YDR398W / UTP5

Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR398W / UTP5

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-4.25|P-value:2.07E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.41|P-value:3.77E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.69|P-value:1.90E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:4.03|P-value:3.47E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.42|P-value:3.63E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.03|P-value:5.66E-7 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.32|P-value:7.00E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.88|P-value:7.59E-7 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.44|P-value:4.59E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.34|P-value:6.57E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.29|P-value:5.59E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.21|P-value:7.34E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.41|P-value:5.19E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.73|P-value:1.16E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.47|P-value:3.00E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.52|P-value:2.52E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.94|P-value:7.13E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.89|P-value:1.58E-22 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.75|P-value:1.45E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.44|P-value:6.04E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.15|P-value:1.96E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.05|P-value:4.69E-5 ID:SGTC_1664|Compound:st014217|FD-Score:-3.72|P-value:1.67E-4 ID:SGTC_1712|Compound:st032288|FD-Score:11.60|P-value:2.78E-30 ID:SGTC_1766|Compound:st045414|FD-Score:-8.09|P-value:2.04E-15 ID:SGTC_2021|Compound:4019055|FD-Score:3.33|P-value:4.97E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.76|P-value:1.02E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.56|P-value:2.17E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.24|P-value:1.43E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.35|P-value:6.32E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.94|P-value:4.93E-5 ID:SGTC_2358|Compound:9037157|FD-Score:6.56|P-value:5.90E-11 ID:SGTC_2360|Compound:9040895|FD-Score:9.31|P-value:3.36E-20 ID:SGTC_2471|Compound:5466956|FD-Score:-3.31|P-value:7.32E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.23|P-value:9.41E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.59|P-value:2.74E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.59|P-value:3.14E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.95|P-value:8.02E-12 ID:SGTC_2583|Compound:asiatic acid|FD-Score:7.59|P-value:4.54E-14 ID:SGTC_2584|Compound:androsterone|FD-Score:-10.60|P-value:2.37E-25 ID:SGTC_2585|Compound:alliin|FD-Score:7.10|P-value:1.54E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.97|P-value:4.96E-7 ID:SGTC_2692|Compound:st077426|FD-Score:4.61|P-value:2.72E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.23|P-value:7.02E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.28|P-value:5.79E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.28|P-value:7.88E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.85|P-value:7.09E-5 ID:SGTC_2840|Compound:9008771|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.15|P-value:9.05E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.31|P-value:5.36E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.14|P-value:9.32E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.27|P-value:8.35E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.25|P-value:2.07E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.41|P-value:3.77E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.69|P-value:1.90E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:4.03|P-value:3.47E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.42|P-value:3.63E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.03|P-value:5.66E-7 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.32|P-value:7.00E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.88|P-value:7.59E-7 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.44|P-value:4.59E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.34|P-value:6.57E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.29|P-value:5.59E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.21|P-value:7.34E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.41|P-value:5.19E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.73|P-value:1.16E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.47|P-value:3.00E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.52|P-value:2.52E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.94|P-value:7.13E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.89|P-value:1.58E-22 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.75|P-value:1.45E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.44|P-value:6.04E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.15|P-value:1.96E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.05|P-value:4.69E-5 ID:SGTC_1664|Compound:st014217|FD-Score:-3.72|P-value:1.67E-4 ID:SGTC_1712|Compound:st032288|FD-Score:11.60|P-value:2.78E-30 ID:SGTC_1766|Compound:st045414|FD-Score:-8.09|P-value:2.04E-15 ID:SGTC_2021|Compound:4019055|FD-Score:3.33|P-value:4.97E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.76|P-value:1.02E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.56|P-value:2.17E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.24|P-value:1.43E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.35|P-value:6.32E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.94|P-value:4.93E-5 ID:SGTC_2358|Compound:9037157|FD-Score:6.56|P-value:5.90E-11 ID:SGTC_2360|Compound:9040895|FD-Score:9.31|P-value:3.36E-20 ID:SGTC_2471|Compound:5466956|FD-Score:-3.31|P-value:7.32E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.23|P-value:9.41E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.59|P-value:2.74E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.59|P-value:3.14E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.95|P-value:8.02E-12 ID:SGTC_2583|Compound:asiatic acid|FD-Score:7.59|P-value:4.54E-14 ID:SGTC_2584|Compound:androsterone|FD-Score:-10.60|P-value:2.37E-25 ID:SGTC_2585|Compound:alliin|FD-Score:7.10|P-value:1.54E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.97|P-value:4.96E-7 ID:SGTC_2692|Compound:st077426|FD-Score:4.61|P-value:2.72E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.23|P-value:7.02E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.28|P-value:5.79E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.28|P-value:7.88E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.85|P-value:7.09E-5 ID:SGTC_2840|Compound:9008771|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.15|P-value:9.05E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.31|P-value:5.36E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.14|P-value:9.32E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.27|P-value:8.35E-4

Top fitness defect scores for YDR398W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1712 st032288 11.60 53.4 µM 2.78E-30 calcium & mitochondrial duress 2 1.81E-31 2.06
2 SGTC_1083 didemethylchlorpromazine sulfoxide 9.89 707.4 nM 1.58E-22 redox potentiating 7 2.31E-23 0.45
3 SGTC_2360 9040895 9.31 200.0 µM 3.36E-20 RPP1 & pyrimidine depletion 1 6.26E-21 2.11
4 SGTC_2583 asiatic acid 7.59 100.0 µM 4.54E-14 1 1.57E-14 2.11
5 SGTC_2585 alliin 7.10 100.0 µM 1.54E-12 1 6.19E-13 0.72
6 SGTC_2358 9037157 6.56 4.0 µM 5.90E-11 2 2.77E-11 0.43
7 SGTC_1374 2889-5571 5.15 141.0 µM 1.96E-7 RSC complex & mRNA processing 26 1.28E-7 0.09
8 SGTC_2688 kanamycin b 4.97 96.7 µM 4.96E-7 calcium & mitochondrial duress 5 3.37E-7 0.14
9 SGTC_497 capsazepine 4.88 133.0 µM 7.59E-7 3 5.25E-7 0.68
10 SGTC_1230 0170-0365 4.75 3.8 µM 1.45E-6 endomembrane recycling 17 1.03E-6 0.03
11 SGTC_2692 st077426 4.61 47.7 µM 2.72E-6 4 1.98E-6 0.63
12 SGTC_1246 0422-0085 4.44 105.0 µM 6.04E-6 5 4.52E-6 0.13
13 SGTC_2198 6589944 4.24 200.0 µM 1.43E-5 1 1.11E-5 0.36
14 SGTC_325 2810-4341 4.03 181.0 µM 3.47E-5 amide catabolism 5 2.78E-5 0.13
15 SGTC_2322 7413319 3.94 38.2 µM 4.93E-5 ERAD & cell cycle 25 4.00E-5 0.02
16 SGTC_2839 9003951 3.85 26.0 µM 7.09E-5 3 5.82E-5 0.32
17 SGTC_2061 5245884 3.76 81.0 µM 1.02E-4 tubulin folding & SWR complex 7 8.53E-5 0.04
18 SGTC_784 4579-0127 3.73 173.0 µM 1.16E-4 5 9.69E-5 0.23
19 SGTC_3014 9081533 3.61 49.5 µM 1.82E-4 5 1.55E-4 0.08
20 SGTC_445 e6 berbamine 3.57 66.0 µM 2.07E-4 NEO1-PIK1 33 1.77E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.246 1.45E-47 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.222 6.96E-39 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.199 3.42E-31 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.192 3.36E-29 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.186 1.32E-27 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.186 1.57E-27 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.170 3.21E-23 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.168 1.05E-22 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.166 3.41E-22 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.152 8.02E-19 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.149 4.56E-18 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.148 6.13E-18 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.146 2.44E-17 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.144 4.64E-17 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.142 1.68E-16 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene