YDR425W / SNX41

Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR425W / SNX41

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.53|P-value:6.73E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.44|P-value:9.77E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.46|P-value:8.86E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.27|P-value:1.96E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:2.87|P-value:9.43E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.37|P-value:1.31E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.17|P-value:3.48E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.87|P-value:6.96E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.54|P-value:7.34E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.31|P-value:1.71E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.10|P-value:5.55E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.74|P-value:2.64E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.13|P-value:4.10E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.31|P-value:1.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.04|P-value:5.71E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.76|P-value:2.35E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.96|P-value:7.62E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.99|P-value:6.83E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.07|P-value:5.24E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:-2.97|P-value:7.46E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.23|P-value:2.77E-4 ID:SGTC_1618|Compound:st003135|FD-Score:2.89|P-value:8.74E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.02|P-value:6.15E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:2.91|P-value:8.20E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.18|P-value:3.15E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.97|P-value:3.86E-8 ID:SGTC_2117|Compound:5521686|FD-Score:-3.40|P-value:1.33E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.57|P-value:5.46E-5 ID:SGTC_2439|Compound:5492030|FD-Score:3.42|P-value:1.09E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.32|P-value:1.87E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.09|P-value:4.72E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.63|P-value:4.99E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-4.46|P-value:8.46E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:3.53|P-value:6.73E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.44|P-value:9.77E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.46|P-value:8.86E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.27|P-value:1.96E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:2.87|P-value:9.43E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.37|P-value:1.31E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.17|P-value:3.48E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.87|P-value:6.96E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.54|P-value:7.34E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.31|P-value:1.71E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.10|P-value:5.55E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.74|P-value:2.64E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.13|P-value:4.10E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.31|P-value:1.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.04|P-value:5.71E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.76|P-value:2.35E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.96|P-value:7.62E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.99|P-value:6.83E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.07|P-value:5.24E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:-2.97|P-value:7.46E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.23|P-value:2.77E-4 ID:SGTC_1618|Compound:st003135|FD-Score:2.89|P-value:8.74E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.02|P-value:6.15E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:2.91|P-value:8.20E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.18|P-value:3.15E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.97|P-value:3.86E-8 ID:SGTC_2117|Compound:5521686|FD-Score:-3.40|P-value:1.33E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.57|P-value:5.46E-5 ID:SGTC_2439|Compound:5492030|FD-Score:3.42|P-value:1.09E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.32|P-value:1.87E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.09|P-value:4.72E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.63|P-value:4.99E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-4.46|P-value:8.46E-7

Top fitness defect scores for YDR425W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1916 st067606 4.97 49.2 µM 3.86E-8 17 3.31E-7
2 SGTC_344 k064-0035 4.87 6.4 µM 6.96E-8 60S ribosome export 13 5.51E-7
3 SGTC_1913 st060213 4.18 96.1 µM 3.15E-6 25 1.49E-5
4 SGTC_1043 0916-0009 4.07 19.3 µM 5.24E-6 19 2.31E-5
5 SGTC_1320 1313-0481 3.79 95.3 µM 2.04E-5 27 7.48E-5
6 SGTC_987 1497-1013 3.76 404.0 µM 2.35E-5 16 8.44E-5
7 SGTC_604 1000-0114 3.74 314.0 µM 2.64E-5 28 9.33E-5
8 SGTC_2354 9060492 3.57 162.0 µM 5.46E-5 29 1.75E-4
9 SGTC_59 0330-0160 3.53 1.3 µM 6.73E-5 143 2.10E-4
10 SGTC_143 4032-1194 3.46 15.7 µM 8.86E-5 93 2.66E-4
11 SGTC_70 0141-0289 3.44 43.3 µM 9.77E-5 mitochondrial stress 221 2.90E-4
12 SGTC_2439 5492030 3.42 7.2 µM 1.09E-4 24 3.18E-4
13 SGTC_259 usnic acid 3.37 108.9 µM 1.31E-4 35 3.74E-4
14 SGTC_397 arbidol 3.31 50.0 µM 1.71E-4 cell wall 41 4.72E-4
15 SGTC_245 methotrexate 3.27 289.6 µM 1.96E-4 68 5.29E-4
16 SGTC_1872 amphotericin b 2.91 148.0 nM 8.20E-4 RNA pol III & RNase P/MRP 69 0.00183
17 SGTC_1618 st003135 2.89 44.5 µM 8.74E-4 53 0.00194
18 SGTC_247 mechlorethamine 2.87 29.7 µM 9.43E-4 DNA damage response 49 0.00207
19 SGTC_2426 5582046 2.83 32.2 µM 0.00109 81 0.00234
20 SGTC_239 5hr heat shock (37°C) + mitomycin C 2.82 819.4 µM 0.00112 heat shock/prefoldin 86 0.00241

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.74E-14 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.115 2.15E-11 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.112 7.02E-11 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.096 2.86E-8 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.094 5.47E-8 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.092 9.56E-8 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.30E-7 YLR436C ECM30 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.090 1.75E-7 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.24E-7 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.089 2.70E-7 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.087 4.41E-7 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.086 5.64E-7 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.086 5.97E-7 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.085 8.78E-7 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.082 2.14E-6 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S