YDR404C / RPB7

RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR404C / RPB7

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:4.72|P-value:1.04E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.36|P-value:1.34E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.96|P-value:8.63E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.94|P-value:9.05E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.87|P-value:2.26E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.29|P-value:8.45E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:8.53|P-value:2.02E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:3.98|P-value:8.21E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:4.04|P-value:6.98E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.97|P-value:3.02E-8 ID:SGTC_344|Compound:k064-0035|FD-Score:-5.63|P-value:1.59E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:6.72|P-value:8.51E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:6.28|P-value:4.80E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.03|P-value:7.27E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:6.35|P-value:3.67E-7 ID:SGTC_558|Compound:k064-0027|FD-Score:5.71|P-value:4.02E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:4.56|P-value:1.64E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:5.56|P-value:6.97E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:9.06|P-value:1.21E-12 ID:SGTC_640|Compound:3381-0960|FD-Score:5.62|P-value:5.57E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:4.37|P-value:2.85E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.21|P-value:6.14E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.16|P-value:7.04E-13 ID:SGTC_692|Compound:k241-0027|FD-Score:3.94|P-value:9.24E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.66|P-value:1.26E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:7.31|P-value:6.65E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:4.29|P-value:3.60E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.46|P-value:2.25E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.24|P-value:2.02E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.64|P-value:1.30E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.36|P-value:2.91E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:9.05|P-value:1.26E-12 ID:SGTC_945|Compound:3381-0768|FD-Score:6.70|P-value:9.29E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:7.71|P-value:1.08E-9 ID:SGTC_952|Compound:1185-0122|FD-Score:4.81|P-value:7.86E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:4.52|P-value:1.86E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.52|P-value:7.81E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.12|P-value:5.69E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:9.45|P-value:1.37E-13 ID:SGTC_1063|Compound:disulfiram|FD-Score:6.98|P-value:2.87E-8 ID:SGTC_1079|Compound:idarubicin|FD-Score:6.14|P-value:8.47E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.00|P-value:1.39E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.10|P-value:6.04E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.05|P-value:6.77E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:5.68|P-value:4.52E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.84|P-value:7.30E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.61|P-value:1.43E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.99|P-value:7.96E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.80|P-value:8.07E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:9.78|P-value:2.04E-14 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.36|P-value:7.03E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.94|P-value:9.19E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.19|P-value:1.14E-8 ID:SGTC_1615|Compound:st002656|FD-Score:5.45|P-value:1.01E-5 ID:SGTC_1643|Compound:st009866|FD-Score:-4.23|P-value:9.96E-4 ID:SGTC_1644|Compound:st010134|FD-Score:5.38|P-value:1.25E-5 ID:SGTC_1651|Compound:st011928|FD-Score:7.48|P-value:3.10E-9 ID:SGTC_1652|Compound:st011932|FD-Score:9.55|P-value:7.81E-14 ID:SGTC_1665|Compound:st014639|FD-Score:4.62|P-value:1.40E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.15|P-value:5.29E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.47|P-value:2.16E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.41|P-value:2.57E-4 ID:SGTC_1707|Compound:st032323|FD-Score:6.05|P-value:1.17E-6 ID:SGTC_1719|Compound:st032227|FD-Score:6.22|P-value:6.27E-7 ID:SGTC_1723|Compound:st034307|FD-Score:4.80|P-value:8.19E-5 ID:SGTC_1761|Compound:st044296|FD-Score:4.03|P-value:7.21E-4 ID:SGTC_1779|Compound:st039427|FD-Score:5.19|P-value:2.42E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.68|P-value:2.91E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.50|P-value:1.99E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.54|P-value:1.78E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.97|P-value:4.80E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.69|P-value:1.13E-4 ID:SGTC_1960|Compound:st011366|FD-Score:6.21|P-value:6.31E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.95|P-value:8.96E-4 ID:SGTC_2041|Compound:5107442|FD-Score:5.98|P-value:1.51E-6 ID:SGTC_2069|Compound:5228469|FD-Score:5.52|P-value:7.78E-6 ID:SGTC_2109|Compound:5483026|FD-Score:8.37|P-value:4.50E-11 ID:SGTC_2111|Compound:5486399|FD-Score:6.43|P-value:2.68E-7 ID:SGTC_2124|Compound:5246320|FD-Score:4.67|P-value:1.20E-4 ID:SGTC_2180|Compound:6301957|FD-Score:5.87|P-value:2.26E-6 ID:SGTC_2186|Compound:6124449|FD-Score:4.63|P-value:1.35E-4 ID:SGTC_2187|Compound:6125751|FD-Score:6.14|P-value:8.43E-7 ID:SGTC_2229|Compound:7354935|FD-Score:5.91|P-value:1.99E-6 ID:SGTC_2277|Compound:7947813|FD-Score:12.10|P-value:6.71E-21 ID:SGTC_2289|Compound:7946404|FD-Score:4.77|P-value:8.82E-5 ID:SGTC_2301|Compound:7769476|FD-Score:8.45|P-value:2.99E-11 ID:SGTC_2311|Compound:7694451|FD-Score:4.94|P-value:5.28E-5 ID:SGTC_2315|Compound:7733312|FD-Score:5.12|P-value:2.94E-5 ID:SGTC_2361|Compound:9034121|FD-Score:8.15|P-value:1.34E-10 ID:SGTC_2378|Compound:9074213|FD-Score:6.94|P-value:3.38E-8 ID:SGTC_2380|Compound:9035439|FD-Score:4.25|P-value:4.04E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.52|P-value:4.59E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.48|P-value:9.10E-6 ID:SGTC_2485|Compound:5633444|FD-Score:5.06|P-value:3.56E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:8.09|P-value:1.75E-10 ID:SGTC_2556|Compound:citropten|FD-Score:5.48|P-value:8.96E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.58|P-value:6.31E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.63|P-value:1.37E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.39|P-value:4.72E-9 ID:SGTC_2671|Compound:danthron|FD-Score:4.18|P-value:4.83E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:4.15|P-value:5.31E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.91|P-value:9.88E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.05|P-value:6.90E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.52|P-value:1.84E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.11|P-value:5.81E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.25|P-value:4.04E-4 ID:SGTC_3243|Compound:9134147|FD-Score:-4.51|P-value:4.72E-4 ID:SGTC_3247|Compound:9135149|FD-Score:8.48|P-value:2.50E-11 ID:SGTC_3254|Compound:9136651|FD-Score:4.02|P-value:7.35E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.08|P-value:6.36E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.30|P-value:3.47E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.72|P-value:1.04E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.36|P-value:1.34E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.96|P-value:8.63E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.94|P-value:9.05E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.87|P-value:2.26E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.29|P-value:8.45E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:8.53|P-value:2.02E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:3.98|P-value:8.21E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:4.04|P-value:6.98E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.97|P-value:3.02E-8 ID:SGTC_344|Compound:k064-0035|FD-Score:-5.63|P-value:1.59E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:6.72|P-value:8.51E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:6.28|P-value:4.80E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.03|P-value:7.27E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:6.35|P-value:3.67E-7 ID:SGTC_558|Compound:k064-0027|FD-Score:5.71|P-value:4.02E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:4.56|P-value:1.64E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:5.56|P-value:6.97E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:9.06|P-value:1.21E-12 ID:SGTC_640|Compound:3381-0960|FD-Score:5.62|P-value:5.57E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:4.37|P-value:2.85E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.21|P-value:6.14E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.16|P-value:7.04E-13 ID:SGTC_692|Compound:k241-0027|FD-Score:3.94|P-value:9.24E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.66|P-value:1.26E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:7.31|P-value:6.65E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:4.29|P-value:3.60E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.46|P-value:2.25E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:5.24|P-value:2.02E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.64|P-value:1.30E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.36|P-value:2.91E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:9.05|P-value:1.26E-12 ID:SGTC_945|Compound:3381-0768|FD-Score:6.70|P-value:9.29E-8 ID:SGTC_951|Compound:1171-0579|FD-Score:7.71|P-value:1.08E-9 ID:SGTC_952|Compound:1185-0122|FD-Score:4.81|P-value:7.86E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:4.52|P-value:1.86E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.52|P-value:7.81E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.12|P-value:5.69E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:9.45|P-value:1.37E-13 ID:SGTC_1063|Compound:disulfiram|FD-Score:6.98|P-value:2.87E-8 ID:SGTC_1079|Compound:idarubicin|FD-Score:6.14|P-value:8.47E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.00|P-value:1.39E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.10|P-value:6.04E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.05|P-value:6.77E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:5.68|P-value:4.52E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.84|P-value:7.30E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.61|P-value:1.43E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.99|P-value:7.96E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.80|P-value:8.07E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:9.78|P-value:2.04E-14 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.36|P-value:7.03E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.94|P-value:9.19E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.19|P-value:1.14E-8 ID:SGTC_1615|Compound:st002656|FD-Score:5.45|P-value:1.01E-5 ID:SGTC_1643|Compound:st009866|FD-Score:-4.23|P-value:9.96E-4 ID:SGTC_1644|Compound:st010134|FD-Score:5.38|P-value:1.25E-5 ID:SGTC_1651|Compound:st011928|FD-Score:7.48|P-value:3.10E-9 ID:SGTC_1652|Compound:st011932|FD-Score:9.55|P-value:7.81E-14 ID:SGTC_1665|Compound:st014639|FD-Score:4.62|P-value:1.40E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.15|P-value:5.29E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.47|P-value:2.16E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.41|P-value:2.57E-4 ID:SGTC_1707|Compound:st032323|FD-Score:6.05|P-value:1.17E-6 ID:SGTC_1719|Compound:st032227|FD-Score:6.22|P-value:6.27E-7 ID:SGTC_1723|Compound:st034307|FD-Score:4.80|P-value:8.19E-5 ID:SGTC_1761|Compound:st044296|FD-Score:4.03|P-value:7.21E-4 ID:SGTC_1779|Compound:st039427|FD-Score:5.19|P-value:2.42E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-4.68|P-value:2.91E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.50|P-value:1.99E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.54|P-value:1.78E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.97|P-value:4.80E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.69|P-value:1.13E-4 ID:SGTC_1960|Compound:st011366|FD-Score:6.21|P-value:6.31E-7 ID:SGTC_1967|Compound:st070177|FD-Score:3.95|P-value:8.96E-4 ID:SGTC_2041|Compound:5107442|FD-Score:5.98|P-value:1.51E-6 ID:SGTC_2069|Compound:5228469|FD-Score:5.52|P-value:7.78E-6 ID:SGTC_2109|Compound:5483026|FD-Score:8.37|P-value:4.50E-11 ID:SGTC_2111|Compound:5486399|FD-Score:6.43|P-value:2.68E-7 ID:SGTC_2124|Compound:5246320|FD-Score:4.67|P-value:1.20E-4 ID:SGTC_2180|Compound:6301957|FD-Score:5.87|P-value:2.26E-6 ID:SGTC_2186|Compound:6124449|FD-Score:4.63|P-value:1.35E-4 ID:SGTC_2187|Compound:6125751|FD-Score:6.14|P-value:8.43E-7 ID:SGTC_2229|Compound:7354935|FD-Score:5.91|P-value:1.99E-6 ID:SGTC_2277|Compound:7947813|FD-Score:12.10|P-value:6.71E-21 ID:SGTC_2289|Compound:7946404|FD-Score:4.77|P-value:8.82E-5 ID:SGTC_2301|Compound:7769476|FD-Score:8.45|P-value:2.99E-11 ID:SGTC_2311|Compound:7694451|FD-Score:4.94|P-value:5.28E-5 ID:SGTC_2315|Compound:7733312|FD-Score:5.12|P-value:2.94E-5 ID:SGTC_2361|Compound:9034121|FD-Score:8.15|P-value:1.34E-10 ID:SGTC_2378|Compound:9074213|FD-Score:6.94|P-value:3.38E-8 ID:SGTC_2380|Compound:9035439|FD-Score:4.25|P-value:4.04E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.52|P-value:4.59E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.48|P-value:9.10E-6 ID:SGTC_2485|Compound:5633444|FD-Score:5.06|P-value:3.56E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:8.09|P-value:1.75E-10 ID:SGTC_2556|Compound:citropten|FD-Score:5.48|P-value:8.96E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.58|P-value:6.31E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.63|P-value:1.37E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.39|P-value:4.72E-9 ID:SGTC_2671|Compound:danthron|FD-Score:4.18|P-value:4.83E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:4.15|P-value:5.31E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.91|P-value:9.88E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.05|P-value:6.90E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.52|P-value:1.84E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.11|P-value:5.81E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.25|P-value:4.04E-4 ID:SGTC_3243|Compound:9134147|FD-Score:-4.51|P-value:4.72E-4 ID:SGTC_3247|Compound:9135149|FD-Score:8.48|P-value:2.50E-11 ID:SGTC_3254|Compound:9136651|FD-Score:4.02|P-value:7.35E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.08|P-value:6.36E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.30|P-value:3.47E-4

Top fitness defect scores for YDR404C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2277 7947813 12.10 106.9 µM 6.71E-21 RSC complex & mRNA processing 1 6.85E-34 1.91
2 SGTC_1374 2889-5571 9.78 141.0 µM 2.04E-14 RSC complex & mRNA processing 13 6.75E-23 0.79
3 SGTC_1652 st011932 9.55 78.0 µM 7.81E-14 RSC complex & mRNA processing 12 6.53E-22 0.58
4 SGTC_1050 3232-1156 9.45 69.3 µM 1.37E-13 RSC complex & mRNA processing 1 1.70E-21 1.03
5 SGTC_682 0kpi-0099 9.16 17.0 µM 7.04E-13 4 2.67E-20 0.31
6 SGTC_586 0957-0265 9.06 8.2 µM 1.21E-12 cell wall 10 6.69E-20 0.41
7 SGTC_871 0574-0004 9.05 149.0 µM 1.26E-12 8 7.16E-20 0.08
8 SGTC_181 1447-1644 8.53 8.1 µM 2.02E-11 endomembrane recycling 2 7.64E-18 1.54
9 SGTC_3247 9135149 8.48 49.5 µM 2.50E-11 DNA damage response 5 1.10E-17 1.39
10 SGTC_2301 7769476 8.45 200.0 µM 2.99E-11 2 1.49E-17 0.43
11 SGTC_2109 5483026 8.37 200.0 µM 4.50E-11 RSC complex & mRNA processing 13 2.95E-17 1.00
12 SGTC_2361 9034121 8.15 116.0 µM 1.34E-10 RSC complex & mRNA processing 6 1.86E-16 0.18
13 SGTC_2544 sphondin 8.09 68.5 µM 1.75E-10 RNA pol III & RNase P/MRP 12 2.89E-16 0.56
14 SGTC_951 1171-0579 7.71 82.7 µM 1.08E-9 cell wall 6 6.20E-15 1.08
15 SGTC_1651 st011928 7.48 86.1 µM 3.10E-9 RSC complex & mRNA processing 4 3.61E-14 0.27
16 SGTC_2651 1327-0036 7.39 5.0 µM 4.72E-9 23 7.29E-14 0.07
17 SGTC_709 3807-1509 7.31 243.0 µM 6.65E-9 RSC complex & mRNA processing 8 1.30E-13 0.98
18 SGTC_1597 7-benzyloxygramine 7.19 47.5 µM 1.14E-8 calcium & mitochondrial duress 26 3.18E-13 0.02
19 SGTC_1063 disulfiram 6.98 1.8 µM 2.87E-8 1 1.49E-12 1.05
20 SGTC_248 streptozotocin 6.97 5.2 mM 3.02E-8 DNA damage response 6 1.63E-12 0.02

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Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.398 1.72E-127 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.364 6.97E-106 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.363 6.25E-105 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.354 6.50E-100 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.328 6.60E-85 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.304 7.42E-73 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.297 2.19E-69 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.293 3.17E-67 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.291 3.18E-66 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.287 1.06E-64 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.287 1.29E-64 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.268 3.80E-56 YIL021W RPB3 het RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
0.267 9.82E-56 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.262 7.47E-54 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.252 7.77E-50 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation