YDR413C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR413C / YDR413C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.80|P-value:1.71E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.35|P-value:7.53E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.33|P-value:8.56E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.72|P-value:2.24E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.27|P-value:3.15E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.99|P-value:8.34E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.63|P-value:3.08E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.12|P-value:6.69E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.62|P-value:3.17E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.68|P-value:2.54E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.37|P-value:1.86E-7 ID:SGTC_519|Compound:k048-0011|FD-Score:5.63|P-value:5.50E-8 ID:SGTC_618|Compound:k072-0232|FD-Score:3.51|P-value:4.63E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.57|P-value:3.81E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.64|P-value:2.69E-13 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.49|P-value:4.82E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:6.85|P-value:5.18E-11 ID:SGTC_839|Compound:0122-0028|FD-Score:3.50|P-value:4.79E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.80|P-value:1.61E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-4.04|P-value:6.62E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.58|P-value:7.04E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.91|P-value:1.07E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.63|P-value:5.50E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.80|P-value:2.84E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.39|P-value:6.84E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.11|P-value:7.03E-7 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.70|P-value:4.35E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.98|P-value:8.36E-9 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.33|P-value:8.24E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.63|P-value:6.29E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.94|P-value:1.01E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.76|P-value:2.51E-8 ID:SGTC_1891|Compound:st059073|FD-Score:3.52|P-value:4.50E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.87|P-value:1.31E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.60|P-value:3.47E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.08|P-value:5.85E-5 ID:SGTC_2126|Compound:5251174|FD-Score:5.01|P-value:1.14E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.60|P-value:3.34E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.32|P-value:8.50E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.81|P-value:1.60E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:5.92|P-value:1.15E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.95|P-value:9.82E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.84|P-value:3.49E-17 ID:SGTC_2779|Compound:methotrexate|FD-Score:-5.50|P-value:9.92E-8 ID:SGTC_2798|Compound:7813637|FD-Score:3.36|P-value:7.66E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.43|P-value:6.01E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.96|P-value:1.46E-6 ID:SGTC_3181|Compound:9108277|FD-Score:-3.59|P-value:3.42E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.30|P-value:9.08E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.28|P-value:9.60E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.56|P-value:3.94E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.83|P-value:2.51E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-3.62|P-value:3.07E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.80|P-value:1.71E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.35|P-value:7.53E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.33|P-value:8.56E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.72|P-value:2.24E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.27|P-value:3.15E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.99|P-value:8.34E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.63|P-value:3.08E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.12|P-value:6.69E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.62|P-value:3.17E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.68|P-value:2.54E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.37|P-value:1.86E-7 ID:SGTC_519|Compound:k048-0011|FD-Score:5.63|P-value:5.50E-8 ID:SGTC_618|Compound:k072-0232|FD-Score:3.51|P-value:4.63E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.57|P-value:3.81E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.64|P-value:2.69E-13 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.49|P-value:4.82E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:6.85|P-value:5.18E-11 ID:SGTC_839|Compound:0122-0028|FD-Score:3.50|P-value:4.79E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.80|P-value:1.61E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-4.04|P-value:6.62E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.58|P-value:7.04E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.91|P-value:1.07E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.63|P-value:5.50E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.80|P-value:2.84E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.39|P-value:6.84E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.11|P-value:7.03E-7 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.70|P-value:4.35E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.98|P-value:8.36E-9 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.33|P-value:8.24E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.63|P-value:6.29E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.94|P-value:1.01E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.76|P-value:2.51E-8 ID:SGTC_1891|Compound:st059073|FD-Score:3.52|P-value:4.50E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.87|P-value:1.31E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.60|P-value:3.47E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.08|P-value:5.85E-5 ID:SGTC_2126|Compound:5251174|FD-Score:5.01|P-value:1.14E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.60|P-value:3.34E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.32|P-value:8.50E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.81|P-value:1.60E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:5.92|P-value:1.15E-8 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.95|P-value:9.82E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.84|P-value:3.49E-17 ID:SGTC_2779|Compound:methotrexate|FD-Score:-5.50|P-value:9.92E-8 ID:SGTC_2798|Compound:7813637|FD-Score:3.36|P-value:7.66E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.43|P-value:6.01E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.96|P-value:1.46E-6 ID:SGTC_3181|Compound:9108277|FD-Score:-3.59|P-value:3.42E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.30|P-value:9.08E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.28|P-value:9.60E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.56|P-value:3.94E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.83|P-value:2.51E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-3.62|P-value:3.07E-4

Top fitness defect scores for YDR413C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2778 tioconazole 8.84 65.1 nM 3.49E-17 ergosterol depletion effects on membrane 5 4.71E-19 0.22
2 SGTC_682 0kpi-0099 7.64 17.0 µM 2.69E-13 10 1.06E-14 0.20
3 SGTC_829 1635-0120 6.85 117.0 µM 5.18E-11 DNA damage response 23 3.81E-12 0.03
4 SGTC_1213 1315-0166 5.98 115.0 µM 8.36E-9 6 1.12E-9 0.68
5 SGTC_2770 toltrazuril 5.92 17.5 µM 1.15E-8 1 1.61E-9 1.65
6 SGTC_519 k048-0011 5.63 62.8 µM 5.50E-8 1 9.22E-9 0.50
7 SGTC_1050 3232-1156 5.63 69.3 µM 5.50E-8 RSC complex & mRNA processing 10 9.22E-9 0.02
8 SGTC_1048 3161-0300 5.58 24.5 µM 7.04E-8 1 1.22E-8 0.81
9 SGTC_268 camptothecin 5.12 39.6 µM 6.69E-7 DNA damage response 29 1.50E-7 0.14
10 SGTC_1072 oxiconazole 5.11 14.9 nM 7.03E-7 ergosterol depletion effects on membrane 14 1.59E-7 0.69
11 SGTC_2126 5251174 5.01 33.9 µM 1.14E-6 4 2.73E-7 0.03
12 SGTC_3152 9099253 4.96 49.5 µM 1.46E-6 NEO1-PIK1 17 3.61E-7 0.23
13 SGTC_1253 0550-0034 4.63 176.0 µM 6.29E-6 4 1.84E-6 0.21
14 SGTC_2111 5486399 4.08 200.0 µM 5.85E-5 22 2.22E-5 0.09
15 SGTC_208 k072-0098 3.99 12.4 µM 8.34E-5 heme biosynthesis & mitochondrial translocase 19 3.29E-5 0.02
16 SGTC_2776 terbinafine 3.95 19.9 µM 9.82E-5 cell wall signaling 9 3.95E-5 0.16
17 SGTC_1707 st032323 3.94 6.3 µM 1.01E-4 DNA damage response 29 4.06E-5 0.03
18 SGTC_1915 st067105 3.87 30.6 µM 1.31E-4 RNA pol III & RNase P/MRP 35 5.46E-5 0.03
19 SGTC_2766 oltipraz 3.81 83.9 µM 1.60E-4 heme requiring 25 6.82E-5 0.22
20 SGTC_58 0957-0393 3.80 9.0 µM 1.71E-4 cell wall 52 7.34E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.85E-26 YMR277W FCP1 het Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
0.176 7.73E-25 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.174 3.50E-24 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.164 1.04E-21 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.157 7.09E-20 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.157 7.77E-20 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.154 2.66E-19 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.151 1.59E-18 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.148 7.73E-18 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.145 2.58E-17 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.145 2.81E-17 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.144 6.22E-17 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.142 1.45E-16 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.135 3.80E-15 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.133 1.17E-14 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya