YDR424C / DYN2

Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR424C / DYN2

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:-3.35|P-value:3.02E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-5.43|P-value:1.54E-8 ID:SGTC_128|Compound:0906-2981|FD-Score:4.71|P-value:1.02E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:5.33|P-value:3.90E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.42|P-value:2.97E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.54|P-value:1.88E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.82|P-value:6.13E-5 ID:SGTC_397|Compound:arbidol|FD-Score:-3.11|P-value:7.36E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.38|P-value:3.35E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.57|P-value:1.62E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.67|P-value:1.10E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.20|P-value:5.27E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.63|P-value:1.55E-6 ID:SGTC_739|Compound:1486-1183|FD-Score:3.44|P-value:2.70E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.81|P-value:6.25E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.44|P-value:3.88E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.15|P-value:7.86E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.55|P-value:2.32E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.80|P-value:6.68E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.19|P-value:6.83E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.28|P-value:3.89E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.41|P-value:2.48E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.79|P-value:6.84E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.72|P-value:8.99E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.23|P-value:5.93E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.16|P-value:6.16E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.71|P-value:9.53E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.38|P-value:3.34E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.39|P-value:3.32E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.84|P-value:5.56E-5 ID:SGTC_1802|Compound:st050112|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.71|P-value:9.41E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.75|P-value:8.19E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.20|P-value:6.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.25|P-value:5.45E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.20|P-value:6.42E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.15|P-value:1.47E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.79|P-value:6.76E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.27|P-value:5.15E-4 ID:SGTC_2623|Compound:humulene|FD-Score:5.47|P-value:1.68E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.12|P-value:8.75E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.84|P-value:5.68E-5 ID:SGTC_2926|Compound:9010726|FD-Score:-3.07|P-value:8.37E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-4.37|P-value:4.13E-6 ID:SGTC_3020|Compound:9089140|FD-Score:-3.06|P-value:8.66E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.10|P-value:9.22E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.13|P-value:8.48E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.28|P-value:8.19E-6 ID:SGTC_3197|Compound:9113331|FD-Score:4.92|P-value:3.60E-7 ID:SGTC_3235|Compound:9132602|FD-Score:-3.85|P-value:4.15E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.99|P-value:3.00E-5 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.35|P-value:3.02E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-5.43|P-value:1.54E-8 ID:SGTC_128|Compound:0906-2981|FD-Score:4.71|P-value:1.02E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:5.33|P-value:3.90E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.42|P-value:2.97E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.54|P-value:1.88E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.82|P-value:6.13E-5 ID:SGTC_397|Compound:arbidol|FD-Score:-3.11|P-value:7.36E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.38|P-value:3.35E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.57|P-value:1.62E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.67|P-value:1.10E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.20|P-value:5.27E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.63|P-value:1.55E-6 ID:SGTC_739|Compound:1486-1183|FD-Score:3.44|P-value:2.70E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.81|P-value:6.25E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.44|P-value:3.88E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.15|P-value:7.86E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.55|P-value:2.32E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.80|P-value:6.68E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.19|P-value:6.83E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.28|P-value:3.89E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.41|P-value:2.48E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.79|P-value:6.84E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.72|P-value:8.99E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.23|P-value:5.93E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.16|P-value:6.16E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.71|P-value:9.53E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.38|P-value:3.34E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.39|P-value:3.32E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.84|P-value:5.56E-5 ID:SGTC_1802|Compound:st050112|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.71|P-value:9.41E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.75|P-value:8.19E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.20|P-value:6.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.25|P-value:5.45E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.20|P-value:6.42E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.15|P-value:1.47E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.79|P-value:6.76E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.27|P-value:5.15E-4 ID:SGTC_2623|Compound:humulene|FD-Score:5.47|P-value:1.68E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.12|P-value:8.75E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.84|P-value:5.68E-5 ID:SGTC_2926|Compound:9010726|FD-Score:-3.07|P-value:8.37E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-4.37|P-value:4.13E-6 ID:SGTC_3020|Compound:9089140|FD-Score:-3.06|P-value:8.66E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.10|P-value:9.22E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.13|P-value:8.48E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.28|P-value:8.19E-6 ID:SGTC_3197|Compound:9113331|FD-Score:4.92|P-value:3.60E-7 ID:SGTC_3235|Compound:9132602|FD-Score:-3.85|P-value:4.15E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.99|P-value:3.00E-5

Top fitness defect scores for YDR424C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2623 humulene 5.47 100.0 µM 1.68E-8 6 2.19E-8
2 SGTC_1284 0929-0043 5.41 16.0 µM 2.48E-8 10 3.21E-8
3 SGTC_135 0933-0004 5.33 26.4 µM 3.90E-8 60S ribosome export 4 5.00E-8
4 SGTC_3197 9113331 4.92 49.5 µM 3.60E-7 18 4.40E-7
5 SGTC_1212 0520-0165 4.80 585.0 µM 6.68E-7 10 8.06E-7
6 SGTC_128 0906-2981 4.71 13.4 µM 1.02E-6 5 1.22E-6
7 SGTC_458 nppb 4.63 133.0 µM 1.55E-6 7 1.83E-6
8 SGTC_1151 3909-8316 4.55 15.3 µM 2.32E-6 6 2.72E-6
9 SGTC_881 0833-0569 4.44 170.0 µM 3.88E-6 16 4.52E-6
10 SGTC_3194 9111903 4.28 49.5 µM 8.19E-6 16 9.38E-6
11 SGTC_2430 5571206 4.15 200.0 µM 1.47E-5 51 1.66E-5
12 SGTC_3329 9141233 3.99 27.6 µM 3.00E-5 15 3.35E-5
13 SGTC_1769 st044406 3.84 64.4 µM 5.56E-5 19 6.13E-5
14 SGTC_2706 st078239 3.84 82.5 µM 5.68E-5 13 6.26E-5
15 SGTC_285 1486-1325 3.82 46.0 µM 6.13E-5 21 6.75E-5
16 SGTC_877 0771-0151 3.81 33.1 µM 6.25E-5 17 6.87E-5
17 SGTC_2501 sodium tetradecyl sulfate 3.79 13.4 µM 6.76E-5 36 7.42E-5
18 SGTC_1370 2001-0092 3.79 44.6 µM 6.84E-5 44 7.51E-5
19 SGTC_2087 5276107 3.75 200.0 µM 8.19E-5 22 8.96E-5
20 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.72 66.5 µM 8.99E-5 20 9.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.81E-8 YOR027W STI1 hom Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.087 3.88E-7 YDR179W-A_p YDR179W-A_p hom Putative protein of unknown function
0.080 3.81E-6 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.073 2.32E-5 YKL086W SRX1 hom Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress
0.073 2.34E-5 YNL004W HRB1 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication
0.072 3.15E-5 YCL064C CHA1 hom Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
0.071 3.43E-5 YDR243C PRP28 het RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
0.071 3.89E-5 YOL077W-A ATP19 hom Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
0.067 9.85E-5 YAL042W ERV46 hom Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
0.066 1.34E-4 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.066 1.40E-4 YOR100C CRC1 hom Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
0.065 1.53E-4 YPL033C SRL4 hom Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.065 1.74E-4 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.064 1.95E-4 YOR347C PYK2 hom Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
0.064 2.20E-4 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I