YDR415C_p

Putative aminopeptidase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR415C / YDR415C

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.13|P-value:2.48E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.81|P-value:9.92E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.05|P-value:3.45E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:-2.87|P-value:8.04E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.88|P-value:6.81E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.19|P-value:2.27E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.44|P-value:6.52E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.03|P-value:4.36E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.20|P-value:1.89E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.25|P-value:1.47E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.81|P-value:8.79E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.29|P-value:1.27E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.94|P-value:5.38E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.08|P-value:8.52E-9 ID:SGTC_1608|Compound:st001473|FD-Score:-3.43|P-value:7.91E-5 ID:SGTC_1624|Compound:st003710|FD-Score:-2.91|P-value:6.74E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.11|P-value:2.67E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.26|P-value:1.67E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.04|P-value:3.58E-6 ID:SGTC_2051|Compound:5263410|FD-Score:-3.42|P-value:8.44E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.33|P-value:1.25E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.90|P-value:2.57E-8 ID:SGTC_2281|Compound:7943571|FD-Score:-3.91|P-value:8.13E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.41|P-value:7.54E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.54|P-value:4.11E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.79|P-value:9.53E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.06|P-value:3.84E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.80|P-value:8.97E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.30|P-value:1.20E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.05|P-value:3.46E-4 ID:SGTC_2930|Compound:9013230|FD-Score:6.71|P-value:4.93E-14 ID:SGTC_2932|Compound:9016711|FD-Score:5.56|P-value:3.43E-10 ID:SGTC_2934|Compound:9036370|FD-Score:4.47|P-value:3.35E-7 ID:SGTC_2937|Compound:9044753|FD-Score:5.43|P-value:8.30E-10 ID:SGTC_2939|Compound:9044578|FD-Score:-5.26|P-value:3.34E-9 ID:SGTC_3105|Compound:9121040|FD-Score:3.06|P-value:3.33E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.13|P-value:2.48E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.81|P-value:9.92E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.05|P-value:3.45E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:-2.87|P-value:8.04E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.88|P-value:6.81E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.19|P-value:2.27E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.44|P-value:6.52E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.03|P-value:4.36E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.20|P-value:1.89E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.25|P-value:1.47E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.81|P-value:8.79E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.29|P-value:1.27E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.94|P-value:5.38E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.08|P-value:8.52E-9 ID:SGTC_1608|Compound:st001473|FD-Score:-3.43|P-value:7.91E-5 ID:SGTC_1624|Compound:st003710|FD-Score:-2.91|P-value:6.74E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.11|P-value:2.67E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.26|P-value:1.67E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.04|P-value:3.58E-6 ID:SGTC_2051|Compound:5263410|FD-Score:-3.42|P-value:8.44E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.33|P-value:1.25E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.90|P-value:2.57E-8 ID:SGTC_2281|Compound:7943571|FD-Score:-3.91|P-value:8.13E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.41|P-value:7.54E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.54|P-value:4.11E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.79|P-value:9.53E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.06|P-value:3.84E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.80|P-value:8.97E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.30|P-value:1.20E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.05|P-value:3.46E-4 ID:SGTC_2930|Compound:9013230|FD-Score:6.71|P-value:4.93E-14 ID:SGTC_2932|Compound:9016711|FD-Score:5.56|P-value:3.43E-10 ID:SGTC_2934|Compound:9036370|FD-Score:4.47|P-value:3.35E-7 ID:SGTC_2937|Compound:9044753|FD-Score:5.43|P-value:8.30E-10 ID:SGTC_2939|Compound:9044578|FD-Score:-5.26|P-value:3.34E-9 ID:SGTC_3105|Compound:9121040|FD-Score:3.06|P-value:3.33E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.18|P-value:2.04E-4

Top fitness defect scores for YDR415C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2930 9013230 6.71 14.9 µM 4.93E-14 heme biosynthesis & mitochondrial translocase 7 9.86E-12
2 SGTC_2932 9016711 5.56 44.5 µM 3.43E-10 17 1.37E-8
3 SGTC_2937 9044753 5.43 11.3 µM 8.30E-10 60S ribosome export 11 2.82E-8
4 SGTC_1310 1188-0297 5.08 994.0 nM 8.52E-9 azole & statin 13 1.90E-7
5 SGTC_2058 5236698 4.90 133.0 µM 2.57E-8 14 4.69E-7
6 SGTC_2934 9036370 4.47 36.9 µM 3.35E-7 19 3.85E-6
7 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 4.04 62.6 µM 3.58E-6 TSC3-RPN4 14 2.69E-5
8 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.54 19.9 µM 4.11E-5 redox potentiating 15 1.99E-4
9 SGTC_658 3253-0951 3.44 102.0 µM 6.52E-5 calcium & mitochondrial duress 85 2.91E-4
10 SGTC_2308 7584454 3.41 197.6 µM 7.54E-5 44 3.28E-4
11 SGTC_2642 cholecalciferol 3.30 100.0 µM 1.20E-4 30 4.81E-4
12 SGTC_1140 3229-1848 3.29 3.0 µM 1.27E-4 21 5.04E-4
13 SGTC_990 3985-0011 3.25 41.3 µM 1.47E-4 amide catabolism 40 5.67E-4
14 SGTC_816 0325-0417 3.20 81.3 µM 1.89E-4 35 6.99E-4
15 SGTC_3346 9158254 3.18 43.6 µM 2.04E-4 53 7.44E-4
16 SGTC_143 4032-1194 3.13 15.7 µM 2.48E-4 125 8.75E-4
17 SGTC_1731 st035964 3.11 63.0 µM 2.67E-4 71 9.30E-4
18 SGTC_3105 9121040 3.06 49.5 µM 3.33E-4 12 0.00111
19 SGTC_217 ketoconazole 3.05 989.0 nM 3.45E-4 ergosterol depletion effects on membrane 66 0.00115
20 SGTC_2687 chenodiol 3.05 100.0 µM 3.46E-4 65 0.00115

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.09E-11 YKR003W OSH6 hom Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion
0.114 3.00E-11 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
0.110 1.80E-10 YDR034C LYS14 hom Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
0.109 2.55E-10 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.107 6.08E-10 YDL062W_d YDL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential
0.104 1.67E-9 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.101 4.01E-9 YFR015C GSY1 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.100 6.93E-9 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.098 1.33E-8 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.093 7.37E-8 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.092 8.51E-8 YOR148C SPP2 het Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
0.087 4.33E-7 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.086 6.24E-7 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.085 8.83E-7 YLL016W SDC25 hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.084 9.78E-7 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE