HIPHOP chemogenomics database
YDR424C / DYN2 
Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR424C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.095 | 3.81E-8 | YOR027W | STI1 | hom | Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop |
| 0.087 | 3.88E-7 | YDR179W-A_p | YDR179W-A_p | hom | Putative protein of unknown function |
| 0.080 | 3.81E-6 | YBR170C | NPL4 | hom | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) |
| 0.073 | 2.32E-5 | YKL086W | SRX1 | hom | Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress |
| 0.073 | 2.34E-5 | YNL004W | HRB1 | hom | Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication |
| 0.072 | 3.15E-5 | YCL064C | CHA1 | hom | Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine |
| 0.071 | 3.43E-5 | YDR243C | PRP28 | het | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
| 0.071 | 3.89E-5 | YOL077W-A | ATP19 | hom | Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase |
| 0.067 | 9.85E-5 | YAL042W | ERV46 | hom | Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport |
| 0.066 | 1.34E-4 | YPL092W | SSU1 | hom | Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein |
| 0.066 | 1.40E-4 | YOR100C | CRC1 | hom | Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
| 0.065 | 1.53E-4 | YPL033C | SRL4 | hom | Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p |
| 0.065 | 1.74E-4 | YNL039W | BDP1 | het | Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs |
| 0.064 | 1.95E-4 | YOR347C | PYK2 | hom | Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication |
| 0.064 | 2.20E-4 | YMR270C | RRN9 | het | Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I |