YDR405W / MRP20

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR405W / MRP20

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.82|P-value:6.09E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.29|P-value:5.65E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.09|P-value:9.15E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.88|P-value:4.87E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:7.18|P-value:3.43E-13 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:10.40|P-value:1.25E-25 ID:SGTC_236|Compound:1509-0011|FD-Score:8.12|P-value:2.57E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.17|P-value:3.32E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:9.22|P-value:1.70E-20 ID:SGTC_314|Compound:1671-0008|FD-Score:3.79|P-value:6.96E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.20|P-value:8.80E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.04|P-value:2.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.54|P-value:2.64E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.84|P-value:1.11E-22 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.33|P-value:5.58E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.27|P-value:4.90E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:6.56|P-value:2.65E-11 ID:SGTC_745|Compound:0469-0705|FD-Score:3.56|P-value:1.69E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.96|P-value:3.49E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.07|P-value:9.95E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.78|P-value:7.07E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.47|P-value:3.69E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:4.34|P-value:6.65E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:6.74|P-value:8.05E-12 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.82|P-value:4.37E-12 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.56|P-value:1.71E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:5.14|P-value:1.26E-7 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.53|P-value:1.90E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.31|P-value:4.33E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-3.65|P-value:1.71E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.85|P-value:9.11E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.63|P-value:1.87E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.34|P-value:5.35E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.39|P-value:3.19E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.23|P-value:1.06E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.50|P-value:3.01E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.38|P-value:3.56E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.55|P-value:2.44E-6 ID:SGTC_2277|Compound:7947813|FD-Score:3.23|P-value:5.57E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.50|P-value:2.11E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.05|P-value:2.38E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.20|P-value:6.34E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.58|P-value:2.26E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.35|P-value:6.25E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.60|P-value:1.46E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.53|P-value:1.87E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.14|P-value:1.59E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.33|P-value:1.04E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.37|P-value:3.48E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.43|P-value:2.79E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.08|P-value:2.89E-7 ID:SGTC_2923|Compound:7992654|FD-Score:-3.86|P-value:7.62E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.28|P-value:4.69E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.49|P-value:2.22E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.13|P-value:7.89E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.71|P-value:5.33E-9 ID:SGTC_3137|Compound:9097352|FD-Score:3.12|P-value:8.25E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.85|P-value:5.84E-7 ID:SGTC_3234|Compound:9132280|FD-Score:3.33|P-value:4.03E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.82|P-value:6.09E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.29|P-value:5.65E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.09|P-value:9.15E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.88|P-value:4.87E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:7.18|P-value:3.43E-13 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:10.40|P-value:1.25E-25 ID:SGTC_236|Compound:1509-0011|FD-Score:8.12|P-value:2.57E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.17|P-value:3.32E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:9.22|P-value:1.70E-20 ID:SGTC_314|Compound:1671-0008|FD-Score:3.79|P-value:6.96E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.20|P-value:8.80E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.04|P-value:2.49E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.54|P-value:2.64E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.84|P-value:1.11E-22 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.33|P-value:5.58E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.27|P-value:4.90E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:6.56|P-value:2.65E-11 ID:SGTC_745|Compound:0469-0705|FD-Score:3.56|P-value:1.69E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.96|P-value:3.49E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.07|P-value:9.95E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.78|P-value:7.07E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.47|P-value:3.69E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:4.34|P-value:6.65E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:6.74|P-value:8.05E-12 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.82|P-value:4.37E-12 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.56|P-value:1.71E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:5.14|P-value:1.26E-7 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.53|P-value:1.90E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.31|P-value:4.33E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-3.65|P-value:1.71E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.85|P-value:9.11E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.63|P-value:1.87E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.34|P-value:5.35E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.39|P-value:3.19E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.23|P-value:1.06E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.50|P-value:3.01E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.38|P-value:3.56E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.55|P-value:2.44E-6 ID:SGTC_2277|Compound:7947813|FD-Score:3.23|P-value:5.57E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.50|P-value:2.11E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.05|P-value:2.38E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.20|P-value:6.34E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.58|P-value:2.26E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.35|P-value:6.25E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.60|P-value:1.46E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.53|P-value:1.87E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.14|P-value:1.59E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.33|P-value:1.04E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.37|P-value:3.48E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.43|P-value:2.79E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.08|P-value:2.89E-7 ID:SGTC_2923|Compound:7992654|FD-Score:-3.86|P-value:7.62E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.28|P-value:4.69E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.49|P-value:2.22E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.13|P-value:7.89E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.71|P-value:5.33E-9 ID:SGTC_3137|Compound:9097352|FD-Score:3.12|P-value:8.25E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.85|P-value:5.84E-7 ID:SGTC_3234|Compound:9132280|FD-Score:3.33|P-value:4.03E-4

Top fitness defect scores for YDR405W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_219 mitoxanthrone 10.40 164.4 µM 1.25E-25 DNA intercalators 6 9.79E-26
2 SGTC_310 1273-0058 9.22 1.1 µM 1.70E-20 mitochondrial stress 59 1.48E-20
3 SGTC_236 1509-0011 8.12 5.3 µM 2.57E-16 246 2.41E-16
4 SGTC_173 1273-0061 7.18 2.7 µM 3.43E-13 mitochondrial stress 82 3.39E-13
5 SGTC_1274 0865-0114 6.82 173.0 µM 4.37E-12 2 4.40E-12
6 SGTC_908 3448-7491 6.74 47.7 µM 8.05E-12 mitochondrial stress 32 8.14E-12
7 SGTC_720 r052-1644 6.56 49.9 µM 2.65E-11 TSC3-RPN4 6 2.70E-11
8 SGTC_275 trichlorophene 6.17 5.7 µM 3.32E-10 mitochondrial stress 112 3.44E-10
9 SGTC_3126 9127922 5.71 49.5 µM 5.33E-9 fatty acid desaturase (OLE1) 18 5.60E-9
10 SGTC_2232 chlorophetanol 5.38 41.5 µM 3.56E-8 TRP & mitochondrial translation 60 3.78E-8
11 SGTC_63 0099-0242 5.29 26.7 µM 5.65E-8 mitochondrial stress 48 6.01E-8
12 SGTC_1361 1608-0041 5.14 5.6 µM 1.26E-7 RPP1 & pyrimidine depletion 7 1.35E-7
13 SGTC_3194 9111903 4.85 49.5 µM 5.84E-7 9 6.28E-7
14 SGTC_2250 alverine citrate 4.55 130.0 µM 2.44E-6 120 2.63E-6
15 SGTC_430 0958-0115 4.54 16.4 µM 2.64E-6 15 2.85E-6
16 SGTC_882 0843-0131 4.47 351.0 µM 3.69E-6 10 3.99E-6
17 SGTC_2526 patulin 4.35 37.6 µM 6.25E-6 69 6.77E-6
18 SGTC_903 1134-0042 4.34 114.0 µM 6.65E-6 16 7.21E-6
19 SGTC_1742 st038235 4.23 28.9 µM 1.06E-5 mitochondrial stress 107 1.15E-5
20 SGTC_2688 kanamycin b 4.14 96.7 µM 1.59E-5 calcium & mitochondrial duress 341 1.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.429 2.69E-150 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.427 7.11E-149 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.424 2.26E-146 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.416 5.82E-141 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.414 4.24E-139 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.408 3.67E-135 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.408 6.86E-135 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.408 1.32E-134 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.406 3.45E-133 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.406 2.43E-133 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.406 1.63E-132 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.405 1.14E-132 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.404 3.21E-132 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.398 2.04E-127 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.395 1.51E-125 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria