YDR434W / GPI17

Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR434W / GPI17

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.51|P-value:1.39E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.67|P-value:6.86E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:2.95|P-value:2.18E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.06|P-value:1.28E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.22|P-value:5.91E-5 ID:SGTC_406|Compound:estrone|FD-Score:3.32|P-value:3.70E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.67|P-value:6.84E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.12|P-value:9.36E-5 ID:SGTC_493|Compound:zm226600|FD-Score:4.04|P-value:6.95E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:2.73|P-value:5.68E-4 ID:SGTC_512|Compound:prima-1|FD-Score:-2.69|P-value:6.37E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.39|P-value:5.76E-11 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.10|P-value:1.02E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.18|P-value:7.15E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.46|P-value:4.66E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.61|P-value:8.66E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:2.69|P-value:6.68E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.32|P-value:1.20E-7 ID:SGTC_781|Compound:4335-2806|FD-Score:3.80|P-value:2.80E-6 ID:SGTC_898|Compound:1000-0849|FD-Score:2.71|P-value:6.12E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.68|P-value:6.94E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.46|P-value:4.54E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:3.13|P-value:9.23E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.34|P-value:9.67E-8 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.43|P-value:2.00E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:2.86|P-value:3.22E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:2.70|P-value:6.39E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:2.69|P-value:6.66E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.02|P-value:1.49E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.71|P-value:9.32E-9 ID:SGTC_1283|Compound:0922-0125|FD-Score:-2.67|P-value:6.74E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.07|P-value:1.18E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-2.82|P-value:3.60E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.17|P-value:7.20E-5 ID:SGTC_1516|Compound:st013856|FD-Score:2.65|P-value:7.91E-4 ID:SGTC_1531|Compound:st059297|FD-Score:2.84|P-value:3.55E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-2.63|P-value:8.02E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.88|P-value:2.72E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.74|P-value:5.11E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.51|P-value:3.31E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-5.63|P-value:7.69E-12 ID:SGTC_2079|Compound:5212404|FD-Score:3.28|P-value:4.38E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-2.98|P-value:1.78E-4 ID:SGTC_2258|Compound:7960471|FD-Score:2.84|P-value:3.47E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.20|P-value:6.74E-5 ID:SGTC_2456|Compound:5770359|FD-Score:2.99|P-value:1.75E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.53|P-value:1.18E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.77|P-value:4.42E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:2.84|P-value:3.53E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.66|P-value:7.45E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.72|P-value:5.87E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.31|P-value:3.72E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.96|P-value:1.03E-6 ID:SGTC_2937|Compound:9044753|FD-Score:3.26|P-value:5.04E-5 ID:SGTC_2967|Compound:9089538|FD-Score:2.91|P-value:2.60E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.53|P-value:1.24E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-2.73|P-value:5.35E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.06|P-value:1.21E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-2.64|P-value:7.61E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.19|P-value:6.57E-5 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.84|P-value:2.22E-6 ID:SGTC_3150|Compound:9097574|FD-Score:-2.76|P-value:4.67E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.88|P-value:1.78E-6 ID:SGTC_3193|Compound:9111931|FD-Score:2.63|P-value:8.48E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-2.65|P-value:7.51E-4 ID:SGTC_3237|Compound:9133362|FD-Score:2.80|P-value:4.18E-4 ID:SGTC_3271|Compound:9137798|FD-Score:2.70|P-value:6.29E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.04|P-value:1.38E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.51|P-value:1.39E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.67|P-value:6.86E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:2.95|P-value:2.18E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.06|P-value:1.28E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.22|P-value:5.91E-5 ID:SGTC_406|Compound:estrone|FD-Score:3.32|P-value:3.70E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.67|P-value:6.84E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.12|P-value:9.36E-5 ID:SGTC_493|Compound:zm226600|FD-Score:4.04|P-value:6.95E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:2.73|P-value:5.68E-4 ID:SGTC_512|Compound:prima-1|FD-Score:-2.69|P-value:6.37E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.39|P-value:5.76E-11 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.10|P-value:1.02E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.18|P-value:7.15E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.46|P-value:4.66E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.61|P-value:8.66E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:2.69|P-value:6.68E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.32|P-value:1.20E-7 ID:SGTC_781|Compound:4335-2806|FD-Score:3.80|P-value:2.80E-6 ID:SGTC_898|Compound:1000-0849|FD-Score:2.71|P-value:6.12E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.68|P-value:6.94E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.46|P-value:4.54E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:3.13|P-value:9.23E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.34|P-value:9.67E-8 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.43|P-value:2.00E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:2.86|P-value:3.22E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:2.70|P-value:6.39E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:2.69|P-value:6.66E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.02|P-value:1.49E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.71|P-value:9.32E-9 ID:SGTC_1283|Compound:0922-0125|FD-Score:-2.67|P-value:6.74E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.07|P-value:1.18E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-2.82|P-value:3.60E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.17|P-value:7.20E-5 ID:SGTC_1516|Compound:st013856|FD-Score:2.65|P-value:7.91E-4 ID:SGTC_1531|Compound:st059297|FD-Score:2.84|P-value:3.55E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-2.63|P-value:8.02E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.88|P-value:2.72E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.74|P-value:5.11E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.51|P-value:3.31E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-5.63|P-value:7.69E-12 ID:SGTC_2079|Compound:5212404|FD-Score:3.28|P-value:4.38E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-2.98|P-value:1.78E-4 ID:SGTC_2258|Compound:7960471|FD-Score:2.84|P-value:3.47E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.20|P-value:6.74E-5 ID:SGTC_2456|Compound:5770359|FD-Score:2.99|P-value:1.75E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.53|P-value:1.18E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.77|P-value:4.42E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:2.84|P-value:3.53E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.66|P-value:7.45E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.72|P-value:5.87E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.31|P-value:3.72E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.96|P-value:1.03E-6 ID:SGTC_2937|Compound:9044753|FD-Score:3.26|P-value:5.04E-5 ID:SGTC_2967|Compound:9089538|FD-Score:2.91|P-value:2.60E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.53|P-value:1.24E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-2.73|P-value:5.35E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.06|P-value:1.21E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-2.64|P-value:7.61E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.19|P-value:6.57E-5 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.84|P-value:2.22E-6 ID:SGTC_3150|Compound:9097574|FD-Score:-2.76|P-value:4.67E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.88|P-value:1.78E-6 ID:SGTC_3193|Compound:9111931|FD-Score:2.63|P-value:8.48E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-2.65|P-value:7.51E-4 ID:SGTC_3237|Compound:9133362|FD-Score:2.80|P-value:4.18E-4 ID:SGTC_3271|Compound:9137798|FD-Score:2.70|P-value:6.29E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.04|P-value:1.38E-4

Top fitness defect scores for YDR434W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_513 4245-1575 5.39 41.7 µM 5.76E-11 unfolded protein response 14 3.47E-8 0.06
2 SGTC_1282 0886-0010 4.71 32.4 µM 9.32E-9 endomembrane recycling 11 1.26E-6 0.60
3 SGTC_779 1360-0071 4.32 233.0 µM 1.20E-7 fatty acid desaturase (OLE1) 3 7.69E-6 0.30
4 SGTC_493 zm226600 4.04 134.0 µM 6.95E-7 mitochondrial processes 3 2.68E-5 0.13
5 SGTC_3154 9100113 3.88 49.5 µM 1.78E-6 12 5.22E-5 0.02
6 SGTC_3064 1327-0027 3.84 10.0 µM 2.22E-6 6 6.11E-5 0.44
7 SGTC_781 4335-2806 3.80 94.4 µM 2.80E-6 4 7.21E-5 0.01
8 SGTC_3014 9081533 3.53 49.5 µM 1.24E-5 6 2.08E-4 0.04
9 SGTC_52 0329-0193 3.51 875.0 nM 1.39E-5 TSC3-RPN4 10 2.25E-4 0.02
10 SGTC_406 estrone 3.32 100.0 µM 3.70E-5 4 4.53E-4 0.07
11 SGTC_2079 5212404 3.28 121.0 µM 4.38E-5 7 5.12E-4 0.16
12 SGTC_2937 9044753 3.26 11.3 µM 5.04E-5 60S ribosome export 17 5.65E-4 0.24
13 SGTC_367 0335-0881 3.22 7.1 µM 5.91E-5 ubiquinone biosynthesis & proteasome 34 6.34E-4 0.04
14 SGTC_2321 7390090 3.20 138.8 µM 6.74E-5 11 6.96E-4 0.11
15 SGTC_699 0375-0592 3.18 111.0 µM 7.15E-5 iron homeostasis 7 7.26E-4 0.01
16 SGTC_997 3996-0078 3.13 137.0 µM 9.23E-5 17 8.72E-4 0.03
17 SGTC_360 0957-0399 3.06 1.0 µM 1.28E-4 cell wall 25 0.00110 0.03
18 SGTC_3342 9147791 3.04 14.5 µM 1.38E-4 7 0.00116 0.03
19 SGTC_2456 5770359 2.99 74.5 µM 1.75E-4 14 0.00138 0.13
20 SGTC_317 4495-0002 2.95 170.0 µM 2.18E-4 11 0.00161 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.54E-20 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.133 9.50E-15 YDR013W PSF1 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.133 1.13E-14 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.127 1.28E-13 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.121 1.72E-12 YDR037W KRS1 het Lysyl-tRNA synthetase
0.118 6.48E-12 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.102 3.73E-9 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.101 4.21E-9 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.100 7.49E-9 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.096 2.25E-8 YDL151C_d BUD30_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.096 2.66E-8 YDR365C ESF1 het Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
0.095 3.82E-8 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.094 4.35E-8 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.092 9.06E-8 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.090 1.89E-7 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication