YDR439W / LRS4

Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR439W / LRS4

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:3.39|P-value:5.41E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:6.52|P-value:1.02E-10 ID:SGTC_71|Compound:0417-1750|FD-Score:22.30|P-value:6.30E-107 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.23|P-value:5.78E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.50|P-value:4.50E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:9.51|P-value:7.00E-21 ID:SGTC_93|Compound:0109-0045|FD-Score:3.95|P-value:6.61E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.24|P-value:1.11E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:5.07|P-value:4.10E-7 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.53|P-value:2.03E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.25|P-value:8.65E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.92|P-value:7.25E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:3.57|P-value:2.83E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.22|P-value:6.16E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:7.27|P-value:6.68E-13 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.50|P-value:2.20E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:4.28|P-value:1.67E-5 ID:SGTC_389|Compound:tpck|FD-Score:4.67|P-value:2.92E-6 ID:SGTC_394|Compound:menadione|FD-Score:6.83|P-value:1.33E-11 ID:SGTC_422|Compound:cantharidin|FD-Score:3.44|P-value:4.47E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.43|P-value:2.86E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.15|P-value:2.84E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.75|P-value:1.43E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.64|P-value:2.15E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.21|P-value:9.97E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.33|P-value:6.44E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.53|P-value:3.23E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.28|P-value:7.84E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:5.26|P-value:1.57E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:5.29|P-value:1.36E-7 ID:SGTC_736|Compound:0958-0254|FD-Score:3.41|P-value:4.89E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:5.14|P-value:2.96E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:4.42|P-value:8.98E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.67|P-value:1.93E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:7.42|P-value:2.17E-13 ID:SGTC_828|Compound:2074-0507|FD-Score:9.26|P-value:6.80E-20 ID:SGTC_829|Compound:1635-0120|FD-Score:4.99|P-value:6.30E-7 ID:SGTC_845|Compound:0330-0138|FD-Score:3.95|P-value:6.60E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:4.51|P-value:6.09E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:4.11|P-value:3.44E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.92|P-value:8.89E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.91|P-value:9.02E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:7.69|P-value:2.92E-14 ID:SGTC_1049|Compound:3226-0134|FD-Score:7.32|P-value:4.58E-13 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.89|P-value:8.18E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:7.82|P-value:1.10E-14 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.61|P-value:2.38E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-5.96|P-value:1.47E-9 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.71|P-value:1.65E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.14|P-value:3.03E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.60|P-value:2.49E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.85|P-value:9.86E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.30|P-value:5.40E-13 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.34|P-value:1.30E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.39|P-value:1.03E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.24|P-value:8.81E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.24|P-value:8.98E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:5.14|P-value:2.99E-7 ID:SGTC_1765|Compound:st044815|FD-Score:3.36|P-value:5.92E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.57|P-value:2.78E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.35|P-value:6.93E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.99|P-value:5.59E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.98|P-value:5.92E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.11|P-value:3.40E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.36|P-value:5.97E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.71|P-value:1.67E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.06|P-value:4.22E-5 ID:SGTC_2093|Compound:5331342|FD-Score:4.69|P-value:2.62E-6 ID:SGTC_2108|Compound:5365811|FD-Score:4.89|P-value:1.03E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.02|P-value:4.92E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.47|P-value:4.02E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.32|P-value:4.26E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.36|P-value:3.68E-4 ID:SGTC_2376|Compound:9072922|FD-Score:5.67|P-value:1.74E-8 ID:SGTC_2387|Compound:9077560|FD-Score:3.41|P-value:4.95E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.23|P-value:2.09E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.46|P-value:2.60E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.69|P-value:1.11E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.73|P-value:1.52E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.99|P-value:5.54E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.24|P-value:9.01E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.00|P-value:5.32E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.39|P-value:5.30E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.34|P-value:6.27E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.40|P-value:3.19E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.97|P-value:3.09E-9 ID:SGTC_3282|Compound:9108498|FD-Score:3.57|P-value:2.83E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.39|P-value:5.41E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:6.52|P-value:1.02E-10 ID:SGTC_71|Compound:0417-1750|FD-Score:22.30|P-value:6.30E-107 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.23|P-value:5.78E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.50|P-value:4.50E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:9.51|P-value:7.00E-21 ID:SGTC_93|Compound:0109-0045|FD-Score:3.95|P-value:6.61E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.24|P-value:1.11E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:5.07|P-value:4.10E-7 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.53|P-value:2.03E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.25|P-value:8.65E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.92|P-value:7.25E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:3.57|P-value:2.83E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.22|P-value:6.16E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:7.27|P-value:6.68E-13 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.50|P-value:2.20E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:4.28|P-value:1.67E-5 ID:SGTC_389|Compound:tpck|FD-Score:4.67|P-value:2.92E-6 ID:SGTC_394|Compound:menadione|FD-Score:6.83|P-value:1.33E-11 ID:SGTC_422|Compound:cantharidin|FD-Score:3.44|P-value:4.47E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.43|P-value:2.86E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.15|P-value:2.84E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.75|P-value:1.43E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.64|P-value:2.15E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.21|P-value:9.97E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.33|P-value:6.44E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.53|P-value:3.23E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.28|P-value:7.84E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:5.26|P-value:1.57E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:5.29|P-value:1.36E-7 ID:SGTC_736|Compound:0958-0254|FD-Score:3.41|P-value:4.89E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:5.14|P-value:2.96E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:4.42|P-value:8.98E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.67|P-value:1.93E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:7.42|P-value:2.17E-13 ID:SGTC_828|Compound:2074-0507|FD-Score:9.26|P-value:6.80E-20 ID:SGTC_829|Compound:1635-0120|FD-Score:4.99|P-value:6.30E-7 ID:SGTC_845|Compound:0330-0138|FD-Score:3.95|P-value:6.60E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:4.51|P-value:6.09E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:4.11|P-value:3.44E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.92|P-value:8.89E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.91|P-value:9.02E-7 ID:SGTC_964|Compound:1287-0107|FD-Score:7.69|P-value:2.92E-14 ID:SGTC_1049|Compound:3226-0134|FD-Score:7.32|P-value:4.58E-13 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.89|P-value:8.18E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:7.82|P-value:1.10E-14 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.61|P-value:2.38E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-5.96|P-value:1.47E-9 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.71|P-value:1.65E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.14|P-value:3.03E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.60|P-value:2.49E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.85|P-value:9.86E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.30|P-value:5.40E-13 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.34|P-value:1.30E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.39|P-value:1.03E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.24|P-value:8.81E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.24|P-value:8.98E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:5.14|P-value:2.99E-7 ID:SGTC_1765|Compound:st044815|FD-Score:3.36|P-value:5.92E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.57|P-value:2.78E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.35|P-value:6.93E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.99|P-value:5.59E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.98|P-value:5.92E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.11|P-value:3.40E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.36|P-value:5.97E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.71|P-value:1.67E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.06|P-value:4.22E-5 ID:SGTC_2093|Compound:5331342|FD-Score:4.69|P-value:2.62E-6 ID:SGTC_2108|Compound:5365811|FD-Score:4.89|P-value:1.03E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.02|P-value:4.92E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.47|P-value:4.02E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.32|P-value:4.26E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.36|P-value:3.68E-4 ID:SGTC_2376|Compound:9072922|FD-Score:5.67|P-value:1.74E-8 ID:SGTC_2387|Compound:9077560|FD-Score:3.41|P-value:4.95E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.23|P-value:2.09E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.46|P-value:2.60E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.69|P-value:1.11E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.73|P-value:1.52E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.99|P-value:5.54E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.24|P-value:9.01E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.00|P-value:5.32E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.39|P-value:5.30E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.34|P-value:6.27E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.40|P-value:3.19E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.97|P-value:3.09E-9 ID:SGTC_3282|Compound:9108498|FD-Score:3.57|P-value:2.83E-4

Top fitness defect scores for YDR439W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_71 0417-1750 22.30 47.8 µM 6.30E-107 Golgi 2 7.31E-111
2 SGTC_91 0417-1751 9.51 58.4 µM 7.00E-21 Golgi 8 9.40E-22
3 SGTC_828 2074-0507 9.26 139.0 µM 6.80E-20 RPP1 & pyrimidine depletion 1 9.95E-21
4 SGTC_1136 pergolide 7.82 1.1 µM 1.10E-14 1 2.57E-15
5 SGTC_964 1287-0107 7.69 19.4 µM 2.92E-14 cell wall 8 7.09E-15
6 SGTC_813 k007-0158 7.42 173.0 µM 2.17E-13 fatty acid desaturase (OLE1) 8 5.70E-14
7 SGTC_1049 3226-0134 7.32 66.0 µM 4.58E-13 2 1.24E-13
8 SGTC_1525 8-methoxypsoralen 7.30 92.5 µM 5.40E-13 DNA damage response 4 1.47E-13
9 SGTC_315 k915-0449 7.27 187.0 µM 6.68E-13 13 1.84E-13
10 SGTC_163 1327-0036 6.92 7.5 µM 7.25E-12 32 2.19E-12
11 SGTC_394 menadione 6.83 8.3 µM 1.33E-11 superoxide 8 4.13E-12
12 SGTC_31 0508-1974 6.52 57.2 µM 1.02E-10 1 3.45E-11
13 SGTC_3247 9135149 5.97 49.5 µM 3.09E-9 DNA damage response 12 1.20E-9
14 SGTC_2376 9072922 5.67 81.3 µM 1.74E-8 6 7.25E-9
15 SGTC_78 0336-0123 5.50 156.8 µM 4.50E-8 7 1.95E-8
16 SGTC_711 k292-0785 5.29 179.0 µM 1.36E-7 DNA intercalators 8 6.19E-8
17 SGTC_697 0508-1955 5.26 564.0 µM 1.57E-7 8 7.19E-8
18 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 5.15 150.0 µM 2.84E-7 Golgi 24 1.33E-7
19 SGTC_770 0389-1121 5.14 67.2 µM 2.96E-7 RPP1 & pyrimidine depletion 9 1.39E-7
20 SGTC_1693 xanthone 5.14 101.9 µM 2.99E-7 DNA damage response 4 1.40E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 8.29E-37 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.171 1.60E-23 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.153 5.22E-19 YER083C GET2 hom Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
0.151 1.38E-18 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.151 1.89E-18 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.141 1.90E-16 YGL020C GET1 hom Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
0.138 7.86E-16 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.137 1.93E-15 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.133 1.27E-14 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.126 2.30E-13 YCR086W CSM1 hom Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.126 2.99E-13 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.117 8.80E-12 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.116 1.58E-11 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.112 8.58E-11 YNL248C RPA49 hom RNA polymerase I subunit A49
0.111 1.17E-10 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene