YDR437W / GPI19

Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR437W / GPI19

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:-3.23|P-value:4.14E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.12|P-value:1.12E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.06|P-value:8.27E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.29|P-value:3.25E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.47|P-value:1.81E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.20|P-value:6.68E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.16|P-value:5.76E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.75|P-value:5.16E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.16|P-value:5.66E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.21|P-value:6.55E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.95|P-value:2.39E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:3.76|P-value:5.41E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.05|P-value:8.60E-8 ID:SGTC_724|Compound:3910-0327|FD-Score:-5.13|P-value:5.35E-8 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.26|P-value:3.63E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-4.58|P-value:1.08E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:-4.15|P-value:8.42E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:-4.86|P-value:2.40E-7 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.13|P-value:5.79E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.01|P-value:9.96E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.08|P-value:7.63E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.79|P-value:4.12E-7 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.01|P-value:9.79E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.86|P-value:2.71E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.65|P-value:8.18E-7 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.80|P-value:4.50E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.43|P-value:1.86E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.94|P-value:2.50E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.96|P-value:2.27E-5 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.36|P-value:2.71E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.04|P-value:8.91E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.37|P-value:2.39E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.76|P-value:4.89E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.78|P-value:4.97E-5 ID:SGTC_2305|Compound:7443522|FD-Score:3.36|P-value:2.71E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.23|P-value:3.48E-8 ID:SGTC_2309|Compound:7664088|FD-Score:4.40|P-value:2.92E-6 ID:SGTC_2396|Compound:5342950|FD-Score:3.34|P-value:2.94E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.02|P-value:1.55E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.34|P-value:3.88E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.04|P-value:8.93E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.08|P-value:7.61E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.26|P-value:3.63E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.34|P-value:2.90E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.23|P-value:4.14E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.12|P-value:1.12E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.06|P-value:8.27E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.29|P-value:3.25E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.47|P-value:1.81E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.20|P-value:6.68E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.16|P-value:5.76E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.75|P-value:5.16E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.16|P-value:5.66E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.21|P-value:6.55E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.95|P-value:2.39E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:3.76|P-value:5.41E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.05|P-value:8.60E-8 ID:SGTC_724|Compound:3910-0327|FD-Score:-5.13|P-value:5.35E-8 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.26|P-value:3.63E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-4.58|P-value:1.08E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:-4.15|P-value:8.42E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:-4.86|P-value:2.40E-7 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.13|P-value:5.79E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.01|P-value:9.96E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.08|P-value:7.63E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.79|P-value:4.12E-7 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.01|P-value:9.79E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.86|P-value:2.71E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.65|P-value:8.18E-7 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.80|P-value:4.50E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.43|P-value:1.86E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.94|P-value:2.50E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.96|P-value:2.27E-5 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.36|P-value:2.71E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.37|P-value:2.58E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.04|P-value:8.91E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.37|P-value:2.39E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.76|P-value:4.89E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.78|P-value:4.97E-5 ID:SGTC_2305|Compound:7443522|FD-Score:3.36|P-value:2.71E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.23|P-value:3.48E-8 ID:SGTC_2309|Compound:7664088|FD-Score:4.40|P-value:2.92E-6 ID:SGTC_2396|Compound:5342950|FD-Score:3.34|P-value:2.94E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.02|P-value:1.55E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.34|P-value:3.88E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.04|P-value:8.93E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.08|P-value:7.61E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.26|P-value:3.63E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.34|P-value:2.90E-4

Top fitness defect scores for YDR437W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2307 7538926 5.23 6.3 µM 3.48E-8 12 8.30E-8 0.08
2 SGTC_1082 camptothecin 4.86 424.9 nM 2.71E-7 DNA damage response 10 5.74E-7 0.07
3 SGTC_1024 4507-0395 4.79 26.0 µM 4.12E-7 TSC3-RPN4 4 8.53E-7 0.15
4 SGTC_1153 4055-0057 4.65 267.0 µM 8.18E-7 3 1.63E-6 0.32
5 SGTC_2309 7664088 4.40 163.9 µM 2.92E-6 6 5.40E-6 0.01
6 SGTC_2519 cryptotanshinone 4.34 88.0 µM 3.88E-6 heme biosynthesis & mitochondrial translocase 16 7.05E-6 0.06
7 SGTC_184 1494-0393 4.12 24.7 µM 1.12E-5 26 1.92E-5 0.05
8 SGTC_1250 0485-0349 3.96 40.2 µM 2.27E-5 10 3.73E-5 0.13
9 SGTC_581 0958-0271 3.95 211.0 µM 2.39E-5 5 3.91E-5 0.03
10 SGTC_1232 0279-0259 3.94 161.0 µM 2.50E-5 5 4.09E-5 0.29
11 SGTC_715 0868-0130 3.91 184.0 µM 2.90E-5 1 4.70E-5 0.56
12 SGTC_1158 4092-0494 3.80 91.8 µM 4.50E-5 6 7.11E-5 0.08
13 SGTC_2172 5754775 3.78 163.9 µM 4.97E-5 11 7.82E-5 0.30
14 SGTC_615 k087-0205 3.76 167.0 µM 5.41E-5 4 8.46E-5 0.56
15 SGTC_402 epigallocatechin gallate 3.55 10.0 µM 1.30E-4 5 1.93E-4 0.13
16 SGTC_431 k089-0097 3.47 107.0 µM 1.81E-4 iron homeostasis 19 2.64E-4 0.02
17 SGTC_1897 st060201 3.37 15.0 µM 2.58E-4 mitochondrial processes 10 3.69E-4 0.04
18 SGTC_2305 7443522 3.36 69.2 µM 2.71E-4 13 3.87E-4 0.05
19 SGTC_1525 8-methoxypsoralen 3.36 92.5 µM 2.71E-4 DNA damage response 24 3.87E-4 0.01
20 SGTC_3340 9146634 3.34 11.1 µM 2.90E-4 6 4.13E-4 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.90E-10 YPR019W MCM4 het Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
0.103 2.39E-9 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.090 2.06E-7 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.086 5.59E-7 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.084 1.05E-6 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.080 3.46E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.080 3.68E-6 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.079 4.12E-6 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.078 5.31E-6 YOR156C NFI1 hom SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length
0.076 9.83E-6 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.074 1.61E-5 YMR311C GLC8 hom Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
0.073 2.12E-5 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.073 2.15E-5 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.073 2.39E-5 YBR215W HPC2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
0.073 2.59E-5 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein