YDR429C / TIF35

eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR429C / TIF35

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-4.60|P-value:8.42E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:7.81|P-value:5.00E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:4.56|P-value:9.36E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.68|P-value:5.41E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.08|P-value:2.69E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.65|P-value:5.86E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-6.17|P-value:1.23E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-10.30|P-value:1.19E-12 ID:SGTC_177|Compound:1327-0068|FD-Score:-6.93|P-value:1.10E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:11.80|P-value:4.74E-16 ID:SGTC_257|Compound:daunorubicin|FD-Score:6.51|P-value:4.62E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.52|P-value:8.38E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.09|P-value:2.65E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:6.09|P-value:1.64E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:6.98|P-value:9.87E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:4.95|P-value:3.74E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.27|P-value:9.15E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:4.95|P-value:3.75E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.89|P-value:4.34E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.96|P-value:3.50E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.04|P-value:2.85E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.42|P-value:1.06E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:5.88|P-value:3.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:12.10|P-value:7.51E-17 ID:SGTC_831|Compound:k061-1017|FD-Score:4.60|P-value:8.72E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:7.42|P-value:2.10E-7 ID:SGTC_894|Compound:0960-0238|FD-Score:8.94|P-value:5.47E-10 ID:SGTC_966|Compound:1300-0360|FD-Score:-6.46|P-value:5.13E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:-4.72|P-value:6.26E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.97|P-value:3.40E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.72|P-value:2.18E-6 ID:SGTC_1357|Compound:1503-1303|FD-Score:-4.70|P-value:6.59E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.91|P-value:3.95E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.14|P-value:2.23E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.40|P-value:1.12E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.45|P-value:9.76E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.10|P-value:1.60E-5 ID:SGTC_2007|Compound:4011539|FD-Score:5.02|P-value:3.14E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.80|P-value:5.37E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.56|P-value:9.51E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.10|P-value:2.49E-4 ID:SGTC_2126|Compound:5251174|FD-Score:5.94|P-value:2.56E-5 ID:SGTC_2166|Compound:5933061|FD-Score:6.57|P-value:3.81E-6 ID:SGTC_2172|Compound:5754775|FD-Score:4.57|P-value:9.16E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.66|P-value:5.58E-5 ID:SGTC_2283|Compound:7944793|FD-Score:5.29|P-value:1.56E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.70|P-value:5.07E-5 ID:SGTC_2357|Compound:9067248|FD-Score:5.98|P-value:2.31E-5 ID:SGTC_2358|Compound:9037157|FD-Score:6.11|P-value:1.58E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.16|P-value:2.11E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.81|P-value:5.18E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-4.80|P-value:5.19E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:9.28|P-value:1.22E-10 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.52|P-value:4.44E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.86|P-value:4.51E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.80|P-value:5.15E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.67|P-value:7.40E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.91|P-value:2.72E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.91|P-value:2.71E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-5.80|P-value:3.70E-5 ID:SGTC_3075|Compound:9116269|FD-Score:12.50|P-value:9.83E-18 ID:SGTC_3077|Compound:9117319|FD-Score:4.72|P-value:6.45E-4 ID:SGTC_3103|Compound:9120822|FD-Score:5.40|P-value:1.16E-4 ID:SGTC_3131|Compound:9127911|FD-Score:5.57|P-value:7.34E-5 ID:SGTC_3145|Compound:9085516|FD-Score:5.10|P-value:2.57E-4 ID:SGTC_3193|Compound:9111931|FD-Score:6.07|P-value:1.76E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-5.12|P-value:2.33E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.86|P-value:4.68E-4 ID:SGTC_3286|Compound:9117135|FD-Score:5.47|P-value:9.55E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-5.02|P-value:2.98E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.60|P-value:8.42E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:7.81|P-value:5.00E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:4.56|P-value:9.36E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.68|P-value:5.41E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.08|P-value:2.69E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.65|P-value:5.86E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-6.17|P-value:1.23E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-10.30|P-value:1.19E-12 ID:SGTC_177|Compound:1327-0068|FD-Score:-6.93|P-value:1.10E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:11.80|P-value:4.74E-16 ID:SGTC_257|Compound:daunorubicin|FD-Score:6.51|P-value:4.62E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.52|P-value:8.38E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.09|P-value:2.65E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:6.09|P-value:1.64E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:6.98|P-value:9.87E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:4.95|P-value:3.74E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.27|P-value:9.15E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:4.95|P-value:3.75E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.89|P-value:4.34E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.96|P-value:3.50E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-5.04|P-value:2.85E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.42|P-value:1.06E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:5.88|P-value:3.10E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:12.10|P-value:7.51E-17 ID:SGTC_831|Compound:k061-1017|FD-Score:4.60|P-value:8.72E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:7.42|P-value:2.10E-7 ID:SGTC_894|Compound:0960-0238|FD-Score:8.94|P-value:5.47E-10 ID:SGTC_966|Compound:1300-0360|FD-Score:-6.46|P-value:5.13E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:-4.72|P-value:6.26E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.97|P-value:3.40E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-6.72|P-value:2.18E-6 ID:SGTC_1357|Compound:1503-1303|FD-Score:-4.70|P-value:6.59E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.91|P-value:3.95E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.14|P-value:2.23E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.40|P-value:1.12E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.45|P-value:9.76E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.10|P-value:1.60E-5 ID:SGTC_2007|Compound:4011539|FD-Score:5.02|P-value:3.14E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.80|P-value:5.37E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.56|P-value:9.51E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.10|P-value:2.49E-4 ID:SGTC_2126|Compound:5251174|FD-Score:5.94|P-value:2.56E-5 ID:SGTC_2166|Compound:5933061|FD-Score:6.57|P-value:3.81E-6 ID:SGTC_2172|Compound:5754775|FD-Score:4.57|P-value:9.16E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.66|P-value:5.58E-5 ID:SGTC_2283|Compound:7944793|FD-Score:5.29|P-value:1.56E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.70|P-value:5.07E-5 ID:SGTC_2357|Compound:9067248|FD-Score:5.98|P-value:2.31E-5 ID:SGTC_2358|Compound:9037157|FD-Score:6.11|P-value:1.58E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.16|P-value:2.11E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.81|P-value:5.18E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-4.80|P-value:5.19E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:9.28|P-value:1.22E-10 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.52|P-value:4.44E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.86|P-value:4.51E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.80|P-value:5.15E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.67|P-value:7.40E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.91|P-value:2.72E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.91|P-value:2.71E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-5.80|P-value:3.70E-5 ID:SGTC_3075|Compound:9116269|FD-Score:12.50|P-value:9.83E-18 ID:SGTC_3077|Compound:9117319|FD-Score:4.72|P-value:6.45E-4 ID:SGTC_3103|Compound:9120822|FD-Score:5.40|P-value:1.16E-4 ID:SGTC_3131|Compound:9127911|FD-Score:5.57|P-value:7.34E-5 ID:SGTC_3145|Compound:9085516|FD-Score:5.10|P-value:2.57E-4 ID:SGTC_3193|Compound:9111931|FD-Score:6.07|P-value:1.76E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-5.12|P-value:2.33E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.86|P-value:4.68E-4 ID:SGTC_3286|Compound:9117135|FD-Score:5.47|P-value:9.55E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-5.02|P-value:2.98E-4

Top fitness defect scores for YDR429C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3075 9116269 12.50 49.5 µM 9.83E-18 2 6.36E-36 6.49
2 SGTC_800 3448-7362 12.10 155.0 µM 7.51E-17 translation 3 4.87E-34 2.06
3 SGTC_241 5hr heat shock (37°C) + cantharidin 11.80 155.4 µM 4.74E-16 cell wall signaling 2 2.48E-32 3.00
4 SGTC_2489 cantharidin 9.28 73.4 µM 1.22E-10 cell wall signaling 2 8.14E-21 4.14
5 SGTC_894 0960-0238 8.94 55.9 µM 5.47E-10 2 1.96E-19 2.02
6 SGTC_71 0417-1750 7.81 47.8 µM 5.00E-8 Golgi 2 2.79E-15 0.71
7 SGTC_832 4083-0019 7.42 164.0 µM 2.10E-7 translation 3 5.78E-14 0.31
8 SGTC_408 cantharidin 6.98 100.0 µM 9.87E-7 cell wall signaling 2 1.51E-12 0.45
9 SGTC_2166 5933061 6.57 31.5 µM 3.81E-6 tubulin folding & SWR complex 1 2.58E-11 2.60
10 SGTC_2539 epi(13)torulosol 6.52 80.0 µM 4.44E-6 2 3.56E-11 2.48
11 SGTC_257 daunorubicin 6.51 18.5 µM 4.62E-6 anthracycline transcription coupled DNA repair 6 3.88E-11 0.31
12 SGTC_2358 9037157 6.11 4.0 µM 1.58E-5 4 5.14E-10 0.52
13 SGTC_1991 st073000 6.10 8.9 µM 1.60E-5 NEO1 6 5.28E-10 0.51
14 SGTC_330 1488-0319 6.09 80.1 µM 1.64E-5 RPP1 & pyrimidine depletion 2 5.54E-10 0.61
15 SGTC_3193 9111931 6.07 49.5 µM 1.76E-5 1 6.43E-10 0.82
16 SGTC_2357 9067248 5.98 200.0 µM 2.31E-5 1 1.13E-9 1.54
17 SGTC_2126 5251174 5.94 33.9 µM 2.56E-5 3 1.40E-9 0.93
18 SGTC_756 0508-1999 5.88 28.3 µM 3.10E-5 RPP1 & pyrimidine depletion 3 2.09E-9 0.81
19 SGTC_2322 7413319 5.70 38.2 µM 5.07E-5 ERAD & cell cycle 12 5.85E-9 0.07
20 SGTC_91 0417-1751 5.68 58.4 µM 5.41E-5 Golgi 4 6.70E-9 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 3.54E-49 YMR146C TIF34 het eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation
0.234 4.30E-43 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.217 6.36E-37 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.208 3.85E-34 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.205 2.83E-33 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.192 3.05E-29 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.184 5.53E-27 YER025W GCD11 het Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.183 8.84E-27 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.168 1.55E-22 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.159 1.80E-20 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.157 4.89E-20 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.157 6.67E-20 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.156 1.12E-19 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.153 5.18E-19 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.149 4.76E-18 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication