YDR435C / PPM1

Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR435C / PPM1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.66|P-value:7.57E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:9.27|P-value:3.25E-16 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.42|P-value:4.97E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.55|P-value:8.55E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.72|P-value:1.20E-17 ID:SGTC_62|Compound:0180-0423|FD-Score:-5.56|P-value:5.15E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:4.76|P-value:1.79E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.23|P-value:1.23E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.01|P-value:6.77E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:5.20|P-value:3.15E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:4.53|P-value:4.14E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:8.33|P-value:2.05E-13 ID:SGTC_366|Compound:0181-0206|FD-Score:5.05|P-value:5.65E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.52|P-value:4.29E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.57|P-value:9.92E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.82|P-value:1.47E-9 ID:SGTC_435|Compound:c-PAF|FD-Score:9.73|P-value:1.14E-17 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.40|P-value:1.31E-13 ID:SGTC_455|Compound:paf C-16|FD-Score:6.48|P-value:8.55E-9 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.57|P-value:3.62E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.86|P-value:1.19E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.02|P-value:2.47E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.92|P-value:9.71E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:6.15|P-value:4.37E-8 ID:SGTC_659|Compound:k018-0002|FD-Score:6.58|P-value:5.15E-9 ID:SGTC_660|Compound:4031-1742|FD-Score:6.82|P-value:1.45E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.83|P-value:3.63E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.92|P-value:9.69E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:5.36|P-value:1.56E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.53|P-value:9.21E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:5.08|P-value:5.11E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:5.00|P-value:7.04E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:5.21|P-value:2.95E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.64|P-value:2.84E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.15|P-value:1.56E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.15|P-value:1.61E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.74|P-value:4.87E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.75|P-value:7.65E-12 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.13|P-value:1.71E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.21|P-value:1.04E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.85|P-value:1.29E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.27|P-value:2.30E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.82|P-value:4.71E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.96|P-value:2.98E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.59|P-value:3.39E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.76|P-value:5.63E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:6.23|P-value:2.95E-8 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.80|P-value:4.08E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.43|P-value:6.05E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.67|P-value:3.20E-9 ID:SGTC_1717|Compound:st033143|FD-Score:4.59|P-value:3.34E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.58|P-value:7.89E-4 ID:SGTC_1731|Compound:st035964|FD-Score:7.48|P-value:3.68E-11 ID:SGTC_1736|Compound:st036774|FD-Score:4.16|P-value:1.56E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.62|P-value:8.61E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.58|P-value:3.44E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-9.17|P-value:4.25E-16 ID:SGTC_1884|Compound:5633444|FD-Score:4.28|P-value:1.02E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:4.43E-6 ID:SGTC_1962|Compound:st076595|FD-Score:4.09|P-value:1.97E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.53|P-value:7.60E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.84|P-value:4.30E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.59|P-value:3.34E-5 ID:SGTC_2314|Compound:7727897|FD-Score:5.86|P-value:1.78E-7 ID:SGTC_2318|Compound:6029776|FD-Score:-3.72|P-value:5.19E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.54|P-value:3.15E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.09|P-value:4.91E-6 ID:SGTC_2412|Compound:st077135|FD-Score:4.09|P-value:1.97E-4 ID:SGTC_2416|Compound:tofa|FD-Score:5.36|P-value:1.58E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-3.77|P-value:4.45E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.70|P-value:6.69E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.60|P-value:3.22E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.57|P-value:8.14E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.85|P-value:3.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:18.20|P-value:3.55E-57 ID:SGTC_2584|Compound:androsterone|FD-Score:11.60|P-value:2.55E-24 ID:SGTC_2619|Compound:obliquin|FD-Score:7.11|P-value:3.12E-10 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.57|P-value:5.50E-9 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.86|P-value:4.08E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.85|P-value:2.71E-12 ID:SGTC_2784|Compound:7567673|FD-Score:7.98|P-value:1.82E-12 ID:SGTC_2824|Compound:7998404|FD-Score:11.40|P-value:1.90E-23 ID:SGTC_2857|Compound:9024691|FD-Score:-4.09|P-value:1.56E-4 ID:SGTC_2867|Compound:9039098|FD-Score:8.24|P-value:3.56E-13 ID:SGTC_2883|Compound:9059145|FD-Score:-3.85|P-value:3.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.81|P-value:1.57E-9 ID:SGTC_2912|Compound:7964298|FD-Score:6.48|P-value:8.85E-9 ID:SGTC_2921|Compound:7974240|FD-Score:-3.71|P-value:5.30E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.10|P-value:1.52E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-4.25|P-value:9.19E-5 ID:SGTC_3019|Compound:9081971|FD-Score:7.44|P-value:4.62E-11 ID:SGTC_3059|Compound:1327-0034|FD-Score:-5.40|P-value:1.01E-6 ID:SGTC_3141|Compound:9094609|FD-Score:4.67|P-value:2.53E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.52|P-value:8.16E-7 ID:SGTC_3189|Compound:9110682|FD-Score:4.14|P-value:1.65E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.36|P-value:1.59E-6 ID:SGTC_3311|Compound:9131146|FD-Score:6.19|P-value:3.58E-8 ID:SGTC_3339|Compound:9145883|FD-Score:-3.64|P-value:6.53E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.11|P-value:4.48E-6 ID:SGTC_1|Compound:0258-0098|FD-Score:3.66|P-value:7.57E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:9.27|P-value:3.25E-16 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.42|P-value:4.97E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.55|P-value:8.55E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.72|P-value:1.20E-17 ID:SGTC_62|Compound:0180-0423|FD-Score:-5.56|P-value:5.15E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:4.76|P-value:1.79E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.23|P-value:1.23E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.01|P-value:6.77E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:5.20|P-value:3.15E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:4.53|P-value:4.14E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:8.33|P-value:2.05E-13 ID:SGTC_366|Compound:0181-0206|FD-Score:5.05|P-value:5.65E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.52|P-value:4.29E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.57|P-value:9.92E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.82|P-value:1.47E-9 ID:SGTC_435|Compound:c-PAF|FD-Score:9.73|P-value:1.14E-17 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.40|P-value:1.31E-13 ID:SGTC_455|Compound:paf C-16|FD-Score:6.48|P-value:8.55E-9 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.57|P-value:3.62E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.86|P-value:1.19E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.02|P-value:2.47E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.92|P-value:9.71E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:6.15|P-value:4.37E-8 ID:SGTC_659|Compound:k018-0002|FD-Score:6.58|P-value:5.15E-9 ID:SGTC_660|Compound:4031-1742|FD-Score:6.82|P-value:1.45E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.83|P-value:3.63E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.92|P-value:9.69E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:5.36|P-value:1.56E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.53|P-value:9.21E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:5.08|P-value:5.11E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:5.00|P-value:7.04E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:5.21|P-value:2.95E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.64|P-value:2.84E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.15|P-value:1.56E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.15|P-value:1.61E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.74|P-value:4.87E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.75|P-value:7.65E-12 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.13|P-value:1.71E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.21|P-value:1.04E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.85|P-value:1.29E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.27|P-value:2.30E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.82|P-value:4.71E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.96|P-value:2.98E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.59|P-value:3.39E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.76|P-value:5.63E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:6.23|P-value:2.95E-8 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.80|P-value:4.08E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.43|P-value:6.05E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.67|P-value:3.20E-9 ID:SGTC_1717|Compound:st033143|FD-Score:4.59|P-value:3.34E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.58|P-value:7.89E-4 ID:SGTC_1731|Compound:st035964|FD-Score:7.48|P-value:3.68E-11 ID:SGTC_1736|Compound:st036774|FD-Score:4.16|P-value:1.56E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.62|P-value:8.61E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.58|P-value:3.44E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-9.17|P-value:4.25E-16 ID:SGTC_1884|Compound:5633444|FD-Score:4.28|P-value:1.02E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:4.43E-6 ID:SGTC_1962|Compound:st076595|FD-Score:4.09|P-value:1.97E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.53|P-value:7.60E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.84|P-value:4.30E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.59|P-value:3.34E-5 ID:SGTC_2314|Compound:7727897|FD-Score:5.86|P-value:1.78E-7 ID:SGTC_2318|Compound:6029776|FD-Score:-3.72|P-value:5.19E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.54|P-value:3.15E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.09|P-value:4.91E-6 ID:SGTC_2412|Compound:st077135|FD-Score:4.09|P-value:1.97E-4 ID:SGTC_2416|Compound:tofa|FD-Score:5.36|P-value:1.58E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-3.77|P-value:4.45E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.70|P-value:6.69E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.60|P-value:3.22E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.57|P-value:8.14E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.85|P-value:3.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:18.20|P-value:3.55E-57 ID:SGTC_2584|Compound:androsterone|FD-Score:11.60|P-value:2.55E-24 ID:SGTC_2619|Compound:obliquin|FD-Score:7.11|P-value:3.12E-10 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.57|P-value:5.50E-9 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.86|P-value:4.08E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.85|P-value:2.71E-12 ID:SGTC_2784|Compound:7567673|FD-Score:7.98|P-value:1.82E-12 ID:SGTC_2824|Compound:7998404|FD-Score:11.40|P-value:1.90E-23 ID:SGTC_2857|Compound:9024691|FD-Score:-4.09|P-value:1.56E-4 ID:SGTC_2867|Compound:9039098|FD-Score:8.24|P-value:3.56E-13 ID:SGTC_2883|Compound:9059145|FD-Score:-3.85|P-value:3.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.81|P-value:1.57E-9 ID:SGTC_2912|Compound:7964298|FD-Score:6.48|P-value:8.85E-9 ID:SGTC_2921|Compound:7974240|FD-Score:-3.71|P-value:5.30E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.10|P-value:1.52E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-4.25|P-value:9.19E-5 ID:SGTC_3019|Compound:9081971|FD-Score:7.44|P-value:4.62E-11 ID:SGTC_3059|Compound:1327-0034|FD-Score:-5.40|P-value:1.01E-6 ID:SGTC_3141|Compound:9094609|FD-Score:4.67|P-value:2.53E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.52|P-value:8.16E-7 ID:SGTC_3189|Compound:9110682|FD-Score:4.14|P-value:1.65E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.36|P-value:1.59E-6 ID:SGTC_3311|Compound:9131146|FD-Score:6.19|P-value:3.58E-8 ID:SGTC_3339|Compound:9145883|FD-Score:-3.64|P-value:6.53E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.11|P-value:4.48E-6

Top fitness defect scores for YDR435C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 18.20 100.0 µM 3.55E-57 redox potentiating 4 2.19E-74
2 SGTC_2584 androsterone 11.60 48.7 µM 2.55E-24 cell wall 13 2.24E-31
3 SGTC_2824 7998404 11.40 52.0 µM 1.90E-23 1 3.10E-30
4 SGTC_435 c-PAF 9.73 6.7 µM 1.14E-17 3 1.12E-22
5 SGTC_58 0957-0393 9.72 9.0 µM 1.20E-17 cell wall 86 1.21E-22
6 SGTC_29 0299-0004 9.27 13.0 µM 3.25E-16 3 9.06E-21
7 SGTC_453 enantio-paf c16 8.40 10.0 µM 1.31E-13 10 2.32E-17
8 SGTC_360 0957-0399 8.33 1.0 µM 2.05E-13 cell wall 7 4.15E-17
9 SGTC_2867 9039098 8.24 71.4 µM 3.56E-13 iron homeostasis 2 8.53E-17
10 SGTC_2784 7567673 7.98 72.7 µM 1.82E-12 iron homeostasis 2 7.21E-16
11 SGTC_1026 k007-1105 7.75 30.6 µM 7.65E-12 ERAD & cell cycle 20 4.71E-15
12 SGTC_1731 st035964 7.48 63.0 µM 3.68E-11 4 3.67E-14
13 SGTC_3019 9081971 7.44 49.5 µM 4.62E-11 1 4.94E-14
14 SGTC_2619 obliquin 7.11 87.9 µM 3.12E-10 cell wall 57 6.01E-13
15 SGTC_660 4031-1742 6.82 102.0 µM 1.45E-9 redox potentiating 7 4.48E-12
16 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 6.82 8.0 µM 1.47E-9 4 4.54E-12
17 SGTC_2896 9052656 6.81 71.4 µM 1.57E-9 endomembrane recycling 29 4.93E-12
18 SGTC_1679 4130-1276 6.67 6.7 µM 3.20E-9 Golgi 20 1.26E-11
19 SGTC_659 k018-0002 6.58 107.0 µM 5.15E-9 2 2.34E-11
20 SGTC_2666 tannic acid 6.57 100.0 µM 5.50E-9 iron homeostasis 8 2.55E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.281 6.79E-62 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.261 2.46E-53 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.259 2.37E-52 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.248 3.70E-48 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.240 2.84E-45 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.239 1.05E-44 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.237 3.73E-44 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.236 1.06E-43 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.235 3.96E-43 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.232 3.33E-42 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.232 3.78E-42 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.230 2.37E-41 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.229 5.53E-41 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.226 6.47E-40 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.225 7.93E-40 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data