YDR428C / BNA7

Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR428C / BNA7

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-2.98|P-value:4.37E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.09|P-value:2.84E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.30|P-value:1.24E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.85|P-value:7.99E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.61|P-value:3.11E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.87|P-value:7.37E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.03|P-value:3.93E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-4.35|P-value:6.23E-7 ID:SGTC_662|Compound:k832-1615|FD-Score:-2.92|P-value:5.57E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:2.98|P-value:4.74E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.86|P-value:7.12E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.69|P-value:1.91E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.14|P-value:2.00E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.42|P-value:7.27E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:4.04|P-value:3.65E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:2.89|P-value:6.87E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.41|P-value:7.23E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.36|P-value:8.92E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.12|P-value:2.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.04|P-value:3.26E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.23|P-value:1.68E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.56|P-value:2.04E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.60|P-value:2.98E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.10|P-value:2.92E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.96|P-value:5.10E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.80|P-value:9.62E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.22|P-value:1.29E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.09|P-value:7.70E-9 ID:SGTC_1812|Compound:st052057|FD-Score:-3.07|P-value:3.04E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.84|P-value:9.17E-6 ID:SGTC_1830|Compound:st055982|FD-Score:3.20|P-value:1.95E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.10|P-value:2.96E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-2.81|P-value:8.65E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.02|P-value:3.67E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.86|P-value:9.11E-6 ID:SGTC_2245|Compound:6637752|FD-Score:7.16|P-value:9.24E-16 ID:SGTC_2260|Compound:7964312|FD-Score:3.15|P-value:2.42E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.87|P-value:7.34E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.94|P-value:5.06E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.54|P-value:3.98E-5 ID:SGTC_2327|Compound:6189656|FD-Score:-2.87|P-value:6.86E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.70|P-value:1.84E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.07|P-value:3.07E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.85|P-value:9.44E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-2.94|P-value:5.24E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.18|P-value:1.72E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-2.98|P-value:4.37E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.09|P-value:2.84E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.30|P-value:1.24E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.85|P-value:7.99E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.61|P-value:3.11E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.87|P-value:7.37E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.03|P-value:3.93E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-4.35|P-value:6.23E-7 ID:SGTC_662|Compound:k832-1615|FD-Score:-2.92|P-value:5.57E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:2.98|P-value:4.74E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.86|P-value:7.12E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.69|P-value:1.91E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.14|P-value:2.00E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.42|P-value:7.27E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:4.04|P-value:3.65E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:2.89|P-value:6.87E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.41|P-value:7.23E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.36|P-value:8.92E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.12|P-value:2.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.04|P-value:3.26E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.23|P-value:1.68E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.56|P-value:2.04E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.60|P-value:2.98E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.10|P-value:2.92E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.96|P-value:5.10E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.80|P-value:9.62E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.22|P-value:1.29E-6 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.09|P-value:7.70E-9 ID:SGTC_1812|Compound:st052057|FD-Score:-3.07|P-value:3.04E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.84|P-value:9.17E-6 ID:SGTC_1830|Compound:st055982|FD-Score:3.20|P-value:1.95E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.10|P-value:2.96E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-2.81|P-value:8.65E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.02|P-value:3.67E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.86|P-value:9.11E-6 ID:SGTC_2245|Compound:6637752|FD-Score:7.16|P-value:9.24E-16 ID:SGTC_2260|Compound:7964312|FD-Score:3.15|P-value:2.42E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.87|P-value:7.34E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.94|P-value:5.06E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.54|P-value:3.98E-5 ID:SGTC_2327|Compound:6189656|FD-Score:-2.87|P-value:6.86E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.70|P-value:1.84E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.07|P-value:3.07E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.85|P-value:9.44E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-2.94|P-value:5.24E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.18|P-value:1.72E-6

Top fitness defect scores for YDR428C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2245 6637752 7.16 200.0 µM 9.24E-16 5 4.14E-13
2 SGTC_1512 0259-0544 5.09 12.2 µM 7.70E-9 6 1.75E-7
3 SGTC_1282 0886-0010 4.56 32.4 µM 2.04E-7 endomembrane recycling 22 2.53E-6
4 SGTC_2876 9059903 4.18 26.0 µM 1.72E-6 7 1.44E-5
5 SGTC_762 1165-0429 4.04 115.0 µM 3.65E-6 TSC3-RPN4 14 2.66E-5
6 SGTC_2239 6685329 3.86 187.6 µM 9.11E-6 31 5.62E-5
7 SGTC_2763 lisinopril 3.85 49.3 µM 9.44E-6 14 5.79E-5
8 SGTC_387 norethindrone acetate 3.61 66.7 µM 3.11E-5 26 1.54E-4
9 SGTC_761 k216-0224 3.42 480.0 µM 7.27E-5 43 3.08E-4
10 SGTC_363 0455-0021 3.30 3.1 µM 1.24E-4 azole & statin 104 4.77E-4
11 SGTC_1222 0366-0074 3.23 1.2 µM 1.68E-4 TSC3-RPN4 42 6.13E-4
12 SGTC_1830 st055982 3.20 50.3 µM 1.95E-4 55 6.91E-4
13 SGTC_2260 7964312 3.15 200.0 µM 2.42E-4 41 8.26E-4
14 SGTC_1376 2910-0861 3.10 41.3 µM 2.92E-4 60 9.63E-4
15 SGTC_1996 st072960 3.10 66.8 µM 2.96E-4 48 9.75E-4
16 SGTC_486 niguldipine 3.03 82.0 µM 3.93E-4 amide catabolism 41 0.00123
17 SGTC_688 0527-0193 2.98 473.0 µM 4.74E-4 fatty acid desaturase (OLE1) 38 0.00144
18 SGTC_1380 2291-0730 2.96 164.0 µM 5.10E-4 62 0.00152
19 SGTC_790 1575-0012 2.89 79.1 µM 6.87E-4 TSC3-RPN4 79 0.00195
20 SGTC_2316 5844804 2.87 197.4 µM 7.34E-4 111 0.00206

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 8.37E-20 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.149 5.02E-18 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.136 2.63E-15 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.119 4.75E-12 YDR445C_d YDR445C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 7.47E-10 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.096 2.28E-8 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.096 2.63E-8 YPL277C_p YPL277C_p hom Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
0.095 4.18E-8 YGL196W DSD1 hom D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate
0.094 4.89E-8 YDL166C FAP7 het Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
0.093 7.69E-8 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.092 9.59E-8 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.088 3.55E-7 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.083 1.67E-6 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.083 1.72E-6 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.92E-6 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene