YDR444W_p

Putative hydrolase acting on ester bonds

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR444W / YDR444W

Click on Significant Values for Screen Details ID:SGTC_222|Compound:nsc-310342|FD-Score:3.28|P-value:5.65E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.57|P-value:1.97E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.18|P-value:8.04E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.12|P-value:9.75E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.31|P-value:5.05E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.90|P-value:5.53E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.22|P-value:1.41E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.13|P-value:9.48E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.40|P-value:3.62E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.39|P-value:3.87E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.20|P-value:1.56E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.18|P-value:8.16E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.38|P-value:4.06E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.26|P-value:6.14E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.44|P-value:3.17E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.02|P-value:3.33E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.77|P-value:8.90E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.30|P-value:5.23E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.64|P-value:1.52E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.31|P-value:5.09E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.63|P-value:1.56E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.63|P-value:2.21E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-4.19|P-value:1.59E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.13|P-value:9.40E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.54|P-value:2.16E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-5.22|P-value:1.08E-7 ID:SGTC_2305|Compound:7443522|FD-Score:3.38|P-value:3.96E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.58|P-value:1.92E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.16|P-value:1.79E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-5.68|P-value:8.07E-9 ID:SGTC_2377|Compound:9073351|FD-Score:-3.17|P-value:8.18E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.79|P-value:9.89E-7 ID:SGTC_2437|Compound:5741531|FD-Score:3.71|P-value:1.16E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.23|P-value:6.72E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.16|P-value:8.29E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.85|P-value:6.79E-5 ID:SGTC_2691|Compound:st077356|FD-Score:6.21|P-value:3.52E-10 ID:SGTC_2701|Compound:st077767|FD-Score:3.24|P-value:6.64E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.82|P-value:8.44E-7 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.47|P-value:2.94E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.25|P-value:9.25E-8 ID:SGTC_2830|Compound:7992007|FD-Score:4.16|P-value:1.85E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.22|P-value:7.10E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.22|P-value:6.83E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.23|P-value:6.69E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.15|P-value:1.82E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-3.56|P-value:1.99E-4 ID:SGTC_3009|Compound:9080819|FD-Score:-3.22|P-value:6.84E-4 ID:SGTC_3124|Compound:9127567|FD-Score:5.74|P-value:5.98E-9 ID:SGTC_3125|Compound:9127534|FD-Score:-3.51|P-value:2.45E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.16|P-value:8.48E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.57|P-value:1.92E-4 ID:SGTC_3173|Compound:9105693|FD-Score:5.09|P-value:2.16E-7 ID:SGTC_3244|Compound:9134489|FD-Score:-3.99|P-value:3.60E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-3.28|P-value:5.56E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.28|P-value:1.07E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.28|P-value:5.65E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.57|P-value:1.97E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.18|P-value:8.04E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.12|P-value:9.75E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.31|P-value:5.05E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.90|P-value:5.53E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:4.22|P-value:1.41E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.13|P-value:9.48E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.40|P-value:3.62E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.39|P-value:3.87E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.20|P-value:1.56E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.18|P-value:8.16E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.38|P-value:4.06E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.26|P-value:6.14E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.44|P-value:3.17E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.02|P-value:3.33E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.77|P-value:8.90E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.30|P-value:5.23E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.64|P-value:1.52E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.31|P-value:5.09E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.63|P-value:1.56E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.63|P-value:2.21E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-4.19|P-value:1.59E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.13|P-value:9.40E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.54|P-value:2.16E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-5.22|P-value:1.08E-7 ID:SGTC_2305|Compound:7443522|FD-Score:3.38|P-value:3.96E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.58|P-value:1.92E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.16|P-value:1.79E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-5.68|P-value:8.07E-9 ID:SGTC_2377|Compound:9073351|FD-Score:-3.17|P-value:8.18E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.79|P-value:9.89E-7 ID:SGTC_2437|Compound:5741531|FD-Score:3.71|P-value:1.16E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.23|P-value:6.72E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.16|P-value:8.29E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.85|P-value:6.79E-5 ID:SGTC_2691|Compound:st077356|FD-Score:6.21|P-value:3.52E-10 ID:SGTC_2701|Compound:st077767|FD-Score:3.24|P-value:6.64E-4 ID:SGTC_2712|Compound:st079126|FD-Score:4.82|P-value:8.44E-7 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.47|P-value:2.94E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.25|P-value:9.25E-8 ID:SGTC_2830|Compound:7992007|FD-Score:4.16|P-value:1.85E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.22|P-value:7.10E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.22|P-value:6.83E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.23|P-value:6.69E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.15|P-value:1.82E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-3.56|P-value:1.99E-4 ID:SGTC_3009|Compound:9080819|FD-Score:-3.22|P-value:6.84E-4 ID:SGTC_3124|Compound:9127567|FD-Score:5.74|P-value:5.98E-9 ID:SGTC_3125|Compound:9127534|FD-Score:-3.51|P-value:2.45E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.16|P-value:8.48E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.57|P-value:1.92E-4 ID:SGTC_3173|Compound:9105693|FD-Score:5.09|P-value:2.16E-7 ID:SGTC_3244|Compound:9134489|FD-Score:-3.99|P-value:3.60E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-3.28|P-value:5.56E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.28|P-value:1.07E-5

Top fitness defect scores for YDR444W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2691 st077356 6.21 60.2 µM 3.52E-10 5 2.62E-10
2 SGTC_3124 9127567 5.74 49.5 µM 5.98E-9 DNA damage response 4 4.64E-9
3 SGTC_2761 levamisole 5.25 97.9 µM 9.25E-8 3 7.45E-8
4 SGTC_3173 9105693 5.09 49.5 µM 2.16E-7 6 1.76E-7
5 SGTC_2712 st079126 4.82 47.7 µM 8.44E-7 3 7.02E-7
6 SGTC_2385 9074692 4.79 200.0 µM 9.89E-7 23 8.25E-7
7 SGTC_1687 st020778 4.63 55.4 µM 2.21E-6 143 1.86E-6
8 SGTC_566 0958-0068 4.22 16.5 µM 1.41E-5 RSC & ERG11 15 1.22E-5
9 SGTC_996 3970-0799 4.20 1.8 µM 1.56E-5 75 1.36E-5
10 SGTC_2830 7992007 4.16 71.4 µM 1.85E-5 16 1.61E-5
11 SGTC_1195 1502-0147 4.02 41.1 µM 3.33E-5 28 2.92E-5
12 SGTC_528 3492-0019 3.90 172.0 µM 5.53E-5 calcium & mitochondrial duress 224 4.88E-5
13 SGTC_2601 securinine 3.85 100.0 µM 6.79E-5 32 6.01E-5
14 SGTC_2437 5741531 3.71 144.2 µM 1.16E-4 41 1.03E-4
15 SGTC_1853 st056710 3.68 91.2 µM 1.29E-4 amide catabolism 37 1.15E-4
16 SGTC_1403 3909-7815 3.64 62.9 µM 1.52E-4 23 1.36E-4
17 SGTC_769 0302-0231 3.60 76.0 µM 1.80E-4 58 1.61E-4
18 SGTC_2309 7664088 3.58 163.9 µM 1.92E-4 54 1.72E-4
19 SGTC_297 0986-0032 3.57 24.0 µM 1.97E-4 60S ribosome export 10 1.77E-4
20 SGTC_2719 novobiocin 3.47 32.6 µM 2.94E-4 9 2.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.11E-13 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.116 1.85E-11 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.107 4.71E-10 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.099 8.05E-9 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.098 1.40E-8 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.095 3.21E-8 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.095 3.88E-8 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.094 4.77E-8 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.093 7.82E-8 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.091 1.43E-7 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.089 2.27E-7 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.089 2.47E-7 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.087 4.01E-7 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.087 4.19E-7 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.087 4.30E-7 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact