YDR431W_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR431W / YDR431W

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.47|P-value:3.22E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:5.67|P-value:1.04E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.26|P-value:1.25E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.10|P-value:2.42E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.25|P-value:1.52E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.45|P-value:2.90E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:2.92|P-value:5.02E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.89|P-value:6.22E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:-2.84|P-value:7.99E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.14|P-value:2.41E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.77|P-value:1.17E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:2.82|P-value:7.53E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.05|P-value:3.39E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.06|P-value:3.38E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-2.98|P-value:4.62E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.42|P-value:7.11E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.43|P-value:5.68E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.82|P-value:8.67E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.48|P-value:5.27E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.16|P-value:1.74E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:19.50|P-value:2.45E-106 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.28|P-value:1.13E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.90|P-value:5.62E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.21|P-value:1.13E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.94|P-value:4.92E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:7.63E-5 ID:SGTC_1625|Compound:st003711|FD-Score:2.92|P-value:5.10E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.02|P-value:3.45E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.00|P-value:3.77E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.16|P-value:1.88E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.10|P-value:2.52E-6 ID:SGTC_1751|Compound:st044839|FD-Score:2.83|P-value:7.19E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.13|P-value:2.14E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.29|P-value:7.36E-7 ID:SGTC_1973|Compound:st070275|FD-Score:3.72|P-value:1.48E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.32|P-value:9.58E-5 ID:SGTC_1994|Compound:st072947|FD-Score:2.82|P-value:7.50E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.76|P-value:9.45E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.46|P-value:5.98E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-4.35|P-value:6.29E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-3.21|P-value:1.74E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.24|P-value:1.34E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.48|P-value:2.44E-7 ID:SGTC_2650|Compound:prasterone|FD-Score:3.20|P-value:1.61E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.34|P-value:5.59E-7 ID:SGTC_2782|Compound:7736369|FD-Score:2.99|P-value:3.82E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-5.33|P-value:1.37E-9 ID:SGTC_3300|Compound:9124615|FD-Score:3.81|P-value:9.40E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.99|P-value:3.70E-6 ID:SGTC_3307|Compound:9126885|FD-Score:5.31|P-value:1.26E-9 ID:SGTC_3313|Compound:9133968|FD-Score:3.05|P-value:3.02E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.27|P-value:1.19E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.47|P-value:3.22E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:5.67|P-value:1.04E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.26|P-value:1.25E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.10|P-value:2.42E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.25|P-value:1.52E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.45|P-value:2.90E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:2.92|P-value:5.02E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.89|P-value:6.22E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:-2.84|P-value:7.99E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.14|P-value:2.41E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.77|P-value:1.17E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:2.82|P-value:7.53E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.05|P-value:3.39E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.06|P-value:3.38E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-2.98|P-value:4.62E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.42|P-value:7.11E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.43|P-value:5.68E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.82|P-value:8.67E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.48|P-value:5.27E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.16|P-value:1.74E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:19.50|P-value:2.45E-106 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.28|P-value:1.13E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.90|P-value:5.62E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.21|P-value:1.13E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.94|P-value:4.92E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:7.63E-5 ID:SGTC_1625|Compound:st003711|FD-Score:2.92|P-value:5.10E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.02|P-value:3.45E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.00|P-value:3.77E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.16|P-value:1.88E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.10|P-value:2.52E-6 ID:SGTC_1751|Compound:st044839|FD-Score:2.83|P-value:7.19E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.13|P-value:2.14E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.29|P-value:7.36E-7 ID:SGTC_1973|Compound:st070275|FD-Score:3.72|P-value:1.48E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.32|P-value:9.58E-5 ID:SGTC_1994|Compound:st072947|FD-Score:2.82|P-value:7.50E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.76|P-value:9.45E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.46|P-value:5.98E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-4.35|P-value:6.29E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-3.21|P-value:1.74E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.24|P-value:1.34E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.48|P-value:2.44E-7 ID:SGTC_2650|Compound:prasterone|FD-Score:3.20|P-value:1.61E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.34|P-value:5.59E-7 ID:SGTC_2782|Compound:7736369|FD-Score:2.99|P-value:3.82E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-5.33|P-value:1.37E-9 ID:SGTC_3300|Compound:9124615|FD-Score:3.81|P-value:9.40E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.99|P-value:3.70E-6 ID:SGTC_3307|Compound:9126885|FD-Score:5.31|P-value:1.26E-9 ID:SGTC_3313|Compound:9133968|FD-Score:3.05|P-value:3.02E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.27|P-value:1.19E-4

Top fitness defect scores for YDR431W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 19.50 707.4 nM 2.45E-106 redox potentiating 2 2.69E-85
2 SGTC_43 0570-0105 5.67 72.5 µM 1.04E-10 ERG2 40 7.33E-9
3 SGTC_3307 9126885 5.31 69.3 µM 1.26E-9 9 5.40E-8
4 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.48 70.0 µM 2.44E-7 redox potentiating 60 3.71E-6
5 SGTC_273 hydroxyurea 4.45 18.1 mM 2.90E-7 heme biosynthesis & mitochondrial translocase 23 4.26E-6
6 SGTC_2752 diclazuril 4.34 33.1 µM 5.59E-7 99 7.21E-6
7 SGTC_1971 st069429 4.29 63.5 µM 7.36E-7 60S ribosome export 7 9.00E-6
8 SGTC_1210 3013-0140 4.21 750.0 nM 1.13E-6 2 1.27E-5
9 SGTC_3306 9127676 3.99 59.8 µM 3.70E-6 21 3.29E-5
10 SGTC_1395 3486-0190 3.94 4.3 µM 4.92E-6 10 4.15E-5
11 SGTC_377 3970-0964 3.89 33.1 µM 6.22E-6 42 5.00E-5
12 SGTC_3300 9124615 3.81 50.5 µM 9.40E-6 20 6.98E-5
13 SGTC_706 4262-0057 3.77 46.9 µM 1.17E-5 fatty acid desaturase (OLE1) 38 8.31E-5
14 SGTC_1973 st070275 3.72 50.2 µM 1.48E-5 16 1.01E-4
15 SGTC_881 0833-0569 3.43 170.0 µM 5.68E-5 52 2.97E-4
16 SGTC_1975 st070967 3.32 30.8 µM 9.58E-5 57 4.53E-4
17 SGTC_1117 retinoic acid 3.28 1.1 µM 1.13E-4 37 5.16E-4
18 SGTC_3314 9135860 3.27 59.4 µM 1.19E-4 37 5.39E-4
19 SGTC_214 4373-3496 3.26 70.0 µM 1.25E-4 111 5.62E-4
20 SGTC_2354 9060492 3.24 162.0 µM 1.34E-4 43 5.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.561 8.29E-277 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.484 1.04E-196 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.294 8.76E-68 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.246 3.43E-47 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.239 1.01E-44 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.234 8.45E-43 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.216 8.44E-37 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.215 2.67E-36 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.214 3.80E-36 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.202 5.13E-32 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.199 2.54E-31 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.195 3.67E-30 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.191 5.97E-29 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.188 3.79E-28 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.169 8.07E-23 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication