032288	11.60	53.4 µM	2.78E-30	calcium & mitochondrial duress	2	1.81E-31	2.06
2	SGTC_1083	didemethylchlorpromazine sulfoxide	9.89	707.4 nM	1.58E-22	redox potentiating	7	2.31E-23	0.45
3	SGTC_2360	9040895	9.31	200.0 µM	3.36E-20	RPP1 & pyrimidine depletion	1	6.26E-21	2.11
4	SGTC_2583	asiatic acid	7.59	100.0 µM	4.54E-14		1	1.57E-14	2.11
5	SGTC_2585	alliin	7.10	100.0 µM	1.54E-12		1	6.19E-13	0.72
6	SGTC_2358	9037157	6.56	4.0 µM	5.90E-11		2	2.77E-11	0.43
7	SGTC_1374	2889-5571	5.15	141.0 µM	1.96E-7	RSC complex & mRNA processing	26	1.28E-7	0.09
8	SGTC_2688	kanamycin b	4.97	96.7 µM	4.96E-7	calcium & mitochondrial duress	5	3.37E-7	0.14
9	SGTC_497	capsazepine	4.88	133.0 µM	7.59E-7		3	5.25E-7	0.68
10	SGTC_1230	0170-0365	4.75	3.8 µM	1.45E-6	endomembrane recycling	17	1.03E-6	0.03
11	SGTC_2692	st077426	4.61	47.7 µM	2.72E-6		4	1.98E-6	0.63
12	SGTC_1246	0422-0085	4.44	105.0 µM	6.04E-6		5	4.52E-6	0.13
13	SGTC_2198	6589944	4.24	200.0 µM	1.43E-5		1	1.11E-5	0.36
14	SGTC_325	2810-4341	4.03	181.0 µM	3.47E-5	amide catabolism	5	2.78E-5	0.13
15	SGTC_2322	7413319	3.94	38.2 µM	4.93E-5	ERAD & cell cycle	25	4.00E-5	0.02
16	SGTC_2839	9003951	3.85	26.0 µM	7.09E-5		3	5.82E-5	0.32
17	SGTC_2061	5245884	3.76	81.0 µM	1.02E-4	tubulin folding & SWR complex	7	8.53E-5	0.04
18	SGTC_784	4579-0127	3.73	173.0 µM	1.16E-4		5	9.69E-5	0.23
19	SGTC_3014	9081533	3.61	49.5 µM	1.82E-4		5	1.55E-4	0.08
20	SGTC_445	e6 berbamine	3.57	66.0 µM	2.07E-4	NEO1-PIK1	33	1.77E-4	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.246	1.45E-47	YKL051W	SFK1	hom	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.222	6.96E-39	YPL251W_d	YPL251W_d	het	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.199	3.42E-31	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.192	3.36E-29	YLR367W	RPS22B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.186	1.32E-27	YPL252C	YAH1	het	Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.186	1.57E-27	YOR086C	TCB1	hom	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.170	3.21E-23	YCR093W	CDC39	het	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.168	1.05E-22	YDR431W_d	YDR431W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.166	3.41E-22	YDL019C	OSH2	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.152	8.02E-19	YPL145C	KES1	hom	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.149	4.56E-18	YEL022W	GEA2	hom	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.148	6.13E-18	YBR258C	SHG1	hom	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.146	2.44E-17	YMR093W	UTP15	het	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.144	4.64E-17	YGR214W	RPS0A	hom	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.142	1.68E-16	YLR408C_p	BLS1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene