YDR414C / ERD1

Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR414C / ERD1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.51|P-value:4.03E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:19.40|P-value:1.06E-77 ID:SGTC_86|Compound:0417-1630|FD-Score:3.25|P-value:9.80E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.88|P-value:1.54E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.86|P-value:1.15E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:6.12|P-value:2.33E-9 ID:SGTC_206|Compound:4546-0025|FD-Score:5.03|P-value:7.45E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.29|P-value:7.22E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.39|P-value:6.05E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.34|P-value:6.41E-10 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.91|P-value:7.56E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:6.69|P-value:7.15E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.94|P-value:8.20E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.94|P-value:8.28E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.35|P-value:5.76E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.20|P-value:3.29E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:6.50|P-value:2.42E-10 ID:SGTC_365|Compound:0121-0052|FD-Score:3.45|P-value:4.91E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.26|P-value:2.29E-5 ID:SGTC_397|Compound:arbidol|FD-Score:5.23|P-value:2.86E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.08|P-value:3.89E-5 ID:SGTC_406|Compound:estrone|FD-Score:4.27|P-value:2.19E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.84|P-value:1.83E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:3.63|P-value:2.60E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.18|P-value:3.22E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.44|P-value:3.38E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.10|P-value:2.65E-9 ID:SGTC_459|Compound:nigericin|FD-Score:3.36|P-value:6.71E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:8.15|P-value:2.87E-15 ID:SGTC_528|Compound:3492-0019|FD-Score:4.11|P-value:4.24E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:7.65|P-value:1.12E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:3.29|P-value:8.51E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.80|P-value:1.36E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:3.63|P-value:2.67E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.39|P-value:5.02E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:8.01|P-value:7.87E-15 ID:SGTC_800|Compound:3448-7362|FD-Score:4.23|P-value:2.62E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.91|P-value:9.40E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.13|P-value:3.89E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.64|P-value:2.51E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.62|P-value:2.76E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.44|P-value:4.25E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.42|P-value:5.41E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.64|P-value:4.56E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.88|P-value:1.04E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.61|P-value:2.87E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.47|P-value:9.41E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.30|P-value:8.08E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.33|P-value:6.54E-10 ID:SGTC_1707|Compound:st032323|FD-Score:-3.96|P-value:6.34E-5 ID:SGTC_1708|Compound:st033234|FD-Score:-3.57|P-value:2.67E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.89|P-value:6.22E-9 ID:SGTC_1729|Compound:st035615|FD-Score:5.68|P-value:2.74E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-3.55|P-value:2.87E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.56|P-value:3.37E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.34|P-value:7.11E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.59|P-value:5.57E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.38|P-value:1.14E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.51|P-value:4.06E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.35|P-value:1.58E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-4.78|P-value:1.92E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-4.50|P-value:6.82E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.30|P-value:2.09E-23 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.01|P-value:5.16E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.81|P-value:1.32E-8 ID:SGTC_2602|Compound:kawain|FD-Score:3.44|P-value:5.13E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.76|P-value:1.62E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.90|P-value:9.65E-5 ID:SGTC_2981|Compound:9013952|FD-Score:5.20|P-value:3.26E-7 ID:SGTC_3024|Compound:9090631|FD-Score:3.33|P-value:7.51E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.46|P-value:9.83E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.69|P-value:1.74E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.26|P-value:9.21E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.51|P-value:4.03E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:19.40|P-value:1.06E-77 ID:SGTC_86|Compound:0417-1630|FD-Score:3.25|P-value:9.80E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.88|P-value:1.54E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:3.86|P-value:1.15E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:6.12|P-value:2.33E-9 ID:SGTC_206|Compound:4546-0025|FD-Score:5.03|P-value:7.45E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.29|P-value:7.22E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.39|P-value:6.05E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.34|P-value:6.41E-10 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.91|P-value:7.56E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:6.69|P-value:7.15E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.94|P-value:8.20E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.94|P-value:8.28E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.35|P-value:5.76E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.20|P-value:3.29E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:6.50|P-value:2.42E-10 ID:SGTC_365|Compound:0121-0052|FD-Score:3.45|P-value:4.91E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.26|P-value:2.29E-5 ID:SGTC_397|Compound:arbidol|FD-Score:5.23|P-value:2.86E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.08|P-value:3.89E-5 ID:SGTC_406|Compound:estrone|FD-Score:4.27|P-value:2.19E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.84|P-value:1.83E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:3.63|P-value:2.60E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.18|P-value:3.22E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.44|P-value:3.38E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.10|P-value:2.65E-9 ID:SGTC_459|Compound:nigericin|FD-Score:3.36|P-value:6.71E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:8.15|P-value:2.87E-15 ID:SGTC_528|Compound:3492-0019|FD-Score:4.11|P-value:4.24E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:7.65|P-value:1.12E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:3.29|P-value:8.51E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.80|P-value:1.36E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:3.63|P-value:2.67E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.39|P-value:5.02E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:8.01|P-value:7.87E-15 ID:SGTC_800|Compound:3448-7362|FD-Score:4.23|P-value:2.62E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.91|P-value:9.40E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.13|P-value:3.89E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.64|P-value:2.51E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.62|P-value:2.76E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.44|P-value:4.25E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.42|P-value:5.41E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.64|P-value:4.56E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.88|P-value:1.04E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.61|P-value:2.87E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.47|P-value:9.41E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.30|P-value:8.08E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.33|P-value:6.54E-10 ID:SGTC_1707|Compound:st032323|FD-Score:-3.96|P-value:6.34E-5 ID:SGTC_1708|Compound:st033234|FD-Score:-3.57|P-value:2.67E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.89|P-value:6.22E-9 ID:SGTC_1729|Compound:st035615|FD-Score:5.68|P-value:2.74E-8 ID:SGTC_1818|Compound:st052136|FD-Score:-3.55|P-value:2.87E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.56|P-value:3.37E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.34|P-value:7.11E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.59|P-value:5.57E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.38|P-value:1.14E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.51|P-value:4.06E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.35|P-value:1.58E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-4.78|P-value:1.92E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-4.50|P-value:6.82E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.30|P-value:2.09E-23 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.01|P-value:5.16E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.81|P-value:1.32E-8 ID:SGTC_2602|Compound:kawain|FD-Score:3.44|P-value:5.13E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.76|P-value:1.62E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.90|P-value:9.65E-5 ID:SGTC_2981|Compound:9013952|FD-Score:5.20|P-value:3.26E-7 ID:SGTC_3024|Compound:9090631|FD-Score:3.33|P-value:7.51E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.46|P-value:9.83E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.69|P-value:1.74E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.26|P-value:9.21E-4

Top fitness defect scores for YDR414C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 19.40 43.3 µM 1.06E-77 mitochondrial stress 2 4.82E-84
2 SGTC_2567 aureobasidin a 10.30 60.0 nM 2.09E-23 13 2.89E-25
3 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 8.15 150.0 µM 2.87E-15 Golgi 6 1.88E-16
4 SGTC_786 4544-0069 8.01 423.0 µM 7.87E-15 2 5.62E-16
5 SGTC_625 k213-0058 7.65 121.0 µM 1.12E-13 translation 14 9.98E-15
6 SGTC_266 formosanin C 6.69 406.0 nM 7.15E-11 sphingolipid biosynthesis & PDR1 19 1.09E-11
7 SGTC_310 1273-0058 6.50 1.1 µM 2.42E-10 mitochondrial stress 131 4.08E-11
8 SGTC_439 amiodarone 6.44 34.4 µM 3.38E-10 NEO1-PIK1 41 5.86E-11
9 SGTC_255 tunicamycin 6.34 200.5 nM 6.41E-10 unfolded protein response 28 1.17E-10
10 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 6.33 54.9 µM 6.54E-10 redox potentiating 29 1.20E-10
11 SGTC_204 1543-0184 6.12 62.4 µM 2.33E-9 TRP & mitochondrial translation 11 4.76E-10
12 SGTC_453 enantio-paf c16 6.10 10.0 µM 2.65E-9 43 5.46E-10
13 SGTC_2582 agaric acid 5.81 100.0 µM 1.32E-8 redox potentiating 169 3.11E-9
14 SGTC_748 0136-0228 5.80 77.9 µM 1.36E-8 redox potentiating 40 3.22E-9
15 SGTC_1729 st035615 5.68 46.0 µM 2.74E-8 10 6.87E-9
16 SGTC_397 arbidol 5.23 50.0 µM 2.86E-7 cell wall 6 8.70E-8
17 SGTC_2981 9013952 5.20 39.0 µM 3.26E-7 21 1.00E-7
18 SGTC_299 1273-0059 5.20 1.4 µM 3.29E-7 10 1.01E-7
19 SGTC_206 4546-0025 5.03 72.0 µM 7.45E-7 NEO1 41 2.46E-7
20 SGTC_121 0557-0495 4.88 61.3 µM 1.54E-6 calcium & mitochondrial duress 32 5.41E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 1.89E-71 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.293 2.43E-67 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.266 1.34E-55 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.231 4.78E-42 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.223 3.87E-39 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.218 2.04E-37 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.203 1.33E-32 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.203 2.12E-32 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.202 3.81E-32 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.193 1.54E-29 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187 8.58E-28 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.175 1.64E-24 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.173 5.76E-24 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.173 6.71E-24 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.172 1.20E-23 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate