YDR436W / PPZ2

Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR436W / PPZ2

Click on Significant Values for Screen Details ID:SGTC_229|Compound:benomyl|FD-Score:4.39|P-value:2.82E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:-4.22|P-value:5.94E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:3.31|P-value:3.15E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.65|P-value:7.55E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.69|P-value:6.63E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.12|P-value:6.08E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-5.05|P-value:8.17E-8 ID:SGTC_428|Compound:3448-4153|FD-Score:-5.60|P-value:3.11E-9 ID:SGTC_431|Compound:k089-0097|FD-Score:8.62|P-value:2.30E-19 ID:SGTC_435|Compound:c-PAF|FD-Score:4.53|P-value:1.40E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.92|P-value:2.52E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.46|P-value:1.76E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.38|P-value:2.29E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.03|P-value:8.27E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.55|P-value:1.24E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.23|P-value:4.20E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.32|P-value:2.87E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.29|P-value:3.26E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.24|P-value:3.88E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.84|P-value:3.35E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.14|P-value:5.78E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.19|P-value:4.67E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.48|P-value:1.60E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.26|P-value:3.66E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.91|P-value:1.74E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.96|P-value:2.03E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.23|P-value:3.96E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.00|P-value:9.11E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.87|P-value:3.08E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.31|P-value:3.13E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.13|P-value:6.04E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-2.98|P-value:9.96E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.80|P-value:4.22E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.84|P-value:3.38E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.26|P-value:3.57E-4 ID:SGTC_3174|Compound:9107204|FD-Score:5.80|P-value:9.77E-10 ID:SGTC_3214|Compound:9129694|FD-Score:3.09|P-value:6.97E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.36|P-value:3.18E-6 ID:SGTC_3219|Compound:9131112|FD-Score:4.37|P-value:3.14E-6 ID:SGTC_229|Compound:benomyl|FD-Score:4.39|P-value:2.82E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:-4.22|P-value:5.94E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:3.31|P-value:3.15E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.65|P-value:7.55E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.69|P-value:6.63E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.12|P-value:6.08E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-5.05|P-value:8.17E-8 ID:SGTC_428|Compound:3448-4153|FD-Score:-5.60|P-value:3.11E-9 ID:SGTC_431|Compound:k089-0097|FD-Score:8.62|P-value:2.30E-19 ID:SGTC_435|Compound:c-PAF|FD-Score:4.53|P-value:1.40E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.92|P-value:2.52E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.46|P-value:1.76E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.38|P-value:2.29E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.03|P-value:8.27E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.55|P-value:1.24E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.23|P-value:4.20E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.32|P-value:2.87E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.29|P-value:3.26E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.24|P-value:3.88E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.84|P-value:3.35E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.14|P-value:5.78E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.03|P-value:8.53E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.19|P-value:4.67E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.48|P-value:1.60E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.26|P-value:3.66E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.91|P-value:1.74E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.96|P-value:2.03E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.23|P-value:3.96E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.00|P-value:9.11E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.87|P-value:3.08E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.31|P-value:3.13E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.13|P-value:6.04E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-2.98|P-value:9.96E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.80|P-value:4.22E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.84|P-value:3.38E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.26|P-value:3.57E-4 ID:SGTC_3174|Compound:9107204|FD-Score:5.80|P-value:9.77E-10 ID:SGTC_3214|Compound:9129694|FD-Score:3.09|P-value:6.97E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.36|P-value:3.18E-6 ID:SGTC_3219|Compound:9131112|FD-Score:4.37|P-value:3.14E-6

Top fitness defect scores for YDR436W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_431 k089-0097 8.62 107.0 µM 2.30E-19 iron homeostasis 1 3.42E-18
2 SGTC_3174 9107204 5.80 49.5 µM 9.77E-10 ERG2 7 3.34E-9
3 SGTC_1636 st007707 4.55 68.9 µM 1.24E-6 37 2.65E-6
4 SGTC_435 c-PAF 4.53 6.7 µM 1.40E-6 24 2.98E-6
5 SGTC_229 benomyl 4.39 22.9 µM 2.82E-6 tubulin folding & SWR complex 23 5.73E-6
6 SGTC_3219 9131112 4.37 49.5 µM 3.14E-6 Golgi 31 6.35E-6
7 SGTC_3217 9129673 4.36 49.5 µM 3.18E-6 25 6.41E-6
8 SGTC_453 enantio-paf c16 3.92 10.0 µM 2.52E-5 144 4.46E-5
9 SGTC_2754 granisetron 3.87 64.0 µM 3.08E-5 33 5.38E-5
10 SGTC_3065 9113888 3.80 49.5 µM 4.22E-5 27 7.23E-5
11 SGTC_1292 0kpi-0043 3.77 232.0 µM 4.79E-5 19 8.13E-5
12 SGTC_377 3970-0964 3.69 33.1 µM 6.63E-5 46 1.10E-4
13 SGTC_2572 astragaloside iv 3.48 100.0 µM 1.60E-4 45 2.51E-4
14 SGTC_544 k015-0020 3.46 52.4 µM 1.76E-4 22 2.75E-4
15 SGTC_2354 9060492 3.37 162.0 µM 2.43E-4 37 3.73E-4
16 SGTC_2829 7992743 3.31 58.4 µM 3.13E-4 65 4.72E-4
17 SGTC_245 methotrexate 3.31 289.6 µM 3.15E-4 67 4.75E-4
18 SGTC_1895 st058434 3.23 18.3 µM 4.20E-4 35 6.22E-4
19 SGTC_2340 7987427 3.14 183.4 µM 5.78E-4 70 8.38E-4
20 SGTC_2598 perillyl alcohol 3.13 100.0 µM 5.94E-4 72 8.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.67E-19 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.147 8.60E-18 YBR066C NRG2 hom Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication
0.136 2.90E-15 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.124 5.70E-13 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.120 2.63E-12 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.117 1.16E-11 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.116 1.53E-11 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.112 7.48E-11 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.112 9.32E-11 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.109 2.31E-10 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.108 4.03E-10 YDL114W_p YDL114W_p hom Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene
0.103 1.84E-9 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.102 3.07E-9 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.101 4.41E-9 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.100 7.61E-9 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm