YDR433W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR433W / YDR433W

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.43|P-value:2.09E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.93|P-value:1.37E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.45|P-value:6.92E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.36|P-value:9.30E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.23|P-value:4.50E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.15|P-value:5.98E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.61|P-value:4.09E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.22|P-value:4.73E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.91|P-value:1.48E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.83|P-value:1.97E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:7.87|P-value:1.63E-13 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.09|P-value:8.77E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.35|P-value:2.80E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.56|P-value:4.95E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.60|P-value:4.40E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.21|P-value:4.62E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:6.44|P-value:1.26E-9 ID:SGTC_401|Compound:neomycin|FD-Score:-3.34|P-value:9.99E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.89|P-value:3.03E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:4.02|P-value:9.70E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.40|P-value:8.12E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.64|P-value:3.72E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.53|P-value:5.41E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.13|P-value:6.67E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.87|P-value:1.70E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.47|P-value:6.50E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.08|P-value:7.85E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.62|P-value:4.08E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.66|P-value:3.46E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.75|P-value:2.58E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.46|P-value:6.83E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.68|P-value:7.23E-6 ID:SGTC_1651|Compound:st011928|FD-Score:4.20|P-value:5.13E-5 ID:SGTC_1666|Compound:st014829|FD-Score:5.54|P-value:1.47E-7 ID:SGTC_1675|Compound:st018485|FD-Score:-3.58|P-value:4.70E-4 ID:SGTC_1682|Compound:st012968|FD-Score:5.17|P-value:8.52E-7 ID:SGTC_1972|Compound:st070201|FD-Score:9.67|P-value:1.72E-19 ID:SGTC_2106|Compound:5357045|FD-Score:3.51|P-value:5.86E-4 ID:SGTC_2164|Compound:5685496|FD-Score:5.14|P-value:9.73E-7 ID:SGTC_2332|Compound:7982454|FD-Score:6.45|P-value:1.21E-9 ID:SGTC_2333|Compound:9017922|FD-Score:8.45|P-value:2.64E-15 ID:SGTC_2337|Compound:9009472|FD-Score:3.92|P-value:1.40E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.78|P-value:4.81E-6 ID:SGTC_2485|Compound:5633444|FD-Score:3.89|P-value:1.56E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.98|P-value:1.15E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.09|P-value:7.50E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.83|P-value:1.96E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.33|P-value:3.99E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.57|P-value:4.81E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.25|P-value:4.17E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.68|P-value:3.27E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.51|P-value:1.50E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.80|P-value:2.15E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.11|P-value:7.87E-9 ID:SGTC_2963|Compound:9082507|FD-Score:-4.93|P-value:2.60E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.70|P-value:6.98E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-3.37|P-value:9.17E-4 ID:SGTC_2991|Compound:9074669|FD-Score:6.22|P-value:4.16E-9 ID:SGTC_3098|Compound:9119039|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.40|P-value:8.32E-4 ID:SGTC_3128|Compound:9127691|FD-Score:5.03|P-value:1.63E-6 ID:SGTC_3148|Compound:9097893|FD-Score:4.64|P-value:8.58E-6 ID:SGTC_3174|Compound:9107204|FD-Score:4.00|P-value:1.06E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.86|P-value:1.74E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.68|P-value:7.34E-6 ID:SGTC_3337|Compound:9144342|FD-Score:9.54|P-value:5.35E-19 ID:SGTC_18|Compound:0111-0177|FD-Score:4.43|P-value:2.09E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.93|P-value:1.37E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.45|P-value:6.92E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.36|P-value:9.30E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.23|P-value:4.50E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.15|P-value:5.98E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.61|P-value:4.09E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.22|P-value:4.73E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.91|P-value:1.48E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.83|P-value:1.97E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:7.87|P-value:1.63E-13 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.09|P-value:8.77E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.35|P-value:2.80E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.56|P-value:4.95E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.60|P-value:4.40E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.21|P-value:4.62E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:6.44|P-value:1.26E-9 ID:SGTC_401|Compound:neomycin|FD-Score:-3.34|P-value:9.99E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.89|P-value:3.03E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:4.02|P-value:9.70E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.40|P-value:8.12E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.64|P-value:3.72E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.53|P-value:5.41E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.13|P-value:6.67E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.87|P-value:1.70E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.47|P-value:6.50E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.08|P-value:7.85E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.62|P-value:4.08E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.66|P-value:3.46E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.75|P-value:2.58E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.46|P-value:6.83E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.68|P-value:7.23E-6 ID:SGTC_1651|Compound:st011928|FD-Score:4.20|P-value:5.13E-5 ID:SGTC_1666|Compound:st014829|FD-Score:5.54|P-value:1.47E-7 ID:SGTC_1675|Compound:st018485|FD-Score:-3.58|P-value:4.70E-4 ID:SGTC_1682|Compound:st012968|FD-Score:5.17|P-value:8.52E-7 ID:SGTC_1972|Compound:st070201|FD-Score:9.67|P-value:1.72E-19 ID:SGTC_2106|Compound:5357045|FD-Score:3.51|P-value:5.86E-4 ID:SGTC_2164|Compound:5685496|FD-Score:5.14|P-value:9.73E-7 ID:SGTC_2332|Compound:7982454|FD-Score:6.45|P-value:1.21E-9 ID:SGTC_2333|Compound:9017922|FD-Score:8.45|P-value:2.64E-15 ID:SGTC_2337|Compound:9009472|FD-Score:3.92|P-value:1.40E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.78|P-value:4.81E-6 ID:SGTC_2485|Compound:5633444|FD-Score:3.89|P-value:1.56E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.98|P-value:1.15E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.09|P-value:7.50E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.83|P-value:1.96E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.33|P-value:3.99E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.57|P-value:4.81E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.25|P-value:4.17E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.68|P-value:3.27E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.51|P-value:1.50E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.80|P-value:2.15E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.11|P-value:7.87E-9 ID:SGTC_2963|Compound:9082507|FD-Score:-4.93|P-value:2.60E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.70|P-value:6.98E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-3.37|P-value:9.17E-4 ID:SGTC_2991|Compound:9074669|FD-Score:6.22|P-value:4.16E-9 ID:SGTC_3098|Compound:9119039|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.40|P-value:8.32E-4 ID:SGTC_3128|Compound:9127691|FD-Score:5.03|P-value:1.63E-6 ID:SGTC_3148|Compound:9097893|FD-Score:4.64|P-value:8.58E-6 ID:SGTC_3174|Compound:9107204|FD-Score:4.00|P-value:1.06E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.86|P-value:1.74E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.68|P-value:7.34E-6 ID:SGTC_3337|Compound:9144342|FD-Score:9.54|P-value:5.35E-19

Top fitness defect scores for YDR433W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1972 st070201 9.67 17.4 µM 1.72E-19 2 1.96E-22
2 SGTC_3337 9144342 9.54 33.5 µM 5.35E-19 4 7.35E-22
3 SGTC_2333 9017922 8.45 200.0 µM 2.64E-15 1 1.48E-17
4 SGTC_238 5hr heat shock (37°C) + nsc-638432 7.87 8.9 µM 1.63E-13 heat shock/prefoldin 10 1.81E-15
5 SGTC_2332 7982454 6.45 138.9 µM 1.21E-9 15 5.77E-11
6 SGTC_351 caspofungin 6.44 25.0 nM 1.26E-9 cell wall 36 6.05E-11
7 SGTC_2991 9074669 6.22 71.4 µM 4.16E-9 azole & statin 17 2.42E-10
8 SGTC_2959 9079155 6.11 11.0 µM 7.87E-9 7 5.08E-10
9 SGTC_240 5hr heat shock (37°C) + Streptovitacin 6.09 300.0 µM 8.77E-9 heat shock/prefoldin 17 5.76E-10
10 SGTC_1666 st014829 5.54 29.0 µM 1.47E-7 calcium & mitochondrial duress 12 1.53E-8
11 SGTC_2601 securinine 5.33 100.0 µM 3.99E-7 10 4.86E-8
12 SGTC_1682 st012968 5.17 530.0 nM 8.52E-7 3 1.18E-7
13 SGTC_2164 5685496 5.14 200.0 µM 9.73E-7 10 1.37E-7
14 SGTC_3128 9127691 5.03 49.5 µM 1.63E-6 6 2.49E-7
15 SGTC_2385 9074692 4.78 200.0 µM 4.81E-6 25 8.76E-7
16 SGTC_1649 st011737 4.68 51.3 µM 7.23E-6 20 1.41E-6
17 SGTC_3334 9142812 4.68 21.9 µM 7.34E-6 16 1.43E-6
18 SGTC_3148 9097893 4.64 49.5 µM 8.58E-6 26 1.72E-6
19 SGTC_2833 9001315 4.51 45.5 µM 1.50E-5 amide catabolism 37 3.28E-6
20 SGTC_18 0111-0177 4.43 500.0 nM 2.09E-5 48 4.80E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 2.01E-31 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.161 6.71E-21 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.155 2.35E-19 YDR432W NPL3 hom RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress
0.140 4.77E-16 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.137 1.76E-15 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.133 9.50E-15 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.130 3.60E-14 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.129 7.26E-14 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.129 7.50E-14 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.127 1.76E-13 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.108 3.13E-10 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.105 9.40E-10 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.098 1.11E-8 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.098 1.22E-8 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.095 3.41E-8 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it