YDR441C / APT2

Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR441C / APT2

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.10|P-value:6.25E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.11|P-value:5.96E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.32|P-value:2.55E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.95|P-value:9.89E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.19|P-value:4.39E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.18|P-value:6.59E-6 ID:SGTC_442|Compound:cape|FD-Score:4.07|P-value:1.13E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.16|P-value:4.74E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.43|P-value:1.93E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.06|P-value:7.17E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.21|P-value:4.14E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.19|P-value:4.26E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-2.99|P-value:8.76E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.16|P-value:5.04E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.97|P-value:1.67E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.90|P-value:2.43E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.81|P-value:2.71E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.04|P-value:7.21E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.31|P-value:2.69E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.72|P-value:5.40E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.97|P-value:1.75E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.69|P-value:5.96E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.49|P-value:1.30E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.56|P-value:9.58E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.07|P-value:6.91E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.60|P-value:8.12E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.57|P-value:9.82E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.54|P-value:1.08E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.64|P-value:7.56E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.08|P-value:6.23E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-2.98|P-value:9.01E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.34|P-value:2.32E-4 ID:SGTC_2999|Compound:9069765|FD-Score:2.97|P-value:9.83E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.67|P-value:5.72E-7 ID:SGTC_3087|Compound:9117406|FD-Score:-4.08|P-value:9.71E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.81|P-value:3.32E-5 ID:SGTC_3156|Compound:9099931|FD-Score:2.98|P-value:9.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.14|P-value:4.97E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.10|P-value:6.25E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.11|P-value:5.96E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.32|P-value:2.55E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.95|P-value:9.89E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.19|P-value:4.39E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.18|P-value:6.59E-6 ID:SGTC_442|Compound:cape|FD-Score:4.07|P-value:1.13E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.16|P-value:4.74E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.43|P-value:1.93E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.06|P-value:7.17E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.21|P-value:4.14E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.19|P-value:4.26E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-2.99|P-value:8.76E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.16|P-value:5.04E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.97|P-value:1.67E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.90|P-value:2.43E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.81|P-value:2.71E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.04|P-value:7.21E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.31|P-value:2.69E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.72|P-value:5.40E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.97|P-value:1.75E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.69|P-value:5.96E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.49|P-value:1.30E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.56|P-value:9.58E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.07|P-value:6.91E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.60|P-value:8.12E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.57|P-value:9.82E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.54|P-value:1.08E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.64|P-value:7.56E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.08|P-value:6.23E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-2.98|P-value:9.01E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.34|P-value:2.32E-4 ID:SGTC_2999|Compound:9069765|FD-Score:2.97|P-value:9.83E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.67|P-value:5.72E-7 ID:SGTC_3087|Compound:9117406|FD-Score:-4.08|P-value:9.71E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.81|P-value:3.32E-5 ID:SGTC_3156|Compound:9099931|FD-Score:2.98|P-value:9.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.14|P-value:4.97E-4

Top fitness defect scores for YDR441C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1069 diphenylcyclopropenone 4.81 8.5 µM 2.71E-7 14 7.70E-7
2 SGTC_3033 9090887 4.67 49.5 µM 5.72E-7 fatty acid desaturase (OLE1) 10 1.53E-6
3 SGTC_2275 7947463 4.54 200.0 µM 1.08E-6 iron homeostasis 26 2.75E-6
4 SGTC_568 1193-0097 4.43 7.5 µM 1.93E-6 ERAD & cell cycle 114 4.69E-6
5 SGTC_404 fumagillin 4.18 50.0 µM 6.59E-6 15 1.46E-5
6 SGTC_442 cape 4.07 100.0 µM 1.13E-5 11 2.39E-5
7 SGTC_1227 3909-8010 3.97 46.6 µM 1.75E-5 17 3.59E-5
8 SGTC_1047 2043-3044 3.90 82.0 µM 2.43E-5 36 4.86E-5
9 SGTC_1129 3453-1384 3.72 223.0 µM 5.40E-5 47 1.01E-4
10 SGTC_1230 0170-0365 3.69 3.8 µM 5.96E-5 endomembrane recycling 82 1.11E-4
11 SGTC_2563 tomatine 3.64 8.5 µM 7.56E-5 66 1.38E-4
12 SGTC_2113 5491891 3.57 107.0 µM 9.82E-5 TSC3-RPN4 37 1.76E-4
13 SGTC_77 0828-0286 3.56 12.5 µM 1.05E-4 TSC3-RPN4 53 1.87E-4
14 SGTC_1199 1638-0010 3.48 4.5 µM 1.42E-4 endomembrane recycling 44 2.48E-4
15 SGTC_1556 plumbagin 3.41 1.5 µM 1.90E-4 superoxide 31 3.24E-4
16 SGTC_1795 st049545 3.38 62.3 µM 2.15E-4 TSC3-RPN4 22 3.64E-4
17 SGTC_212 3807-4682 3.32 38.8 µM 2.70E-4 tubulin folding & SWR complex 104 4.48E-4
18 SGTC_1914 st062367 3.22 72.6 µM 4.01E-4 46 6.45E-4
19 SGTC_727 3032-0951 3.21 202.0 µM 4.14E-4 52 6.65E-4
20 SGTC_402 epigallocatechin gallate 3.19 10.0 µM 4.39E-4 68 7.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.61E-12 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.104 1.85E-9 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.099 7.67E-9 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.094 5.16E-8 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.092 1.03E-7 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.089 2.53E-7 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.089 2.86E-7 YOL164W BDS1 hom Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources
0.085 7.33E-7 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.083 1.33E-6 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.083 1.53E-6 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.081 2.57E-6 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.080 3.30E-6 YNL231C PDR16 hom Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress
0.080 3.99E-6 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.079 4.05E-6 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.079 4.30E-6 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain