YDR448W / ADA2

Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR448W / ADA2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.79|P-value:9.34E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.74|P-value:6.31E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.71|P-value:6.85E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.85|P-value:7.72E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:5.16|P-value:9.80E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.67|P-value:5.87E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:5.41|P-value:3.77E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:3.91|P-value:6.47E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.20|P-value:2.74E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.02|P-value:2.68E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.52|P-value:1.15E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:4.30|P-value:1.98E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.71|P-value:6.89E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.44|P-value:1.25E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.78|P-value:9.57E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.88|P-value:7.16E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:9.77|P-value:1.83E-16 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.39|P-value:1.47E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.00|P-value:2.89E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.31|P-value:1.92E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.83|P-value:8.20E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.49|P-value:1.06E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.74|P-value:4.62E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-4.07|P-value:2.29E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.66|P-value:7.80E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.50|P-value:2.62E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.69|P-value:5.37E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:6.07|P-value:2.39E-7 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.80|P-value:5.23E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.70|P-value:5.25E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:7.31|P-value:6.02E-10 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.12|P-value:3.48E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.76|P-value:4.30E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.33|P-value:1.81E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:6.43|P-value:4.70E-8 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.81|P-value:7.45E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.78|P-value:9.55E-4 ID:SGTC_1623|Compound:st003709|FD-Score:6.52|P-value:3.16E-8 ID:SGTC_1624|Compound:st003710|FD-Score:4.81|P-value:3.62E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.13|P-value:1.13E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.27|P-value:1.21E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.85|P-value:7.77E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.91|P-value:4.82E-7 ID:SGTC_1750|Compound:st081859|FD-Score:9.07|P-value:2.07E-14 ID:SGTC_1962|Compound:st076595|FD-Score:3.87|P-value:7.39E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.24|P-value:2.41E-4 ID:SGTC_2036|Compound:5160441|FD-Score:7.85|P-value:3.25E-11 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.93|P-value:6.19E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.39|P-value:1.50E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.54|P-value:9.05E-5 ID:SGTC_2322|Compound:7413319|FD-Score:8.47|P-value:8.81E-13 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.92|P-value:4.49E-9 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.90|P-value:6.81E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.28|P-value:6.31E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.16|P-value:3.10E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.17|P-value:9.64E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:8.94|P-value:4.60E-14 ID:SGTC_2806|Compound:7952793|FD-Score:-3.69|P-value:7.22E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.41|P-value:1.38E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.29|P-value:2.04E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-4.26|P-value:1.24E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.77|P-value:2.11E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.80|P-value:9.09E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.61|P-value:9.02E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.55|P-value:8.86E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.94|P-value:6.02E-4 ID:SGTC_3350|Compound:9150499|FD-Score:6.02|P-value:2.95E-7 ID:SGTC_3351|Compound:9150312|FD-Score:4.27|P-value:2.22E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.79|P-value:9.34E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.74|P-value:6.31E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.71|P-value:6.85E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.85|P-value:7.72E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:5.16|P-value:9.80E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.67|P-value:5.87E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:5.41|P-value:3.77E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:3.91|P-value:6.47E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.20|P-value:2.74E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.02|P-value:2.68E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.52|P-value:1.15E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:4.30|P-value:1.98E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.71|P-value:6.89E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.44|P-value:1.25E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.78|P-value:9.57E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.88|P-value:7.16E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:9.77|P-value:1.83E-16 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.39|P-value:1.47E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.00|P-value:2.89E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.31|P-value:1.92E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.83|P-value:8.20E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.49|P-value:1.06E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.74|P-value:4.62E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:-4.07|P-value:2.29E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.66|P-value:7.80E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.50|P-value:2.62E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.69|P-value:5.37E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:6.07|P-value:2.39E-7 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.80|P-value:5.23E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.70|P-value:5.25E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:7.31|P-value:6.02E-10 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.12|P-value:3.48E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.76|P-value:4.30E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.33|P-value:1.81E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:6.43|P-value:4.70E-8 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.81|P-value:7.45E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.78|P-value:9.55E-4 ID:SGTC_1623|Compound:st003709|FD-Score:6.52|P-value:3.16E-8 ID:SGTC_1624|Compound:st003710|FD-Score:4.81|P-value:3.62E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.13|P-value:1.13E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.27|P-value:1.21E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.85|P-value:7.77E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.91|P-value:4.82E-7 ID:SGTC_1750|Compound:st081859|FD-Score:9.07|P-value:2.07E-14 ID:SGTC_1962|Compound:st076595|FD-Score:3.87|P-value:7.39E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.24|P-value:2.41E-4 ID:SGTC_2036|Compound:5160441|FD-Score:7.85|P-value:3.25E-11 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.93|P-value:6.19E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.39|P-value:1.50E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.54|P-value:9.05E-5 ID:SGTC_2322|Compound:7413319|FD-Score:8.47|P-value:8.81E-13 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.92|P-value:4.49E-9 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.90|P-value:6.81E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.28|P-value:6.31E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.16|P-value:3.10E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.17|P-value:9.64E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:8.94|P-value:4.60E-14 ID:SGTC_2806|Compound:7952793|FD-Score:-3.69|P-value:7.22E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.41|P-value:1.38E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.29|P-value:2.04E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-4.26|P-value:1.24E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.77|P-value:2.11E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.80|P-value:9.09E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.61|P-value:9.02E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.55|P-value:8.86E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.94|P-value:6.02E-4 ID:SGTC_3350|Compound:9150499|FD-Score:6.02|P-value:2.95E-7 ID:SGTC_3351|Compound:9150312|FD-Score:4.27|P-value:2.22E-4

Top fitness defect scores for YDR448W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_429 1112-0049 9.77 25.5 µM 1.83E-16 DNA damage response 2 7.45E-23
2 SGTC_1750 st081859 9.07 2.4 µM 2.07E-14 endomembrane recycling 50 6.06E-20
3 SGTC_2603 homopterocarpin 8.94 100.0 µM 4.60E-14 1 1.88E-19
4 SGTC_2322 7413319 8.47 38.2 µM 8.81E-13 ERAD & cell cycle 30 1.24E-17
5 SGTC_2036 5160441 7.85 105.0 µM 3.25E-11 NEO1 29 2.07E-15
6 SGTC_1281 0884-0031 7.31 11.8 µM 6.02E-10 fatty acid desaturase (OLE1) 4 1.30E-13
7 SGTC_2409 alverine citrate 6.92 64.0 µM 4.49E-9 17 2.25E-12
8 SGTC_1623 st003709 6.52 20.3 µM 3.16E-8 calcium & mitochondrial duress 9 3.58E-11
9 SGTC_1471 k673-0312 6.43 37.0 µM 4.70E-8 RNA processing & uracil transport 4 6.27E-11
10 SGTC_1121 fusaric acid 6.07 630.5 nM 2.39E-7 10 6.27E-10
11 SGTC_3350 9150499 6.02 3.6 µM 2.95E-7 cell wall 14 8.47E-10
12 SGTC_1745 st081495 5.91 74.0 µM 4.82E-7 RNA processing & uracil transport 28 1.70E-9
13 SGTC_1482 3346-2049 5.81 8.5 µM 7.45E-7 14 3.15E-9
14 SGTC_1083 didemethylchlorpromazine sulfoxide 5.50 707.4 nM 2.62E-6 redox potentiating 36 1.87E-8
15 SGTC_162 k030-0015 5.41 37.8 µM 3.77E-6 iron homeostasis 6 3.13E-8
16 SGTC_2500 5-alpha-androstan-3,17-dione 5.28 61.4 µM 6.31E-6 17 6.49E-8
17 SGTC_2596 sinensetin 5.17 100.0 µM 9.64E-6 9 1.18E-7
18 SGTC_121 0557-0495 5.16 61.3 µM 9.80E-6 calcium & mitochondrial duress 26 1.21E-7
19 SGTC_1674 st016616 5.13 23.6 µM 1.13E-5 8 1.49E-7
20 SGTC_1624 st003710 4.81 6.2 µM 3.62E-5 calcium & mitochondrial duress 26 7.72E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.34E-19 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.150 1.95E-18 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.143 9.36E-17 YGR252W GCN5 hom Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
0.142 1.11E-16 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.139 5.87E-16 YDR176W NGG1 hom Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
0.138 9.75E-16 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.135 4.06E-15 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.131 2.12E-14 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.128 1.14E-13 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.126 3.10E-13 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.124 6.83E-13 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.120 2.92E-12 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.120 2.71E-12 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.120 3.61E-12 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.118 7.68E-12 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling