YDR412W / RRP17

Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR412W / RRP17

Click on Significant Values for Screen Details ID:SGTC_284|Compound:0988-0104|FD-Score:-3.86|P-value:2.19E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.89|P-value:1.41E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:-2.65|P-value:8.13E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.88|P-value:2.60E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.01|P-value:1.42E-4 ID:SGTC_394|Compound:menadione|FD-Score:-2.66|P-value:8.00E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.25|P-value:1.56E-7 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.15|P-value:8.90E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.00|P-value:1.45E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.56|P-value:8.87E-6 ID:SGTC_645|Compound:0845-0943|FD-Score:2.62|P-value:7.87E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-2.99|P-value:1.87E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.20|P-value:2.18E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.25|P-value:5.61E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:2.67|P-value:6.42E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.13|P-value:8.25E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.68|P-value:5.97E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:3.46|P-value:1.50E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:2.58|P-value:9.36E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.83|P-value:3.94E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.25|P-value:5.55E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:5.74|P-value:2.59E-12 ID:SGTC_976|Compound:1348-1067|FD-Score:4.11|P-value:3.72E-7 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.61|P-value:8.17E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.02|P-value:6.69E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.42|P-value:1.85E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.78|P-value:2.61E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.62|P-value:7.90E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.81|P-value:3.54E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:2.66|P-value:6.50E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.64|P-value:1.21E-8 ID:SGTC_1694|Compound:st024011|FD-Score:-2.75|P-value:5.43E-4 ID:SGTC_1699|Compound:st031318|FD-Score:2.61|P-value:8.21E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.57|P-value:8.40E-6 ID:SGTC_1711|Compound:st032263|FD-Score:3.03|P-value:1.28E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-2.72|P-value:6.25E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.19|P-value:5.92E-5 ID:SGTC_2388|Compound:9080168|FD-Score:2.75|P-value:4.62E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.68|P-value:1.22E-8 ID:SGTC_2457|Compound:5731572|FD-Score:2.84|P-value:3.13E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-2.94|P-value:2.43E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.33|P-value:3.83E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.99|P-value:1.53E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.13|P-value:1.01E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.75|P-value:3.18E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.22|P-value:6.58E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.01|P-value:1.42E-4 ID:SGTC_2816|Compound:7982706|FD-Score:2.81|P-value:3.43E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.18|P-value:6.31E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.46|P-value:1.54E-5 ID:SGTC_2875|Compound:9039966|FD-Score:2.83|P-value:3.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.97|P-value:8.75E-7 ID:SGTC_2942|Compound:9052777|FD-Score:2.60|P-value:8.49E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.38|P-value:2.92E-5 ID:SGTC_3015|Compound:9080845|FD-Score:2.80|P-value:3.69E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-2.80|P-value:4.33E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.03|P-value:1.56E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.02|P-value:1.34E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.10|P-value:9.44E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.86|P-value:2.19E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.89|P-value:1.41E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:-2.65|P-value:8.13E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.88|P-value:2.60E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.01|P-value:1.42E-4 ID:SGTC_394|Compound:menadione|FD-Score:-2.66|P-value:8.00E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.25|P-value:1.56E-7 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.15|P-value:8.90E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.00|P-value:1.45E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.56|P-value:8.87E-6 ID:SGTC_645|Compound:0845-0943|FD-Score:2.62|P-value:7.87E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-2.99|P-value:1.87E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.20|P-value:2.18E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.25|P-value:5.61E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:2.67|P-value:6.42E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.13|P-value:8.25E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.68|P-value:5.97E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:3.46|P-value:1.50E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:2.58|P-value:9.36E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.83|P-value:3.94E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.25|P-value:5.55E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:5.74|P-value:2.59E-12 ID:SGTC_976|Compound:1348-1067|FD-Score:4.11|P-value:3.72E-7 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.61|P-value:8.17E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.02|P-value:6.69E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.42|P-value:1.85E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.78|P-value:2.61E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.62|P-value:7.90E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.81|P-value:3.54E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:2.66|P-value:6.50E-4 ID:SGTC_1691|Compound:st019933|FD-Score:4.64|P-value:1.21E-8 ID:SGTC_1694|Compound:st024011|FD-Score:-2.75|P-value:5.43E-4 ID:SGTC_1699|Compound:st031318|FD-Score:2.61|P-value:8.21E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.57|P-value:8.40E-6 ID:SGTC_1711|Compound:st032263|FD-Score:3.03|P-value:1.28E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-2.72|P-value:6.25E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.19|P-value:5.92E-5 ID:SGTC_2388|Compound:9080168|FD-Score:2.75|P-value:4.62E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.68|P-value:1.22E-8 ID:SGTC_2457|Compound:5731572|FD-Score:2.84|P-value:3.13E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-2.94|P-value:2.43E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.33|P-value:3.83E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.99|P-value:1.53E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.13|P-value:1.01E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.75|P-value:3.18E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.22|P-value:6.58E-5 ID:SGTC_2815|Compound:7968870|FD-Score:3.01|P-value:1.42E-4 ID:SGTC_2816|Compound:7982706|FD-Score:2.81|P-value:3.43E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.18|P-value:6.31E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.46|P-value:1.54E-5 ID:SGTC_2875|Compound:9039966|FD-Score:2.83|P-value:3.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.97|P-value:8.75E-7 ID:SGTC_2942|Compound:9052777|FD-Score:2.60|P-value:8.49E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.38|P-value:2.92E-5 ID:SGTC_3015|Compound:9080845|FD-Score:2.80|P-value:3.69E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-2.80|P-value:4.33E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.03|P-value:1.56E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.02|P-value:1.34E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.10|P-value:9.44E-5

Top fitness defect scores for YDR412W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_972 1319-0219 5.74 195.0 µM 2.59E-12 2 4.67E-9 0.20
2 SGTC_1691 st019933 4.64 84.6 µM 1.21E-8 1 1.76E-6 1.18
3 SGTC_407 eburnamonine 4.25 100.0 µM 1.56E-7 4 1.06E-5 0.56
4 SGTC_724 3910-0327 4.20 137.0 µM 2.18E-7 ERG2 2 1.34E-5 0.15
5 SGTC_976 1348-1067 4.11 47.6 µM 3.72E-7 60S ribosome export 6 1.96E-5 0.02
6 SGTC_1129 3453-1384 4.02 223.0 µM 6.69E-7 17 2.96E-5 0.06
7 SGTC_2917 7979103 3.97 53.8 µM 8.75E-7 7 3.57E-5 0.35
8 SGTC_286 k060-0067 3.89 22.9 µM 1.41E-6 tubulin folding & SWR complex 5 5.01E-5 0.05
9 SGTC_1226 3909-7979 3.78 35.4 µM 2.61E-6 6 7.72E-5 0.09
10 SGTC_2758 dehydroepiandrosterone 3.75 69.3 µM 3.18E-6 9 8.87E-5 0.25
11 SGTC_1703 st026983 3.57 48.3 µM 8.40E-6 3 1.76E-4 0.12
12 SGTC_605 1315-0399 3.56 119.0 µM 8.87E-6 Golgi 13 1.83E-4 0.38
13 SGTC_768 0384-0033 3.46 77.3 µM 1.50E-5 fatty acid desaturase (OLE1) 24 2.66E-4 0.20
14 SGTC_2846 9008642 3.46 19.5 µM 1.54E-5 11 2.71E-4 0.13
15 SGTC_1168 k815-0004 3.42 80.5 µM 1.85E-5 DNA damage response 21 3.08E-4 0.03
16 SGTC_2372 9071633 3.19 200.0 µM 5.92E-5 6 7.02E-4 0.03
17 SGTC_2826 7992541 3.18 19.5 µM 6.31E-5 7 7.35E-4 0.04
18 SGTC_761 k216-0224 3.13 480.0 µM 8.25E-5 17 8.88E-4 0.01
19 SGTC_3264 9137442 3.10 49.5 µM 9.44E-5 11 9.77E-4 0.13
20 SGTC_1711 st032263 3.03 62.8 µM 1.28E-4 8 0.00121 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.27E-12 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.112 7.34E-11 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.104 1.45E-9 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.103 2.16E-9 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.101 4.17E-9 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.099 9.20E-9 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.096 2.85E-8 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.084 1.01E-6 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.083 1.34E-6 YOR356W CIR2 hom Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response
0.080 3.04E-6 YJL196C ELO1 hom Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication
0.080 3.44E-6 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.079 4.83E-6 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.079 4.82E-6 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.078 6.85E-6 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.077 7.80E-6 YHR005C-A TIM10 het Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane