YDR403W / DIT1

Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR403W / DIT1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.48|P-value:9.56E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:3.76|P-value:3.12E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.04|P-value:6.41E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.47|P-value:3.05E-9 ID:SGTC_309|Compound:k408-0051|FD-Score:3.09|P-value:4.99E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.01|P-value:1.02E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.54|P-value:8.40E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.22|P-value:3.11E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.94|P-value:8.81E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.45|P-value:1.22E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.12|P-value:5.78E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.74|P-value:3.43E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.27|P-value:2.48E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.88|P-value:1.86E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.05|P-value:5.80E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.63|P-value:5.75E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.80|P-value:2.65E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.37|P-value:1.68E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.34|P-value:1.89E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.06|P-value:5.68E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.05|P-value:5.81E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.71|P-value:3.93E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.43|P-value:1.24E-6 ID:SGTC_2047|Compound:4141938|FD-Score:-3.22|P-value:3.00E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.11|P-value:4.68E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.41|P-value:1.45E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.33|P-value:1.99E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.80|P-value:2.71E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-3.30|P-value:2.22E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.04|P-value:8.79E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_2380|Compound:9035439|FD-Score:2.91|P-value:9.82E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.20|P-value:3.30E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.70|P-value:4.15E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.66|P-value:5.01E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.32|P-value:7.78E-9 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.10|P-value:4.85E-4 ID:SGTC_2794|Compound:7785382|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.05|P-value:5.89E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.09|P-value:5.11E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.99|P-value:5.69E-8 ID:SGTC_2858|Compound:9025781|FD-Score:6.87|P-value:1.35E-13 ID:SGTC_2871|Compound:9038510|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.74|P-value:2.24E-7 ID:SGTC_2876|Compound:9059903|FD-Score:3.15|P-value:4.07E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-5.25|P-value:1.14E-8 ID:SGTC_2879|Compound:9041815|FD-Score:2.93|P-value:9.07E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.96|P-value:8.26E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-2.97|P-value:7.75E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_3065|Compound:9113888|FD-Score:5.42|P-value:4.09E-9 ID:SGTC_3107|Compound:9121808|FD-Score:2.93|P-value:9.08E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-2.97|P-value:7.78E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.13|P-value:4.31E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-4.82|P-value:1.42E-7 ID:SGTC_3219|Compound:9131112|FD-Score:3.88|P-value:1.81E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.48|P-value:9.56E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:3.76|P-value:3.12E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:6.04|P-value:6.41E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.47|P-value:3.05E-9 ID:SGTC_309|Compound:k408-0051|FD-Score:3.09|P-value:4.99E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.01|P-value:1.02E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.54|P-value:8.40E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.22|P-value:3.11E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.94|P-value:8.81E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.45|P-value:1.22E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.12|P-value:5.78E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.74|P-value:3.43E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.27|P-value:2.48E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.88|P-value:1.86E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.05|P-value:5.80E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.63|P-value:5.75E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.80|P-value:2.65E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.37|P-value:1.68E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.34|P-value:1.89E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.06|P-value:5.68E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.05|P-value:5.81E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.71|P-value:3.93E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.43|P-value:1.24E-6 ID:SGTC_2047|Compound:4141938|FD-Score:-3.22|P-value:3.00E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.11|P-value:4.68E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.41|P-value:1.45E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.33|P-value:1.99E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.80|P-value:2.71E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-3.30|P-value:2.22E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.04|P-value:8.79E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_2380|Compound:9035439|FD-Score:2.91|P-value:9.82E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.20|P-value:3.30E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.70|P-value:4.15E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.66|P-value:5.01E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.32|P-value:7.78E-9 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.10|P-value:4.85E-4 ID:SGTC_2794|Compound:7785382|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.05|P-value:5.89E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.09|P-value:5.11E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.99|P-value:5.69E-8 ID:SGTC_2858|Compound:9025781|FD-Score:6.87|P-value:1.35E-13 ID:SGTC_2871|Compound:9038510|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.74|P-value:2.24E-7 ID:SGTC_2876|Compound:9059903|FD-Score:3.15|P-value:4.07E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-5.25|P-value:1.14E-8 ID:SGTC_2879|Compound:9041815|FD-Score:2.93|P-value:9.07E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.96|P-value:8.26E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-2.97|P-value:7.75E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_3065|Compound:9113888|FD-Score:5.42|P-value:4.09E-9 ID:SGTC_3107|Compound:9121808|FD-Score:2.93|P-value:9.08E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-2.97|P-value:7.78E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.13|P-value:4.31E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-4.82|P-value:1.42E-7 ID:SGTC_3219|Compound:9131112|FD-Score:3.88|P-value:1.81E-5

Top fitness defect scores for YDR403W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 6.87 9.0 µM 1.35E-13 sphingolipid biosynthesis & PDR1 37 3.20E-12
2 SGTC_163 1327-0036 6.04 7.5 µM 6.41E-11 47 7.51E-10
3 SGTC_219 mitoxanthrone 5.47 164.4 µM 3.05E-9 DNA intercalators 22 2.30E-8
4 SGTC_3065 9113888 5.42 49.5 µM 4.09E-9 8 2.99E-8
5 SGTC_2651 1327-0036 5.32 5.0 µM 7.78E-9 95 5.29E-8
6 SGTC_2849 9019321 4.99 13.0 µM 5.69E-8 16 3.09E-7
7 SGTC_58 0957-0393 4.48 9.0 µM 9.56E-7 cell wall 331 3.78E-6
8 SGTC_1230 0170-0365 4.37 3.8 µM 1.68E-6 endomembrane recycling 51 6.23E-6
9 SGTC_863 0466-0191 4.12 129.0 µM 5.78E-6 cell wall 65 1.87E-5
10 SGTC_2301 7769476 4.04 200.0 µM 8.79E-6 22 2.71E-5
11 SGTC_354 2783-3500 4.01 4.9 µM 1.02E-5 cell wall 46 3.10E-5
12 SGTC_3219 9131112 3.88 49.5 µM 1.81E-5 Golgi 36 5.15E-5
13 SGTC_2145 5634607 3.80 200.0 µM 2.71E-5 8 7.38E-5
14 SGTC_138 0850-0259 3.76 40.9 µM 3.12E-5 cell wall 211 8.37E-5
15 SGTC_1493 4348-0038 3.71 111.0 µM 3.93E-5 RSC complex & mRNA processing 40 1.03E-4
16 SGTC_2443 5493264 3.70 126.7 µM 4.15E-5 25 1.08E-4
17 SGTC_2582 agaric acid 3.66 100.0 µM 5.01E-5 redox potentiating 349 1.27E-4
18 SGTC_1217 1183-1422 3.63 255.0 µM 5.75E-5 19 1.44E-4
19 SGTC_2103 5378138 3.41 10.0 µM 1.45E-4 34 3.28E-4
20 SGTC_2111 5486399 3.33 200.0 µM 1.99E-4 85 4.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 3.64E-50 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.222 1.07E-38 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.212 2.46E-35 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.210 9.77E-35 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.201 5.86E-32 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.200 1.70E-31 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.186 2.16E-27 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.185 2.86E-27 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.183 1.03E-26 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.182 2.05E-26 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.181 3.41E-26 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.181 3.49E-26 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.180 9.69E-26 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.178 3.00E-25 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.178 3.63E-25 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member