YDR407C / TRS120

One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR407C / TRS120

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.08|P-value:9.76E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.44|P-value:4.08E-11 ID:SGTC_183|Compound:3914-0051|FD-Score:3.30|P-value:4.50E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.64|P-value:1.27E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.95|P-value:3.56E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:7.44|P-value:3.09E-14 ID:SGTC_320|Compound:4092-0846|FD-Score:5.93|P-value:1.11E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.84|P-value:4.84E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.38|P-value:3.35E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.26|P-value:5.26E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.14|P-value:7.96E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.42|P-value:2.89E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.34|P-value:3.90E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.44|P-value:2.67E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.26|P-value:9.15E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.27|P-value:4.34E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.32|P-value:4.14E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.79|P-value:6.82E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.95|P-value:3.00E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:6.84|P-value:2.58E-12 ID:SGTC_1366|Compound:1683-0113|FD-Score:-5.10|P-value:1.11E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:3.52|P-value:1.97E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.73|P-value:7.41E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-3.07|P-value:8.85E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.91|P-value:3.84E-7 ID:SGTC_1693|Compound:xanthone|FD-Score:3.13|P-value:8.38E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.34|P-value:6.46E-14 ID:SGTC_1765|Compound:st044815|FD-Score:-3.12|P-value:7.49E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.16|P-value:9.91E-8 ID:SGTC_1825|Compound:st052143|FD-Score:3.81|P-value:6.20E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.53|P-value:1.69E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.72|P-value:9.23E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.41|P-value:3.84E-14 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.17|P-value:1.35E-5 ID:SGTC_2257|Compound:7960413|FD-Score:5.34|P-value:3.68E-8 ID:SGTC_2285|Compound:7945142|FD-Score:6.18|P-value:2.31E-10 ID:SGTC_2289|Compound:7946404|FD-Score:7.96|P-value:4.88E-16 ID:SGTC_2318|Compound:6029776|FD-Score:3.83|P-value:5.90E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-4.13|P-value:1.36E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.83|P-value:5.75E-5 ID:SGTC_2437|Compound:5741531|FD-Score:4.02|P-value:2.62E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.13|P-value:8.30E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.10|P-value:8.13E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.24|P-value:9.93E-6 ID:SGTC_2948|Compound:9070189|FD-Score:3.14|P-value:7.94E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.93|P-value:2.83E-7 ID:SGTC_3136|Compound:9095672|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.08|P-value:9.69E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.08|P-value:9.76E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.44|P-value:4.08E-11 ID:SGTC_183|Compound:3914-0051|FD-Score:3.30|P-value:4.50E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.64|P-value:1.27E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.95|P-value:3.56E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:7.44|P-value:3.09E-14 ID:SGTC_320|Compound:4092-0846|FD-Score:5.93|P-value:1.11E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.84|P-value:4.84E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.38|P-value:3.35E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.26|P-value:5.26E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.14|P-value:7.96E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.42|P-value:2.89E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.34|P-value:3.90E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.44|P-value:2.67E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.26|P-value:9.15E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.27|P-value:4.34E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.32|P-value:4.14E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.79|P-value:6.82E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.95|P-value:3.00E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:6.84|P-value:2.58E-12 ID:SGTC_1366|Compound:1683-0113|FD-Score:-5.10|P-value:1.11E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:3.52|P-value:1.97E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.73|P-value:7.41E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-3.07|P-value:8.85E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.91|P-value:3.84E-7 ID:SGTC_1693|Compound:xanthone|FD-Score:3.13|P-value:8.38E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.34|P-value:6.46E-14 ID:SGTC_1765|Compound:st044815|FD-Score:-3.12|P-value:7.49E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.16|P-value:9.91E-8 ID:SGTC_1825|Compound:st052143|FD-Score:3.81|P-value:6.20E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.53|P-value:1.69E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.72|P-value:9.23E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.41|P-value:3.84E-14 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.17|P-value:1.35E-5 ID:SGTC_2257|Compound:7960413|FD-Score:5.34|P-value:3.68E-8 ID:SGTC_2285|Compound:7945142|FD-Score:6.18|P-value:2.31E-10 ID:SGTC_2289|Compound:7946404|FD-Score:7.96|P-value:4.88E-16 ID:SGTC_2318|Compound:6029776|FD-Score:3.83|P-value:5.90E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-4.13|P-value:1.36E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.83|P-value:5.75E-5 ID:SGTC_2437|Compound:5741531|FD-Score:4.02|P-value:2.62E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.13|P-value:8.30E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.10|P-value:8.13E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.24|P-value:9.93E-6 ID:SGTC_2948|Compound:9070189|FD-Score:3.14|P-value:7.94E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.93|P-value:2.83E-7 ID:SGTC_3136|Compound:9095672|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.08|P-value:9.69E-4

Top fitness defect scores for YDR407C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2289 7946404 7.96 165.1 µM 4.88E-16 5 8.63E-16 1.91
2 SGTC_312 4092-0653 7.44 6.8 µM 3.09E-14 ergosterol depletion effects on membrane 11 5.04E-14 1.04
3 SGTC_2249 haloperidol 7.41 116.4 µM 3.84E-14 ergosterol depletion effects on membrane 9 6.24E-14 0.31
4 SGTC_1754 st042065 7.34 16.1 µM 6.46E-14 NEO1-PIK1 9 1.04E-13 0.25
5 SGTC_1364 1653-0028 6.84 37.6 µM 2.58E-12 1 3.87E-12 1.57
6 SGTC_178 4092-0806 6.44 87.5 µM 4.08E-11 ergosterol depletion effects on membrane 8 5.81E-11 0.04
7 SGTC_2285 7945142 6.18 200.0 µM 2.31E-10 4 3.19E-10 0.52
8 SGTC_320 4092-0846 5.93 5.3 µM 1.11E-9 ergosterol depletion effects on membrane 8 1.48E-9 0.03
9 SGTC_2257 7960413 5.34 200.0 µM 3.68E-8 NEO1-PIK1 12 4.61E-8 0.18
10 SGTC_1818 st052136 5.16 56.3 µM 9.91E-8 NEO1-PIK1 9 1.22E-7 0.04
11 SGTC_1628 st004252 4.91 77.7 µM 3.84E-7 4 4.62E-7 1.32
12 SGTC_1072 oxiconazole 4.26 14.9 nM 9.15E-6 ergosterol depletion effects on membrane 17 1.04E-5 0.00
13 SGTC_2688 kanamycin b 4.24 96.7 µM 9.93E-6 calcium & mitochondrial duress 17 1.13E-5 0.08
14 SGTC_2250 alverine citrate 4.17 130.0 µM 1.35E-5 29 1.52E-5 0.07
15 SGTC_2437 5741531 4.02 144.2 µM 2.62E-5 5 2.93E-5 0.19
16 SGTC_262 fenpropimorph 3.95 62.5 µM 3.56E-5 ergosterol depletion effects on membrane 14 3.96E-5 0.00
17 SGTC_2418 pentamidine 3.83 31.7 µM 5.75E-5 mitochondrial processes 14 6.34E-5 0.02
18 SGTC_2318 6029776 3.83 164.0 µM 5.90E-5 4 6.50E-5 0.02
19 SGTC_1825 st052143 3.81 62.6 µM 6.20E-5 7 6.83E-5 0.06
20 SGTC_1297 1068-0111 3.79 14.1 µM 6.82E-5 5 7.50E-5 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.285 1.19E-63 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.244 9.43E-47 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.218 1.68E-37 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.218 2.73E-37 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.216 1.05E-36 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.215 1.93E-36 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.208 2.79E-34 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.205 2.60E-33 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.205 4.48E-33 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.202 3.69E-32 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.198 7.60E-31 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.186 2.04E-27 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.185 2.69E-27 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.181 4.47E-26 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.179 1.48E-25 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress